20152019

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2019

A Genomic Analysis Workflow for Colorectal Cancer Precision Oncology

Corti, G., Bartolini, A., Crisafulli, G., Novara, L., Rospo, G., Montone, M., Negrino, C., Mussolin, B., Buscarino, M., Isella, C., Barault, L., Siravegna, G., Siena, S., Marsoni, S., Di Nicolantonio, F., Medico, E. & Bardelli, A., Jun 2019, In : Clinical Colorectal Cancer. 18, 2, p. 91-101.e3

Research output: Contribution to journalArticle

A Subset of Colorectal Cancers with Cross-Sensitivity to Olaparib and Oxaliplatin

Arena, S., Corti, G., Durinikova, E., Montone, M., Reilly, N. M., Russo, M., Lorenzato, A., Arcella, P., Lazzari, L., Rospo, G., Pagani, M., Cancelliere, C., Negrino, C., Isella, C., Bartolini, A., Cassingena, A., Amatu, A., Mauri, G., Sartore-Bianchi, A., Mittica, G. & 7 others, Medico, E., Marsoni, S., Linnebacher, M., Abrignani, S., Siena, S., Di Nicolantonio, F. & Bardelli, A., Dec 12 2019, In : Clin. Cancer Res..

Research output: Contribution to journalArticle

Evolving neoantigen profiles in colorectal cancers with DNA repair defects

Rospo, G., Lorenzato, A., Amirouchene-Angelozzi, N., Magrì, A., Cancelliere, C., Corti, G., Negrino, C., Amodio, V., Montone, M., Bartolini, A., Barault, L., Novara, L., Isella, C., Medico, E., Bertotti, A., Trusolino, L., Germano, G., Di Nicolantonio, F. & Bardelli, A., Jun 28 2019, In : Genome Medicine. 11, 1, p. 42

Research output: Contribution to journalArticle

2018

Efficacy of Sym004 in Patients With Metastatic Colorectal Cancer With Acquired Resistance to Anti-EGFR Therapy and Molecularly Selected by Circulating Tumor DNA Analyses: A Phase 2 Randomized Clinical Trial

Montagut, C., Argilés, G., Ciardiello, F., Poulsen, T. T., Dienstmann, R., Kragh, M., Kopetz, S., Lindsted, T., Ding, C., Vidal, J., Clausell-Tormos, J., Siravegna, G., Sánchez-Martín, F. J., Koefoed, K., Pedersen, M. W., Grandal, M. M., Dvorkin, M., Wyrwicz, L., Rovira, A., Cubillo, A. & 12 others, Salazar, R., Desseigne, F., Nadal, C., Albanell, J., Zagonel, V., Siena, S., Fumi, G., Rospo, G., Nadler, P., Horak, I. D., Bardelli, A. & Tabernero, J., Apr 12 2018, In : JAMA oncology. 4, 4, p. e175245

Research output: Contribution to journalArticle

Efficacy of Sym004 in patients with metastatic colorectal cancer with acquired resistance to anti-EGFR therapy and molecularly selected by circulating tumor DNA analyses a phase 2 randomized clinical trial

Montagut, C., Argilés, G., Ciardiello, F., Poulsen, T. T., Dienstmann, R., Kragh, M., Kopetz, S., Lindsted, T., Ding, C., Vidal, J., Clausell-Tormos, J., Siravegna, G., Sánchez-Martín, F. J., Koefoed, K., Pedersen, M. W., Grandal, M. M., Dvorkin, M., Wyrwicz, L., Rovira, A., Cubillo, A. & 12 others, Salazar, R., Desseigne, F., Nadal, C., Albanell, J., Zagonel, V., Siena, S., Fumi, G., Rospo, G., Nadler, P., Horak, I. D., Bardelli, A. & Tabernero, J., Apr 1 2018, In : JAMA oncology. 4, 4, e175245.

