• 1195 Citations
  • 18 h-Index
1992 …2018
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Research Output 1992 2018

  • 1195 Citations
  • 18 h-Index
  • 45 Article
  • 2 Review article
2018
4 Citations (Scopus)

Detection of four regulated grapevine viruses in a qualitative, single tube real-time PCR with melting curve analysis

Aloisio, M., Morelli, M., Elicio, V., Saldarelli, P., Ura, B., Bortot, B., Severini, G. M. & Minafra, A., Jul 1 2018, In : Journal of Virological Methods. 257, p. 42-47 6 p.

Research output: Contribution to journalArticle

Freezing
Real-Time Polymerase Chain Reaction
Viruses
Certification
European Union

Genetics of Dilated Cardiomyopathy: Clinical Implications

Paldino, A., De Angelis, G., Merlo, M., Gigli, M., Dal Ferro, M., Severini, G. M., Mestroni, L. & Sinagra, G., Oct 1 2018, In : Current Cardiology Reports. 20, 10, 83.

Research output: Contribution to journalReview article

Dilated Cardiomyopathy
Genetic Association Studies
Mutation
Filamins
Lamin Type A
8 Citations (Scopus)
Ovarian Neoplasms
Nanoparticles
Nanomedicine
Drug Therapy
Neoplasms
2017
2 Citations (Scopus)

A semi-nested real-time PCR method to detect low chimerism percentage in small quantity of hematopoietic stem cell transplant DNA samples

Aloisio, M., Bortot, B., Gandin, I., Severini, G. M., Athanasakis, E. & Xu, Z. S., 2017, In : Genome. 60, 2, p. 183-192 10 p.

Research output: Contribution to journalArticle

Chimerism
Hematopoietic Stem Cells
Real-Time Polymerase Chain Reaction
Transplants
DNA
26 Citations (Scopus)

Synthesis of Lipophilic Core-Shell Fe3O4@SiO2@Au Nanoparticles and Polymeric Entrapment into Nanomicelles: A Novel Nanosystem for in Vivo Active Targeting and Magnetic Resonance-Photoacoustic Dual Imaging

Monaco, I., Arena, F., Biffi, S., Locatelli, E., Bortot, B., La Cava, F., Marini, G. M., Severini, G. M., Terreno, E. & Comes Franchini, M., May 17 2017, In : Bioconjugate Chemistry. 28, 5, p. 1382-1390 9 p.

Research output: Contribution to journalArticle

Nanosystems
Photoacoustic effect
Magnetic resonance
Nanoparticles
Magnetic Resonance Spectroscopy
2016
7 Citations (Scopus)

A technical application of quantitative next generation sequencing for chimerism evaluation

Aloisio, M., Licastro, D., Caenazzo, L., Torboli, V., D'Eustacchio, A., Severini, G. M. & Athanasakis, E., Oct 1 2016, In : Molecular Medicine Reports. 14, 4, p. 2967-2974 8 p.

Research output: Contribution to journalArticle

Chimerism
Ions
Bioinformatics
Pipelines
Capillary electrophoresis
18 Citations (Scopus)

Clinical Spectrum of PRKAG2 Syndrome

Porto, A. G., Brun, F., Severini, G. M., Losurdo, P., Fabris, E., Taylor, M. R. G., Mestroni, L. & Sinagra, G., Jan 1 2016, In : Circulation: Arrhythmia and Electrophysiology. 9, 1, e003121.

Research output: Contribution to journalArticle

2015
9 Citations (Scopus)

Genetic profiling of autoinflammatory disorders in patients with periodic fever: A prospective study

De Pieri, C., Vuch, J., De Martino, E., Bianco, A. M., Ronfani, L., Athanasakis, E., Bortot, B., Crovella, S., Taddio, A., Severini, G. M. & Tommasini, A., Apr 10 2015, In : Pediatric Rheumatology. 13, 1, 11.

