• 6885 Citations
  • 42 h-Index
1988 …2019
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Research Output 1988 2019

  • 6885 Citations
  • 42 h-Index
  • 139 Article
  • 6 Review article
  • 5 Chapter
  • 1 Comment/debate
2019

Baroreflex activation therapy systems: current status and future prospects

Seravalle, G., Dell’Oro, R. & Grassi, G., Dec 2 2019, In : Expert Review of Medical Devices. 16, 12, p. 1025-1033 9 p.

Research output: Contribution to journalReview article

The importance of endothelial dysfunction in resistance artery remodelling and cardiovascular risk

Masi, S., Georgiopoulos, G., Chiriacò, M., Grassi, G., Seravalle, G., Savoia, C., Volpe, M., Taddei, S., Rizzoni, D. & Virdis, A., Apr 8 2019, In : Cardiovascular Research.

Research output: Contribution to journalArticle

Arteries
Nitric Oxide
Myography
Hypertension
Pressure
2018
5 Citations (Scopus)

Age- and sex-specific reference values for media/lumen ratio in small arteries and relationship with risk factors

Study Group on Micro- and Macrocirculation of the Italian Society of Hypertension (SIIA), Jan 1 2018, In : Hypertension. 71, 6, p. 1193-1200 8 p.

Research output: Contribution to journalArticle

Reference Values
Arteries
Blood Pressure
Cholesterol
Body Mass Index
13 Citations (Scopus)

Obesity and cardiovascular risk: A call for action from the European Society of Hypertension Working Group of Obesity, Diabetes and the High-risk Patient and European Association for the Study of Obesity: Part A: Mechanisms of obesity induced hypertension, diabetes and dyslipidemia and practice guidelines for treatment

Kotsis, V., Jordan, J., Micic, D., Finer, N., Leitner, D. R., Toplak, H., Tokgozoglu, L., Athyros, V., Elisaf, M., Filippatos, T. D., Redon, J., Redon, P., Antza, C., Tsioufis, K., Grassi, G., Seravalle, G., Coca, A., Sierra, C., Lurbe, E., Stabouli, S. & 2 others, Jelakovic, B. & Nilsson, P. M., Jul 1 2018, In : Journal of Hypertension. 36, 7, p. 1427-1440 14 p.

Research output: Contribution to journalReview article

Dyslipidemias
Practice Guidelines
Obesity
Hypertension
Therapeutics
13 Citations (Scopus)

Obesity and cardiovascular risk: A call for action from the European Society of Hypertension Working Group of Obesity, Diabetes and the High-risk Patient and European Association for the Study of Obesity: Part B: Obesity-induced cardiovascular disease, early prevention strategies and future research directions

Kotsis, V., Tsioufis, K., Antza, C., Seravalle, G., Coca, A., Sierra, C., Lurbe, E., Stabouli, S., Jelakovic, B., Redon, J., Redon, P., Nilsson, P. M., Jordan, J., Micic, D., Finer, N., Leitner, D. R., Toplak, H., Tokgozoglu, L., Athyros, V., Elisaf, M. & 2 others, Filippatos, T. D. & Grassi, G., Jul 1 2018, In : Journal of Hypertension. 36, 7, p. 1441-1455 15 p.

Research output: Contribution to journalReview article

Cardiovascular Diseases
Obesity
Sudden Cardiac Death
Health Policy
Atrial Fibrillation

Sympathetic and baroreflex abnormalities in the uncomplicated prediabetic state

Dell'Oro, R., Trevano, F. Q., Gamba, P., Ciuffarella, C., Seravalle, G., Mancia, G. & Grassi, G., May 1 2018, In : Journal of Hypertension. 36, 5, p. 1195-1200 6 p.