Research output: Contribution to journalArticle

Radiologic and Genomic Evolution of Individual Metastases during HER2 Blockade in Colorectal Cancer

Siravegna, G., Lazzari, L., Crisafulli, G., Sartore-Bianchi, A., Mussolin, B., Cassingena, A., Martino, C., Lanman, R. B., Nagy, R. J., Fairclough, S., Rospo, G., Corti, G., Bartolini, A., Arcella, P., Montone, M., Lodi, F., Lorenzato, A., Vanzati, A., Valtorta, E., Cappello, G. & 17 others, Bertotti, A., Lonardi, S., Zagonel, V., Leone, F., Russo, M., Balsamo, A., Truini, M., Di Nicolantonio, F., Amatu, A., Bonazzina, E., Ghezzi, S., Regge, D., Vanzulli, A., Trusolino, L., Siena, S., Marsoni, S. & Bardelli, A., Jul 9 2018, In : Cancer Cell. 34, 1, p. 148-162.e7

Research output: Contribution to journalArticle

Radiologic and Genomic Evolution of Individual Metastases during HER2 Blockade in Colorectal Cancer

Siravegna, G., Lazzari, L., Crisafulli, G., Sartore-Bianchi, A., Mussolin, B., Cassingena, A., Martino, C., Lanman, R. B., Nagy, R. J., Fairclough, S., Rospo, G., Corti, G., Bartolini, A., Arcella, P., Montone, M., Lodi, F., Lorenzato, A., Vanzati, A., Valtorta, E., Cappello, G. & 17 others, Bertotti, A., Lonardi, S., Zagonel, V., Leone, F., Russo, M., Balsamo, A., Truini, M., Di Nicolantonio, F., Amatu, A., Bonazzina, E., Ghezzi, S., Regge, D., Vanzulli, A., Trusolino, L., Siena, S., Marsoni, S. & Bardelli, A., Jul 9 2018, In : Cancer Cell. 34, 1, p. 148-162.e7

Research output: Contribution to journalArticle

Reliance upon ancestral mutations is maintained in colorectal cancers that heterogeneously evolve during targeted therapies

Russo, M., Lamba, S., Lorenzato, A., Sogari, A., Corti, G., Rospo, G., Mussolin, B., Montone, M., Lazzari, L., Arena, S., Oddo, D., Linnebacher, M., Sartore-Bianchi, A., Pietrantonio, F., Siena, S., Di Nicolantonio, F. & Bardelli, A., 2018, In : Nature Communications. 9, 1

Research output: Contribution to journalArticle

Reliance upon ancestral mutations is maintained in colorectal cancers that heterogeneously evolve during targeted therapies

Russo, M., Lamba, S., Lorenzato, A., Sogari, A., Corti, G., Rospo, G., Mussolin, B., Montone, M., Lazzari, L., Arena, S., Oddo, D., Linnebacher, M., Sartore-Bianchi, A., Pietrantonio, F., Siena, S., Di Nicolantonio, F. & Bardelli, A., Dec 1 2018, In : Nature Communications. 9, 1, 2287.

Research output: Contribution to journalArticle

TRKA expression and NTRK1 gene copy number across solid tumours

Mauri, G., Valtorta, E., Cerea, G., Amatu, A., Schirru, M., Marrapese, G., Fiorillo, V., Recchimuzzo, P., Cavenago, I. S., Bonazzina, E. F., Motta, V., Lauricella, C., Veronese, S., Tosi, F., Maiolani, M., Rospo, G., Truini, M., Bonoldi, E., Christiansen, J., Potts, S. J. & 2 others, Siena, S. & Sartore-Bianchi, A., Oct 1 2018, In : Journal of Clinical Pathology. 71, 10, p. 926-931 6 p.

Research output: Contribution to journalArticle

2017

Emergence of MET hyper-amplification at progression to MET and BRAF inhibition in colorectal cancer

Oddo, D., Siravegna, G., Gloghini, A., Vernieri, C., Mussolin, B., Morano, F., Crisafulli, G., Berenato, R., Corti, G., Volpi, C. C., Buscarino, M., Niger, M., Dunne, P. D., Rospo, G., Valtorta, E., Bartolini, A., Fucà, G., Lamba, S., Martinetti, A., Di Bartolomeo, M. & 4 others, De Braud, F., Bardelli, A., Pietrantonio, F. & Di Nicolantonio, F., 2017, In : British Journal of Cancer. 117, 3, p. 347-352 6 p.

Research output: Contribution to journalArticle

Emergence of MET hyper-amplification at progression to MET and BRAF inhibition in colorectal cancer

Oddo, D., Siravegna, G., Gloghini, A., Vernieri, C., Mussolin, B., Morano, F., Crisafulli, G., Berenato, R., Corti, G., Volpi, C. C., Buscarino, M., Niger, M., Dunne, P. D., Rospo, G., Valtorta, E., Bartolini, A., Fucà, G., Lamba, S., Martinetti, A., Di Bartolomeo, M. & 4 others, De Braud, F., Bardelli, A., Pietrantonio, F. & Di Nicolantonio, F., Jul 25 2017, In : British Journal of Cancer. 117, 3, p. 347-352 6 p.

