19952019

Research output per year

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Research Output

2019

Rhomboid-Like-2 Intramembrane Protease Mediates Metalloprotease-Independent Regulation of Cadherins

Battistini, C., Rehman, M., Avolio, M., Arduin, A., Valdembri, D., Serini, G. & Tamagnone, L., Nov 27 2019, In : International Journal of Molecular Sciences. 20, 23

Research output: Contribution to journalArticle

2018

A rationally designed NRP1-independent superagonist SEMA3A mutant is an effective anticancer agent

Gioelli, N., Maione, F., Camillo, C., Ghitti, M., Valdembri, D., Morello, N., Darche, M., Zentilin, L., Cagnoni, G., Qiu, Y., Giacca, M., Giustetto, M., Paques, M., Cascone, I., Musco, G., Tamagnone, L., Giraudo, E. & Serini, G., May 23 2018, In : Science Translational Medicine. 10, 442, eaah4807.

Research output: Contribution to journalArticle

Kinesin-2 controls the motility of RAB5 endosomes and their association with the spindle in mitosis

Pupo, E., Avanzato, D., Scianna, M., Oldani, A., Serini, G. & Lanzetti, L., Sep 1 2018, In : International Journal of Molecular Sciences. 19, 9, 2575.

Research output: Contribution to journalArticle

2017

TRPM8 inhibits endothelial cell migration via a nonchannel function by trapping the small GTPase Rap1

Genova, T., Grolez, G. P., Camillo, C., Bernardini, M., Bokhobza, A., Richard, E., Scianna, M., Lemonnier, L., Valdembri, D., Munaron, L., Philips, M. R., Mattot, V., Serini, G., Prevarskaya, N., Gkika, D. & Pla, A. F., Jul 1 2017, In : Journal of Cell Biology. 216, 7, p. 2107-2130 24 p.

Research output: Contribution to journalArticle

2016

Class 3 semaphorins in cardiovascular development

Valdembri, D., Regano, D., Maione, F., Giraudo, E. & Serini, G., 2016, In : Cell Adhesion and Migration. p. 1-11 11 p.

Research output: Contribution to journalArticle

PPFIA1 drives active a5b1 integrin recycling and controls fibronectin fibrillogenesis and vascular morphogenesis

Mana, G., caplero, F., Panieri, E., Panero, V., bottcher, R., Tseng, H-Y., Saltarin, F., Astanina, E., Wolanska, K., Morgan, M., humphries, M., Santoro, M., Serini, G. & Valdembri, D., 2016, In : Nature Communications.

Research output: Contribution to journalArticle

2015

Bad vessels beware! Semaphorins will sort you out!

Serini, G. & Tamagnone, L., Oct 1 2015, In : EMBO Molecular Medicine. 7, 10, p. 1251-1253 3 p.

Research output: Contribution to journalArticle

Linifanib: Current status and future potential in cancer therapy

Aversa, C., Leone, F., Zucchini, G., Serini, G., Geuna, E., Milani, A., Valdembri, D., Martinello, R. & Montemurro, F., Jun 1 2015, In : Expert Review of Anticancer Therapy. 15, 6, p. 677-687 11 p.

Research output: Contribution to journalArticle

2014

Class 3 semaphorin in angiogenesis and lymphangiogenesis

Bussolino, F., Giraudo, E. & Serini, G., 2014, In : Chemical Immunology and Allergy. 99, p. 71-88 18 p.

Research output: Contribution to journalArticle

Endothelial podosome rosettes regulate vascular branching in tumour angiogenesis

Seano, G., Chiaverina, G., Gagliardi, P. A., Di Blasio, L., Puliafito, A., Bouvard, C., Sessa, R., Tarone, G., Sorokin, L., Helley, D., Jain, R. K., Serini, G., Bussolino, F. & Primo, L., Jan 1 2014, In : Nature Cell Biology. 16, 10, p. 931-941 11 p.

