20062019

Research output per year

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2019

Combined blockade of MEK and PI3KCA as an effective antitumor strategy in HER2 gene amplified human colorectal cancer models

Belli, V., Matrone, N., Napolitano, S., Migliardi, G., Cottino, F., Bertotti, A., Trusolino, L., Martinelli, E., Morgillo, F., Ciardiello, D., De Falco, V., Giunta, E. F., Bracale, U., Ciardiello, F. & Troiani, T., Jun 4 2019, In : Journal of experimental & clinical cancer research : CR. 38, 1, p. 236

Research output: Contribution to journalArticle

Prioritization of cancer therapeutic targets using CRISPR–Cas9 screens

Behan, F. M., Iorio, F., Picco, G., Gonçalves, E., Beaver, C. M., Migliardi, G., Santos, R., Rao, Y., Sassi, F., Pinnelli, M., Ansari, R., Harper, S., Jackson, D. A., McRae, R., Pooley, R., Wilkinson, P., van der Meer, D., Dow, D., Buser-Doepner, C., Bertotti, A. & 5 others, Trusolino, L., Stronach, E. A., Saez-Rodriguez, J., Yusa, K. & Garnett, M. J., Apr 25 2019, In : Nature. 568, 7753, p. 511-516 6 p.

Research output: Contribution to journalArticle

2017
2016

C-met inhibition blocks bone metastasis development induced by renal cancer stem cells

D'Amico, L., Belisario, D., Migliardi, G., Grange, C., Bussolati, B., D'Amelio, P., Perera, T., Dalmasso, E., Carbonare, L. D., Godio, L., Comoglio, P., Trusolino, L., Ferracini, R. & Roato, I., 2016, In : Oncotarget. 7, 29, p. 45525-45537 13 p.

Research output: Contribution to journalArticle

Lenalidomide normalizes tumor vessels in colorectal cancer improving chemotherapy activity

Leuci, V., Maione, F., Rotolo, R., Giraudo, E., Sassi, F., Migliardi, G., Todorovic, M., Gammaitoni, L., Mesiano, G., Giraudo, L., Luraghi, P., Leone, F., Bussolino, F., Grignani, G., Aglietta, M., Trusolino, L., Bertotti, A. & Sangiolo, D., May 5 2016, In : Journal of Translational Medicine. 14, 1, 119.

Research output: Contribution to journalArticle

2015

HER2 activating mutations are targets for colorectal cancer treatment

Kavuri, S. M., Jain, N., Galimi, F., Cottino, F., Leto, S. M., Migliardi, G., Searleman, A. C., Shen, W., Monsey, J., Trusolino, L., Jacobs, S. A., Bertotti, A. & Bose, R., Aug 1 2015, In : Cancer Discovery. 5, 8, p. 832-841 10 p.

Research output: Contribution to journalArticle

IGF2 is an actionable target that identifies a distinct subpopulation of colorectal cancer patients with marginal response to anti-EGFR therapies

Zanella, E. R., Galimi, F., Sassi, F., Migliardi, G., Cottino, F., Leto, S. M., Lupo, B., Erriquez, J., Isella, C., Comoglio, P. M., Medico, E., Tejpar, S., Budinská, E., Trusolino, L. & Bertotti, A., Jan 28 2015, In : Science Translational Medicine. 7, 272, 272ra12.

Research output: Contribution to journalArticle

Sustained Inhibition of HER3 and EGFR Is Necessary to Induce Regression of HER2-Amplified Gastrointestinal Carcinomas

Leto, S. M., Sassi, F., Catalano, I., Torri, V., Migliardi, G., Zanella, E. R., Throsby, M., Bertotti, A. & Trusolino, L., Dec 15 2015, In : Clinical Cancer Research. 21, 24, p. 5519-5531 13 p.