Research output: Contribution to journalArticle

Inactivation of DNA repair triggers neoantigen generation and impairs tumour growth

Germano, G., Lamba, S., Rospo, G., Barault, L., Magri, A., Maione, F., Russo, M., Crisafulli, G., Bartolini, A., Lerda, G., Siravegna, G., Mussolin, B., Frapolli, R., Montone, M., Morano, F., De Braud, F., Amirouchene-Angelozzi, N., Marsoni, S., D'Incalci, M., Orlandi, A. & 6 others, Giraudo, E., Sartore-Bianchi, A., Siena, S., Pietrantonio, F., Di Nicolantonio, F. & Bardelli, A., Jan 1 2017, In : Nature. 552, p. 1-5 5 p.

Research output: Contribution to journalArticle

Inactivation of DNA repair triggers neoantigen generation and impairs tumour growth

Germano, G., Lamba, S., Rospo, G., Barault, L., Magrì, A., Maione, F., Russo, M., Crisafulli, G., Bartolini, A., Lerda, G., Siravegna, G., Mussolin, B., Frapolli, R., Montone, M., Morano, F., de Braud, F., Amirouchene-Angelozzi, N., Marsoni, S., D'Incalci, M., Orlandi, A. & 6 others, Giraudo, E., Sartore-Bianchi, A., Siena, S., Pietrantonio, F., Di Nicolantonio, F. & Bardelli, A., Dec 7 2017, In : Nature. 552, 7683, p. 116-120 5 p.

Research output: Contribution to journalArticle

2016

Acquired resistance to the TRK inhibitor entrectinib in colorectal cancer

Russo, M., Misale, S., Wei, G., Siravegna, G., Crisafulli, G., Lazzari, L., Corti, G., Rospo, G., Novara, L., Mussolin, B., Bartolini, A., Cam, N., Patel, R., Yan, S., Shoemaker, R., Wild, R., di Nicolantonio, F., Sartore-Bianchi, A., Li, G., Siena, S. & 1 others, Bardelli, A., Jan 1 2016, In : Cancer Discovery. 6, 1, p. 36-44 9 p.

Research output: Contribution to journalArticle

DeCoClu: Density consensus clustering approach for public transport data

Fiori, A., Mignone, A. & Rospo, G., Jan 20 2016, In : Information Sciences. 328, p. 378-388 11 p.

Research output: Contribution to journalArticle

2015

Clonal evolution and resistance to EGFR blockade in the blood of colorectal cancer patients

Siravegna, G., Mussolin, B., Buscarino, M., Corti, G., Cassingena, A., Crisafulli, G., Ponzetti, A., Cremolini, C., Amatu, A., Lauricella, C., Lamba, S., Hobor, S., Avallone, A., Valtorta, E., Rospo, G., Medico, E., Motta, V., Antoniotti, C., Tatangelo, F., Bellosillo, B. & 12 others, Veronese, S., Budillon, A., Montagut, C., Racca, P., Marsoni, S., Falcone, A., Corcoran, R. B., Di Nicolantonio, F., Loupakis, F., Siena, S., Sartore-Bianchi, A. & Bardelli, A., Jun 1 2015, In : Nature Medicine. 21, 7, p. 795-801 7 p.

Research output: Contribution to journalArticle

Erratum: Clonal evolution and resistance to EGFR blockade in the blood of colorectal cancer patients

Siravegna, G., Mussolin, B., Buscarino, M., Corti, G., Cassingena, A., Crisafulli, G., Ponzetti, A., Cremolini, C., Amatu, A., Lauricella, C., Lamba, S., Hobor, S., Avallone, A., Valtorta, E., Rospo, G., Medico, E., Motta, V., Antoniotti, C., Tatangelo, F., Bellosillo, B. & 12 others, Veronese, S., Budillon, A., Montagut, C., Racca, P., Marsoni, S., Falcone, A., Corcoran, R. B., Di Nicolantonio, F., Loupakis, F., Siena, S., Sartore-Bianchi, A. & Bardelli, A., Jul 7 2015, In : Nature Medicine. 21, 7, p. 827 1 p.

Research output: Contribution to journalArticle