Research output: Contribution to journalArticle

Fever
Prospective Studies
Genes
Glucocorticoids
Genotype
8 Citations (Scopus)

Use of polylactide-co-glycolide-nanoparticles for lysosomal delivery of a therapeutic enzyme in glycogenosis type II fibroblasts

Tancini, B., Tosi, G., Bortot, B., Dolcetta, D., Magini, A., De Martino, E., Urbanelli, L., Ruozi, B., Forni, F., Emiliani, C., Vandelli, M. A. & Severini, G. M., Apr 1 2015, In : Journal of Nanoscience and Nanotechnology. 15, 4, p. 2657-2666 10 p.

Research output: Contribution to journalArticle

Glycogen Storage Disease Type II
fibroblasts
Fibroblasts
Nanoparticles
enzymes
2014
13 Citations (Scopus)

Detection of PLGA-based nanoparticles at a single-cell level by synchrotron radiation FTIR spectromicroscopy and correlation with X-ray fluorescence microscopy

Pascolo, L., Bortot, B., Benseny-Cases, N., Gianoncelli, A., Tosi, G., Ruozi, B., Rizzardi, C., De Martino, E., Vandelli, M. A. & Severini, G. M., Jun 7 2014, In : International Journal of Nanomedicine. 9, 1, p. 2791-2801 11 p.

Research output: Contribution to journalArticle

Synchrotrons
Fluorescence microscopy
Fourier Transform Infrared Spectroscopy
Synchrotron radiation
Fluorescence Microscopy
14 Citations (Scopus)

F402L variant in NLRP12 in subjects with undiagnosed periodic fevers and in healthy controls

De Pieri, C., Vuch, J., Athanasakis, E., Severini, G. M., Crovella, S., Bianco, A. M. & Tommasini, A., 2014, In : Clinical and Experimental Rheumatology. 32, 6, p. 993-994 2 p.

Research output: Contribution to journalArticle

2013
9 Citations (Scopus)

Cardiac hypertrophy, accessory pathway, and conduction system disease in an adolescent: The PRKAG2 cardiac syndrome

Fabris, E., Brun, F., Porto, A. G., Losurdo, P., Vitali Serdoz, L., Zecchin, M., Severini, G. M., Mestroni, L., Di Chiara, A. & Sinagra, G., Aug 27 2013, In : Journal of the American College of Cardiology. 62, 9

Research output: Contribution to journalArticle

11 Citations (Scopus)

Clinical genetic testing of periodic fever syndromes

Marcuzzi, A., Piscianz, E., Kleiner, G., Tommasini, A., Severini, G. M., Monasta, L. & Crovella, S., 2013, In : BioMed Research International. 2013, 501305.

Research output: Contribution to journalArticle

Genetic Testing
Fever
Testing
Genes
Bioinformatics
6 Citations (Scopus)

PMM2-CDG: Phenotype and genotype in four affected family members

Bortot, B., Cosentini, D., Faletra, F., Biffi, S., De Martino, E., Carrozzi, M. & Severini, G. M., Dec 1 2013, In : Gene. 531, 2, p. 506-509 4 p.

Research output: Contribution to journalArticle

Congenital Disorders of Glycosylation
Genotype
Phenotype
Glycosylation
Mutation
72 Citations (Scopus)

Potential use of polymeric nanoparticles for drug delivery across the blood-brain barrier

Tosi, G., Bortot, B., Ruozi, B., Dolcetta, D., Vandelli, M. A., Forni, F. & Severini, G. M., Jun 2013, In : Current Medicinal Chemistry. 20, 17, p. 2212-2225 14 p.

Research output: Contribution to journalArticle

Blood-Brain Barrier
Drug delivery
Nanoparticles
Brain
Pharmaceutical Preparations
2012
36 Citations (Scopus)

Cell-based therapies for diabetic complications

Secchiero, P., Bernardi, S., Severini, G. M. & Zauli, G., 2012, In : Experimental Diabetes Research. 2012, 872504.