Research output: Contribution to journalArticle

The genomic landscape of response to EGFR blockade in colorectal cancer

Bertotti, A., Papp, E., Jones, S., Adleff, V., Anagnostou, V., Lupo, B., Sausen, M., Phallen, J., Hruban, C. A., Tokheim, C., Niknafs, N., Nesselbush, M., Lytle, K., Sassi, F., Cottino, F., Migliardi, G., Zanella, E. R., Ribero, D., Russolillo, N., Mellano, A. & 15 others, Muratore, A., Paraluppi, G., Salizzoni, M., Marsoni, S., Kragh, M., Lantto, J., Cassingena, A., Li, Q. K., Karchin, R., Scharpf, R., Sartore-Bianchi, A., Siena, S., Diaz, L. A., Trusolino, L. & Velculescu, V. E., Oct 8 2015, In : Nature. 526, 7572, p. 263-267 5 p.

Research output: Contribution to journalArticle

The tissue inhibitor of metalloproteinases 1 increases the clonogenic efficiency of human hematopoietic progenitor cells through CD63/PI3K/Akt signaling

Rossi, L., Forte, D., Migliardi, G., Salvestrini, V., Buzzi, M., Ricciardi, M. R., Licchetta, R., Tafuri, A., Bicciato, S., Cavo, M., Catani, L., Lemoli, R. M. & Curti, A., Nov 1 2015, In : Experimental Hematology. 43, 11, p. 974-985.e1

Research output: Contribution to journalArticle

2014

HSP27 is required for invasion and metastasis triggered by hepatocyte growth factor

Pavan, S., Musiani, D., Torchiaro, E., Migliardi, G., Gai, M., Di Cunto, F., Erriquez, J., Olivero, M. & Di Renzo, M. F., Mar 15 2014, In : International Journal of Cancer. 134, 6, p. 1289-1299 11 p.

Research output: Contribution to journalArticle

2013

Amplification of the MET receptor drives resistance to anti-EGFR therapies in colorectal cancer

Bardelli, A., Corso, S., Bertotti, A., Hobor, S., Valtorta, E., Siravegna, G., Sartore-Bianchi, A., Scala, E., Cassingena, A., Zecchin, D., Apicella, M., Migliardi, G., Galimi, F., Lauricella, C., Zanon, C., Perera, T., Veronese, S., Corti, G., Amatu, A., Gambacorta, M. & 8 others, Diaz, L. A., Sausen, M., Velculescu, V. E., Comoglio, P., Trusolino, L., Di Nicolantonio, F., Giordano, S. & Siena, S., 2013, In : Cancer Discovery. 3, 6, p. 658-673 16 p.

Research output: Contribution to journalArticle

Met signaling regulates growth, repopulating potential and basal cell-fate commitment of mammary luminal progenitors: Implications for basal-like breast cancer

Gastaldi, S., Sassi, F., Accornero, P., Torti, D., Galimi, F., Migliardi, G., Molyneux, G., Perera, T., Comoglio, P. M., Boccaccio, C., Smalley, M. J., Bertotti, A. & Trusolino, L., Mar 14 2013, In : Oncogene. 32, 11, p. 1428-1440 13 p.

Research output: Contribution to journalArticle

2012

Inhibition of MEK and PI3K/mTOR suppresses tumor growth but does not cause tumor regression in patient-derived xenografts of RAS-mutant colorectal carcinomas

Migliardi, G., Sassi, F., Torti, D., Galimi, F., Zanella, E. R., Buscarino, M., Ribero, D., Muratore, A., Massucco, P., Pisacane, A., Risio, M., Capussotti, L., Marsoni, S., Di Nicolantonio, F., Bardelli, A., Comoglio, P. M., Trusolino, L. & Bertotti, A., May 1 2012, In : Clinical Cancer Research. 18, 9, p. 2515-2525 11 p.

Research output: Contribution to journalArticle

Purinergic signaling inhibits human acute myeloblastic leukemia cell proliferation, migration, and engraftment in immunodeficient mice

Salvestrini, V., Zini, R., Rossi, L., Gulinelli, S., Manfredini, R., Bianchi, E., Piacibello, W., Caione, L., Migliardi, G., Ricciardi, M. R., Tafuri, A., Romano, M., Salati, S., Di Virgilio, F., Ferrari, S., Baccarani, M., Ferrari, D. & Lemoli, R. M., Jan 5 2012, In : Blood. 119, 1, p. 217-226 10 p.

