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Research Output 1987 2019

2019
Neuromyelitis Optica
Hematopoietic Stem Cell Transplantation
T-Lymphocytes
Pediatrics
Immune System Diseases
2017

Identification of a Genetic Variation in ERAP1 Aminopeptidase that Prevents Human Cytomegalovirus miR-UL112-5p-Mediated Immunoevasion

Romania, P., Cifaldi, L., Pignoloni, B., Starc, N., D'Alicandro, V., Melaiu, O., Pira, G. L., Giorda, E., Carrozzo, R., Bergvall, M., Bergström, T., Alfredsson, L., Olsson, T., Kockum, I., Seppälä, I., Lehtimäki, T., Hurme, M. A., Hengel, H., Santoni, A., Cerboni, C. & 3 others, Locatelli, F., D'Amato, M. & Fruci, D., Jul 25 2017, In : Cell Reports. 20, 4, p. 846-853 8 p.

Research output: Contribution to journalArticle

Aminopeptidases
3' Untranslated Regions
Cytomegalovirus
Fibroblasts
Immune Evasion

Outcome of children with acute leukemia given HLA-haploidentical HSCT after ab T-cell and B-cell depletion

Locatelli, F., Locatelli, F., Merli, P., Pagliara, D., Li Pira, G., Falco, M., Pende, D., Rondelli, R., Lucarelli, B., Brescia, L. P., Masetti, R., Milano, G. M., Bertaina, V., Algeri, M., Pinto, R. M., Strocchio, L., Meazza, R., Grapulin, L., Handgretinger, R., Moretta, A. & 2 others, Bertaina, A. & Moretta, L., Aug 3 2017, In : Blood. 130, 5, p. 677-685 9 p.

Research output: Contribution to journalArticle

T-cells
Hematopoietic Stem Cell Transplantation
Stem cells
Grafts
Leukemia

Outcome of children with acute leukemia given HLA-haploidentical HSCT after αβ T-cell and B-cell depletion

Locatelli, F., Merli, P., Pagliara, D., Li Pira, G., Falco, M., Pende, D., Rondelli, R., Lucarelli, B., Brescia, L. P., Masetti, R., Milano, G. M., Bertaina, V., Algeri, M., Pinto, R. M., Strocchio, L., Meazza, R., Grapulin, L., Handgretinger, R., Moretta, A., Bertaina, A. & 1 others, Moretta, L., Aug 3 2017, In : Blood. 130, 5, p. 677-685 9 p.

Research output: Contribution to journalArticle

T-cells
Hematopoietic Stem Cell Transplantation
Stem cells
Grafts
Leukemia
2016

Immunoselection techniques in hematopoietic stem cell transplantation

Li Pira, G., Biagini, S., Cicchetti, E., Merli, P., Brescia, L. P., Milano, G. M. & Montanari, M., Jun 1 2016, In : Transfusion and Apheresis Science. 54, 3, p. 356-363 8 p.

Research output: Contribution to journalArticle

Hematopoietic Stem Cell Transplantation
Graft vs Host Disease
T-Lymphocytes
Opportunistic Infections
Hematopoietic Stem Cells

Selective Depletion of αβ T Cells and B Cells for Human Leukocyte Antigen–Haploidentical Hematopoietic Stem Cell Transplantation. A Three-Year Follow-Up of Procedure Efficiency

Li Pira, G., Malaspina, D., Girolami, E., Biagini, S., Cicchetti, E., Conflitti, G., Broglia, M., Ceccarelli, S., Lazzaro, S., Pagliara, D., Meschini, A., Bertaina, A., Montanari, M. & Locatelli, F., Nov 1 2016, In : Biology of Blood and Marrow Transplantation. 22, 11, p. 2056-2064 9 p.

Research output: Contribution to journalArticle

Hematopoietic Stem Cell Transplantation
Hematopoietic Stem Cells
Leukocytes
B-Lymphocytes
T-Lymphocytes

Specific removal of alloreactive T-cells to prevent GvHD in hemopoietic stem cell transplantation: Rationale, strategies and perspectives

Li Pira, G., Di Cecca, S., Montanari, M., Moretta, L. & Manca, F., 2016, (Accepted/In press) In : Blood Reviews.