Research output: Contribution to journalArticle

Diabetes Complications
Cell- and Tissue-Based Therapy
Diabetic Angiopathies
Adult Stem Cells
Mesenchymal Stromal Cells
4 Citations (Scopus)

β-Hexosaminidase over-expression affects lysosomal glycohydrolases expression and glycosphingolipid metabolism in mammalian cells

Tancini, B., Magini, A., Bortot, B., Polchi, A., Urbanelli, L., Sonnino, S., Severini, G. M. & Emiliani, C., Apr 2012, In : Molecular and Cellular Biochemistry. 363, 1-2, p. 109-118 10 p.

Research output: Contribution to journalArticle

Hexosaminidases
Glycosphingolipids
Glycoside Hydrolases
Metabolism
Cell membranes
2011
11 Citations (Scopus)

High-throughput genotyping robot-assisted method for mutation detection in patients with hypertrophic cardiomyopathy

Bortot, B., Athanasakis, E., Brun, F., Rizzotti, D., Mestroni, L., Sinagra, G. & Severini, G. M., Sep 2011, In : Diagnostic Molecular Pathology. 20, 3, p. 175-179 5 p.

Research output: Contribution to journalArticle

Hypertrophic Cardiomyopathy
Mutation
Genetic Testing
Polymerase Chain Reaction
Genetic Heterogeneity
31 Citations (Scopus)

NIR-labeled nanoparticles engineered for brain targeting: In vivo optical imaging application and fluorescent microscopy evidences

Tosi, G., Bondioli, L., Ruozi, B., Badiali, L., Severini, G. M., Biffi, S., De Vita, A., Bortot, B., Dolcetta, D., Forni, F. & Vandelli, M. A., Jan 2011, In : Journal of Neural Transmission. 118, 1, p. 145-153 9 p.

Research output: Contribution to journalArticle

Optical Imaging
Nanoparticles
Microscopy
Brain
Blood-Brain Barrier
4 Citations (Scopus)
Mitochondrial DNA
Polymerase Chain Reaction
Mutation
DNA
Mitochondrial Diseases
2009
14 Citations (Scopus)
Autoimmune Polyendocrinopathies
RNA, Transfer, Met
Exercise
Mutation
Muscles
5 Citations (Scopus)

Two novel POLG mutations causing hepatic mitochondrial DNA depletion with recurrent hypoketotic hypoglycaemia and fatal liver dysfunction

Bortot, B., Barbi, E., Biffi, S., Lunazzi, G., Bussani, R., Burlina, A., Norbedo, S., Ventura, A., Carrozzi, M. & Severini, G. M., Jul 2009, In : Digestive and Liver Disease. 41, 7, p. 494-499 6 p.

Research output: Contribution to journalArticle

Mitochondrial DNA
Hypoglycemia
Liver Diseases
Mutation
Liver
2007
11 Citations (Scopus)
Congenital Disorders of Glycosylation
Glycosylation
Screening
High Pressure Liquid Chromatography
Pediatrics
19 Citations (Scopus)

Metabolic correction in oligodendrocytes derived from metachromatic leukodystrophy mouse model by using encapsulated recombinant myoblasts

Consiglio, A., Martino, S., Dolcetta, D., Cusella, G., Conese, M., Marchesini, S., Benaglia, G., Wrabetz, L., Orlacchio, A., Déglon, N., Aebischer, P., Severini, G. M. & Bordignon, C., Apr 15 2007, In : Journal of the Neurological Sciences. 255, 1-2, p. 7-16 10 p.

Research output: Contribution to journalArticle

Cerebroside-Sulfatase
Metachromatic Leukodystrophy
Myoblasts
Oligodendroglia
Enzymes
2005
18 Citations (Scopus)

Expression and purification of a human, soluble Arylsulfatase a for Metachromatic Leukodystrophy enzyme replacement therapy

Martino, S., Consiglio, A., Cavalieri, C., Tiribuzi, R., Costanzi, E., Severini, G. M., Emiliani, C., Bordignon, C. & Orlacchio, A., May 25 2005, In : Journal of Biotechnology. 117, 3, p. 243-251 9 p.

