• 1752 Citations
  • 23 h-Index
19962019
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Research Output 1996 2019

  • 1752 Citations
  • 23 h-Index
  • 42 Article
  • 1 Conference contribution
  • 1 Review article
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Article
2019
2 Citations (Scopus)

Hydrogen sulfide-releasing silk fibroin scaffold for bone tissue engineering

Gambari, L., Amore, E., Raggio, R., Bonani, W., Barone, M., Lisignoli, G., Grigolo, B., Motta, A. & Grassi, F., Sep 1 2019, In : Materials Science and Engineering C. 102, p. 471-482 12 p.

Research output: Contribution to journalArticle

Fibroins
silk
Hydrogen Sulfide
Silk
hydrogen sulfide
2018
1 Citation (Scopus)

Silk Fibroin Porous Scaffolds Loaded with a Slow-Releasing Hydrogen Sulfide Agent (GYY4137) for Applications of Tissue Engineering

Raggio, R., Bonani, W., Callone, E., Dirè, S., Gambari, L., Grassi, F. & Motta, A., Jul 6 2018, In : ACS Biomaterials Science and Engineering. 4, 8, p. 2956-2966 11 p.

Research output: Contribution to journalArticle

Fibroins
Hydrogen Sulfide
Silk
Hydrogen sulfide
Tissue engineering
2017
5 Citations (Scopus)

A Novel H2S-releasing Amino-Bisphosphonate which combines bone anti-catabolic and anabolic functions.

Rapposelli, S., Gambari, L., Digiacomo, M., Citi, V., Lisignoli, G., Manferdini, C., Calderone, V. & Grassi, F., Sep 20 2017, In : Scientific Reports. 7, 1, p. 1-12 12 p.

Research output: Contribution to journalArticle

Diphosphonates
Osteoclasts
Alendronate
Bone and Bones
Mesenchymal Stromal Cells
7 Citations (Scopus)
Cystathionine
Lyases
Osteoblasts
Mesenchymal Stromal Cells
Osteogenesis
2 Citations (Scopus)

The expression of cystathionine gamma-lyase is regulated by estrogen receptor alpha in human osteoblasts

Lambertini, E., Penolazzi, L., Angelozzi, M., Grassi, F., Gambari, L., Lisignoli, G., Bonis, P. D., Cavallo, M. & Piva, R., Oct 4 2017, In : Oncotarget. 8, 60, p. 101686-101696 11 p.

Research output: Contribution to journalArticle

Cystathionine gamma-Lyase
Cystathionine
Lyases
Osteoblasts
Estrogen Receptor alpha
2015
27 Citations (Scopus)

Hydrogen Sulfide Is a Novel Regulator of Bone Formation Implicated in the Bone Loss Induced by Estrogen Deficiency

Grassi, F., Tyagi, A. M., Calvert, J. W., Gambari, L., Walker, L. D., Yu, M., Robinson, J., Li, J. Y., Lisignoli, G., Vaccaro, C., Adams, J. & Pacifici, R., 2015, (Accepted/In press) In : Journal of Bone and Mineral Research.

Research output: Contribution to journalArticle

Hydrogen Sulfide
Osteogenesis
Estrogens
Bone and Bones
Postmenopausal Osteoporosis
13 Citations (Scopus)

Lack of anti-inflammatory and anti-catabolic effects on basal inflamed osteoarthritic chondrocytes or synoviocytes by adipose stem cell-conditioned medium

Manferdini, C., Maumus, M., Gabusi, E., Paolella, F., Grassi, F., Jorgensen, C., Fleury-Cappellesso, S., Noël, D. & Lisignoli, G., Nov 1 2015, In : Osteoarthritis and Cartilage. 23, 11, p. 2045-2057 13 p.