Research output: Contribution to journalArticle

2013

Polarity, cell division, and out-of-equilibrium dynamics control the growth of epithelial structures

Cerruti, B., Puliafito, A., Shewan, A. M., Yu, W., Combes, A. N., Little, M. H., Chianale, F., Primo, L., Serini, G., Mostov, K. E., Celani, A. & Gamba, A., Oct 28 2013, In : Journal of Cell Biology. 203, 2, p. 359-372 14 p.

Research output: Contribution to journalArticle

The GTPase-activating protein RN-tre controls focal adhesion turnover and cell migration

Palamidessi, A., Frittoli, E., Ducano, N., Offenhauser, N., Sigismund, S., Kajiho, H., Parazzoli, D., Oldani, A., Gobbi, M., Serini, G., Di Fiore, P. P., Scita, G. & Lanzetti, L., Dec 2 2013, In : Current Biology. 23, 23, p. 2355-2364 10 p.

Research output: Contribution to journalArticle

Tivantinib (ARQ197) displays cytotoxic activity that is independent of its ability to bind MET

Basilico, C., Pennacchietti, S., Vigna, E., Chiriaco, C., Arena, S., Bardelli, A., Valdembri, D., Serini, G. & Michieli, P., May 1 2013, In : Clinical Cancer Research. 19, 9, p. 2381-2392 12 p.

Research output: Contribution to journalArticle

2012

A bistable model of cell polarity

Semplice, M., Veglio, A., Naldi, G., Serini, G. & Gamba, A., Feb 23 2012, In : PLoS One. 7, 2, e30977.

Research output: Contribution to journalArticle

Neuropilin-1-dependent regulation of EGF-receptor Signaling

Rizzolio, S., Rabinowicz, N., Rainero, E., Lanzetti, L., Serini, G., Norman, J., Neufeld, G. & Tamagnone, L., Nov 15 2012, In : Cancer Research. 72, 22, p. 5801-5811 11 p.

Research output: Contribution to journalArticle

Neuropilin-1 identifies a subset of bone marrow Gr1-monocytes that can induce tumor vessel normalization and inhibit tumor growth

Carrer, A., Moimas, S., Zacchigna, S., Pattarini, L., Zentilin, L., Ruozi, G., Mano, M., Sinigaglia, M., Maione, F., Serini, G., Giraudo, E., Bussolino, F. & Giacca, M., Dec 15 2012, In : Cancer Research. 72, 24, p. 6371-6381 11 p.

Research output: Contribution to journalArticle

Regulation of adhesion site dynamics by integrin traffic

Valdembri, D. & Serini, G., Oct 2012, In : Current Opinion in Cell Biology. 24, 5, p. 582-591 10 p.

Research output: Contribution to journalArticle

Semaphorin 3A overcomes cancer hypoxia and metastatic dissemination induced by antiangiogenic treatment in mice

Maione, F., Capano, S., Regano, D., Zentilin, L., Giacca, M., Casanovas, O., Bussolino, F., Serini, G. & Giraudo, E., May 1 2012, In : Journal of Clinical Investigation. 122, 5, p. 1832-1848 17 p.

Research output: Contribution to journalArticle

The R-Ras/RIN2/Rab5 complex controls endothelial cell adhesion and morphogenesis via active integrin endocytosis and Rac signaling

Sandri, C., Caccavari, F., Valdembri, D., Camillo, C., Veltel, S., Santambrogio, M., Lanzetti, L., Bussolino, F., Ivaska, J. & Serini, G., Oct 2012, In : Cell Research. 22, 10, p. 1479-1501 23 p.

Research output: Contribution to journalArticle

The vesicular SNARE Synaptobrevin is required for Semaphorin 3A axonal repulsion

Zylbersztejn, K., Petkovic, M., Burgo, A., Deck, M., Garel, S., Marcos, S., Bloch-Gallego, E., Nothias, F., Serini, G., Bagnard, D., Binz, T. & Galli, T., Jan 2012, In : Journal of Cell Biology. 196, 1, p. 37-46 10 p.

