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Research Output 2010 2019

2019

Autophagy and cancer stem cells: molecular mechanisms and therapeutic applications

Nazio, F., Bordi, M., Cianfanelli, V., Locatelli, F. & Cecconi, F., Mar 2019, In : Cell Death and Differentiation. 26, 4, p. 690-702 13 p.

Research output: Contribution to journalReview article

Neoplastic Stem Cells
Autophagy
Mitochondrial Degradation
Neoplasms
Therapeutics

Selective autophagy maintains centrosome integrity and accurate mitosis by turnover of centriolar satellites

Holdgaard, S. G., Cianfanelli, V., Pupo, E., Lambrughi, M., Lubas, M., Nielsen, J. C., Eibes, S., Maiani, E., Harder, L. M., Wesch, N., Foged, M. M., Maeda, K., Nazio, F., de la Ballina, L. R., Dötsch, V., Brech, A., Frankel, L. B., Jäättelä, M., Locatelli, F., Barisic, M. & 8 others, Andersen, J. S., Bekker-Jensen, S., Lund, A. H., Rogov, V. V., Papaleo, E., Lanzetti, L., De Zio, D. & Cecconi, F., Sep 13 2019, In : Nature Communications. 10, 1, p. 4176

Research output: Contribution to journalArticle

mitosis
Centrosome
Autophagy
Mitosis
integrity
2018

AMBRA1 Controls Regulatory T-Cell Differentiation and Homeostasis Upstream of the FOXO3-FOXP3 Axis

Becher, J., Simula, L., Volpe, E., Procaccini, C., La Rocca, C., D'Acunzo, P., Cianfanelli, V., Strappazzon, F., Caruana, I., Nazio, F., Weber, G., Gigantino, V., Botti, G., Ciccosanti, F., Borsellino, G., Campello, S., Mandolesi, G., De Bardi, M., Fimia, G. M., D'Amelio, M. & 11 others, Ruffini, F., Furlan, R., Centonze, D., Martino, G., Braghetta, P., Chrisam, M., Bonaldo, P., Matarese, G., Locatelli, F., Battistini, L. & Cecconi, F., Dec 3 2018, In : Developmental Cell. p. 592-607 16 p.

Research output: Contribution to journalArticle

T-cells
Regulatory T-Lymphocytes
Cell Differentiation
Homeostasis
Disease Susceptibility

AMBRA1 Controls Regulatory T-Cell Differentiation and Homeostasis Upstream of the FOXO3-FOXP3 Axis

Becher, J., Simula, L., Volpe, E., Procaccini, C., La Rocca, C., D'Acunzo, P., Cianfanelli, V., Strappazzon, F., Caruana, I., Nazio, F., Weber, G., Gigantino, V., Botti, G., Ciccosanti, F., Borsellino, G., Campello, S., Mandolesi, G., De Bardi, M., Fimia, G. M., D'Amelio, M. & 11 others, Ruffini, F., Furlan, R., Centonze, D., Martino, G., Braghetta, P., Chrisam, M., Bonaldo, P., Matarese, G., Locatelli, F., Battistini, L. & Cecconi, F., 2018, In : Developmental Cell. 47, 5, p. 592-607.e6

Research output: Contribution to journalArticle

AMBRA1 Controls Regulatory T-Cell Differentiation and Homeostasis Upstream of the FOXO3-FOXP3 Axis

Becher, J., Simula, L., Volpe, E., Procaccini, C., La Rocca, C., D'Acunzo, P., Cianfanelli, V., Strappazzon, F., Caruana, I., Nazio, F., Weber, G., Gigantino, V., Botti, G., Ciccosanti, F., Borsellino, G., Campello, S., Mandolesi, G., De Bardi, M., Fimia, G. M., D'Amelio, M. & 11 others, Ruffini, F., Furlan, R., Centonze, D., Martino, G., Braghetta, P., Chrisam, M., Bonaldo, P., Matarese, G., Locatelli, F., Battistini, L. & Cecconi, F., Dec 3 2018, In : Developmental Cell. 47, 5, p. 592-607 15 p.

Research output: Contribution to journalArticle

T-cells
Regulatory T-Lymphocytes
Cell Differentiation
Homeostasis
Complex networks

Effects of caloric restriction on neuropathic pain, peripheral nerve degeneration and inflammation in normometabolic and autophagy defective prediabetic Ambra1 mice

Coccurello, R., Nazio, F., Rossi, C., De Angelis, F., Vacca, V., Giacovazzo, G., Procacci, P., Magnaghi, V., Ciavardelli, D. & Marinelli, S., Dec 1 2018, In : PLoS One. 13, 12, e0208596.

