1986 …2020

Research output per year

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Research Output

2020

The Shc protein Rai enhances T-cell survival under hypoxia

Criscuoli, M., Ulivieri, C., Filippi, I., Monaci, S., Guerrini, G., Crifò, B., De Tommaso, D., Pelicci, G., Baldari, C. T., Taylor, C. T., Carraro, F. & Naldini, A., Jan 1 2020, (Accepted/In press) In : Journal of Cellular Physiology.

Research output: Contribution to journalArticle

2019

A T cell suppressive circuitry mediated by CD39 and regulated by ShcC/RAI is induced in astrocytes by encephalitogenic T cells

Ulivieri, C., De Tommaso, D., Finetti, F., Ortensi, B., Pelicci, G., D'Elios, M. M., Ballerini, C. & Baldari, C. T., Jan 1 2019, In : Frontiers in Immunology. 10, MAY, 1041.

Research output: Contribution to journalArticle

Open Access

Clinical significance of extracellular vesicles in plasma from glioblastoma patients

Osti, D., Bene, M. D., Rappa, G., Santos, M., Matafora, V., Richichi, C., Faletti, S., Beznoussenko, G. V., Mironov, A., Bachi, A., Fornasari, L., Bongetta, D., Gaetani, P., DiMeco, F., Lorico, A. & Pelicci, G., 2019, In : Clinical Cancer Research. 25, 1, p. 266-276 11 p.

Research output: Contribution to journalArticle

Clinical significance of extracellular vesicles in plasma from glioblastoma patients

Osti, D., Bene, M. D., Rappa, G., Santos, M., Matafora, V., Richichi, C., Faletti, S., Beznoussenko, G. V., Mironov, A., Bachi, A., Fornasari, L., Bongetta, D., Gaetani, P., DiMeco, F., Lorico, A. & Pelicci, G., Jan 1 2019, In : Clinical Cancer Research. 25, 1, p. 266-276 11 p.

Research output: Contribution to journalArticle

Clinical significance of extracellular vesicles in plasma from glioblastoma patients: Clinical Cancer Research

Osti, D., Bene, M. D., Rappa, G., Santos, M., Matafora, V., Richichi, C., Faletti, S., Beznoussenko, G. V., Mironov, A., Bachi, A., Fornasari, L., Bongetta, D., Gaetani, P., DiMeco, F., Lorico, A. & Pelicci, G., 2019, In : Clin. Cancer Res.. 25, 1, p. 266-276 11 p.

Research output: Contribution to journalArticle

Open Access
2018

Extensive and systematic rewiring of histone post-translational modifications in cancer model systems

Noberini, R., Osti, D., Miccolo, C., Richichi, C., Lupia, M., Corleone, G., Hong, S-P., Colombo, P., Pollo, B., Fornasari, L., Pruneri, G., Magnani, L., Cavallaro, U., Chiocca, S., Minucci, S., Pelicci, G. & Bonaldi, T., May 4 2018, In : Nucleic Acids Research. 46, 8, p. 3817-3832 16 p.

Research output: Contribution to journalArticle

Extensive and systematic rewiring of histone post-translational modifications in cancer model systems

Noberini, R., Osti, D., Miccolo, C., Richichi, C., Lupia, M., Corleone, G., Hong, S. P., Colombo, P., Pollo, B., Fornasari, L., Pruneri, G., Magnani, L., Cavallaro, U., Chiocca, S., Minucci, S., Pelicci, G. & Bonaldi, T., Jan 1 2018, In : Nucleic Acids Research. 46, 8, p. 3817-3832 16 p.

Research output: Contribution to journalArticle

The Shc protein RAI promotes an adaptive cell survival program in hypoxic neuroblastoma cells

Criscuoli, M., Filippi, I., Osti, D., Aldinucci, C., Guerrini, G., Pelicci, G., Carraro, F. & Naldini, A., May 1 2018, In : Journal of Cellular Physiology. 233, 5, p. 4282-4293 12 p.

Research output: Contribution to journalArticle

2017

Mutations targeting the coagulation pathway are enriched in brain metastases

Richichi, C., Fornasari, L., Melloni, G. E. M., Brescia, P., Patanè, M., Del Bene, M., Mustafa, D. A. M., Kros, J. M., Pollo, B., Pruneri, G., Sciandivasci, A., Munzone, E., Dimeco, F., Pelicci, P. G., Riva, L. & Pelicci, G., Dec 1 2017, In : Scientific Reports. 7, 1, 6573.