Research output: Contribution to journalArticle

Conditioned Culture Medium
Chondrocytes
Stem cells
Anti-Inflammatory Agents
Stem Cells
2014
32 Citations (Scopus)
Osteoclasts
Stem Cells
sodium bisulfide
Down-Regulation
Antioxidants
2013
4 Citations (Scopus)
T-cells
T-Lymphocyte Subsets
Mesenchymal Stromal Cells
Cells
T-Lymphocytes
2012
16 Citations (Scopus)

Extracellular calcium chronically induced human osteoblasts effects: Specific modulation of osteocalcin and collagen type XV

Gabusi, E., Manferdini, C., Grassi, F., Piacentini, A., Cattini, L., Filardo, G., Lambertini, E., Piva, R., Zini, N., Facchini, A. & Lisignoli, G., Aug 2012, In : Journal of Cellular Physiology. 227, 8, p. 3151-3161 11 p.

Research output: Contribution to journalArticle

Osteocalcin
Osteoblasts
Collagen
Modulation
Calcium
2011
14 Citations (Scopus)

Evidence of specific characteristics and osteogenic potentiality in bone cells from Tibia

Manferdini, C., Gabusi, E., Grassi, F., Piacentini, A., Cattini, L., Zini, N., Filardo, G., Facchini, A. & Lisignoli, G., Oct 2011, In : Journal of Cellular Physiology. 226, 10, p. 2675-2682 8 p.

Research output: Contribution to journalArticle

Osteoblasts
Tibia
Mesenchymal Stromal Cells
Bone
Bone and Bones
20 Citations (Scopus)

T cell suppression by osteoclasts in vitro

Grassi, F., Manferdini, C., Cattini, L., Piacentini, A., Gabusi, E., Facchini, A. & Lisignoli, G., Apr 2011, In : Journal of Cellular Physiology. 226, 4, p. 982-990 9 p.

Research output: Contribution to journalArticle

T-cells
Osteoclasts
T-Lymphocytes
In Vitro Techniques
Apoptosis
2010
29 Citations (Scopus)

Mineralization behavior with mesenchymal stromal cells in a biomimetic hyaluronic acid-based scaffold

Manferdini, C., Guarino, V., Zini, N., Raucci, M. G., Ferrari, A., Grassi, F., Gabusi, E., Squarzoni, S., Facchini, A., Ambrosio, L. & Lisignoli, G., May 2010, In : Biomaterials. 31, 14, p. 3986-3996 11 p.

Research output: Contribution to journalArticle

Hyaluronic acid
Biomimetics
Hyaluronic Acid
Scaffolds (biology)
Mesenchymal Stromal Cells
2009
17 Citations (Scopus)
CCR6 Receptors
Chemokine Receptors
Osteoblasts
Osteoarthritis
Rheumatoid Arthritis
20 Citations (Scopus)

Gene array profile identifies collagen type XV as a novel human osteoblast-secreted matrix protein

Lisignoli, G., Codeluppi, K., Todoerti, K., Manferdini, C., Piacentini, A., Zini, N., Grassi, F., Cattini, L., Piva, R., Rizzoli, V., Facchini, A., Giuliani, N. & Neri, A., Aug 2009, In : Journal of Cellular Physiology. 220, 2, p. 401-409 9 p.

Research output: Contribution to journalArticle

Osteoblasts
Collagen
Genes
Bone
Proteins
2008
23 Citations (Scopus)
CXCR Receptors
Cartilage
Stem cells
Mesenchymal Stromal Cells
Scaffolds
86 Citations (Scopus)

T Cells Potentiate PTH-Induced Cortical Bone Loss through CD40L Signaling

Gao, Y., Wu, X., Terauchi, M., Li, J. Y., Grassi, F., Galley, S., Yang, X., Weitzmann, M. N. & Pacifici, R., Aug 6 2008, In : Cell Metabolism. 8, 2, p. 132-145 14 p.

Research output: Contribution to journalArticle

CD40 Ligand
Stromal Cells
Parathyroid Hormone
T-Lymphocytes
Hyperparathyroidism
25 Citations (Scopus)

The role of nitric oxide in the mechanical repression of RANKL in bone stromal cells

Rahnert, J., Fan, X., Case, N., Murphy, T. C., Grassi, F., Sen, B. & Rubin, J., Jul 2008, In : Bone. 43, 1, p. 48-54 7 p.

