1987 …2019

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2019

3D gelatin-chitosan hybrid hydrogels combined with human platelet lysate highly support human mesenchymal stem cell proliferation and osteogenic differentiation

Re, F., Sartore, L., Moulisova, V., Cantini, M., Almici, C., Bianchetti, A., Chinello, C., Dey, K., Agnelli, S., Manferdini, C., Bernardi, S., Lopomo, N. F., Sardini, E., Borsani, E., Rodella, L. F., Savoldi, F., Paganelli, C., Guizzi, P., Lisignoli, G., Magni, F. & 2 others, Salmeron-Sanchez, M. & Russo, D., May 2 2019, In : Journal of Tissue Engineering. 10, p. 1-16 16 p.

Research output: Contribution to journalArticle

Chitosan-based Scaffold Counteracts Hypertrophic and Fibrotic Markers in Chondrogenic Differentiated Mesenchymal Stromal Cells

Manferdini, C., Gabusi, E., Sartore, L., Dey, K., Agnelli, S., Almici, C., Bianchetti, A., Zini, N., Russo, D., Re, F., Mariani, E. & Lisignoli, G., Oct 2019, In : Journal of Tissue Engineering and Regenerative Medicine. 13, 10, p. 1896-1911 16 p.

Research output: Contribution to journalArticle

Hydrogen sulfide-releasing silk fibroin scaffold for bone tissue engineering

Gambari, L., Amore, E., Raggio, R., Bonani, W., Barone, M., Lisignoli, G., Grigolo, B., Motta, A. & Grassi, F., Sep 1 2019, In : Materials Science and Engineering C. 102, p. 471-482 12 p.

Research output: Contribution to journalArticle

Investigating the Role of Sustained Calcium Release in Silk-Gelatin-Based Three-Dimensional Bioprinted Constructs for Enhancing the Osteogenic Differentiation of Human Bone Marrow Derived Mesenchymal Stromal Cells

Sharma, A., Desando, G., Petretta, M., Chawla, S., Bartolotti, I., Manferdini, C., Paolella, F., Gabusi, E., Trucco, D., Ghosh, S. & Lisignoli, G., Feb 12 2019, In : ACS Biomaterials Science and Engineering. 5, 3, p. 1518-1533 16 p.

Research output: Contribution to journalArticle

Osteoarthritic Milieu Affects Adipose-Derived Mesenchymal Stromal Cells

Manferdini, C., Paolella, F., Gabusi, E., Cattini, L., Rojewski, M., Schrezenmeier, H., Addimanda, O., Meliconi, R. & Lisignoli, G., Aug 19 2019, In : Journal of Orthopaedic Research. p. 1-12 12 p.

Research output: Contribution to journalArticle

Rational Design and Development of Anisotropic and Mechanically Strong Gelatin-Based Stress Relaxing Hydrogels for Osteogenic/Chondrogenic Differentiation

Dey, K., Agnelli, S., Re, F., Russo, D., Lisignoli, G., Manferdini, C., Bernardi, S., Gabusi, E. & Sartore, L., Jul 12 2019, In : Macromolecular Bioscience. 19, 8, p. 1-18 18 p.

Research output: Contribution to journalArticle

2018

Clinical and Biological Signature of Osteochondritis Dissecans in a Cross-Sectional Study

Gabusi, E., Manferdini, C., Paolella, F., Gambari, L., Kon, E., Filardo, G., Mariani, E. & Lisignoli, G., May 2018, In : BioMed Research International. 2018, p. 1-9 9 p.

Research output: Contribution to journalArticle

Effect of microfragmented adipose tissue on osteoarthritic synovial macrophage factors

Paolella, F., Manferdini, C., Gabusi, E., Gambari, L., Filardo, G., Kon, E., Mariani, E. & Lisignoli, G., Sep 6 2018, In : Journal of Cellular Physiology. 234, 4, p. 5044-5055 12 p.