Research output: Contribution to journalArticle

2011

Increasing traffic on vascular routes

Santambrogio, M., Valdembri, D. & Serini, G., Apr 2011, In : Molecular Aspects of Medicine. 32, 2, p. 112-122 11 p.

Research output: Contribution to journalArticle

Nervous vascular parallels: Axon guidance and beyond

Arese, M., Serini, G. & Bussolino, F., 2011, In : International Journal of Developmental Biology. 55, 4-5, p. 439-445 7 p.

Research output: Contribution to journalArticle

Regulation of integrins by conformation and traffic: It takes two to tango

Valdembri, D., Sandri, C., Santambrogio, M. & Serini, G., Sep 1 2011, In : Molecular BioSystems. 7, 9, p. 2539-2546 8 p.

Research output: Contribution to journalArticle

2010

Diacylglycerol kinase α mediates HGF-induced Rac activation and membrane ruffling by regulating atypical PKC and RhoGDI

Chianale, F., Rainero, E., Cianflone, C., Bettio, V., Pighini, A., Porporato, P. E., Filigheddu, N., Serini, G., Sinigaglia, F., Baldanzi, G. & Graziani, A., Mar 2 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 9, p. 4182-4187 6 p.

Research output: Contribution to journalArticle

Integrin signaling and lung cancer

Caccavari, F., Valdembri, D., Sandri, C., Bussolino, F. & Serini, G., Jan 2010, In : Cell Adhesion and Migration. 4, 1, p. 124-129 6 p.

Research output: Contribution to journalArticle

2009

Angiogenesis: A balancing act between integrin activation and inhibition?

Bussolino, F., Caccavari, F., Valdembri, D. & Serini, G., Dec 2009, In : European Cytokine Network. 20, 4, p. 191-196 6 p.

Research output: Contribution to journalArticle

Neuropilin-1/GIPC1 signaling regulates α5β1 integrin traffic and function in endothelial cells

Valdembri, D., Caswell, P. T., Anderson, K. I., Schwarz, J. P., König, I., Astanina, E., Caccavari, F., Norman, J. C., Humphries, M. J., Bussolino, F. & Serini, G., Jan 2009, In : PLoS Biology. 7, 1, e1000025.

Research output: Contribution to journalArticle

Plexins and neuropilins regulate integrin conformation and trafficking in endothelial cells

Serini, G., Valdembri, D. & Bussolino, F., 2009, Recent Advances in Angiogenesis and Antiangiogenesis. Bentham Science Publishers Ltd., p. 1-9 9 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Semaphorin 3A is an endogenous angiogenesis inhibitor that blocks tumor growth and normalizes tumor vasculature in transgenic mouse models

Maione, F., Molla, F., Meda, C., Latini, R., Zentilin, L., Giacca, M., Seano, G., Serini, G., Bussolino, F. & Giraudo, E., Nov 2 2009, In : Journal of Clinical Investigation. 119, 11, p. 3356-3372 17 p.

Research output: Contribution to journalArticle

Semaphorins and tumor angiogenesis

Serini, G., Maione, F., Giraudo, E. & Bussolino, F., Jun 2009, In : Angiogenesis. 12, 2, p. 187-193 7 p.

Research output: Contribution to journalArticle

Symmetry breaking mechanism for epithelial cell polarization

Veglio, A., Gamba, A., Nicodemi, M., Bussolino, F. & Serini, G., Sep 29 2009, In : Physical Review E - Statistical, Nonlinear, and Soft Matter Physics. 80, 3, 031919.

