1978 …2020

Research output per year

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Research Output

2015

Prospective study on nanoparticle albumin-bound paclitaxel in advanced breast cancer: Clinical results and biological observations in taxane-pretreated patients

Fabi, A., Giannarelli, D., Malaguti, P., Ferretti, G., Vari, S., Papaldo, P., Nisticò, C., Caterino, M., De Vita, R., Mottolese, M., Iacorossi, L. & Cognetti, F., Nov 20 2015, In : Drug Design, Development and Therapy. 9, p. 6177-6183 7 p.

Research output: Contribution to journalArticle

PTEN: Multiple functions in human malignant tumors

Milella, M., Falcone, I., Conciatori, F., Incani, U. C., Del Curatolo, A., Inzerilli, N., Nuzzo, C. M. A., Vaccaro, V., Vari, S., Cognetti, F. & Ciuffreda, L., 2015, In : Frontiers in Oncology. 5, FEB, 024.

Research output: Contribution to journalArticle

2014

Activity and safety of bevacizumab plus fotemustine for recurrent malignant gliomas

Vaccaro, V., Fabi, A., Vidiri, A., Giannarelli, D., Metro, G., Telera, S., Vari, S., Piludu, F., Carosi, M. A., Villani, V., Cognetti, F., Pompili, A., Marucci, L., Carapella, C. M. & Pace, A., 2014, In : BioMed Research International. 2014, 351252.

Research output: Contribution to journalArticle

Clinical experience with ipilimumab 3 mg/kg: Real-world efficacy and safety data from an expanded access programme cohort

Ascierto, P. A., Simeone, E., Sileni, V. C., Pigozzo, J., Maio, M., Altomonte, M., Del Vecchio, M., Di Guardo, L., Marchetti, P., Ridolfi, R., Cognetti, F., Testori, A., Bernengo, M. G., Guida, M., Marconcini, R., Mandalà, M., Cimminiello, C., Rinaldi, G., Aglietta, M. & Queirolo, P., May 7 2014, In : Journal of Translational Medicine. 12, 1, 116.

Research output: Contribution to journalArticle

Efficacy and safety of ipilimumab in patients with advanced melanoma and brain metastases

Queirolo, P., Spagnolo, F., Ascierto, P. A., Simeone, E., Marchetti, P., Scoppola, A., Del Vecchio, M., Di Guardo, L., Maio, M., Di Giacomo, A. M., Antonuzzo, A., Cognetti, F., Ferraresi, V., Ridolfi, L., Guidoboni, M., Guida, M., Pigozzo, J. & Chiarion Sileni, V., 2014, In : Journal of Neuro-Oncology. 118, 1, p. 109-116 8 p.

Research output: Contribution to journalArticle

KRAS early testing: Consensus initiative and cost-effectiveness evaluation for metastatic colorectal patients in an italian setting

Barone, C., Pinto, C., Normanno, N., Capussotti, L., Cognetti, F., Falcone, A. & Mantovani, L., Jan 20 2014, In : PLoS One. 9, 1, e85897.

Research output: Contribution to journalArticle

Prognostic impact of alternative splicing-derived hMENA isoforms in resected, node-negative, non-small-cell lung cancer

Bria, E., Di Modugno, F., Sperduti, I., Iapicca, P., Visca, P., Alessandrini, G., Antoniani, B., Pilotto, S., Ludovini, V., Vannucci, J., Bellezza, G., Sidoni, A., Tortora, G., Radisky, D. C., Crinò, L., Cognetti, F., Facciolo, F., Mottolese, M., Milella, M. & Nisticò, P., 2014, In : Oncotarget. 5, 22, p. 11054-11063 10 p.

Research output: Contribution to journalArticle

PTEN expression and function in adult cancer stem cells and prospects for therapeutic targeting

Ciuffreda, L., Falcone, I., Cesta Incani, U., Del Curatolo, A., Conciatori, F., Matteoni, S., Vari, S., Vaccaro, V., Cognetti, F. & Milella, M., 2014, In : Advances in Biological Regulation. 56, p. 66-80 15 p.