Research output: Contribution to journalArticle

Stromal Cells
Nitric Oxide
Bone and Bones
omega-N-Methylarginine
Messenger RNA
2007
46 Citations (Scopus)
Chemokine CCL20
Osteoblasts
Osteoclasts
Rheumatoid Arthritis
Bone
271 Citations (Scopus)

IFN-γ stimulates osteoclast formation and bone loss in vivo via antigen-driven T cell activation

Gao, Y., Grassi, F., Ryan, M. R., Terauchi, M., Page, K., Yang, X., Weitzmann, M. N. & Pacifici, R., Jan 4 2007, In : Journal of Clinical Investigation. 117, 1, p. 122-132 11 p.

Research output: Contribution to journalArticle

CD27 Antigens
Osteoclasts
Osteogenesis
Bone Resorption
Bone and Bones
87 Citations (Scopus)

Oxidative stress causes bone loss in estrogen-deficient mice through enhanced bone marrow dendritic cell activation

Grassi, F., Tell, G., Robbie-Ryan, M., Gao, Y., Terauchi, M., Yang, X., Romanello, M., Jones, D. P., Weitzmann, M. N. & Pacifici, R., Sep 18 2007, In : Proceedings of the National Academy of Sciences of the United States of America. 104, 38, p. 15087-15092 6 p.

Research output: Contribution to journalArticle

Bone Marrow Cells
Dendritic Cells
Estrogens
Oxidative Stress
T-Lymphocytes
2006
26 Citations (Scopus)

Bone re/modeling is more dynamic in the endothelial nitric oxide synthase(-/-) mouse

Grassi, F., Fan, X., Rahnert, J., Weitzmann, M. N., Pacifici, R., Nanes, M. S. & Rubin, J., 2006, In : Endocrinology. 147, 9, p. 4392-4399 8 p.

Research output: Contribution to journalArticle

Nitric Oxide Synthase Type III
Nitric Oxide Synthase
Ovariectomy
Bone and Bones
Bone Remodeling
55 Citations (Scopus)

CXCL12 (SDF-1) and CXCL13 (BCA-1) chemokines significantly induce proliferation and collagen type I expression in osteoblasts from osteoarthritis patients

Lisignoli, G., Toneguzzi, S., Piacentini, A., Cristino, S., Grassi, F., Cavallo, C. & Facchini, A., Jan 2006, In : Journal of Cellular Physiology. 206, 1, p. 78-85 8 p.

Research output: Contribution to journalArticle

Osteoblasts
Collagen Type I
Chemokines
Osteoarthritis
Bone
2005
81 Citations (Scopus)

Analysis of mesenchymal stem cells grown on a three-dimensional HYAFF 11®-based prototype ligament scaffold

Cristino, S., Grassi, F., Toneguzzi, S., Piacentini, A., Grigolo, B., Santi, S., Riccio, M., Tognana, E., Facchini, A. & Lisignoli, G., Jun 1 2005, In : Journal of Biomedical Materials Research - Part A. 73, 3, p. 275-283 9 p.

Research output: Contribution to journalArticle

Ligaments
Stem cells
Mesenchymal Stromal Cells
Scaffolds
Scaffolds (biology)
95 Citations (Scopus)

An IL-7-dependent rebound in thymic T cell output contributes to the bone loss induced by estrogen deficiency

Ryan, M. R., Shepherd, R., Leavey, J. K., Gao, Y., Grassi, F., Schnell, F. J., Qian, W. P., Kersh, G. J., Weitzmann, M. N. & Pacifici, R., Nov 15 2005, In : Proceedings of the National Academy of Sciences of the United States of America. 102, 46, p. 16735-16740 6 p.

Research output: Contribution to journalArticle

Interleukin-7
Estrogens
Lymphopoiesis
T-Lymphocytes
Bone and Bones
91 Citations (Scopus)

Cellular and molecular events during chondrogenesis of human mesenchymal stromal cells grown in a three-dimensional hyaluronan based scaffold

Lisignoli, G., Cristino, S., Piacentini, A., Toneguzzi, S., Grassi, F., Cavallo, C., Zini, N., Solimando, L., Mario Maraldi, N. & Facchini, A., Oct 2005, In : Biomaterials. 26, 28, p. 5677-5686 10 p.