Research output: Contribution to journalArticle

Nerve Degeneration
Caloric Restriction
autophagy
peripheral nerves
Autophagy

Rapamycin and fasting sustain autophagy response activated by ischemia/reperfusion injury and promote retinal ganglion cell survival

Russo, R., Varano, G. P., Adornetto, A., Nazio, F., Tettamanti, G., Girardello, R., Cianfanelli, V., Cavaliere, F., Morrone, L. A., Corasaniti, M. T., Cecconi, F., Bagetta, G. & Nucci, C., Sep 24 2018, In : Cell Death and Disease. 9, 10, p. 981

Research output: Contribution to journalArticle

Retinal Ganglion Cells
Autophagy
Sirolimus
Reperfusion Injury
Fasting
2017

Autophagy up and down by outsmarting the incredible ULK

Nazio, F. & Cecconi, F., May 4 2017, In : Autophagy. 13, 5, p. 967-968 2 p.

Research output: Contribution to journalComment/debate

Autophagy
Phosphorylation
Personnel Selection
Ubiquitin-Protein Ligases
Ubiquitination

The Close interconnection between mitochondrial dynamics and mitophagy in cancer

Bordi, M., Nazio, F. & Campello, S., May 1 2017, In : Frontiers in Oncology. 7, 81.

Research output: Contribution to journalReview article

Mitochondrial Degradation
Mitochondrial Dynamics
Mitochondria
Organelles
Cell Physiological Phenomena

The mitochondrial dynamics in cancer and immune-surveillance

Simula, L., Nazio, F. & Campello, S., Dec 1 2017, In : Seminars in Cancer Biology. 47, p. 29-42 14 p.

Research output: Contribution to journalReview article

Mitochondrial Dynamics
Neoplasms
Immune System
Mitochondria
Aptitude

The mitochondrial dynamics in cancer and immune-surveillance

Simula, L., Nazio, F. & Campello, S., Dec 2017, In : Seminars in Cancer Biology. 47, p. 29-42 14 p.

Research output: Contribution to journalReview article

Mitochondrial Dynamics
Neoplasms
Immune System
Mitochondria
Aptitude

ULK1 ubiquitylation is regulated by phosphorylation on its carboxy terminus

Nazio, F., Carinci, M. & Cecconi, F., Oct 2 2017, In : Cell Cycle. 16, 19, p. 1744-1747 4 p.

Research output: Contribution to journalComment/debate

Ubiquitination
Autophagy
Phosphorylation
Acetylesterase
Post Translational Protein Processing
2016

Autophagy regulates satellite cell ability to regenerate normal and dystrophic muscles

Fiacco, E., Castagnetti, F., Bianconi, V., Madaro, L., De Bardi, M., Nazio, F., D'Amico, A., Bertini, E. S., Cecconi, F., Puri, P. L. & Latella, L., Jul 22 2016, (Accepted/In press) In : Cell Death and Differentiation.

Research output: Contribution to journalArticle

Autophagy
Duchenne Muscular Dystrophy
Muscles
Regeneration
Inbred mdx Mouse

Autophagy regulates satellite cell ability to regenerate normal and dystrophic muscles

Fiacco, E., Castagnetti, F., Bianconi, V., Madaro, L., de Bardi, M., Nazio, F., D'Amico, A., Bertini, E., Cecconi, F., Puri, P. L. & Latella, L., Jul 22 2016, (Accepted/In press) In : Cell Death and Differentiation.

Research output: Contribution to journalArticle

Autophagy
Duchenne Muscular Dystrophy
Muscles
Regeneration
Inbred mdx Mouse

Fine-tuning of ULK1 mRNA and protein levels is required for autophagy oscillation

Nazio, F., Carinci, M., Valacca, C., Bielli, P., Strappazzon, F., Antonioli, M., Ciccosanti, F., Rodolfo, C., Campello, S., Fimia, G. M., Sette, C., Bonaldo, P. & Cecconi, F., 2016, In : Journal of Cell Biology. 215, 6, p. 841-856 16 p.

Research output: Contribution to journalArticle

Autophagy
Messenger RNA
Proteins
TOR Serine-Threonine Kinases
Ubiquitin-Protein Ligases

Fine-tuning of ULK1 mRNA and protein levels is required for autophagy oscillation

Nazio, F., Carinci, M., Valacca, C., Bielli, P., Strappazzon, F., Antonioli, M., Ciccosanti, F., Rodolfo, C., Campello, S., Fimia, G. M., Sette, C., Bonaldo, P. & Cecconi, F., Dec 19 2016, In : Journal of Cell Biology. 215, 6, p. 841-856 16 p.