Research output: Contribution to journalArticle

Prediabetic State
Baroreflex
Adrenergic Agents
Reflex
Disease Progression
2017
Obesity
Pharmacology
Hypertension
Research
corrigendum
2 Citations (Scopus)

Follow-up of Antihypertensive Therapy Improves Blood Pressure Control: Results of HYT (HYperTension survey) Follow-up

Fici, F., Seravalle, G., Koylan, N., Nalbantgil, I., Cagla, N., Korkut, Y., Quarti-Trevano, F., Makel, W. & Grassi, G., Sep 1 2017, In : High Blood Pressure and Cardiovascular Prevention. 24, 3, p. 289-296 8 p.

Research output: Contribution to journalArticle

Antihypertensive Agents
Blood Pressure
Hypertension
Therapeutics
Renin-Angiotensin System

Multicenter Randomized Double-Blind Comparison of Nebivolol plus HCTZ and Irbesartan plus HCTZ in the Treatment of Isolated Systolic Hypertension in Elderly Patients: Results of the NEHIS Study

Grassi, G., Seravalle, G. L., Brambilla, G., Delloro, R., Trevano, F. Q., Fici, F., Van Bortel, L. M. & Mancia, G., 2017, In : Advances in Therapy. p. 1-15 15 p.

Research output: Contribution to journalArticle

irbesartan
Nebivolol
Hydrochlorothiazide
Blood Pressure
Hypertension
21 Citations (Scopus)

Obesity and hypertension

Seravalle, G. & Grassi, G., Aug 1 2017, In : Pharmacological Research. 122, p. 1-7 7 p.

Research output: Contribution to journalReview article

Obesity
Hypertension
Intra-Abdominal Fat
R Factors
Sympathetic Nervous System
3 Citations (Scopus)

Reliability of heart rate as neuroadrenergic marker in the metabolic syndrome

Quarti Trevano, F., Seravalle, G., MacChiarulo, M., Villa, P., Valena, C., Dell'Oro, R., Mancia, G. & Grassi, G., Aug 1 2017, In : Journal of Hypertension. 35, 8, p. 1685-1690 6 p.

Research output: Contribution to journalArticle

Heart Rate
Norepinephrine
Adrenergic Agents
Muscles
Blood Pressure
9 Citations (Scopus)

Restoration of normal sympathetic neural function in heart failure following baroreflex activation therapy: Final 43-month study report

Dell'Oro, R., Gronda, E., Seravalle, G., Costantino, G., Alberti, L., Baronio, B., Staine, T., Vanoli, E., Mancia, G. & Grassi, G., Dec 1 2017, In : Journal of Hypertension. 35, 12, p. 2532-2536 5 p.

Research output: Contribution to journalArticle

Baroreflex
Heart Failure
Hospitalization
Therapeutics
Stroke Volume
2016

Alterations in sympathetic nerve traffic in genetic haemochromatosis before and after iron depletion therapy: A microneurographic study

Seravalle, G. L., Piperno, A., Mariani, R., Pelloni, I., Facchetti, R., Dell'Oro, R., Cuspidi, C., Mancia, G. & Grassi, G., Mar 21 2016, In : European Heart Journal. 37, 12, p. 988-995 8 p.

Research output: Contribution to journalArticle

Hemochromatosis
Iron
Iron Overload
Baroreflex
Therapeutics
2 Citations (Scopus)

Alterations in sympathetic nerve traffic in genetic haemochromatosis before and after iron depletion therapy: A microneurographic study

Seravalle, G., Piperno, A., Mariani, R., Pelloni, I., Facchetti, R., Dell'oro, R., Cuspidi, C., Mancia, G. & Grassi, G., Mar 21 2016, In : European Heart Journal. 37, 12, p. 988-995 8 p.

Research output: Contribution to journalArticle

Hemochromatosis
Iron
Iron Overload
Baroreflex
Therapeutics

Baroreflex Activation Therapy in Congestive Heart Failure: Novel Findings and Future Insights

Grassi, G., Brambilla, G., Pizzalla, D. P. & Seravalle, G. L., Aug 1 2016, In : Current Hypertension Reports. 18, 8, 60.