Research output: Contribution to journalArticle

Chondrogenesis
Cartilage
Hyaluronic Acid
Mesenchymal Stromal Cells
Collagen
2004
85 Citations (Scopus)

CXCL12 Chemokine Up-Regulates Bone Resorption and MMP-9 Release by Human Osteoclasts: CXCL12 Levels Are Increased in Synovial and Bone Tissue of Rheumatoid Arthritis Patients

Grassi, F., Cristino, S., Toneguzzi, S., Piacentini, A., Facchini, A. & Lisignoli, G., May 2004, In : Journal of Cellular Physiology. 199, 2, p. 244-251 8 p.

Research output: Contribution to journalArticle

Chemokine CXCL12
Osteoclasts
Bone Resorption
Matrix Metalloproteinases
Rheumatoid Arthritis
32 Citations (Scopus)

IL1β and TNFα differently modulate CXCL13 chemokine in stromal cells and osteoblasts isolated from osteoarthritis patients: Evidence of changes associated to cell maturation

Lisignoli, G., Cristino, S., Toneguzzi, S., Grassi, F., Piacentini, A., Cavallo, C., Facchini, A. & Mariani, E., Apr 2004, In : Experimental Gerontology. 39, 4, p. 659-665 7 p.

Research output: Contribution to journalArticle

Chemokine CXCL13
Osteoblasts
Stromal Cells
Osteoarthritis
Bone
14 Citations (Scopus)

Inhibition of CD95 Apoptotic Signaling by Interferon-γ in Human Osteoarthritic Chondrocytes Is Associated with Increased Expression of FLICE Inhibitory Protein

Grassi, F., Piacentini, A., Cristino, S., Toneguzzi, S., Facchini, A. & Lisignoli, G., Feb 2004, In : Arthritis and Rheumatism. 50, 2, p. 498-506 9 p.

Research output: Contribution to journalArticle

CASP8 and FADD-Like Apoptosis Regulating Protein
Chondrocytes
Caspase 8
Interferons
Osteoarthritis
23 Citations (Scopus)
CXCR3 Receptors
T-cells
Vascular Cell Adhesion Molecule-1
Chemokine Receptors
Osteoblasts
2003
12 Citations (Scopus)

Age-associated changes in functional response to CXCR3 and CXCR5 chemokine receptors in human osteoblasts

Lisignoli, G., Piacentini, A., Toneguzzi, S., Grassi, F., Tschon, M., Cristino, S., Facchini, A. & Mariani, E., 2003, In : Biogerontology. 4, 5, p. 309-317 9 p.

Research output: Contribution to journalArticle

CXCR5 Receptors
Chemokine Receptors
Osteoblasts
Hexosaminidases
Cell Proliferation
54 Citations (Scopus)
CXCR5 Receptors
CXCR3 Receptors
Osteoblasts
Alkaline Phosphatase
Chemical activation
61 Citations (Scopus)

Human osteoclasts express different CXC chemokines depending on cell culture substrate: Molecular and immunocytochemical evidence of high levels of CXCL10 and CXCL12

Grassi, F., Piacentini, A., Cristino, S., Toneguzzi, S., Cavallo, C., Facchini, A. & Lisignoli, G., Nov 2003, In : Histochemistry and Cell Biology. 120, 5, p. 391-400 10 p.

Research output: Contribution to journalArticle

CXC Chemokines
Calcium phosphate
Osteoclasts
Cell culture
calcium phosphates
7 Citations (Scopus)

Hyaluronan-based biomaterial (Hyaff-11) as scaffold to support mineralization of bone marrow stromal cells.

Lisignoli, G., Toneguzzi, S., Zini, N., Piacentini, A., Cristino, S., Tschon, M., Grassi, F., Fini, M., Giardino, R., Maraldi, N. M. & Facchini, A., 2003, In : La Chirurgia degli organi di movimento. 88, 4, p. 363-367 5 p.