Research output: Contribution to journalArticle

Stem Cell Transplantation
Graft vs Host Disease
T-Lymphocytes
Tissue Donors
Minor Histocompatibility Antigens
2015
Acute Myeloid Leukemia
Natural Killer Cells
Down-Regulation
Cell Degranulation
Leukemia
2014
Adoptive Immunotherapy
Extracorporeal Membrane Oxygenation
Stem Cell Transplantation
Human Adenoviruses
Adenoviridae

A registry of HLA-typed donors for production of virus-specific CD4 and CD8 T lymphocytes for adoptive reconstitution of immune-compromised patients

Li Pira, G., Ivaldi, F., Starc, N., Landi, F., Rutella, S., Locatelli, F., Sacchi, N., Tripodi, G. & Manca, F., Dec 1 2014, In : Transfusion. 54, 12, p. 3145-3154 10 p.

Research output: Contribution to journalArticle

Registries
Tissue Donors
Viruses
T-Lymphocytes
Cytomegalovirus

HLA-haploidentical stem cell transplantation after removal of αβ+ T and B cells in children with nonmalignant disorders

Bertaina, A., Merli, P., Rutella, S., Pagliara, D., Bernardo, M. E., Masetti, R., Pende, D., Falco, M., Handgretinger, R., Moretta, F., Lucarelli, B., Brescia, L. P., Pira, G. L., Testi, M., Cancrini, C., Kabbara, N., Carsetti, R., Finocchi, A., Moretta, A., Moretta, L. & 1 others, Locatelli, F., Jul 31 2014, In : Blood. 124, 5, p. 822-826 5 p.

Research output: Contribution to journalArticle

Stem Cell Transplantation
Stem cells
Graft vs Host Disease
B-Lymphocytes
Cells

Miniaturized and high-throughput assays for analysis of T-cell immunity specific for opportunistic pathogens and HIV

Li Pira, G., Ivaldi, F., Starc, N., Landi, F., Locatelli, F., Rutella, S., Tripodi, G. & Manca, F., 2014, In : Clinical and Vaccine Immunology. 21, 4, p. 488-495 8 p.

Research output: Contribution to journalArticle

T-cells
Pathogens
Miniaturization
Immunity
Assays

Mobilization of healthy donors with plerixafor affects the cellular composition of T-cell receptor (TCR)-αβ/CD19-depleted haploidentical stem cell grafts

Rutella, S., Filippini, P., Bertaina, V., Li Pira, G., Altomare, L., Ceccarelli, S., Brescia, L. P., Lucarelli, B., Girolami, E., Conflitti, G., Cefalo, M. G., Bertaina, A., Corsetti, T., Moretta, L. & Locatelli, F., Sep 2 2014, In : Journal of Translational Medicine. 12, 1, 240.

Research output: Contribution to journalArticle

Granulocyte Colony-Stimulating Factor
T-Cell Antigen Receptor
Stem cells
Grafts
Dendritic Cells

Serum soluble ST2 as diagnostic marker of systemic inflammatory reactive syndrome of bacterial etiology in children

Calò Carducci, F. I., Aufiero, L. R., Folgori, L., Vittucci, A. C., Amodio, D., De Luca, M., Li Pira, G., Bergamini, A., Pontrelli, G., Finocchi, A. & D'argenio, P., 2014, In : Pediatric Infectious Disease Journal. 33, 2, p. 199-203 5 p.

Research output: Contribution to journalArticle

Systemic Inflammatory Response Syndrome
Calcitonin
C-Reactive Protein
Serum
Virus Diseases
2013

Biological, functional and genetic characterization of bone marrow-derived mesenchymal stromal cells from pediatric patients affected by acute lymphoblastic leukemia

Conforti, A., Biagini, S., Del Bufalo, F., Sirleto, P., Angioni, A., Starc, N., Li Pira, G., Moretta, F., Proia, A., Contoli, B., Genovese, S., Ciardi, C., Antonietta Avanzini, M., Rosti, V., Lo-Coco, F., Locatelli, F. & Bernardo, M. E., Nov 7 2013, In : PLoS One. 8, 11, e76989.