Research output: Contribution to journalReview article

Baroreflex
Heart Failure
Pressoreceptors
Therapeutics
Disease Progression
7 Citations (Scopus)

Differential effects of enalapril-felodipine versus enalapril-lercanidipine combination drug treatment on sympathetic nerve traffic and metabolic profile in obesity-related hypertension

Seravalle, G., Brambilla, G., Pizzalla, D. P., Casati, A., Riva, M., Cuspidi, C., Bombelli, M., Mancia, G. & Grassi, G., Mar 1 2016, In : Journal of the American Society of Hypertension. 10, 3, p. 244-251 8 p.

Research output: Contribution to journalArticle

Felodipine
Enalapril
Metabolome
Drug Combinations
Obesity

Effects of chronic carotid baroreceptor activation on arterial stiffness in severe heart failure

Gronda, E., Brambilla, G., Seravalle, G. L., Maloberti, A., Cairo, M., Costantino, G., Lovett, E. G., Vanoli, E., Mancia, G. & Grassi, G., Oct 1 2016, In : Clinical Research in Cardiology. 105, 10, p. 838-846 9 p.

Research output: Contribution to journalArticle

Vascular Stiffness
Pressoreceptors
Heart Failure
Baroreflex
Muscles
Sympathetic Nervous System
Obesity
Hypertension
Clinical Studies
2015

Arterial alterations in hypertension

Seravalle, G., Grassi, G. & Mancia, G., Jan 1 2015, Arterial Disorders: Definition, Clinical Manifestations, Mechanisms and Therapeutic Approaches. Springer International Publishing, p. 285-297 13 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Kidney Diseases
Cardiovascular System
Lung Diseases
Blood Vessels
Liver Diseases
4 Citations (Scopus)

Asymmetric and symmetric dimethylarginine and sympathetic nerve traffic after renal denervation in patients with resistant hypertension

Grassi, G., Seravalle, G., Trevano, F. Q., Spaziani, D., Scalise, F., Auguadro, C., Pizzini, P., Tripepi, G., D’Arrigo, G., Mallamaci, F., Mancia, G. & Zoccali, C., Sep 4 2015, In : Clinical Journal of the American Society of Nephrology. 10, 9, p. 1560-1567 8 p.

Research output: Contribution to journalArticle

Denervation
Hypertension
Kidney
Control Groups
Sympathetic Nervous System
27 Citations (Scopus)

Blood Pressure Responses to Renal Denervation Precede and Are Independent of the Sympathetic and Baroreflex Effects

Grassi, G., Seravalle, G., Brambilla, G., Trabattoni, D., Cuspidi, C., Corso, R., Pieruzzi, F., Genovesi, S., Stella, A., Facchetti, R., Spaziani, D., Bartorelli, A. & Mancia, G., Jun 20 2015, In : Hypertension. 65, 6, p. 1209-1216 8 p.

Research output: Contribution to journalArticle

Baroreflex
Denervation
Blood Pressure
Kidney
Muscles
Pressoreceptors
Heart Failure
Hypertension
Carotid Sinus
Health Care Costs
4 Citations (Scopus)

HYT-Hypertension in Turkey: A Cross-Sectional Survey on Blood Pressure Control with Calcium Channel Blockers Alone or Combined with Other Antihypertensive Drugs

Seravalle, G., Koylan, N., Nalbantgil, I., Caglar, N., Quarti-Trevano, F., Makel, W., Grassi, G. & Fici, F., Jun 11 2015, In : High Blood Pressure and Cardiovascular Prevention. 22, 2, p. 165-172 8 p.