Research output: Contribution to journalArticle

Mutations targeting the coagulation pathway are enriched in brain metastases

Richichi, C., Fornasari, L., Melloni, G. E. M., Brescia, P., Patanè, M., Del Bene, M., Mustafa, D. A. M., Kros, J. M., Pollo, B., Pruneri, G., Sciandivasci, A., Munzone, E., Dimeco, F., Pelicci, P. G., Riva, L. & Pelicci, G., 2017, In : Scientific Reports. 7, 1

Research output: Contribution to journalArticle

2016

The adaptor protein Rai/ShcC promotes astrocyte-dependent inflammation during experimental autoimmune encephalomyelitis

Ulivieri, C., Savino, M. T., Luccarini, I., Fanigliulo, E., Aldinucci, A., Bonechi, E., Benagiano, M., Ortensi, B., Pelicci, G., D'Elios, M. M., Ballerini, C. & Baldari, C. T., Jul 15 2016, In : Journal of Immunology. 197, 2, p. 480-490 11 p.

Research output: Contribution to journalArticle

Tumor-initiating cell frequency is relevant for glioblastoma aggressiveness

Richichi, C., Osti, D., Del Bene, M., Fornasari, L., Patanè, M., Pollo, B., Dimeco, F. & Pelicci, G., 2016, In : Oncotarget. 7, 44, p. 71491-71503 13 p.

Research output: Contribution to journalArticle

Tumor-initiating cell frequency is relevant for glioblastoma aggressiveness

Richichi, C., Osti, D., Del Bene, M., Fornasari, L., Patanè, M., Pollo, B., DiMeco, F. & Pelicci, G., 2016, In : Oncotarget. 7, 44, p. 71491-71503 13 p.

Research output: Contribution to journalArticle

2015

Extracellular vesicle-mediated transfer of CLIC1 protein is a novel mechanism for the regulation of glioblastoma growth

Setti, M., Osti, D., Richichi, C., Ortensi, B., Del Bene, M., Fornasari, L., Beznoussenko, G., Mironov, A., Rappa, G., Cuomo, A., Faretta, M., Bonaldi, T., Lorico, A. & Pelicci, G., 2015, In : Oncotarget. 6, 31, p. 31413-31427 15 p.

Research output: Contribution to journalArticle

2013

Cancer stem cell contribution to glioblastoma invasiveness

Ortensi, B., Setti, M., Osti, D. & Pelicci, G., 2013, In : Stem Cell Research and Therapy. 4, 1, 18.

Research output: Contribution to journalArticle

CD133 is essential for glioblastoma stem cell maintenance

Brescia, P., Ortensi, B., Fornasari, L., Levi, D., Broggi, G. & Pelicci, G., May 2013, In : Stem Cells. 31, 5, p. 857-869 13 p.

Research output: Contribution to journalArticle

Functional role of CLIC1 ion channel in glioblastoma-derived stem/progenitor cells

Setti, M., Savalli, N., Osti, D., Richichi, C., Angelini, M., Brescia, P., Fornasari, L., Carro, M. S., Mazzanti, M. & Pelicci, G., Nov 6 2013, In : Journal of the National Cancer Institute. 105, 21, p. 1644-1655 12 p.

Research output: Contribution to journalArticle

Marker-independent method for isolating slow-dividing cancer stem cells in human glioblastoma

Richichi, C., Brescia, P., Alberizzi, V., Fornasari, L. & Pelicci, G., Jul 2013, In : Neoplasia (United States). 15, 7, p. 840-847 8 p.

Research output: Contribution to journalArticle

The Shc family protein adaptor, Rai, acts as a negative regulator of Th17 and Th1 cell development

Savino, M. T., Ulivieri, C., Emmi, G., Prisco, D., de Falco, G., Ortensi, B., Beccastrini, E., Emmi, L., Pelicci, G., D'Elios, M. M. & Baldari, C. T., Apr 2013, In : Journal of Leukocyte Biology. 93, 4, p. 549-559 11 p.

Research output: Contribution to journalArticle

2012

Current strategies for identification of glioma stem cells: Adequate or unsatisfactory?

Brescia, P., Richichi, C. & Pelicci, G., 2012, In : Journal of Oncology. 376894.

Research output: Contribution to journalArticle

Rai is a new regulator of neural progenitor migration and glioblastoma invasion

Ortensi, B., Osti, D., Pellegatta, S., Pisati, F., Brescia, P., Fornasari, L., Levi, D., Gaetani, P., Colombo, P., Ferri, A., Nicolis, S., Finocchiaro, G. & Pelicci, G., May 2012, In : Stem Cells. 30, 5, p. 817-832 16 p.

Research output: Contribution to journalArticle

2011

The shc family protein adaptor, Rai, negatively regulates T cell antigen receptor signaling by inhibiting ZAP-70 recruitment and activation

Ferro, M., Savino, M. T., Ortensi, B., Finetti, F., Genovese, L., Masi, G., Ulivieri, C., Benati, D., Pelicci, G. & Baldari, C. T., Dec 29 2011, In : PLoS One. 6, 12, e29899.

