If you made any changes in Pure these will be visible here soon.

Research Output 2016 2019

2019

KCTD1: A novel modulator of adipogenesis through the interaction with the transcription factor AP2α

Pirone, L., Smaldone, G., Spinelli, R., Barberisi, M., Beguinot, F., Vitagliano, L., Miele, C., Di Gaetano, S., Raciti, G. A. & Pedone, E., Dec 2019, In : Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 1864, 12, 158514.

Research output: Contribution to journalArticle

Transcription Factor AP-2
Adipogenesis
3T3-L1 Cells
Potassium Channels
Adiponectin

KCTD15 is overexpressed in human childhood B-cell acute lymphoid leukemia

Smaldone, G., Beneduce, G., Incoronato, M., Pane, K., Franzese, M., Coppola, L., Cordella, A., Parasole, R., Ripaldi, M., Nassa, G., Soricelli, A., Vitagliano, L., Mirabelli, P. & Salvatore, M., Dec 1 2019, In : Scientific Reports. 9, 1, 20108.

Research output: Contribution to journalArticle

Open Access
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Leukemia
B-Lymphocytes
Lymphoid Leukemia
Pokeweed Mitogens

Loop size optimization induces a strong thermal stabilization of the thioredoxin fold

Ruggiero, A., Smaldone, G., Esposito, L., Balasco, N. & Vitagliano, L., May 2019, In : FEBS Journal. 286, 9, p. 1752-1764 13 p.

Research output: Contribution to journalArticle

Thioredoxins
Stabilization
Hot Temperature
Proteins
Escherichia coli

Molecular basis of the scalp-ear-nipple syndrome unraveled by the characterization of disease-causing KCTD1 mutants

Smaldone, G., Balasco, N., Pirone, L., Caruso, D., Di Gaetano, S., Pedone, E. M. & Vitagliano, L., Dec 1 2019, In : Scientific Reports. 9, 1, 10519.

Research output: Contribution to journalArticle

Open Access
Nipples
Mutation
Scalp
Ear
Proteins
Open Access
Purification
Blood Cells
Blood
Liquids
Workflow

The characterization of Thermotoga maritima Arginine Binding Protein variants demonstrates that minimal local strains have an important impact on protein stability

Balasco, N., Smaldone, G., Vigorita, M., Del Vecchio, P., Graziano, G., Ruggiero, A. & Vitagliano, L., Dec 1 2019, In : Scientific Reports. 9, 1, 6617.

Research output: Contribution to journalArticle

Open Access
Thermotoga maritima
Protein Stability
Arginine
Carrier Proteins
Proteins

The non-swapped monomeric structure of the arginine-binding protein from Thermotoga maritima

Smaldone, G., Ruggiero, A., Balasco, N., Abuhammad, A., Autiero, I., Caruso, D., Esposito, D., Ferraro, G., Gelardi, E. L. M., Moreira, M., Quareshy, M., Romano, M., Saaret, A., Selvam, I., Squeglia, F., Troisi, R., Kroon-Batenburg, L. M. J., Esposito, L., Berisio, R. & Vitagliano, L., Nov 1 2019, In : Acta Crystallographica Section F: Structural Biology Communications. 75, p. 707-713 7 p.

Research output: Contribution to journalArticle

Thermotoga maritima
Arginine
Carrier Proteins
proteins
helices

The structural versatility of the BTB domains of KCTD proteins and their recognition of the GABAb receptor

Balasco, N., Smaldone, G. & Vitagliano, L., Aug 2019, In : Biomolecules. 9, 8, 323.

Research output: Contribution to journalArticle

Open Access
Molecular Dynamics Simulation
Potassium Channels
Molecular dynamics
Proteins
Computer simulation
2018

Domain communication in Thermotoga maritima Arginine Binding Protein unraveled through protein dissection

Smaldone, G., Balasco, N., Vigorita, M., Ruggiero, A., Cozzolino, S., Berisio, R., Del Vecchio, P., Graziano, G. & Vitagliano, L., Nov 1 2018, In : International Journal of Biological Macromolecules. 119, p. 758-769 12 p.

Research output: Contribution to journalArticle

Thermotoga maritima
Dissection
Arginine
Carrier Proteins
Communication

Domain swapping dissection in Thermotoga maritima arginine binding protein: How structural flexibility may compensate destabilization

Smaldone, G., Berisio, R., Balasco, N., D'Auria, S., Vitagliano, L. & Ruggiero, A., Sep 1 2018, In : Biochimica et Biophysica Acta - Proteins and Proteomics. 1866, 9, p. 952-962 11 p.

Research output: Contribution to journalArticle

Thermotoga maritima
Dissection
Arginine
Carrier Proteins
Ligands

Local structural motifs in proteins: Detection and characterization of fragments inserted in helices

Balasco, N., Smaldone, G., Ruggiero, A., De Simone, A. & Vitagliano, L., Oct 15 2018, In : International Journal of Biological Macromolecules. 118, p. 1924-1930 7 p.

Research output: Contribution to journalArticle

Amino Acid Motifs
Proteins
Carbon Monoxide
Hydrogen
Databases

The essential player in adipogenesis GRP78 is a novel KCTD15 interactor

Smaldone, G., Pirone, L., Capolupo, A., Vitagliano, L., Monti, M. C., Di Gaetano, S. & Pedone, E., Aug 1 2018, In : International Journal of Biological Macromolecules. 115, p. 469-475 7 p.