Research output: Contribution to journalArticle

Calcium Channel Blockers
Turkey
Antihypertensive Agents
Cross-Sectional Studies
Blood Pressure
23 Citations (Scopus)

Long-term chronic baroreflex activation: Persistent efficacy in patients with heart failure and reduced ejection fraction

Gronda, E., Seravalle, G., Trevano, F. Q., Costantino, G., Casini, A., Alsheraei, A., Lovett, E. G., Vanoli, E., Mancia, G. & Grassi, G., Aug 11 2015, In : Journal of Hypertension. 33, 8, p. 1704-1708 5 p.

Research output: Contribution to journalArticle

Baroreflex
Heart Failure
Hospitalization
Therapeutics
Muscles

Neurohormonal interactions

Seravalle, G. & Grassi, G., Jan 1 2015, Arterial Disorders: Definition, Clinical Manifestations, Mechanisms and Therapeutic Approaches. Springer International Publishing, p. 137-150 14 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Kidney Diseases
Cardiovascular System
Lung Diseases
Blood Vessels
Liver Diseases
26 Citations (Scopus)

Sympathetic activation in cardiovascular disease: Evidence, clinical impact and therapeutic implications

Grassi, G., Seravalle, G. & Mancia, G., Dec 1 2015, In : European Journal of Clinical Investigation. 45, 12, p. 1367-1375 9 p.

Research output: Contribution to journalReview article

Cardiovascular Diseases
Chemical activation
Kidney
Pressoreceptors
Sympathetic Nervous System
30 Citations (Scopus)

Sympathetic nerve traffic and baroreflex function in optimal, normal, and high-normal blood pressure states

Seravalle, G., Lonati, L., Buzzi, S., Cairo, M., Trevano, F. Q., Dell'Oro, R., Facchetti, R., Mancia, G. & Grassi, G., 2015, In : Journal of Hypertension. 33, 7, p. 1411-1417 7 p.

Research output: Contribution to journalArticle

Baroreflex
Blood Pressure
Hypertension
Blood Group Antigens
Masked Hypertension
9 Citations (Scopus)

Within-visit BP variability, cardiovascular risk factors, and BP control in central and eastern Europe: Findings from the BP-CARE study

Grassi, G., Seravalle, G., Maloberti, A., Facchetti, R., Cuspidi, C., Bombelli, M., Laurent, S., Redon, J. & Mancia, G., 2015, In : Journal of Hypertension. 33, 11, p. 2250-2256 7 p.

Research output: Contribution to journalArticle

Eastern Europe
Blood Pressure
Physical Examination
Cardiovascular Diseases
History
2014
84 Citations (Scopus)

Chronic baroreflex activation effects on sympathetic nerve traffic, baroreflex function, and cardiac haemodynamics in heart failure: A proof-of-concept study

Gronda, E., Seravalle, G., Brambilla, G., Costantino, G., Casini, A., Alsheraei, A., Lovett, E. G., Mancia, G. & Grassi, G., 2014, In : European Journal of Heart Failure. 16, 9, p. 977-983 7 p.

Research output: Contribution to journalArticle

Baroreflex
Heart Failure
Hemodynamics
Therapeutics
Carotid Sinus
23 Citations (Scopus)
Hypertension
Arteries
Microscopic Angioscopy
Laser-Doppler Flowmetry
Arterioles
33 Citations (Scopus)

Long-term sympathoinhibitory effects of surgically induced weight loss in severe obese patients

Seravalle, G., Colombo, M., Perego, P., Giardini, V., Volpe, M., Dell'Oro, R., Mancia, G. & Grassi, G., 2014, In : Hypertension. 64, 2, p. 431-437 7 p.

Research output: Contribution to journalArticle

Gastrectomy
Insulin Resistance
Weight Loss
Bariatric Surgery
Baroreflex
48 Citations (Scopus)

Marked sympathetic activation and baroreflex dysfunction in true resistant hypertension

Grassi, G., Seravalle, G., Brambilla, G., Pini, C., Alimento, M., Facchetti, R., Spaziani, D., Cuspidi, C. & Mancia, G., Dec 20 2014, In : International Journal of Cardiology. 177, 3, p. 1020-1025 6 p.