Research output: Contribution to journalArticle

lymphocytic leukemia
Pediatrics
Chemotherapy
stromal cells
Mesenchymal Stromal Cells
2012

Lymphocyte proliferation specific for recall, CMV and HIV antigens in miniaturized and automated format

Li Pira, G., Starc, N., Conforti, A., Bertaina, A., Rutella, S., Locatelli, F. & Manca, F., Oct 31 2012, In : Journal of Immunological Methods. 384, 1-2, p. 135-142 8 p.

Research output: Contribution to journalArticle

HIV Antigens
Lymphocytes
T-Lymphocytes
Epitope Mapping
Antigens

Selective binding of CD4 and CD8 T-cells to antigen presenting cells for enrichment of CMV and HIV specific T-lymphocytes

Li Pira, G., Ivaldi, F. & Manca, F., Feb 28 2012, In : Journal of Immunological Methods. 376, 1-2, p. 125-131 7 p.

Research output: Contribution to journalArticle

Antigen-Presenting Cells
HIV
T-Lymphocytes
Cytokines
Antigens
2011

The PEDVAC trial: Preliminary data from the first therapeutic DNA vaccination in HIV-infected children

Palma, P., Romiti, M. L., Li Pira, G., Montesano, C., Mora, N., Aquilani, A., Santilli, V., Tchidjou, H. K., Ivaldi, F., Giovannelli, L., Pontrelli, G., Borra, G., Blomberg, P., Gudmundsdotter, L., Bråve, A., Montano, M., Bernardi, S., Manca, F., Wahren, B. & Rossi, P., Sep 9 2011, In : Vaccine. 29, 39, p. 6810-6816 7 p.

Research output: Contribution to journalArticle

Vaccination
vaccination
HIV
therapeutics
DNA
2010

High throughput T epitope mapping and vaccine development

Li Pira, G., Ivaldi, F., Moretti, P. & Manca, F., 2010, In : Journal of Biomedicine and Biotechnology. 2010, 325720.

Research output: Contribution to journalArticle

Epitope Mapping
Vaccines
Lymphocytes
Miniaturization
T-Lymphocytes

Validation of a miniaturized assay based on IFNg secretion for assessment of specific T cell immunity

Li Pira, G., Ivaldi, F., Moretti, P., Risso, M., Tripodi, G. & Manca, F., Apr 2010, In : Journal of Immunological Methods. 355, 1-2, p. 68-75 8 p.

Research output: Contribution to journalArticle

Immunity
T-Lymphocytes
Antigens
Enzyme-Linked Immunosorbent Assay
Cytokines
2009

Pathogen specific T-lymphocytes for the reconstitution of the immunocompromised host

Li Pira, G., Kapp, M., Manca, F. & Einsele, H., Oct 2009, In : Current Opinion in Immunology. 21, 5, p. 549-556 8 p.

Research output: Contribution to journalArticle

Immunocompromised Host
T-Lymphocytes
Cellular Immunity
Organ Transplantation
Allergy and Immunology
2008

Antigenic properties of HCMV peptides displayed by filamentous bacteriophages vs. synthetic peptides

Ulivieri, C., Citro, A., Ivaldi, F., Mascolo, D., Ghittoni, R., Fanigliulo, D., Manca, F., Baldari, C. T., Pira, G. L. & Del Pozzo, G., Aug 15 2008, In : Immunology Letters. 119, 1-2, p. 62-70 9 p.

Research output: Contribution to journalArticle

Inovirus
Peptides
Bacteriophages
T-Lymphocytes
Subunit Vaccines

Characterization of migratory activity and cytokine profile of helper and cytotoxic CMV-specific T-cell lines expanded by a selective peptide library

Dander, E., Pira, G. L., Biagi, E., Perseghin, P., Renoldi, G., Gaipa, G., Introna, M., Marin, V., Manca, F., Biondi, A. & D'Amico, G., Apr 2008, In : Experimental Hematology. 36, 4, p. 473-485 13 p.

Research output: Contribution to journalArticle

Peptide Library
Cytomegalovirus
Cytokines
T-Lymphocytes
Cell Line

Evaluation of antigen-specific T-cell responses with a miniaturized and automated method

Li Pira, G., Ivaldi, F., Dentone, C., Righi, E., Del Bono, V., Viscoli, C., Koopman, G. & Manca, F., Dec 2008, In : Clinical and Vaccine Immunology. 15, 12, p. 1811-1818 8 p.