Research output: Contribution to journalArticle

Autophagy
Messenger RNA
Proteins
TOR Serine-Threonine Kinases
Ubiquitin-Protein Ligases

Macroautophagy inhibition maintains fragmented mitochondria to foster T cell receptor-dependent apoptosis

Corrado, M., Mariotti, F. R., Trapani, L., Taraborrelli, L., Nazio, F., Cianfanelli, V., Soriano, M. E., Schrepfer, E., Cecconi, F., Scorrano, L. & Campello, S., 2016, In : EMBO Journal. 35, 16, p. 1793-1809 17 p.

Research output: Contribution to journalArticle

Macroautophagy inhibition maintains fragmented mitochondria to foster T cell receptor-dependent apoptosis

Corrado, M., Mariotti, F. R., Trapani, L., Taraborrelli, L., Nazio, F., Cianfanelli, V., Soriano, M. E., Schrepfer, E., Cecconi, F., Scorrano, L. & Campello, S., Aug 15 2016, In : EMBO Journal. 35, 16, p. 1793-1809 17 p.

Research output: Contribution to journalArticle

Mitochondria
Autophagy
Cell death
T-Cell Antigen Receptor
Chemical activation

Prosurvival AMBRA1 turns into a proapoptotic BH3-like protein during mitochondrial apoptosis

Strappazzon, F., Di Rita, A., Cianfanelli, V., D'Orazio, M., Nazio, F., Fimia, G. M. & Cecconi, F., Jun 2 2016, In : Autophagy. 12, 6, p. 963-975 13 p.

Research output: Contribution to journalArticle

Mitochondrial Proteins
Autophagy
Apoptosis
Cell Death
Therapeutics

Prosurvival AMBRA1 turns into a proapoptotic BH3-like protein during mitochondrial apoptosis

Strappazzon, F., Di Rita, A., Cianfanelli, V., D'Orazio, M., Nazio, F., Fimia, G. M. & Cecconi, F., Jun 2 2016, In : Autophagy. 12, 6, p. 963-975 13 p.

Research output: Contribution to journalArticle

Mitochondrial Proteins
Autophagy
Apoptosis
Cell Death
Therapeutics
2015

Ambra1 at a glance

Cianfanelli, V., De Zio, D., Di Bartolomeo, S., Nazio, F., Strappazzon, F. & Cecconi, F., 2015, In : Journal of Cell Science. 128, 11, p. 2003-2008 6 p.

Research output: Contribution to journalArticle

Autophagy
Ubiquitination
Cullin Proteins
Posters
Caspases

AMBRA1 is able to induce mitophagy via LC3 binding, regardless of PARKIN and p62/SQSTM1

Strappazzon, F., Nazio, F., Corrado, M., Cianfanelli, V., Romagnoli, A., Fimia, G. M., Campello, S., Nardacci, R., Piacentini, M., Campanella, M. & Cecconi, F., 2015, In : Cell Death and Differentiation. 22, 3, p. 419-432 14 p.

Research output: Contribution to journalArticle

Mitochondrial Degradation
Autophagy
Mitochondria
Mitochondrial Membranes
Neurodegenerative Diseases

AMBRA1 links autophagy to cell proliferation and tumorigenesis by promoting c-Myc dephosphorylation and degradation

Cianfanelli, V., Fuoco, C., Lorente, M., Salazar, M., Quondamatteo, F., Gherardini, P. F., De Zio, D., Nazio, F., Antonioli, M., D'Orazio, M., Skobo, T., Bordi, M., Rohde, M., Dalla Valle, L., Helmer-Citterich, M., Gretzmeier, C., Dengjel, J., Fimia, G. M., Piacentini, M., Di Bartolomeo, S. & 2 others, Velasco, G. & Cecconi, F., Jan 1 2015, In : Nature Cell Biology. 17, 1, p. 20-30 11 p.

Research output: Contribution to journalArticle

Autophagy
Carcinogenesis
Cell Proliferation
myc Genes
Tumor Suppressor Genes

Erratum: AMBRA1 links autophagy to cell proliferation and tumorigenesis by promoting c-Myc dephosphorylation and degradation (Nature Cell Biology (2015) 17 (20-30))

Cianfanelli, V., Fuoco, C., Lorente, M., Salazar, M., Quondamatteo, F., Gherardini, P. F., De Zio, D., Nazio, F., Antonioli, M., D'orazio, M., Skobo, T., Bordi, M., Rohde, M., Valle, L. D., Helmer-Citterich, M., Gretzmeier, C., Dengjel, J., Fimia, G. M., Piacentini, M., Di Bartolomeo, S. & 2 others, Velasco, G. & Cecconi, F., May 5 2015, In : Nature Cell Biology. 17, 5, p. 706 1 p.