Research output: Contribution to journalArticle

Hypoxia Preconditioning of Human MSCs: a Direct Evidence of HIF-1α and Collagen Type XV Correlation

Lambertini, E., Penolazzi, L., Angelozzi, M., Bergamin, L. S., Manferdini, C., Vieceli Dalla Sega, F., Paolella, F., Lisignoli, G. & Piva, R., 2018, In : Cellular Physiology and Biochemistry. 51, 5, p. 2237-2249 13 p.

Research output: Contribution to journalArticle

Immunoelectron microscopic localization of Collagen type XV during human mesenchymal stem cells mineralization

Manferdini, C., Zini, N., Gabusi, E., Paolella, F., Lambertini, E., Penolazzi, L., Piva, R. & Lisignoli, G., Dec 2018, In : Connective Tissue Research. 59, sup1, p. 42-45 4 p.

Research output: Contribution to journalArticle

2017

Adipose stromal cells mediated switching of the pro-inflammatory profile of M1-like macrophages is facilitated by PGE2: in vitro evaluation.

Manferdini, C., Paolella, F., Gabusi, E., Gambari, L., Piacentini, A., Filardo, G., Fleury-Cappellesso, S., Barbero, A., Murphy, M. & Lisignoli, G., Jan 30 2017, In : Osteoarthritis and Cartilage. 25, 7, p. 1161-1171 11 p.

Research output: Contribution to journalArticle

A Novel H2S-releasing Amino-Bisphosphonate which combines bone anti-catabolic and anabolic functions.

Rapposelli, S., Gambari, L., Digiacomo, M., Citi, V., Lisignoli, G., Manferdini, C., Calderone, V. & Grassi, F., Sep 20 2017, In : Scientific Reports. 7, 1, p. 1-12 12 p.

Research output: Contribution to journalArticle

Collagen type XV and the 'osteogenic status'

Lisignoli, G., Lambertini, E., Manferdini, C., Gabusi, E., Penolazzi, L., Paolella, F., Angelozzi, M., Casagranda, V. & Piva, R., 2017, (Accepted/In press) In : Journal of Cellular and Molecular Medicine. 21, 9, p. 2236-2244 9 p.

Research output: Contribution to journalArticle

Lenalidomide increases human dendritic cell maturation in multiple myeloma patients targeting monocyte differentiation and modulating mesenchymal stromal cell inhibitory properties.

Costa, F., Vescovini, R., Bolzoni, M., Marchica, V., Storti, P., Toscani, D., Accardi, F., Notarfranchi, L., Dalla Palma, B., Manferdini, C., Manni, S., Todaro, G., Lisignoli, G., Piazza, F., Aversa, F. & Giuliani, N., May 23 2017, In : Oncotarget. 8, 32

Research output: Contribution to journalArticle

The expression of cystathionine gamma-lyase is regulated by estrogen receptor alpha in human osteoblasts

Lambertini, E., Penolazzi, L., Angelozzi, M., Grassi, F., Gambari, L., Lisignoli, G., Bonis, P. D., Cavallo, M. & Piva, R., Oct 4 2017, In : Oncotarget. 8, 60, p. 101686-101696 11 p.

Research output: Contribution to journalArticle

Thrombospondin-1 partly mediates the cartilage protective effect of adipose-derived mesenchymal stem cells in osteoarthritis

Maumus, M., Manferdini, C., Toupet, K., Chuchana, P., Casteilla, L., Gachet, M., Jorgensen, C., Lisignoli, G. & Noël, D., Nov 29 2017, In : Frontiers in Immunology. 8, NOV, p. 1-13 13 p., 1638.

Research output: Contribution to journalArticle

2016

Adipose mesenchymal stromal cell-based therapy for severe osteoarthritis of the knee: A phase I dose-escalation trial

Pers, Y. M., Rackwitz, L., Ferreira, R., Pullig, O., Delfour, C., Barry, F., Sensebe, L., Casteilla, L., Fleury, S., Bourin, P., Noël, D., Canovas, F., Cyteval, C., Lisignoli, G., Schrauth, J., Haddad, D., Domergue, S., Noeth, U. & Jorgensen, C., 2016, In : Stem cells translational medicine. 5, 7, p. 847-856 10 p.