Research output: Contribution to journalArticle

Cerebroside-Sulfatase
Metachromatic Leukodystrophy
Arylsulfatases
Enzyme Replacement Therapy
Purification
2002
26 Citations (Scopus)

Absence of metabolic cross-correction in Tay-Sachs cells: Implications for gene therapy

Martino, S., Emiliani, C., Tancini, B., Severini, G. M., Chigorno, V., Bordignon, C., Sonnino, S. & Orlacchio, A., Jun 7 2002, In : Journal of Biological Chemistry. 277, 23, p. 20177-20184 8 p.

Research output: Contribution to journalArticle

Gene therapy
Genetic Therapy
Hexosaminidase A
Enzymes
Fibroblasts
22 Citations (Scopus)

Restoration of the GM2 ganglioside metabolism in bone marrow-derived stromal cells from Tay-Sachs disease animal model

Martino, S., Cavalieri, C., Emiliani, C., Dolcetta, D., De Cusella Angelis, M. G., Chigorno, V., Severini, G. M., Sandhoff, K., Bordignon, C., Sonnino, S. & Orlacchio, A., Aug 2002, In : Neurochemical Research. 27, 7-8, p. 793-800 8 p.

Research output: Contribution to journalArticle

G(M2) Ganglioside
Tay-Sachs Disease
Mesenchymal Stromal Cells
Metabolism
Restoration
2001
44 Citations (Scopus)

Intractable fever and cortical neuronal glycogen storage in glycogenosis type 2

Martini, C., Ciana, G., Benettoni, A., Katouzian, F., Severini, G. M., Bussani, R. & Bembi, B., Sep 11 2001, In : Neurology. 57, 5, p. 906-908 3 p.

Research output: Contribution to journalArticle

Glycogen Storage Disease Type II
Enzyme Replacement Therapy
Glycogen
Fever
Glucosidases

Progressi e delusioni in malattie rare

Translated title of the contribution: Progress and disappointments in rare diseasesBembi, B., Ciana, G., Martini, C. & Severini, G. M., Mar 31 2001, In : Medico e Bambino. 20, 3 SUPPL., p. 45-50 6 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)

Various cells retrovirally transduced with N-acetylgalactosoamine-6-sulfate sulfatase correct Morquio skin fibroblasts in vitro

Toietta, G., Severini, G. M., Traversari, C., Tomatsu, S., Sukegawa, K., Fukuda, S., Kondo, N., Tortora, P. & Bordignon, C., 2001, In : Human Gene Therapy. 12, 16, p. 2007-2016 10 p.

Research output: Contribution to journalArticle

N-acetylglucosamine-6-sulfatase
Mucopolysaccharidosis IV
Sulfates
Fibroblasts
Skin
1999
60 Citations (Scopus)

Reversal of diabetes in mice by implantation of human fibroblasts genetically engineered to release mature human insulin

Falqui, L., Martinenghi, S., Severini, G. M., Corbella, P., Taglietti, M. V., Arcelloni, C., Sarugeri, E., Monti, L. D., Paroni, R., Dozio, N., Pozza, G. & Bordignon, C., Jul 20 1999, In : Human Gene Therapy. 10, 11, p. 1753-1762 10 p.