Research output: Contribution to journalArticle

2010

Human glioblastoma tumours and neural cancer stem cells express the chemokine CX3CL1 and its receptor CX3CR1

Erreni, M., Solinas, G., Brescia, P., Osti, D., Zunino, F., Colombo, P., Destro, A., Roncalli, M., Mantovani, A., Draghi, R., Levi, D., Rodriguez Y Baena, R., Gaetani, P., Pelicci, G. & Allavena, P., Dec 2010, In : European Journal of Cancer. 46, 18, p. 3383-3392 10 p.

Research output: Contribution to journalArticle

2009

Rai acts as a negative regulator of autoimmunity by inhibiting antigen receptor signaling and lymphocyte activation

Savino, M. T., Ortensi, B., Ferro, M., Ulivieri, C., Fanigliulo, D., Paccagnini, E., Lazzi, S., Osti, D., Pelicci, G. & Baldari, C. T., Jan 1 2009, In : Journal of Immunology. 182, 1, p. 301-308 8 p.

Research output: Contribution to journalArticle

2008

Cathepsin D expression is decreased in Alzheimer's disease fibroblasts

Urbanelli, L., Emiliani, C., Massini, C., Persichetti, E., Orlacchio, A., Pelicci, G., Sorbi, S., Hasilik, A., Bernardi, G. & Orlacchio, A., Jan 2008, In : Neurobiology of Aging. 29, 1, p. 12-22 11 p.

Research output: Contribution to journalArticle

Expression of the Rai (Shc C) adaptor protein in the human enteric nervous system

Villanacci, V., Bassotti, G., Ortensi, B., Fisogni, S., Cathomas, G., Maurer, C. A., Galletti, A., Salerni, B. & Pelicci, G., Mar 2008, In : Neurogastroenterology and Motility. 20, 3, p. 206-212 7 p.

Research output: Contribution to journalArticle

2007
2005

RAI(ShcC/N-Shc)-dependent recruitment of GAB1 to RET oncoproteins potentiates PI3-K signalling in thyroid tumors

De Falco, V., Guarino, V., Malorni, L., Cirafici, A. M., Troglio, F., Erreni, M., Pelicci, G., Santoro, M. & Melillo, R. M., Sep 15 2005, In : Oncogene. 24, 41, p. 6303-6313 11 p.

Research output: Contribution to journalArticle

2004
2003

Up-regulation of glycohydrolases in Alzheimer's Disease fibroblasts correlates with Ras activation

Emiliani, C., Urbanelli, L., Racanicchi, L., Orlacchio, A., Pelicci, G., Sorbi, S., Bernardi, G. & Orlacchio, A., Oct 3 2003, In : Journal of Biological Chemistry. 278, 40, p. 38453-38460 8 p.

Research output: Contribution to journalArticle

2002

The neuron-specific Rai (ShcC) adaptor protein inhibits apoptosis by coupling ret to the phosphatidylinositol 3-kinase/Akt signaling pathway

Pelicci, G., Troglio, F., Bodini, A., Melillo, R. M., Pettirossi, V., Coda, L., De Giuseppe, A., Santoro, M. & Pelicci, P. G., Oct 2002, In : Molecular and Cellular Biology. 22, 20, p. 7351-7363 13 p.

Research output: Contribution to journalArticle

Tyrosine phosphorylation of the β-amyloid precursor protein cytoplasmic tail promotes interaction with Shc

Tarr, P. E., Roncarati, R., Pelicci, G., Pelicci, P. G. & D'Adamio, L., May 10 2002, In : Journal of Biological Chemistry. 277, 19, p. 16798-16804 7 p.

Research output: Contribution to journalArticle

2001

Shc signaling in differentiating neural progenitor cells

Conti, L., Sipione, S., Magrassi, L., Bonfanti, L., Rigamonti, D., Pettirossi, V., Peschanski, M., Haddad, B., Pelicci, P., Milanesi, G., Pelicci, G. & Cattaneo, E., 2001, In : Nature Neuroscience. 4, 6, p. 579-586 8 p.

Research output: Contribution to journalArticle

1999

Polyomavirus large T antigen induces alterations in cytoplasmic signalling pathways involving Shc activation

Gottifredi, V., Pelicci, G., Munarriz, E., Maione, R., Pelicci, P. G. & Amati, P., 1999, In : Journal of Virology. 73, 2, p. 1427-1437 11 p.

Research output: Contribution to journalArticle

The p66(shc) adaptor protein controls oxidative stress response and life span in mammals

Migliaccio, E., Giogio, M., Mele, S., Pelicci, G., Reboldi, P., Pandolfi, P. P., Lanfrancone, L. & Pelicci, P. G., Nov 18 1999, In : Nature. 402, 6759, p. 309-313 5 p.

