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Research Output

2020
2019
Open Access
2017

Stress-Adaptive Response in Ovarian Cancer Drug Resistance: Role of TRAP1 in Oxidative Metabolism-Driven Inflammation

Amoroso, M. R., Matassa, D. S., Agliarulo, I., Avolio, R., Maddalena, F., Condelli, V., Landriscina, M. & Esposito, F., Jan 1 2017, Advances in Protein Chemistry and Structural Biology. Academic Press Inc., Vol. 108. p. 163-198 36 p. (Advances in Protein Chemistry and Structural Biology; vol. 108).

Research output: Chapter in Book/Report/Conference proceedingChapter

TRAP1: a viable therapeutic target for future cancer treatments?

Lettini, G., Maddalena, F., Sisinni, L., Condelli, V., Matassa, D. S., Costi, M. P., Simoni, D., Esposito, F. & Landriscina, M., Aug 2017, In : Expert Opinion on Therapeutic Targets. 21, 8, p. 805-815 11 p.

Research output: Contribution to journalReview article

TRAP1 controls cell cycle G2-M transition through the regulation of CDK1 and MAD2 expression/ubiquitination

Sisinni, L., Maddalena, F., Condelli, V., Pannone, G., Simeon, V., Li Bergolis, V., Lopes, E., Piscazzi, A., Matassa, D. S., Mazzoccoli, C., Nozza, F., Lettini, G., Amoroso, M. R., Bufo, P., Esposito, F. & Landriscina, M., Sep 2017, In : Journal of Pathology. 243, 1, p. 123-134 12 p.

Research output: Contribution to journalArticle

2016

Oxidative metabolism drives inflammation-induced platinum resistance in human ovarian cancer

Matassa, D. S., Amoroso, M. R., Lu, H., Avolio, R., Arzeni, D., Procaccini, C., Faicchia, D., Maddalena, F., Simeon, V., Agliarulo, I., Zanini, E., Mazzoccoli, C., Recchi, C., Stronach, E., Marone, G., Gabra, H., Matarese, G., Landriscina, M. & Esposito, F., May 20 2016, (Accepted/In press) In : Cell Death and Differentiation.

Research output: Contribution to journalArticle

TRAP1 regulates stemness through Wnt/β-catenin pathway in human colorectal carcinoma

Lettini, G., Sisinni, L., Condelli, V., Matassa, D. S., Simeon, V., Maddalena, F., Gemei, M., Lopes, E., Vita, G., Del Vecchio, L., Esposito, F. & Landriscina, M., Nov 1 2016, In : Cell Death and Differentiation. 23, 11, p. 1792-1803 12 p.

Research output: Contribution to journalArticle

2015

Estimation of coronary flow reserve by sestamibi imaging in patients with mild hypertension and normal coronary arteries

Storto, G., Gallicchio, R., Maddalena, F., Pellegrino, T., Petretta, M., Fiumara, G. & Cuocolo, A., Sep 1 2015, In : Quarterly Journal of Nuclear Medicine and Molecular Imaging. 59, 3, p. 336-341 6 p.

Research output: Contribution to journalArticle

Evaluation of glucose uptake in normal and cancer cell lines by positron emission tomography

Maddalena, F., Lettini, G., Gallicchio, R., Sisinni, L., Simeon, V., Nardelli, A., Venetucci, A. A., Storto, G. & Landriscina, M., Sep 1 2015, In : Molecular Imaging. 14, 8, p. 490-498 9 p.

Research output: Contribution to journalArticle

Targeting TRAP1 as a downstream effector of BRAF cytoprotective pathway: A novel strategy for human BRAF-driven colorectal carcinoma

Condelli, V., Maddalena, F., Sisinni, L., Lettini, G., Matassa, D. S., Piscazzi, A., Palladino, G., Amoroso, M. R., Esposito, F. & Landriscina, M., 2015, In : Oncotarget. 6, 26, p. 22298-22309 12 p.

Research output: Contribution to journalArticle

TRAP1 controls cell migration of cancer cells in metabolic stress conditions: Correlations with AKT/p70S6K pathways

Agliarulo, I., Matassa, D. S., Amoroso, M. R., Maddalena, F., Sisinni, L., Sepe, L., Ferrari, M. C., Arzeni, D., Avolio, R., Paolella, G., Landriscina, M. & Esposito, F., Oct 1 2015, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1853, 10, p. 2570-2579 10 p.

Research output: Contribution to journalArticle

2014

Palliative treatment of bone metastases with samarium-153 EDTMP at onset of pain

Gallicchio, R., Giacomobono, S., Nardelli, A., Pellegrino, T., Simeon, V., Gattozzi, D., Maddalena, F., Mainenti, P. & Storto, G., 2014, In : Journal of Bone and Mineral Metabolism. 32, 4, p. 434-440 7 p.

Research output: Contribution to journalArticle

TRAP1-dependent regulation of p70S6K is involved in the attenuation of protein synthesis and cell migration: Relevance in human colorectal tumors

Matassa, D. S., Agliarulo, I., Amoroso, M. R., Maddalena, F., Sepe, L., Ferrari, M. C., Sagar, V., D'Amico, S., Loreni, F., Paolella, G., Landriscina, M. & Esposito, F., Dec 1 2014, In : Molecular Oncology. 8, 8, p. 1482-1494 13 p.