Research output: Contribution to journalArticle

2008

AP-2α and AP-2β regulate tumor progression via specific genetic programs

Orso, F., Penna, E., Cimino, D., Astanina, E., Maione, F., Valdembri, D., Giraudo, E., Serini, G., Sismondi, P., De Bortoli, M. & Taverna, D., Aug 2008, In : FASEB Journal. 22, 8, p. 2702-2714 13 p.

Research output: Contribution to journalArticle

Besides adhesion: New perspectives of integrin functions in angiogenesis

Serini, G., Napione, L., Arese, M. & Bussolino, F., May 2008, In : Cardiovascular Research. 78, 2, p. 213-222 10 p.

Research output: Contribution to journalArticle

Integrins team up with tyrosine kinase receptors and plexins to control angiogenesis

Serini, G., Napione, L. & Bussolino, F., May 2008, In : Current Opinion in Hematology. 15, 3, p. 235-242 8 p.

Research output: Contribution to journalArticle

Modelling of 3D early blood vessel formation: Simulations and morphological analysis

Cavalli, F., Gamba, A., Naldi, G., Oriboni, S., Semplice, M., Valdembri, D. & Serini, G., 2008, AIP Conference Proceedings. Vol. 1028. p. 311-327 17 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2007

3D simulations of early blood vessel formation

Cavalli, F., Gamba, A., Naldi, G., Semplice, M., Valdembri, D. & Serini, G., Aug 10 2007, In : Journal of Computational Physics. 225, 2, p. 2283-2300 18 p.

Research output: Contribution to journalArticle

A simulation environment for directional sensing as a phase separation process.

de Candia, A., Gamba, A., Cavalli, F., Coniglio, A., Di Talia, S., Bussolino, F. & Serini, G., Apr 7 2007, In : Science's STKE : signal transduction knowledge environment. 2007, 378

Research output: Contribution to journalArticle

Embryonic cleavage modeling as a computational approach to sphere packing problem

Zammataro, L., Serini, G., Rowland, T. & Bussolino, F., Mar 7 2007, In : Journal of Theoretical Biology. 245, 1, p. 77-82 6 p.

Research output: Contribution to journalArticle

Integrins: A flexible platform for endothelial vascular tyrosine kinase receptors

Napione, L., Cascone, I., Mitola, S., Serini, G. & Bussolino, F., Nov 2007, In : Autoimmunity Reviews. 7, 1, p. 18-22 5 p.

Research output: Contribution to journalArticle

2006

A computational model for eukaryotic directional sensing

Gamba, A., De Candia, A., Cavalli, F., Di Talia, S., Coniglio, A., Bussolino, F. & Serini, G., 2006, Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics). Springer Verlag, Vol. 4210 LNBI. p. 184-195 12 p. (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); vol. 4210 LNBI).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Integrins and angiogenesis: A sticky business

Serini, G., Valdembri, D. & Bussolino, F., Mar 10 2006, In : Experimental Cell Research. 312, 5, p. 651-658 8 p.

Research output: Contribution to journalArticle

Loss of inhibitory semaphorin 3A (SEMA3A) autocrine loops in bone marrow endothelial cells of patients with multiple myeloma

Vacca, A., Scavelli, C., Serini, G., Di Pietro, G., Cirulli, T., Merchionne, F., Ribatti, D., Bussolino, F., Guidolin, D., Piaggio, G., Bacigalupo, A. & Dammacco, F., Sep 1 2006, In : Blood. 108, 5, p. 1661-1667 7 p.

Research output: Contribution to journalArticle

Regulation of integrin function controls angiogenic remodeling

Serini, G. & Bussolino, F., 2006, In : Haematologica Reports. 2, 3, p. 42-44 3 p.

Research output: Contribution to journalArticle

Role of repulsive factors in vascularization dynamics

Di Talia, S., Gamba, A., Lamberti, F. & Serini, G., 2006, In : Physical Review E - Statistical, Nonlinear, and Soft Matter Physics. 73, 4, 041917.

Research output: Contribution to journalArticle