Research output: Contribution to journalArticle

1998

Eps15R is a tyrosine kinase substrate with characteristics of a docking protein possibly involved in coated pits-mediated internalization

Coda, L., Salcini, A. E., Confalonieri, S., Pelicci, G., Sorkina, T., Sorkin, A., Pelicci, P. G. & Di Fiore, P. P., Jan 30 1998, In : Journal of Biological Chemistry. 273, 5, p. 3003-3012 10 p.

Research output: Contribution to journalArticle

1997

Identification of Shc docking site on Ret tyrosine kinase

Arighi, E., Alberti, L., Torriti, F., Ghizzoni, S., Rizzetti, M. G., Pelicci, G., Pasini, B., Bongarzone, I., Piutti, C., Pierotti, M. A. & Borrello, M. G., 1997, In : Oncogene. 14, 7, p. 773-782 10 p.

Research output: Contribution to journalArticle

Modified phage peptide libraries as a tool to study specificity of phosphorylation and recognition of tyrosine containing peptides

Dente, L., Vetriani, C., Zucconi, A., Pelicci, G., Lanfrancone, L., Pelicci, P. G. & Cesareni, G., Jul 27 1997, In : Journal of Molecular Biology. 269, 5, p. 694-703 10 p.

Research output: Contribution to journalArticle

Opposite effects of the p52(shc)/p46(shc) and p66(shc) splicing isoforms on the EGF receptor-MAP kinase-fos signalling pathway

Migliaccio, E., Mele, S., Salcini, A. E., Pelicci, G., Lai, K. M. V., Superti-Furga, G., Pawson, T., Di Fiore, P. P., Lanfrancone, L. & Pelicci, P. G., Feb 17 1997, In : EMBO Journal. 16, 4, p. 706-716 11 p.

Research output: Contribution to journalArticle

1996

A family of Shc related proteins with conserved PTB, CH1 and SH2 regions

Pelicci, G., Dente, L., De Giuseppe, A., Verducci-Galletti, B., Giuli, S., Mele, S., Vetriani, C., Giorgio, M., Pandolfi, P. P., Cesareni, G. & Pelicci, P. G., 1996, In : Oncogene. 13, 3, p. 633-641 9 p.

Research output: Contribution to journalArticle

Not all Shc's roads lead to Ras

Bonfini, L., Migliaccio, E., Pelicci, G., Lanfrancone, L. & Pelicci, P. G., Jul 1996, In : Trends in Biochemical Sciences. 21, 7, p. 257-261 5 p.

Research output: Contribution to journalArticle

Shc proteins are localized on endoplasmic reticulum membranes and are redistributed after tyrosine kinase receptor activation

Lotti, L. V., Lanfrancone, L., Migliaccio, E., Zompetta, C., Pelicci, G., Salcini, A. E., Falini, B., Pelicci, P. G. & Torrisi, M. R., May 1996, In : Molecular and Cellular Biology. 16, 5, p. 1946-1954 9 p.

Research output: Contribution to journalArticle

1995

Constitutive phosphorylation of Shc proteins in human tumors

Pelicci, G., Lanfrancone, L., Salcini, A. E., Romano, A., Mele, S., Borrello, M. G., Segatto, O., Di Fiore, P. P. & Pelicci, P. G., 1995, In : Oncogene. 11, 5, p. 899-907 9 p.

Research output: Contribution to journalArticle

Inhibition of CD4/p56lck signaling by a dominant negative mutant of the Shc adaptor protein

Baldari, C. T., Pelicci, G., Di Somma, M. M., Milia, E., Giuli, S., Pelicci, P. G. & Telford, J. L., 1995, In : Oncogene. 10, 6, p. 1141-1147 7 p.

Research output: Contribution to journalArticle

Overexpression of Shc proteins potentiates the proliferative response to the granulocyte-macrophage colony-stimulating factor and recruitment of Grb2/S0S and Grb2/p140 complexes to the β receptor subunit

Lanfrancone, L., Pelicci, G., Brizzi, M. F., Arouica, M. G., Casciari, C., Giuli, S., Pegoraro, L., Pawson, T. & Pelicci, P. G., Mar 2 1995, In : Oncogene. 10, 5, p. 907-917 11 p.

Research output: Contribution to journalArticle

The motogenic and mitogenic responses to HGF are amplified by the Shc adaptor protein

Pelicci, G., Giordano, S., Zhen, Z., Salcini, A. E., Lanfrancone, L., Bardelli, A., Panayotou, G., Waterfield, M. D., Ponzetto, C., Pelicci, P. G. & Comoglio, P. M., 1995, In : Oncogene. 10, 8, p. 1631-1638 8 p.

Research output: Contribution to journalArticle