Research output: Contribution to journalArticle

TRAP1 is involved in BRAF regulation and downstream attenuation of ERK phosphorylation and cell-cycle progression: A novel target for BRAF-mutated colorectal tumors

Condelli, V., Piscazzi, A., Sisinni, L., Matassa, D. S., Maddalena, F., Lettini, G., Simeon, V., Palladino, G., Amoroso, M. R., Trino, S., Esposito, F. & Landriscina, M., Nov 15 2014, In : Cancer Research. 74, 22, p. 6693-6704 12 p.

Research output: Contribution to journalArticle

TRAP1 role in endoplasmic reticulum stress protection favors resistance to anthracyclins in breast carcinoma cells

Sisinni, L., Maddalena, F., Lettini, G., Condelli, V., Matassa, D. S., Esposito, F. & Landriscina, M., Feb 2014, In : International Journal of Oncology. 44, 2, p. 573-582 10 p.

Research output: Contribution to journalArticle

2013

Resistance to paclitxel in breast carcinoma cells requires a quality control of mitochondrial antiapoptotic proteins by TRAP1

Maddalena, F., Sisinni, L., Lettini, G., Condelli, V., Matassa, D. S., Piscazzi, A., Amoroso, M. R., La Torre, G., Esposito, F. & Landriscina, M., Oct 2013, In : Molecular Oncology. 7, 5, p. 895-906 12 p.

Research output: Contribution to journalArticle

Translational control in the stress adaptive response of cancer cells: A novel role for the heat shock protein TRAP1

Matassa, D. S., Amoroso, M. R., Agliarulo, I., Maddalena, F., Sisinni, L., Paladino, S., Romano, S., Romano, M. F., Sagar, V., Loreni, F., Landriscina, M. & Esposito, F., Oct 2013, In : Cell Death and Disease. 4, 10, e851.

Research output: Contribution to journalArticle

2012

Activation of the RAS/RAF/ERK signaling pathway contributes to resistance to sunitinib in thyroid carcinoma cell lines

Piscazzi, A., Costantino, E., Maddalena, F., Natalicchio, M. I., Gerardi, A. M. T., Antonetti, R., Cignarelli, M. & Landriscina, M., Jun 2012, In : Journal of Clinical Endocrinology and Metabolism. 97, 6

Research output: Contribution to journalArticle

New insights into TRAP1 pathway

Matassa, D. S., Amoroso, M. R., Maddalena, F., Landriscina, M. & Esposito, F., 2012, In : American Journal of Cancer Research. 2, 2, p. 235-248 14 p.

Research output: Contribution to journalReview article

TRAP1 and the proteasome regulatory particle TBP7/Rpt3 interact in the endoplasmic reticulum and control cellular ubiquitination of specific mitochondrial proteins

Amoroso, M. R., Matassa, D. S., Laudiero, G., Egorova, A. V., Polishchuk, R. S., Maddalena, F., Piscazzi, A., Paladino, S., Sarnataro, D., Garbi, C., Landriscina, M. & Esposito, F., Apr 2012, In : Cell Death and Differentiation. 19, 4, p. 592-602 11 p.

Research output: Contribution to journalArticle

2011

Sorcin induces a drug-resistant phenotype in human colorectal cancer by modulating Ca 2+ homeostasis

Maddalena, F., Laudiero, G., Piscazzi, A., Secondo, A., Scorziello, A., Lombardi, V., Matassa, D. S., Fersini, A., Neri, V., Esposito, F. & Landriscina, M., Dec 15 2011, In : Cancer Research. 71, 24, p. 7659-7669 11 p.

Research output: Contribution to journalArticle

2010

Erlotinib enhances the proapoptotic activity of cytotoxic agents and synergizes with paclitaxel in poorly-differentiated thyroid carcinoma cells

Landriscina, M., Maddalena, F., Fabiano, A., Piscazzi, A., La Macchia, O. & Cignarelli, M., Feb 2010, In : Anticancer Research. 30, 2, p. 473-480 8 p.

Research output: Contribution to journalArticle

Mitochondrial chaperone trap1 and the calcium binding protein sorcin interact and protect cells against apoptosis induced by antiblastic agents

Landriscina, M., Laudiero, G., Maddalena, F., Amoroso, M. R., Piscazzi, A., Cozzolino, F., Monti, M., Garbi, C., Fersini, A., Pucci, P. & Esposito, F., Aug 15 2010, In : Cancer Research. 70, 16, p. 6577-6586 10 p.

Research output: Contribution to journalArticle

2009

Adaptation to oxidative stress, chemoresistance, and cell survival

Landriscina, M., Maddalena, F., Laudiero, G. & Esposito, F., Nov 1 2009, In : Antioxidants and Redox Signaling. 11, 11, p. 2701-2716 16 p.

Research output: Contribution to journalArticle

Targeting epidermal growth factor receptor 1 signaling in human thyroid-stimulating hormone-independent thyroid carcinoma FRO cells results in a more chemosensitive and less angiogenic phenotype.

Landriscina, M., Piscazzi, A., Fabiano, A., Maddalena, F., Costantino, E., Farese, A., Bufo, P. & Cignarelli, M., Jun 2009, In : Thyroid. 19, 6, p. 629-637 9 p.

Research output: Contribution to journalArticle

TRAP1, a novel mitochondrial chaperone responsible for multi-drug resistance and protection from apoptotis in human colorectal carcinoma cells

Costantino, E., Maddalena, F., Calise, S., Piscazzi, A., Tirino, V., Fersini, A., Ambrosi, A., Neri, V., Esposito, F. & Landriscina, M., Jun 28 2009, In : Cancer Letters. 279, 1, p. 39-46 8 p.

Research output: Contribution to journalArticle