Research output: Contribution to journalArticle

T-cells
T-Lymphocytes
Antigens
Blood
Assays

Methylation of CIITA promoter IV causes loss of HLA-II inducibility by IFN-γ in promyelocytic cells

De Lerma Barbaro, A., De Ambrosis, A., Banelli, B., Pira, G. L., Aresu, O., Romani, M., Ferrini, S. & Accolla, R. S., 2008, In : International Immunology. 20, 11, p. 1457-1466 10 p.

Research output: Contribution to journalArticle

Methylation
Azacitidine
Cell Line
Antigen Presentation
HLA-DR Antigens
Cytomegalovirus
T-Lymphocytes
Polytetrafluoroethylene
Immunocompromised Host
Neoplasm Antigens
2007

Comparative analysis of new innovative vaccine formulations based on the use of procaryotic display systems

D'Apice, L., Sartorius, R., Caivano, A., Mascolo, D., Del Pozzo, G., Di Mase, D. S., Ricca, E., Pira, G. L., Manca, F., Malanga, D., De Palma, R. & De Berardinis, P., Mar 1 2007, In : Vaccine. 25, 11, p. 1993-2000 8 p.

Research output: Contribution to journalArticle

epitopes
Vaccines
Inovirus
T-lymphocytes
immune response

Helper function of cytolytic lymphocytes: Switching roles in the immune response

Li Pira, G., Ivaldi, F., Bottone, L., Koopman, G. & Manca, F., Jan 2007, In : European Journal of Immunology. 37, 1, p. 66-77 12 p.

Research output: Contribution to journalArticle

Helper-Inducer T-Lymphocytes
Lymphocytes
T-Lymphocytes
Antigens
B-Lymphocytes

High throughput functional microdissection of pathogen-specific T-cell immunity using antigen and lymphocyte arrays

Li Pira, G., Ivaldi, F., Bottone, L. & Manca, F., Sep 30 2007, In : Journal of Immunological Methods. 326, 1-2, p. 22-32 11 p.

Research output: Contribution to journalArticle

Microdissection
Immunity
Lymphocytes
T-Lymphocytes
Antigens

Measurement of antigen specific immune responses: 2006 Update

Li Pira, G., Kern, F., Gratama, J., Roederer, M. & Manca, F., Mar 15 2007, In : Cytometry Part B - Clinical Cytometry. 72, 2, p. 77-85 9 p.

Research output: Contribution to journalArticle

Histocompatibility Antigens Class II
Flow Cytometry
T-Lymphocytes
Greece
Immunocompromised Host
2006

A sealed and unbreached system for purification, stimulation, and expansion of cytomegalovirus-specific human CD4 and CD8 T lymphocytes

Li Pira, G., Bottone, L., Ivaldi, F., Pelizzoli, R., Risso, M., Tripodi, G. & Manca, F., Dec 2006, In : Transfusion. 46, 12, p. 2053-2062 10 p.

Research output: Contribution to journalArticle

Cytomegalovirus
T-Lymphocytes
Lymphocytes
CD8 Antigens
Transfusion Medicine

Cellular immunity and CMV

Li Pira, G. & Manca, F., 2006, In : Modern Aspects of Immunobiology. 18, p. 5 1 p.

Research output: Contribution to journalArticle

Human Bone Marrow Stromal Cells Hamper Specific Interactions of CD4 and CD8 T Lymphocytes with Antigen-Presenting Cells

Li Pira, G., Ivaldi, F., Bottone, L., Quarto, R. & Manca, F., Dec 2006, In : Human Immunology. 67, 12, p. 976-985 10 p.

Research output: Contribution to journalArticle

Antigen-Presenting Cells
Mesenchymal Stromal Cells
T-Lymphocytes
Viral Tumor Antigens
Graft vs Host Disease
2005

Generation of cytomegalovirus (CMV)-specific CD4 T cell lines devoid of alloreactivity, by use of a mixture of CMV-phosphoprotein 65 peptides for reconstitution of the T helper repertoire

Li Pira, G., Bottone, L., Ivaldi, F., Tagliamacco, A., Fiordoro, S., Ricciardi, A., Barbano, G. & Manca, F., Jan 15 2005, In : Journal of Infectious Diseases. 191, 2, p. 215-226 12 p.