Research output: Contribution to journalArticle

Fibroblasts
Insulin
Proinsulin
Type 1 Diabetes Mellitus
Cell Transplantation
1998
1 Citation (Scopus)

Glucose-induced activity of liver-type pyruvate kinase promoter in primary rat hepatocytes

Rudoni, S., Martinenghi, S., Severini, G. M., Monti, L. D., Pozza, G., Bordignon, C. & Falqui, L., 1998, In : Transplantation Proceedings. 30, 2, p. 584-585 2 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Transduced fibroblasts and metachromatic leukodystrophy lymphocytes transfer arylsulfatase A to myelinating glia and deficient cells in vitro

Sangalli, A., Taveggia, C., Salviati, A., Wrabetz, L., Bordignon, C. & Severini, G. M., Sep 20 1998, In : Human Gene Therapy. 9, 14, p. 2111-2119 9 p.

Research output: Contribution to journalArticle

Cerebroside-Sulfatase
Metachromatic Leukodystrophy
Neuroglia
Fibroblasts
Lymphocytes
1997

Erratum: HLA-A*02 subtype distribution in Caucasians from northern Italy: Identification of A*0220 (Journal of Tissue Antigens(1996)48(673-679)

Fleischhauer, K., Zino, E., Mazzi, B., Severini, G. M., Benazzi, E. & Bordignon, C., 1997, In : Tissue Antigens. 50, 2, p. 208 1 p.

Research output: Contribution to journalArticle

Gene therapy for metachromatic leukodystrophy and Gaucher disease

Severini, G. M., Dec 1997, In : Minerva Biotecnologica. 9, 4, p. 236-241 6 p.

Research output: Contribution to journalArticle

Metachromatic Leukodystrophy
Gene therapy
Gaucher Disease
Genetic Therapy
Central Nervous System
1996
159 Citations (Scopus)

A new locus for arrhythmogenic right ventricular dysplasia on the long arm of chromosome 14

Severini, G. M., Krajinovic, M., Pinamonti, B., Sinagra, G., Fioretti, P., Brunazzi, M. C., Falaschi, A., Camerini, F., Giacca, M., Mestroni, L., Di Lenarda, A., Lardieri, G., Morgera, T., Silvestri, F., Bussani, R., Davanzo, M., Vatta, M. & Milasin, J., Jan 15 1996, In : Genomics. 31, 2, p. 193-200 8 p.

Research output: Contribution to journalArticle

Arrhythmogenic Right Ventricular Dysplasia
Chromosomes, Human, Pair 14
Lod Score
Myocardium
Genetic Heterogeneity
128 Citations (Scopus)

A point mutation in the 5′ splice site of the dystrophin gene first intron responsible for X-linked dilated cardiomyopathy

Milasin, J., Muntoni, F., Severini, G. M., Bartoloni, L., Vatta, M., Krajinovic, M., Mateddu, A., Angelini, C., Camerini, F., Falaschi, A., Mestroni, L., Giacca, M., Pinamonti, B., Sinagra, G., Di Lenarda, A., Silvestri, F., Bussani, R. & Davanzo, M., Jan 1996, In : Human Molecular Genetics. 5, 1, p. 73-79 7 p.

Research output: Contribution to journalArticle

Dystrophin
RNA Splice Sites
Point Mutation
Introns
Genes
20 Citations (Scopus)

HLA-A*02 subtype distribution in Caucasians from northern Italy: Identification of A*0220

Fleischhauer, K., Zino, E., Mazzi, B., Severini, G. M., Benazzi, E. & Bordignon, C., 1996, In : Tissue Antigens. 48, 6, p. 673-679 7 p.

Research output: Contribution to journalArticle

HLA-A Antigens
Italy
HLA-A2 Antigen
Exons
Bone
5 Citations (Scopus)

Sequencing of a new HLA-A*32 subtype (A*3202)

Zino, E., Severini, G. M., Mazzi, B., Bordignon, C., Benazzi, E. & Fleischhauer, K., 1996, In : Immunogenetics. 45, 1, p. 76-77 2 p.