Research output: Contribution to journalArticle

From osteoarthritic synovium to synovialderived cells characterization: Synovial macrophages are key effector cells

Manferdini, C., Paolella, F., Gabusi, E., Silvestri, Y., Gambari, L., Cattini, L., Filardo, G., Fleury-Cappellesso, S. & Lisignoli, G., 2016, In : Arthritis Research and Therapy. 18, 1, 83.

Research output: Contribution to journalArticle

Specific inductive potential of a novel nanocomposite biomimetic biomaterial for osteochondral tissue regeneration.

Manferdini, C., Cavallo, C., Grigolo, B., Fiorini, M., Nicoletti, A., Gabusi, E., Zini, N., Pressato, D., Facchini, A. & Lisignoli, G., May 2016, In : Journal of Tissue Engineering and Regenerative Medicine. p. 374-391 17 p.

Research output: Contribution to journalArticle

Open Access
2015

Age-independent effects of hyaluronan amide derivative and growth hormone on human osteoarthritic chondrocytes

Gabusi, E., Paolella, F., Manferdini, C., Gambari, L., Schiavinato, A. & Lisignoli, G., Nov 2 2015, In : Connective Tissue Research. 56, 6, p. 440-451 12 p.

Research output: Contribution to journalArticle

Chondrogenic potential of human mesenchymal stem cells and expression of Slug transcription factor

Brini, A. T., Niada, S., Lambertini, E., Torreggiani, E., Arrigoni, E., Lisignoli, G. & Piva, R., Jun 1 2015, In : Journal of Tissue Engineering and Regenerative Medicine. 9, 6, p. 740-744 5 p.

Research output: Contribution to journalArticle

Hydrogen Sulfide Is a Novel Regulator of Bone Formation Implicated in the Bone Loss Induced by Estrogen Deficiency

Grassi, F., Tyagi, A. M., Calvert, J. W., Gambari, L., Walker, L. D., Yu, M., Robinson, J., Li, J. Y., Lisignoli, G., Vaccaro, C., Adams, J. & Pacifici, R., 2015, (Accepted/In press) In : Journal of Bone and Mineral Research.

Research output: Contribution to journalArticle

Lack of anti-inflammatory and anti-catabolic effects on basal inflamed osteoarthritic chondrocytes or synoviocytes by adipose stem cell-conditioned medium

Manferdini, C., Maumus, M., Gabusi, E., Paolella, F., Grassi, F., Jorgensen, C., Fleury-Cappellesso, S., Noël, D. & Lisignoli, G., Nov 1 2015, In : Osteoarthritis and Cartilage. 23, 11, p. 2045-2057 13 p.

Research output: Contribution to journalArticle

Osteogenic differentiation of human MSCs: Specific occupancy of the mitochondrial DNA by NFATc1 transcription factor

Lambertini, E., Penolazzi, L., Morganti, C., Lisignoli, G., Zini, N., Angelozzi, M., Bonora, M., Ferroni, L., Pinton, P., Zavan, B. & Piva, R., Jul 1 2015, In : International Journal of Biochemistry and Cell Biology. 64, p. 212-219 8 p., 4603.

Research output: Contribution to journalArticle

Slug transcription factor and nuclear Lamin B1 are upregulated in osteoarthritic chondrocytes

Piva, R., Lambertini, E., Manferdini, C., Capanni, C., Penolazzi, L., Gabusi, E., Paolella, F., Lolli, A., Angelozzi, M., Lattanzi, G. & Lisignoli, G., Jul 1 2015, In : Osteoarthritis and Cartilage. 23, 7, p. 1226-1230 5 p.

Research output: Contribution to journalArticle

2014

Chondrogenic potential of slug-depleted human mesenchymal stem cells

Lisignoli, G., Manferdini, C., Lambertini, E., Zini, N., Angelozzi, M., Gabusi, E., Gambari, L., Penolazzi, L., Lolli, A., Facchini, A. & Piva, R., 2014, In : Tissue Engineering - Part A. 20, 19-20, p. 2795-2805 11 p.