Research output: Contribution to journalArticle

Baroreflex
Hypertension
Adrenergic Agents
Hemodynamics
Blood Pressure
14 Citations (Scopus)

Regional differences in sympathetic activation in lean and obese normotensive individuals with obstructive sleep apnoea

Grassi, G., Seravalle, G., Brambilla, G., Buzzi, S., Volpe, M., Cesana, F., Dell'Oro, R. & Mancia, G., Feb 2014, In : Journal of Hypertension. 32, 2, p. 383-388 6 p.

Research output: Contribution to journalArticle

Obstructive Sleep Apnea
Skin
Muscles
Sleep Apnea Syndromes
Blood Vessels

Role of Sympathetic Nervous System in the Metabolic Syndrome and Sleep Apnea

Seravalle, G. & Grassi, G., Sep 15 2014, Modulation of Sleep by Obesity, Diabetes, Age, and Diet. Elsevier Inc., p. 165-175 11 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Sympathetic Nervous System
Sleep Apnea Syndromes
Adrenergic Agents
Obstructive Sleep Apnea
Cluster Analysis
14 Citations (Scopus)
Sympathetic Nervous System
Cardiac Arrhythmias
Cardiovascular Diseases
Heart Failure
Obesity
4 Citations (Scopus)

Similarities and differences between renal sympathetic denervation and carotid baroreceptor stimulation

Grassi, G., Seravalle, G., Brambilla, G., Cesana, F., Giannattasio, C. & Mancia, G., 2014, In : Current Vascular Pharmacology. 12, 1, p. 63-68 6 p.

Research output: Contribution to journalArticle

Pressoreceptors
Sympathectomy
Blood Pressure
Kidney
Denervation
2013
2 Citations (Scopus)

Differential patterns of regional neuroadrenergic cardiovascular drive in acromegalic disease

Seravalle, G., Carzaniga, C., Sciortino, G., Attanasio, R., Fatti, L. M., Cozzi, R., Montini, M., Vitale, G., Brambilla, G., Cavagnini, F., Mancia, G., Grassi, G. & Scacchi, M., May 2013, In : Clinical and Experimental Pharmacology and Physiology. 40, 5, p. 333-337 5 p.

Research output: Contribution to journalArticle

Leptin
Acromegaly
Hyperprolactinemia
Pituitary Hormones
Cardiomegaly
4 Citations (Scopus)
6 Citations (Scopus)

Home and ambulatory blood pressure in resistant hypertension.

Grassi, G., Facchetti, R., Seravalle, G., Cuspidi, C. & Mancia, G., May 2013, In : EuroIntervention. 9 Suppl R

Research output: Contribution to journalArticle

Blood Pressure
Hypertension
White Coat Hypertension
Therapeutic Uses
Kidney
8 Citations (Scopus)

How to assess sympathetic nervous system activity in clinical practice

Seravalle, G., Dimitriadis, K., Dell'Oro, R. & Grassi, G., 2013, In : Current Clinical Pharmacology. 8, 3, p. 182-188 7 p.

Research output: Contribution to journalArticle

Sympathetic Nervous System
Norepinephrine
Human Activities
10 Citations (Scopus)

Muscle and skin sympathetic nerve traffic during physician and nurse blood pressure measurement

Grassi, G., Seravalle, G., Buzzi, S., Magni, L., Brambilla, G., Quarti-Trevano, F., Dell'Oro, R. & Mancia, G., Jun 2013, In : Journal of Hypertension. 31, 6, p. 1131-1135 5 p.

Research output: Contribution to journalArticle

Nurses
Blood Pressure
Physicians
Muscles
Skin
44 Citations (Scopus)

Prevalence and clinical characteristics of patients with true resistant hypertension in central and Eastern Europe: Data from the BP-CARE study

Brambilla, G., Bombelli, M., Seravalle, G., Cifkova, R., Laurent, S., Narkiewicz, K., Facchetti, R., Redon, J., Mancia, G. & Grassi, G., Oct 2013, In : Journal of Hypertension. 31, 10, p. 2018-2024 7 p.