Research output: Contribution to journalArticle

Sequential treatment with ipilimumab and BRAF inhibitors in patients with metastatic melanoma: Data from the Italian cohort of the ipilimumab expanded access program

Ascierto, P. A., Simeone, E., Sileni, V. C., Vecchio, M. D., Marchetti, P., Cappellini, G. C. A., Ridolfi, R., De Rosa, F., Cognetti, F., Ferraresi, V., Testori, A., Queirolo, P., Bernengo, M. G., Guida, M., Galli, L., Mandalà, M., Cimminiello, C., Rinaldi, G., Carnevale-Schianca, F. & Maio, M., 2014, In : Cancer Investigation. 32, 4, p. 144-149 6 p.

Research output: Contribution to journalArticle

Signaling intermediates (MAPK and PI3K) as therapeutic targets in NSCLC

Ciuffreda, L., Incani, U. C., Steelman, L. S., Abrams, S. L., Falcone, I., Del Curatolo, A., Chappell, W. H., Franklin, R. A., Vari, S., Cognetti, F., Mccubrey, J. A. & Milella, M., 2014, In : Current Pharmaceutical Design. 20, 24, p. 3944-3957 14 p.

Research output: Contribution to journalArticle

Targeting bone metastatic cancer: Role of the mTOR pathway

Bertoldo, F., Silvestris, F., Ibrahim, T., Cognetti, F., Generali, D., Ripamonti, C. I., Amadori, D., Colleoni, M. A., Conte, P., Del Mastro, L., De Placido, S., Ortega, C. & Santini, D., Apr 2014, In : Biochimica et Biophysica Acta - Reviews on Cancer. 1845, 2, p. 248-254 7 p.

Research output: Contribution to journalArticle

2013

Adjuvant treatment for resected renal cell carcinoma: Are all strategies equally negative? Potential implications for trial design with targeted agents

Massari, F., Bria, E., Maines, F., Milella, M., Giannarelli, D., Cognetti, F., Pappagallo, G., Tortora, G. & Porta, C., Dec 2013, In : Clinical Genitourinary Cancer. 11, 4, p. 471-476 6 p.

Research output: Contribution to journalArticle

Advances towards the design and development of personalized non-small-cell lung cancer drug therapy

Vari, S., Pilotto, S., Maugeri-Saccà, M., Ciuffreda, L., Cesta Incani, U., Falcone, I., Del Curatolo, A., Ceribelli, A., Gelibter, A., De Maria, R., Tortora, G., Cognetti, F., Bria, E. & Milella, M., Nov 2013, In : Expert Opinion on Drug Discovery. 8, 11, p. 1381-1397 17 p.

Research output: Contribution to journalArticle

An Italian cost-effectiveness analysis of paclitaxel albumin (nab-paclitaxel) versus conventional paclitaxel for metastatic breast cancer patients: The COSTANza study

Lazzaro, C., Bordonaro, R., Cognetti, F., Fabi, A., De Placido, S., Arpino, G., Marchetti, P., Botticelli, A., Pronzato, P. & Martelli, E., Apr 9 2013, In : ClinicoEconomics and Outcomes Research. 5, 1, p. 125-135 11 p.

Research output: Contribution to journalArticle

Dose-dense FEC followed by dose-dense ixabepilone as neoadjuvant treatment for breast cancer patients: A feasibility study

Clavarezza, M., Bordonaro, R., Daniele, B., Ferrandina, G., Barni, S., Turazza, M., Coati, F., De Matteis, A., De Placido, S., Cognetti, F., Antonina Olmeo, N., Carrozza, F., Bruzzi, P. & Del Mastrol, L., Aug 2013, In : The oncologist. 18, 8, p. 924-925 2 p.

Research output: Contribution to journalArticle

Epidermal growth factor receptor gene copy number may predict lapatinib sensitivity in HER2-positive metastatic breast cancer

Fabi, A., Merola, R., Ferretti, G., Di Benedetto, A., Antoniani, B., Ercolani, C., Nisticò, C., Papaldo, P., Ciccarese, M., Sperduti, I., Vici, P., Marino, M., Gori, S., Botti, C., Malaguti, P., Cognetti, F. & Mottolese, M., Apr 2013, In : Expert Opinion on Pharmacotherapy. 14, 6, p. 699-706 8 p.