Research output: Contribution to journalArticle

Peptide T
Cytomegalovirus
T-Lymphocytes
Cell Line
Peptide Library

Human naive CD4 T-Cell clones specific for HIV envelope persist for years in vivo in the absence of antigenic challenge

Li Pira, G., Bottone, L., Ivaldi, F., Del Galdo, F., Papa, F., Accolla, R., Koopman, G., Abbate, G., De Berardinis, P., D'Apice, L., De Palma, R. & Manca, F., Oct 1 2005, In : Journal of Acquired Immune Deficiency Syndromes. 40, 2, p. 132-139 8 p.

Research output: Contribution to journalArticle

T-Cell Receptor Genes
Clone Cells
HIV
T-Lymphocytes
HIV Antigens

Measuring Ag-specific immune responses: Understanding immunopathogenesis and improving diagnostics in infectious disease, autoimmunity and cancer

Kern, F., LiPira, G., Gratama, J. W., Manca, F. & Roederer, M., Sep 2005, In : Trends in Immunology. 26, 9, p. 477-484 8 p.

Research output: Contribution to journalArticle

Autoimmunity
Communicable Diseases
Modern 1601-history
Histocompatibility Antigens Class II
Neoplasms
2004

Identification of new Th peptides from the cytomegalovirus protein pp65 to design a peptide library for generation of CD4 T cell lines for cellular immunoreconstitution

Li Pira, G., Bottone, L., Ivaldi, F., Pelizzoli, R., Del Galdo, F., Lozzi, L., Bracci, L., Loregian, A., Palù, G., De Palma, R., Einsele, H. & Manca, F., May 2004, In : International Immunology. 16, 5, p. 635-642 8 p.

Research output: Contribution to journalArticle

Peptide Library
Cytomegalovirus
T-Lymphocytes
Cell Line
Peptides

In vitro selection of HIV and CMV specific T-lymphocytes

Li Pira, G., Bottone, L., Ivaldi, F., Ricciardi, A., Barbano, G. & Manca, F., Apr 2004, In : Journal of Biological Regulators and Homeostatic Agents. 18, 2, p. 183-186 4 p.

Research output: Contribution to journalArticle

T-lymphocytes
HIV
T-Lymphocytes
therapeutics
epitopes

Recognition of CMV pp65 protein antigen by human CD4 T-cell lines induced with an immunodominant peptide pool

Li Pira, G., Bottone, L., Ivaldi, F., Pelizzoli, R., Bracci, L., Lozzi, L., Scarso, L., Tripodi, G. & Manca, F., May 2004, In : Human Immunology. 65, 5, p. 537-543 7 p.

Research output: Contribution to journalArticle

CD4 Antigens
Cytomegalovirus
T-Lymphocytes
Cell Line
Peptides
2002

Preservation of clonal heterogeneity of the Pneumocystis carinii-specific CD4 T cell repertoire in HIV infected, asymptomatic individuals

Li Pira, G., Fenoglio, D., Bottone, L., Terranova, P., Pontali, E., Caroli, F., Seri, M., Cailliez, J. C., Koopman, G., Accolla, R., Del Galdo, F., Abbate, G., De Palma, R. & Manca, F., 2002, In : Clinical and Experimental Immunology. 128, 1, p. 155-162 8 p.

Research output: Contribution to journalArticle

Pneumocystis carinii
Clone Cells
HIV
T-Lymphocytes
Lymphocytes
2001

Analysis of the antigen specific T cell repertoires in HIV infection

Li Pira, G., Bottone, L., Fenoglio, D., Terranova, P., Pontali, E., Ivaldi, F., Del Galdo, F., Mortara, L., Loregian, A., Palù, G., Kunkl, A., Accolla, R., De Palma, R. & Manca, F., Nov 1 2001, In : Immunology Letters. 79, 1-2, p. 85-91 7 p.

Research output: Contribution to journalArticle

HIV Infections
CD4 Antigens
T-Lymphocytes
Antigens
Lymphocytes

Epitope focus, clonal composition and Th1 phenotype of the human CD4 response to the secretory mycobacterial antigen Ag85

Valle, M. T., Megiovanni, A. M., Merlo, A., Li Pira, G., Bottone, L., Angelini, G., Bracci, L., Lozzi, L., Huygen, K. & Manca, F., 2001, In : Clinical and Experimental Immunology. 123, 2, p. 226-232 7 p.