Research output: Contribution to journalArticle

Eastern Europe
Blood Pressure
Hypertension
Therapeutics
White Coat Hypertension
16 Citations (Scopus)

Role of ambulatory blood pressure monitoring in resistant hypertension

Grassi, G., Bombelli, M., Seravalle, G., Brambilla, G., Dell'Oro, R. & Mancia, G., Jun 2013, In : Current Hypertension Reports. 15, 3, p. 232-237 6 p.

Research output: Contribution to journalArticle

Ambulatory Blood Pressure Monitoring
Blood Pressure
Hypertension
White Coat Hypertension
Therapeutic Uses
7 Citations (Scopus)

Structural alterations of the retinal microcirculation in the "prehypertensive" high-normal blood pressure state

Grassi, G., Buzzi, S., Dell'Oro, R., Mineo, C., Dimitriadis, K., Seravalle, G., Lonati, L. & Cuspidi, C., 2013, In : Current Pharmaceutical Design. 19, 13, p. 2375-2381 7 p.

Research output: Contribution to journalArticle

Microcirculation
Hypertension
Prehypertension
Retinal Vessels
Hemodynamics

The role of carotid baroreceptor stimulation

Grassi, G., Brambilla, G. & Seravalle, G., Nov 1 2013, Resistant Hypertension: Epidemiology, Pathophysiology, Diagnosis and Treatment. Springer-Verlag Italia s.r.l., p. 137-144 8 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Pressoreceptors
Hypertension
Kidney
Carotid Sinus
Denervation
2012
5 Citations (Scopus)

Blood pressure control and antihypertensive treatment

Grassi, G., Seravalle, G., Trevano, F. Q., Dell'Oro, R. & Mancia, G., Jul 2012, In : Current Vascular Pharmacology. 10, 4, p. 506-511 6 p.

Research output: Contribution to journalArticle

Antihypertensive Agents
Blood Pressure
Therapeutics
Drug Combinations
Patient Compliance
7 Citations (Scopus)

Decreased adrenergic tone in acromegaly: Evidence from direct recording of muscle sympathetic nerve activity

Seravalle, G., Carzaniga, C., Attanasio, R., Grassi, G., Lonati, L., Facchini, C., Cozzi, R., Fatti, L. M., Montini, M., Vitale, G., Sciortino, G., Damanti, S., Brambilla, G., Cavagnini, F., Mancia, G. & Scacchi, M., Aug 2012, In : Clinical Endocrinology. 77, 2, p. 262-267 6 p.

Research output: Contribution to journalArticle

Acromegaly
Adrenergic Agents
Muscles
Leptin
Cardiomegaly
9 Citations (Scopus)

Novel antihypertensive therapies: Renal sympathetic nerve ablation and carotid baroreceptor stimulation

Grassi, G., Seravalle, G., Brambilla, G., Bombelli, M., Dell'Oro, R., Gronda, E. & Mancia, G., Dec 2012, In : Current Hypertension Reports. 14, 6, p. 567-572 6 p.

Research output: Contribution to journalArticle

Pressoreceptors
Antihypertensive Agents
Hypertension
Kidney
Metabolome
71 Citations (Scopus)
Sympathetic Nervous System
Chronic Renal Insufficiency
Hypertension
Chronic Kidney Failure
Renal Insufficiency
81 Citations (Scopus)

Sympathetic regulation of vascular function in health and disease

Bruno, R. M., Ghiadoni, L., Seravalle, G., Dell'Oro, R., Taddei, S. & Grassi, G., 2012, In : Frontiers in Physiology. 3 JUL, p. 1-15 15 p.

Research output: Contribution to journalArticle

Blood Vessels
Sympathetic Nervous System
Arteries
Healthy Volunteers
Health