Research output: Contribution to journalArticle

First-line erlotinib and fixed dose-rate gemcitabine for advanced pancreatic cancer

Vaccaro, V., Bria, E., Sperduti, I., Gelibter, A., Moscetti, L., Mansueto, G., Ruggeri, E. M., Gamucci, T., Cognetti, F. & Milella, M., Jul 28 2013, In : World Journal of Gastroenterology. 19, 28, p. 4511-4519 9 p.

Research output: Contribution to journalArticle

Functional and pharmacodynamic evaluation of metronomic cyclophosphamide and docetaxel regimen in castration-resistant prostate cancer

Cardillo, I., Spugnini, E. P., Galluzzo, P., Contestabile, M., Dellanna, M. L., Picardo, M., Crispi, S., Calogero, R. A., Piccolo, M. T., Arigoni, M., Cantarella, D., Boccellino, M., Quagliuolo, L., Ferretti, G., Carlini, P., Felici, A., Boccardo, F., Cognetti, F. & Baldi, A., Sep 2013, In : Future Oncology. 9, 9, p. 1375-1388 14 p.

Research output: Contribution to journalArticle

Phase III trial of sunitinib in combination with capecitabine versus capecitabine monotherapy for the treatment of patients with pretreated metastatic breast cancer.

Crown, J. P., Diéras, V., Staroslawska, E., Yardley, D. A., Bachelot, T., Davidson, N., Wildiers, H., Fasching, P. A., Capitain, O., Ramos, M., Greil, R., Cognetti, F., Fountzilas, G., Blasinska-Morawiec, M., Liedtke, C., Kreienberg, R., Miller, W. H., Tassell, V., Huang, X., Paolini, J. & 2 others, Kern, K. A. & Romieu, G., Aug 10 2013, In : Journal of Clinical Oncology. 31, 23, p. 2870-2878 9 p.

Research output: Contribution to journalArticle

Randomised phase 3 open-label trial of first-line treatment with gemcitabine in association with docetaxel or paclitaxel in women with metastatic breast cancer: A comparison of different schedules and treatments

Del Mastro, L., Fabi, A., Mansutti, M., De Laurentiis, M., Durando, A., Merlo, D. F., Bruzzi, P., La Torre, I., Ceccarelli, M., Kazeem, G., Marchi, P., Boy, D., Venturini, M., De Placido, S. & Cognetti, F., Mar 28 2013, In : BMC Cancer. 13, 164.

Research output: Contribution to journalArticle

Single-dose palonosetron and dose-reduced regimen of dexamethasone in preventing nausea and vomiting by anthracycline-including chemotherapy in patients with early breast cancer

Pacetti, U., Veltri, E., Fattoruso, S. I. S., Cardillo, F. D. A., Evangelista, S., Cognetti, F. & Fabi, A., Apr 2013, In : Anticancer Research. 33, 4, p. 1721-1724 4 p.

Research output: Contribution to journalArticle

The mammalian target of rapamycin inhibitors in breast cancer: Current evidence and future directions

Malaguti, P., Vari, S., Cognetti, F. & Fabi, A., Jan 2013, In : Anticancer Research. 33, 1, p. 21-28 8 p.

Research output: Contribution to journalArticle

2012

Adjuvant chemotherapy with cisplatin and gemcitabine versus chemotherapy at relapse in patients with muscle-invasive bladder cancer submitted to radical cystectomy: An italian, multicenter, randomized phase iii trial

Cognetti, F., Ruggeri, E. M., Felici, A., Gallucci, M., Muto, G., Pollera, C. F., Massidda, B., Rubagotti, A., Giannarelli, D. & Boccardo, F., Mar 2012, In : Annals of Oncology. 23, 3, p. 695-700 6 p.

Research output: Contribution to journalArticle

Clinical impact of anti-epidermal growth factor receptor monoclonal antibodies in first-line treatment of metastatic colorectal cancer: Meta-analytical estimation and implications for therapeutic strategies

Loupakis, F., Cremolini, C., Salvatore, L., Schirripa, M., Lonardi, S., Vaccaro, V., Cuppone, F., Giannarelli, D., Zagonel, V., Cognetti, F., Tortora, G., Falcone, A. & Bria, E., Mar 15 2012, In : Cancer. 118, 6, p. 1523-1532 10 p.