Research output: Contribution to journalArticle

2011

A molecularly annotated platform of patient- derived xenografts ("xenopatients") identifies HER2 as an effective therapeutic target in cetuximab-resistant colorectal cancer

Bertotti, A., Migliardi, G., Galimi, F., Sassi, F., Torti, D., Isella, C., Corà, D., di Nicolantonio, F., Buscarino, M., Petti, C., Ribero, D., Russolillo, N., Muratore, A., Massucco, P., Pisacane, A., Molinaro, L., Valtorta, E., Sartore-Bianchi, A., Risio, M., Capussotti, L. & 8 others, Gambacorta, M., Siena, S., Medico, E., Sapino, A., Marsoni, S., Comoglio, P. M., Bardelli, A. & Trusolino, L., Nov 2011, In : Cancer Discovery. 1, 6, p. 508-523 16 p.

Research output: Contribution to journalArticle

Epidermal Growth Factor Receptor (EGFR) mutation analysis, gene expression profiling and EGFR protein expression in primary prostate cancer

Peraldo-Neia, C., Migliardi, G., Mello-Grand, M., Montemurro, F., Segir, R., Pignochino, Y., Cavalloni, G., Torchio, B., Mosso, L., Chiorino, G. & Aglietta, M., Jan 25 2011, In : BMC Cancer. 11, 31.

Research output: Contribution to journalArticle

2010

Inhibition of erythropoiesis in malaria anemia: Role of hemozoin and hemozoin-generated 4-hydroxynonenal

Skorokhod, O. A., Caione, L., Marrocco, T., Migliardi, G., Barrera, V., Arese, P., Piacibello, W. & Schwarzer, E., Nov 18 2010, In : Blood. 116, 20, p. 4328-4337 10 p.

Research output: Contribution to journalArticle

Targeting EGFR/HER2 pathways enhances the antiproliferative effect of gemcitabine in biliary tract and gallbladder carcinomas

Pignochino, Y., Sarotto, I., Peraldo-Neia, C., Penachioni, J. Y., Cavalloni, G., Migliardi, G., Casorzo, L., Chiorino, G., Risio, M., Bardelli, A., Aglietta, M. & Leone, F., 2010, In : BMC Cancer. 10, 1, 631.

Research output: Contribution to journalArticle

Targeting EGFR/HER2 pathways enhances the antiproliferative effect of gemcitabine in biliary tract and gallbladder carcinomas

Pignochino, Y., Sarotto, I., Peraldo-Neia, C., Penachioni, J. Y., Cavalloni, G., Migliardi, G., Casorzo, L., Chiorino, G., Risio, M., Bardelli, A., Aglietta, M. & Leone, F., Nov 18 2010, In : BMC Cancer. 10, 361.

Research output: Contribution to journalArticle

2009

Efficient transcriptional targeting of human hematopoietic stem cells and blood cell lineages by lentiviral vectors containing the regulatory element of the Wiskott-Aldrich syndrome gene

Leuci, V., Gammaitoni, L., Capellero, S., Sangiolo, D., Mesuraca, M., Bond, H. M., Migliardi, G., Cammarata, C., Aglietta, M., Morrone, G. & Piacibello, W., Nov 2009, In : Stem Cells. 27, 11, p. 2815-2823 9 p.

Research output: Contribution to journalArticle

Sorafenib blocks tumour growth, angiogenesis and metastatic potential in preclinical models of osteosarcoma through a mechanism potentially involving the inhibition of ERK1/2, MCL-1 and ezrin pathways

Pignochino, Y., Grignani, G., Cavalloni, G., Motta, M., Tapparo, M., Bruno, S., Bottos, A., Gammaitoni, L., Migliardi, G., Camussi, G., Alberghini, M., Torchio, B., Ferrari, S., Bussolino, F., Fagioli, F., Picci, P. & Aglietta, M., Dec 10 2009, In : Molecular Cancer. 8, 118.

Research output: Contribution to journalArticle

2008

Granulocyte-colony stimulating factor upregulates ErbB2 expression on breast cancer cell lines and converts primary resistance to trastuzumab

Cavalloni, G., Sarotto, I., Pignochino, Y., Gammaitoni, L., Migliardi, G., Sgro, L., Piacibello, W., Risio, M., Aglietta, M. & Leone, F., Aug 2008, In : Anti-Cancer Drugs. 19, 7, p. 689-696 8 p.

Research output: Contribution to journalArticle

2006