Research output: Contribution to journalArticle

Sodium hydrosulfide inhibits the differentiation of osteoclast progenitor cells via NRF2-dependent mechanism

Gambari, L., Lisignoli, G., Cattini, L., Manferdini, C., Facchini, A. & Grassi, F., 2014, In : Pharmacological Research. 87, p. 99-112 14 p.

Research output: Contribution to journalArticle

2013

Adipose-derived mesenchymal stem cells exert antiinflammatory effects on chondrocytes and synoviocytes from osteoarthritis patients through prostaglandin E2

Manferdini, C., Maumus, M., Gabusi, E., Piacentini, A., Filardo, G., Peyrafitte, J. A., Jorgensen, C., Bourin, P., Fleury-Cappellesso, S., Facchini, A., Noël, D. & Lisignoli, G., May 2013, In : Arthritis and Rheumatism. 65, 5, p. 1271-1281 11 p.

Research output: Contribution to journalArticle

Adipose mesenchymal stem cells protect chondrocytes from degeneration associated with osteoarthritis

Maumus, M., Manferdini, C., Toupet, K., Peyrafitte, J. A., Ferreira, R., Facchini, A., Gabusi, E., Bourin, P., Jorgensen, C., Lisignoli, G. & Noël, D., Sep 2013, In : Stem Cell Research. 11, 2, p. 834-844 11 p.

Research output: Contribution to journalArticle

Co-Culture of Hematopoietic Stem/Progenitor Cells with Human Osteblasts Favours Mono/Macrophage Differentiation at the Expense of the Erythroid Lineage

Salati, S., Lisignoli, G., Manferdini, C., Pennucci, V., Zini, R., Bianchi, E., Norfo, R., Facchini, A., Ferrari, S. & Manfredini, R., Jan 29 2013, In : PLoS One. 8, 1, e53496.

Research output: Contribution to journalArticle

Myeloma cells inhibit non-canonical wnt co-receptor ror2 expression in human bone marrow osteoprogenitor cells: Effect of wnt5a/ror2 pathway activation on the osteogenic differentiation impairment induced by myeloma cells

Bolzoni, M., Donofrio, G., Storti, P., Guasco, D., Toscani, D., Lazzaretti, M., Bonomini, S., Agnelli, L., Capocefalo, A., Dalla Palma, B., Neri, A., Nicolini, F., Lisignoli, G., Russo, F., Colla, S., Aversa, F. & Giuliani, N., Feb 2013, In : Leukemia. 27, 2, p. 451-463 13 p.

Research output: Contribution to journalArticle

New insights into osteogenic and chondrogenic differentiation of human bone marrow mesenchymal stem cells and their potential clinical applications for bone regeneration in pediatric orthopaedics

Giuliani, N., Lisignoli, G., Magnani, M., Racano, C., Bolzoni, M., Dalla Palma, B., Spolzino, A., Manferdini, C., Abati, C., Toscani, D., Facchini, A. & Aversa, F., 2013, In : Stem Cells International. 312501.

Research output: Contribution to journalArticle

Specific inductive potential of a novel nanocomposite biomimetic biomaterial for osteochondral tissue regeneration

Manferdini, C., Cavallo, C., Grigolo, B., Fiorini, M., Nicoletti, A., Gabusi, E., Zini, N., Pressato, D., Facchini, A. & Lisignoli, G., 2013, (Accepted/In press) In : Journal of Tissue Engineering and Regenerative Medicine.

Research output: Contribution to journalArticle

T cell subsets differently regulate osteogenic differentiation of human mesenchymal stromal cells in vitro

Grassi, F., Cattini, L., Gambari, L., Manferdini, C., Piacentini, A., Gabusi, E., Facchini, A. & Lisignoli, G., 2013, (Accepted/In press) In : Journal of Tissue Engineering and Regenerative Medicine.