Research output: Contribution to journalArticle

EGFR molecular profiling in advanced NSCLC: A prospective phase II study in molecularly/clinically selected patients pretreated with chemotherapy

Milella, M., Nuzzo, C., Bria, E., Sperduti, I., Visca, P., Buttitta, F., Antoniani, B., Merola, R., Gelibter, A., Cuppone, F., D'Alicandro, V., Ceribelli, A., Rinaldi, M., Cianciulli, A., Felicioni, L., Malatesta, S., Marchetti, A., Mottolese, M. & Cognetti, F., Apr 2012, In : Journal of Thoracic Oncology. 7, 4, p. 672-680 9 p.

Research output: Contribution to journalArticle

Maintenance bevacizumab beyond first-line paclitaxel plus bevacizumab in patients with Her2-negative hormone receptor-positive metastatic breast cancer: Efficacy in combination with hormonal therapy

Fabi, A., Russillo, M., Ferretti, G., Metro, G., Nisticò, C., Papaldo, P., De Vita, F., D'Auria, G., Vidiri, A., Giannarelli, D. & Cognetti, F., Oct 19 2012, In : BMC Cancer. 12, 482.

Research output: Contribution to journalArticle

Management and treatment of triple-negative breast cancer patients from the NEMESI study: An Italian experience

Adamo, V., Ricciardi, G. R. R., De Placido, S., Colucci, G., Conte, P., Giuffrida, D., Gebbia, N., Masci, G., Cognetti, F., Dondi, D. & Venturini, M., Mar 2012, In : European Journal of Cancer. 48, 5, p. 642-647 6 p.

Research output: Contribution to journalArticle

Molecular and genetic bases of pancreatic cancer

Vaccaro, V., Gelibter, A., Bria, E., Iapicca, P., Cappello, P., Di Modugno, F., Pino, M. S., Nuzzo, C., Cognetti, F., Novelli, F., Nisticò, P. & Milella, M., Jun 2012, In : Current Drug Targets. 13, 6, p. 731-743 13 p.

Research output: Contribution to journalArticle

Retreatment with trastuzumab-based therapy after disease progression following lapatinib in HER2-positive metastatic breast cancer

Gori, S., Montemurro, F., Spazzapan, S., Metro, G., Foglietta, J., Bisagni, G., Ferzi, A., Silva, R. R., Gamucci, T., Clavarezza, M., Stocchi, L., Fabi, A., Cognetti, F., Torrisi, E. & Crivellari, D., 2012, In : Annals of Oncology. 23, 6, p. 1436-1441 6 p.

Research output: Contribution to journalArticle

Sequential therapy in metastatic clear cell renal carcinoma: TKI-TKI vs TKI-mTOR

Felici, A., Bria, E., Tortora, G., Cognetti, F. & Milella, M., Dec 2012, In : Expert Review of Anticancer Therapy. 12, 12, p. 1545-1557 13 p.

Research output: Contribution to journalArticle

The mitogen-activated protein kinase (MAPK) cascade controls phosphatase and tensin homolog (PTEN) expression through multiple mechanisms

Ciuffreda, L., Di Sanza, C., Cesta Incani, U., Eramo, A., Desideri, M., Biagioni, F., Passeri, D., Falcone, I., Sette, G., Bergamo, P., Anichini, A., Sabapathy, K., McCubrey, J. A., Ricciardi, M. R., Tafuri, A., Blandino, G., Orlandi, A., De Maria, R., Cognetti, F., Del Bufalo, D. & 1 others, Milella, M., Jun 2012, In : Journal of Molecular Medicine. 90, 6, p. 667-679 13 p.

Research output: Contribution to journalArticle

Therapeutic potential of MEK inhibition in acute myelogenous leukemia: Rationale for "vertical" and "lateral" combination strategies

Ricciardi, M. R., Scerpa, M. C., Bergamo, P., Ciuffreda, L., Petrucci, M. T., Chiaretti, S., Tavolaro, S., Mascolo, M. G., Abrams, S. L., Steelman, L. S., Tsao, T., Marchetti, A., Konopleva, M., Del Bufalo, D., Cognetti, F., Foà, R., Andreeff, M., McCubrey, J. A., Tafuri, A. & Milella, M., Oct 2012, In : Journal of Molecular Medicine. 90, 10, p. 1133-1144 12 p.