Research output: Contribution to journalArticle

Biocompatible Materials
Hyaluronic Acid
Mesenchymal Stromal Cells
Osteocalcin
Bone and Bones
19 Citations (Scopus)
Phosphatidylinositol Phosphates
arthritis
osteoblasts
Osteoblasts
Rheumatoid Arthritis
2002
62 Citations (Scopus)

Different chemokines are expressed in human arthritic bone biopsies: IFN-γ and IL-6 differently modulate IL-8, MCP-1 and rantes production by arthritic osteoblasts

Lisignoli, G., Toneguzzi, S., Grassi, F., Piacentini, A., Tschon, M., Cristino, S., Gualtieri, G. & Facchini, A., Dec 2002, In : Cytokine. 20, 5, p. 231-238 8 p.

Research output: Contribution to journalArticle

Biopsy
Osteoblasts
Interleukin-8
Chemokines
Interferons
2001
42 Citations (Scopus)

An elevated number of differentiated osteoblast colonies can be obtained from rat bone marrow stromal cells using a gradient isolation procedure

Lisignoli, G., Remiddi, G., Cattini, L., Cocchini, B., Zini, N., Fini, M., Grassi, F., Piacentini, A. & Facchini, A., 2001, In : Connective Tissue Research. 42, 1, p. 49-58 10 p.

Research output: Contribution to journalArticle

Osteoblasts
Mesenchymal Stromal Cells
Rats
Bone
Fibroblast Growth Factor 2
109 Citations (Scopus)

Anti-Fas-induced apoptosis in chondrocytes reduced by hyaluronan: Evidence for CD44 and CD54 (intercellular adhesion molecule 1) involvement

Lisignoli, G., Grassi, F., Zini, N., Toneguzzi, S., Piacentini, A., Guidolin, D., Bevilacqua, C. & Facchini, A., 2001, In : Arthritis and Rheumatism. 44, 8, p. 1800-1807 8 p.

Research output: Contribution to journalArticle

Intercellular Adhesion Molecule-1
Hyaluronic Acid
Chondrocytes
Apoptosis
Osteoarthritis
13 Citations (Scopus)

Hyaluronan does not affect cytokine and chemokine expression in osteoarthritic chondrocytes and synoviocytes

Lisignoli, G., Grassi, F., Piacentini, A., Cocchini, B., Remiddi, G., Bevilacqua, C. & Facchini, A., 2001, In : Osteoarthritis and Cartilage. 9, 2, p. 161-168 8 p.

Research output: Contribution to journalArticle

Hyaluronic Acid
Chondrocytes
Chemokines
Interleukin-8
Cytokines
2000
42 Citations (Scopus)

Osteoblasts and stromal cells isolated from femora in rheumatoid arthritis (RA) and osteoarthritis (OA) patients express IL-11, leukaemia inhibitory factor and oncostatin M

Lisignoli, G., Piacentini, A., Toneguzzi, S., Grassi, F., Cocchini, B., Ferruzzi, A., Gualtieri, G. & Facchini, A., 2000, In : Clinical and Experimental Immunology. 119, 2, p. 346-353 8 p.

Research output: Contribution to journalArticle

Oncostatin M
Interleukin-11
Leukemia Inhibitory Factor
Stromal Cells
Osteoblasts
1999
47 Citations (Scopus)

Chemokine expression by subchondral bone marrow stromal cells isolated from osteoarthritis (OA) and rheumatoid arthritis (RA) patients

Lisignoli, G., Toneguzzi, S., Pozzi, C., Piacentini, A., Grassi, F., Ferruzzi, A., Gualtieri, G. & Facchini, A., 1999, In : Clinical and Experimental Immunology. 116, 2, p. 371-378 8 p.

Research output: Contribution to journalArticle

Chemokine CCL5
Mesenchymal Stromal Cells
Chemokines
Osteoarthritis
Rheumatoid Arthritis
1996
11 Citations (Scopus)

Cyclodextrins enhance the aerobic degradation and dechlorination of low-chlorinated biphenyls

Fava, F. & Grassi, F., 1996, In : Biotechnology Techniques. 10, 4, p. 291-296 6 p.

Research output: Contribution to journalArticle

Dechlorination
Cyclodextrins
Degradation
Polychlorinated Biphenyls
Pseudomonas