Research output: Contribution to journalArticle

1995
128 Citations (Scopus)

Linkage of familial dilated cardiomyopathy to chromosome 9

Krajinovic, M., Pinamonti, B., Sinagra, G., Vatta, M., Severini, G. M., Milasin, J., Falaschi, A., Camerini, F., Giacca, M., Mestroni, L., Di Lenarda, A., Lardieri, G., Morgera, T., Silvestri, F., Bussani, R., Davanzo, M. & Meringolo, G., 1995, In : American Journal of Human Genetics. 57, 4, p. 846-852 7 p.

Research output: Contribution to journalArticle

Chromosomes, Human, Pair 9
Dilated Cardiomyopathy
Genome
Genes
Lod Score
10 Citations (Scopus)

Molecular genetics of dilated cardiomyopathies

Mestroni, L., Krajinovic, M., Severini, G. M., Milasin, J., Pinamonti, B., Rocco, C., Vatta, M., Falaschi, A., Giacca, M. & Camerini, F., 1995, In : European Heart Journal. 16, SUPPL. O, p. 5-9 5 p.

Research output: Contribution to journalArticle

Dilated Cardiomyopathy
Molecular Biology
Genes
Cardiomyopathies
Cardiac Myosins
1994
7 Citations (Scopus)

Absence of linkage between idiopathic dilated cardiomyopathy and candidate genes involved in the immune function in a large Italian pedigree

Krajinovic, M., Mestroni, L., Severini, G. M., Pinamonti, B., Camerini, F., Falaschi, A. & Giacca, M., Oct 1994, In : Journal of Medical Genetics. 31, 10, p. 766-771 6 p.

Research output: Contribution to journalArticle

Dilated Cardiomyopathy
Pedigree
Immunoglobulin Light Chains
Adenine Nucleotide Translocator 1
Genes
45 Citations (Scopus)

Familial dilated cardiomyopathy

Mestroni, L., Krajinovic, M., Severini, G. M., Pinamonti, B., Di Lenarda, A., Giacca, M., Falaschi, A. & Camerini, F., 1994, In : Heart. 72, 6 SUPPL.

Research output: Contribution to journalArticle

58 Citations (Scopus)

Low frequency of detection by nested polymerase chain reaction of enterovirus ribonucleic acid in endomyocardial tissue of patients with idiopathic dilated cardiomyopathy

Giacca, M., Severini, G. M., Mestroni, L., Salvi, A., Lardieri, G., Falaschi, A. & Camerini, F., 1994, In : Journal of the American College of Cardiology. 24, 4, p. 1033-1040 8 p.

Research output: Contribution to journalArticle

Enterovirus
Myocarditis
Dilated Cardiomyopathy
RNA
Polymerase Chain Reaction
9 Citations (Scopus)

Molecular genetics of dilated cardiomyopathy

Mestroni, L., Krajinovic, M., Severini, G. M., Falaschi, A., Giacca, M. & Camerini, F., 1994, In : Herz. 19, 2, p. 97-104 8 p.

Research output: Contribution to journalArticle

Dilated Cardiomyopathy
Molecular Biology
Genes
Cardiac Myosins
Dystrophin
1993
76 Citations (Scopus)

Nested polymerase chain reaction for high-sensitivity detection of enteroviral RNA in biological samples

Severini, G. M., Mestroni, L., Falaschi, A., Camerini, F. & Giacca, M., 1993, In : Journal of Clinical Microbiology. 31, 5, p. 1345-1349 5 p.

Research output: Contribution to journalArticle

RNA
Human Enterovirus B
Polymerase Chain Reaction
Enterovirus
Myocarditis
1992
2 Citations (Scopus)

Patogenesi della cardiomiopatia dilatativa: recenti progressi.

Translated title of the contribution: The pathogenesis of dilated cardiomyopathy: current progressMestroni, L., Giacca, M., Severini, G. M. & Camerini, F., Jan 1992, In : Giornale Italiano di Cardiologia. 22, 1, p. 53-62 10 p.

Research output: Contribution to journalArticle

Dilated Cardiomyopathy
Immunogenetics
Immune System
Phenotype
Human Enterovirus B