Research output: Contribution to journalArticle

2011

Assessment of PTEN and PI3K status in primary breast cancer and corresponding metastases: Is it worthwhile?

Russillo, M., Di Benedetto, A., Metro, G., Ferretti, G., Papaldo, P., Cognetti, F., Mottolese, M. & Fabi, A., Jul 10 2011, In : Journal of Clinical Oncology. 29, 20, p. 2834-2835 2 p.

Research output: Contribution to journalArticle

Brain metastases from solid tumors: Disease outcome according to type of treatment and therapeutic resources of the treating center

Fabi, A., Felici, A., Metro, G., Mirri, A., Bria, E., Telera, S., Moscetti, L., Russillo, M., Lanzetta, G., Mansueto, G., Pace, A., Maschio, M., Vidiri, A., Sperduti, I., Cognetti, F. & Carapella, C. M., 2011, In : Journal of Experimental and Clinical Cancer Research. 30, 1, 10.

Research output: Contribution to journalArticle

Clinical outcome of patients with brain metastases from HER2-positive breast cancer treated with lapatinib and capecitabine

Metro, G., Foglietta, J., Russillo, M., Stocchi, L., Vidiri, A., Giannarelli, D., Crinò, L., Papaldo, P., Mottolese, M., Cognetti, F., Fabi, A. & Gori, S., Mar 2011, In : Annals of Oncology. 22, 3, p. 625-630 6 p.

Research output: Contribution to journalArticle

Emerging pathways and future targets for the molecular therapy of pancreatic cancer

Vaccaro, V., Melisi, D., Bria, E., Cuppone, F., Ciuffreda, L., Pino, M. S., Gelibter, A., Tortora, G., Cognetti, F. & Milella, M., Oct 2011, In : Expert Opinion on Therapeutic Targets. 15, 10, p. 1183-1196 14 p.

Research output: Contribution to journalArticle

Factors associated with an individuals' decision to withdraw from genetic counseling for BRCA1 and BRCA2 genes mutations: Are personality traits involved?

Caruso, A., Vigna, C., Bigazzi, V., Leone, C., Maggi, G., Martayan, A., Sega, F. M., Cognetti, F. & Savarese, A., Sep 2011, In : Familial Cancer. 10, 3, p. 581-589 9 p.

Research output: Contribution to journalArticle

HER2 protein and gene variation between primary and metastatic breast cancer: Significance and impact on patient care

Fabi, A., Di Benedetto, A., Metro, G., Perracchio, L., Nisticò, C., Di Filippo, F., Ercolani, C., Ferretti, G., Melucci, E., Buglioni, S., Sperduti, I., Papaldo, P., Cognetti, F. & Mottolese, M., Apr 1 2011, In : Clinical Cancer Research. 17, 7, p. 2055-2064 10 p.

Research output: Contribution to journalArticle

Magnitude of risks and benefits of the addition of bevacizumab to chemotherapy for advanced breast cancer patients: Meta-regression analysis of randomized trials

Cuppone, F., Bria, E., Vaccaro, V., Puglisi, F., Fabi, A., Sperduti, I., Carlini, P., Milella, M., Nisticò, C., Russillo, M., Papaldo, P., Ferretti, G., Aapro, M., Giannarelli, D. & Cognetti, F., 2011, In : Journal of Experimental and Clinical Cancer Research. 30, 1, 54.

Research output: Contribution to journalArticle

Outcome of advanced NSCLC patients harboring sensitizing EGFR mutations randomized to EGFR tyrosine kinase inhibitors or chemotherapy as first-line treatment: A meta-analysis

Bria, E., Milella, M., Cuppone, F., Novello, S., Ceribelli, A., Vaccaro, V., Sperduti, I., Gelibter, A., Scagliotti, G. V., Cognetti, F. & Giannarelli, D., Oct 2011, In : Annals of Oncology. 22, 10, p. 2277-2285 9 p.