Research output: Contribution to journalArticle

Adipogenesis
Drosophila
Stabilization
Obesity
3T3-L1 Cells
2017

Cell milieu significantly affects the fate of AApoAI amyloidogenic variants: predestination or serendipity?

Gaglione, R., Smaldone, G., Di Girolamo, R., Piccoli, R., Pedone, E. & Arciello, A., Nov 23 2017, In : Biochimica et Biophysica Acta - General Subjects. 1862, 3, p. 377-384 8 p.

Research output: Contribution to journalArticle

Conformations
Amyloidosis
Apolipoprotein A-I
Dichroism
Dynamic light scattering

Elucidating the role of the pLG72 R30K substitution in schizophrenia susceptibility

Sacchi, S., Cappelletti, P., Pirone, L., Smaldone, G., Pedone, E. & Pollegioni, L., Feb 1 2017, In : FEBS Letters. 591, 4, p. 646-655 10 p.

Research output: Contribution to journalLetter

Serine
Schizophrenia
Substitution reactions
Protein Conformation
Aptitude

Insights into the anticancer properties of the first antimicrobial peptide from Archaea

Gaglione, R., Pirone, L., Farina, B., Fusco, S., Smaldone, G., Aulitto, M., Dell'Olmo, E., Roscetto, E., Del Gatto, A., Fattorusso, R., Notomista, E., Zaccaro, L., Arciello, A., Pedone, E. & Contursi, P., Sep 1 2017, In : Biochimica et Biophysica Acta - General Subjects. 1861, 9, p. 2155-2164 10 p.

Research output: Contribution to journalArticle

Archaea
Cells
Confocal Microscopy
Peptides
Archaeal Proteins

Novel propanamides as fatty acid amide hydrolase inhibitors

Deplano, A., Morgillo, C. M., Demurtas, M., Björklund, E., Cipriano, M., Svensson, M., Hashemian, S., Smaldone, G., Pedone, E., Luque, F. J., Cabiddu, M. G., Novellino, E., Fowler, C. J., Catalanotti, B. & Onnis, V., Jan 1 2017, In : European Journal of Medicinal Chemistry. 136, p. 523-542 20 p.

Research output: Contribution to journalArticle

Cannabinoids
Assays
Cannabinoid Receptor Agonists
Lead compounds
Endocannabinoids
2016

A new cryptic cationic antimicrobial peptide from human apolipoprotein E with antibacterial activity and immunomodulatory effects on human cells

Pane, K., Sgambati, V., Zanfardino, A., Smaldone, G., Cafaro, V., Angrisano, T., Pedone, E., Di Gaetano, S., Capasso, D., Haney, E. F., Izzo, V., Varcamonti, M., Notomista, E., Hancock, R. E. W., Di Donato, A. & Pizzo, E., Jun 1 2016, In : FEBS Journal. 283, 11, p. 2115-2131 17 p.

Research output: Contribution to journalArticle

Antimicrobial Cationic Peptides
Apolipoproteins E
Cells
Peptides
Polysaccharides

Proline 235 plays a key role in the regulation of the oligomeric states of Thermotoga maritima Arginine Binding Protein

Smaldone, G., Vigorita, M., Ruggiero, A., Balasco, N., Dattelbaum, J. D., D'Auria, S., Del Vecchio, P., Graziano, G. & Vitagliano, L., Jul 1 2016, In : Biochimica et Biophysica Acta - Proteins and Proteomics. 1864, 7, p. 814-824 11 p.

Research output: Contribution to journalArticle

Thermotoga maritima
Oligomerization
Dimerization
Proline
glycyllysine

Proteins involved in sleep homeostasis: Biophysical characterization of INC and its partners

Pirone, L., Smaldone, G., Esposito, C. L., Balasco, N., Petoukhov, M. V., Spilotros, A., Svergun, D. I., Di Gaetano, S., Vitagliano, L. & Pedone, E. M., Dec 1 2016, In : Biochimie. 131, p. 106-114 9 p.

Research output: Contribution to journalArticle

Sleep
Homeostasis
Proteins
Drosophila Proteins
Aptitude

Regulating levels of the neuromodulator d-serine in human brain: structural insight into pLG72 and d-amino acid oxidase interaction

Birolo, L., Sacchi, S., Smaldone, G., Molla, G., Leo, G., Caldinelli, L., Pirone, L., Eliometri, P., Di Gaetano, S., Orefice, I., Pedone, E., Pucci, P. & Pollegioni, L., Sep 1 2016, In : FEBS Journal. p. 3353-3370 18 p.

Research output: Contribution to journalArticle

Serine
Neurotransmitter Agents
Brain
Oxidoreductases
Amino Acids

The BTB domains of the potassium channel tetramerization domain proteins prevalently assume pentameric states

Smaldone, G., Pirone, L., Pedone, E., Marlovits, T., Vitagliano, L. & Ciccarelli, L., Jun 1 2016, In : FEBS Letters. p. 1663-1671 9 p.

Research output: Contribution to journalLetter

Potassium Channels
Pathologic Processes
Pedigree
Electron Microscopy
Coloring Agents