Research output: Contribution to journalArticle

Epitopes
Phenotype
Antigens
Peptides
Cell Line

Genetically modified immunocompetent cells in HIV infection

Palù, G., Pira, G. L., Gennari, F., Fenoglio, D., Parolin, C. & Manca, F., 2001, In : Gene Therapy. 8, 21, p. 1593-1600 8 p.

Research output: Contribution to journalArticle

HIV Infections
Genetic Therapy
HIV
Adoptive Immunotherapy
Antigens
2000

Cytogenetic response to autografting in chronic myelogenous leukemia correlates with the amount of BCR-ABL positive cells in the graft

Corsetti, M. T., Lerma, E., Dejana, A., Cavaliere, M., Figari, O., Vassallo, F., Abate, M., Luchetti, S., Piaggio, G., Parodi, C., Pira, G. L., Manca, F. & Carella, A. M., Jan 2000, In : Experimental Hematology. 28, 1, p. 104-111 8 p.

Research output: Contribution to journalArticle

Autologous Transplantation
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Cytogenetics
Transplants
Stem Cells

Cytogenetic response to autografting in chronic myelogenous leukemia correlates with the amount of BCR-ABL positive cells in the graft.

Corsetti, M. T., Lerma, E., Dejana, A., Cavaliere, M., Figari, O., Vassallo, F., Abate, M., Luchetti, S., Piaggio, G., Parodi, C., Pira, G. L., Manca, F. & Carella, A. M., Mar 2000, In : Experimental Hematology. 28, 3, p. 353 1 p.

Research output: Contribution to journalArticle

Autologous Transplantation
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Cytogenetics
Transplants
Stem Cells

Cytokine gene expression and T-cell proliferative responses in lymph node mononuclear cells from children with early stage human immunodeficiency virus infection

Airoldi, I., Saverino, D., Favre, A., Ghiotto, F., Tacchetti, C., Facchetti, P., Piatti, G., Li Pira, G., Fenoglio, D., Duse, M., Ciccone, E., Manca, F., Plebani, A., Grossi, C. E. & Pistoia, V., 2000, In : Haematologica. 85, 12, p. 1237-1247 11 p.

Research output: Contribution to journalArticle

Virus Diseases
Lymph Nodes
HIV
Cytokines
T-Lymphocytes

Erratum: Cytogenetic response to autografting in chronic myelogenous leukemia correlates with the amount of BCR-ABL positive cells in the graft (Experimental Hematology Vol. 28, Number 1, 2000 (104-111))

Corsetti, M. T., Lerma, E., Dejana, A., Cavaliere, M., Figari, O., Vassallo, F., Abate, M., Luchetti, S., Piaggio, G., Parodi, C., Pira, G. L., Manca, F. & Carella, A. M., 2000, In : Experimental Hematology. 28, 3, p. 353 1 p.

Research output: Contribution to journalArticle

Natural analogue peptides of an HIV-1 GP120 T-helper epitope antagonize response of GP120-specific human CD4 T-cell clones

Fenoglio, D., Li Pira, G. L., Lozzi, L., Bracci, L., Saverino, D., Terranova, P., Bottone, L., Lantero, S., Megiovanni, A., Merlo, A. & Manca, F., Jan 1 2000, In : Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology. 23, 1, p. 1-7 7 p.

Research output: Contribution to journalArticle

Cytotoxic T-Lymphocytes
HIV-1
Epitopes
Clone Cells
HIV
1999

Antagonistic activity of HIV-1 T helper peptides flanked by an unrelated carrier protein

Fenoglio, D., Li Pira, G., De Berardinis, P., Saverino, D., Terranova, M. P., Ombra, M. N., Bracci, L., Lozzi, L., Viotti, C., Guardiola, J. & Manca, F., 1999, In : European Journal of Immunology. 29, 5, p. 1448-1455 8 p.

Research output: Contribution to journalArticle

Peptide T
HIV-1
Carrier Proteins
Glutathione Transferase
Peptides