Research output: Contribution to journalArticle

Phase I-II trial of prolonged gemcitabine infusion plus paclitaxel as a biweekly schedule for advanced breast cancer patients pretreated with anthracyclines

Vici, P., Fabi, A., Metro, G., Sergi, D., Giannarelli, D., Di Lauro, L., Bepler, G., Tomao, F., Cognetti, F., Conti, F. & Lopez, M., Mar 2011, In : Cancer Chemotherapy and Pharmacology. 67, 3, p. 687-693 7 p.

Research output: Contribution to journalArticle

Total laparoscopic radical hysterectomy and pelvic lymphadenectomy in locally advanced stage IB2-IIB cervical cancer patients after neoadjuvant chemotherapy

Vizza, E., Pellegrino, A., Milani, R., Fruscio, R., Baiocco, E., Cognetti, F., Savarese, A., Tomao, F., Chen, C. & Corrado, G., Apr 2011, In : European Journal of Surgical Oncology. 37, 4, p. 364-369 6 p.

Research output: Contribution to journalArticle

2010

A novel type of cellular senescence that can be enhanced in mouse models and human tumor xenografts to suppress prostate tumorigenesis

Alimonti, A., Nardella, C., Chen, Z., Clohessy, J. G., Carracedo, A., Trotman, L. C., Cheng, K., Varmeh, S., Kozma, S. C., Thomas, G., Rosivatz, E., Woscholski, R., Cognetti, F., Scher, H. I. & Pandolfi, P. P., Mar 1 2010, In : Journal of Clinical Investigation. 120, 3, p. 681-693 13 p.

Research output: Contribution to journalArticle

Cetuximab plus chronomodulated irinotecan, 5-fluorouracil, leucovorin and oxaliplatin as neoadjuvant chemotherapy in colorectal liver metastases: POCHER trial

Garufi, C., Torsello, A., Tumolo, S., Ettorre, G. M., Zeuli, M., Campanella, C., Vennarecci, G., Mottolese, M., Sperduti, I. & Cognetti, F., Nov 9 2010, In : British Journal of Cancer. 103, 10, p. 1542-1547 6 p.

Research output: Contribution to journalArticle

Chordoma: Clinical characteristics, management and prognosis of a case series of 25 patients

Ferraresi, V., Nuzzo, C., Zoccali, C., Marandino, F., Vidiri, A., Salducca, N., Zeuli, M., Giannarelli, D., Cognetti, F. & Biagini, R., Jan 28 2010, In : BMC Cancer. 10, 22.

Research output: Contribution to journalArticle

Clinical significance of PTEN and p-Akt co-expression in HER2-positive metastatic breast cancer patients treated with trastuzumab-based therapies

Fabi, A., Metro, G., Di Benedetto, A., Nisticò, C., Vici, P., Melucci, E., Antoniani, B., Perracchio, L., Sperduti, I., Milella, M., Cognetti, F. & Mottolese, M., Apr 2010, In : Oncology. 78, 2, p. 141-149 9 p.

Research output: Contribution to journalArticle

Correction: Transforming growth factor α expression drives constitutive epidermal growth factor receptor pathway activation and sensitivity to gefitinib (Iressa) in human pancreatic cancer cell lines (Cancer Research (2006) 66, 7, (3802-3812))

Pino, M. S., Shrader, M., Baker, C. H., Cognetti, F., Xiong, H. Q., Abbruzzese, J. L. & McConkey, D. J., Jan 15 2010, In : Cancer Research. 70, 2, p. 852-853 2 p.

Research output: Contribution to journalArticle

Early recurrence risk: Aromatase inhibitors versus tamoxifen

Bria, E., Carlini, P., Cuppone, F., Vaccaro, V., Milella, M. & Cognetti, F., Aug 2010, In : Expert Review of Anticancer Therapy. 10, 8, p. 1239-1253 15 p.

Research output: Contribution to journalArticle

Epidermal growth factor receptor gene copy number in 101 advanced colorectal cancer patients treated with chemotherapy plus cetuximab

Campanella, C., Mottolese, M., Cianciulli, A., Torsello, A., Merola, R., Sperduti, I., Melucci, E., Conti, S., Diodoro, M. G., Zeuli, M., Paoletti, G., Cognetti, F. & Garufi, C., Apr 16 2010, In : Journal of Translational Medicine. 8, 36.

Research output: Contribution to journalArticle