Research output: Contribution to journalArticle

2014

Acute focal brain damage alters mitochondrial dynamics and autophagy in axotomized neurons

Cavallucci, V., Bisicchia, E., Cencioni, M. T., Ferri, A., Latini, L., Nobili, A., Biamonte, F., Nazio, F., Fanelli, F., Moreno, S., Molinari, M., Viscomi, M. T. & D'Amelio, M., Nov 27 2014, In : Cell Death and Disease. 5, e1545.

Research output: Contribution to journalArticle

Mitochondrial Dynamics
Autophagy
Mitochondria
Neurons
Mitochondrial Degradation

AMBRA1 interplay with cullin E3 Ubiquitin ligases regulates autophagy dynamics

Antonioli, M., Albiero, F., Nazio, F., Vescovo, T., Perdomo, A., Corazzari, M., Marsella, C., Piselli, P., Gretzmeier, C., Dengjel, J., Cecconi, F., Piacentini, M. & Fimia, G., Dec 22 2014, In : Developmental Cell. 31, 6, p. 734-746 13 p.

Research output: Contribution to journalArticle

Cullin Proteins
Ubiquitin-Protein Ligases
Autophagy
Stabilization
Degradation

Schwann cell autophagy counteracts the onset and chronification of neuropathic pain

Marinelli, S., Nazio, F., Tinari, A., Ciarlo, L., D'Amelio, M., Pieroni, L., Vacca, V., Urbani, A., Cecconi, F., Malorni, W. & Pavone, F., Jan 2014, In : Pain. 155, 1, p. 93-107 15 p.

Research output: Contribution to journalArticle

Schwann Cells
Autophagy
Neuralgia
Sirolimus
Myelin Sheath
2013

mTOR, AMBRA1, and autophagy an intricate relationship

Nazio, F. & Cecconi, F., Aug 15 2013, In : Cell Cycle. 12, 16, p. 2524-2525 2 p.

Research output: Contribution to journalArticle

MTOR inhibits autophagy by controlling ULK1 ubiquitylation, self-association and function through AMBRA1 and TRAF6

Nazio, F., Strappazzon, F., Antonioli, M., Bielli, P., Cianfanelli, V., Bordi, M., Gretzmeier, C., Dengjel, J., Piacentini, M., Fimia, G. M. & Cecconi, F., Apr 2013, In : Nature Cell Biology. 15, 4, p. 406-416 11 p.

Research output: Contribution to journalArticle

TNF Receptor-Associated Factor 6
Ubiquitination
Autophagy
Sirolimus
Phosphorylation
2012

Stimulation of autophagy by rapamycin protects neurons from remote degeneration after acute focal brain damage

Viscomi, M. T., D'Amelio, M., Cavallucci, V., Latini, L., Bisicchia, E., Nazio, F., Fanelli, F., Maccarrone, M., Moreno, S., Cecconi, F. & Molinari, M., Feb 2012, In : Autophagy. 8, 2

Research output: Contribution to journalArticle

Nerve Degeneration
Autophagy
Sirolimus
Brain
Recycling
2011

Mitochondrial BCL-2 inhibits AMBRA1-induced autophagy

Strappazzon, F., Vietri-Rudan, M., Campello, S., Nazio, F., Florenzano, F., Fimia, G. M., Piacentini, M., Levine, B. & Cecconi, F., Apr 6 2011, In : EMBO Journal. 30, 7, p. 1195-1208 14 p.

Research output: Contribution to journalArticle

Autophagy
Apoptosis
Mitochondria
Proteins
Endoplasmic Reticulum
2010

The dynamic interaction of AMBRA1 with the dynein motor complex regulates mammalian autophagy

Di Bartolomeo, S., Corazzari, M., Nazio, F., Oliverio, S., Lisi, G., Antonioli, M., Pagliarini, V., Matteoni, S., Fuoco, C., Giunta, L., D'Amelio, M., Nardacci, R., Romagnoli, A., Piacentini, M., Cecconi, F. & Fimia, G. M., Oct 4 2010, In : Journal of Cell Biology. 191, 1, p. 155-168 14 p.

Research output: Contribution to journalArticle

Dyneins
Autophagy
Cytoskeleton
Physiological Phenomena
Pathologic Processes

The Role of Autophagy During Development in Higher Eukaryotes

Di Bartolomeo, S., Nazio, F. & Cecconi, F., Oct 2010, In : Traffic. 11, 10, p. 1280-1289 10 p.

Research output: Contribution to journalArticle

Autophagy
Eukaryota
Genes
Tissue
Mammals