Research output: Contribution to journalArticle

2012

Extracellular calcium chronically induced human osteoblasts effects: Specific modulation of osteocalcin and collagen type XV

Gabusi, E., Manferdini, C., Grassi, F., Piacentini, A., Cattini, L., Filardo, G., Lambertini, E., Piva, R., Zini, N., Facchini, A. & Lisignoli, G., Aug 2012, In : Journal of Cellular Physiology. 227, 8, p. 3151-3161 11 p.

Research output: Contribution to journalArticle

Role of slug transcription factor in human mesenchymal stem cells

Torreggiani, E., Lisignoli, G., Manferdini, C., Lambertini, E., Penolazzi, L., Vecchiatini, R., Gabusi, E., Chieco, P., Facchini, A., Gambari, R. & Piva, R., 2012, In : Journal of Cellular and Molecular Medicine. 16, 4, p. 740-751 12 p.

Research output: Contribution to journalArticle

2011

Chemical-physical properties and in vitro cell culturing of a novel biphasic bio-mimetic scaffold for osteo-chondral tissue regeneration.

Grigolo, B., Fiorini, M., Manferdini, C., Cavallo, C., Gabusi, E., Zini, N., Dolcini, L., Nicoletti, A., Pressato, D., Facchini, A. & Lisignoli, G., Apr 2011, In : Journal of Biological Regulators and Homeostatic Agents. 25, 2 Suppl

Research output: Contribution to journalArticle

Comparison of alternative mesenchymal stem cell sources for cell banking and musculoskeletal advanced therapies

Cavallo, C., Cuomo, C., Fantini, S., Ricci, F., Tazzari, P. L., Lucarelli, E., Donati, D., Facchini, A., Lisignoli, G., Fornasari, P. M., Grigolo, B. & Moroni, L., May 2011, In : Journal of Cellular Biochemistry. 112, 5, p. 1418-1430 13 p.

Research output: Contribution to journalArticle

Evidence of specific characteristics and osteogenic potentiality in bone cells from Tibia

Manferdini, C., Gabusi, E., Grassi, F., Piacentini, A., Cattini, L., Zini, N., Filardo, G., Facchini, A. & Lisignoli, G., Oct 2011, In : Journal of Cellular Physiology. 226, 10, p. 2675-2682 8 p.

Research output: Contribution to journalArticle

HOXB7 expression by myeloma cells regulates their pro-angiogenic properties in multiple myeloma patients

Storti, P., Donofrio, G., Colla, S., Airoldi, I., Bolzoni, M., Agnelli, L., Abeltino, M., Todoerti, K., Lazzaretti, M., Mancini, C., Ribatti, D., Bonomini, S., Franceschi, V., Pistoia, V., Lisignoli, G., Pedrazzini, A., Cavicchi, O., Neri, A., Rizzoli, V. & Giuliani, N., Mar 2011, In : Leukemia. 25, 3, p. 527-537 11 p.

Research output: Contribution to journalArticle

Slug contributes to the regulation of CXCL12 expression in human osteoblasts

Piva, R., Manferdini, C., Lambertini, E., Torreggiani, E., Penolazzi, L., Gambari, R., Pastore, A., Pelucchi, S., Gabusi, E., Piacentini, A., Filardo, G., Facchini, A. & Lisignoli, G., May 1 2011, In : Experimental Cell Research. 317, 8, p. 1159-1168 10 p.

Research output: Contribution to journalArticle

T cell suppression by osteoclasts in vitro

Grassi, F., Manferdini, C., Cattini, L., Piacentini, A., Gabusi, E., Facchini, A. & Lisignoli, G., Apr 2011, In : Journal of Cellular Physiology. 226, 4, p. 982-990 9 p.

Research output: Contribution to journalArticle

Transcription factor decoy against NFATc1 in human primary osteoblasts

Penolazzi, L., Lisignoli, G., Lambertini, E., Torreggiani, E., Manferdini, C., Lolli, A., Vecchiatini, R., Ciardo, F., Gabusi, E., Facchini, A., Gambari, R. & Piva, R., Aug 2011, In : International Journal of Molecular Medicine. 28, 2, p. 199-206 8 p.

Research output: Contribution to journalArticle