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Research Output 2016 2019

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2019

Macrophages and Metabolism in the Tumor Microenvironment.

Vitale, I., Manic, G., Coussens, L. M., Kroemer, G. & Galluzzi, L., Jul 1 2019, In : Cell Metabolism. 30, p. 36-50 15 p.

Research output: Contribution to journalArticle

2018

CHK1-targeted therapy to deplete DNA replication-stressed, p53-deficient, hyperdiploid colorectal cancer stem cells

Manic, G., Signore, M., Sistigu, A., Russo, G., Corradi, F., Siteni, S., Musella, M., Vitale, S., De Angelis, M. L., Pallocca, M., Amoreo, C. A., Sperati, F., Di Franco, S., Barresi, S., Policicchio, E., De Luca, G., De Nicola, F., Mottolese, M., Zeuner, A., Fanciulli, M. & 6 others, Stassi, G., Maugeri-Saccà, M., Baiocchi, M., Tartaglia, M., Vitale, I. & De Maria, R., May 1 2018, In : Gut. 67, 5, p. 903-917 15 p.

Research output: Contribution to journalArticle

Polyploidy
Neoplastic Stem Cells
DNA Replication
Colorectal Neoplasms
Protein Array Analysis

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

Galluzzi, L., Vitale, I., Aaronson, S. A., Abrams, J. M., Adam, D., Agostinis, P., Alnemri, E. S., Altucci, L., Amelio, I., Andrews, D. W., Annicchiarico-Petruzzelli, M., Antonov, A. V., Arama, E., Baehrecke, E. H., Barlev, N. A., Bazan, N. G., Bernassola, F., Bertrand, M. J. M., Bianchi, K., Blagosklonny, M. V. & 149 others, Blomgren, K., Borner, C., Boya, P., Brenner, C., Campanella, M., Candi, E., Carmona-Gutierrez, D., Cecconi, F., Chan, F. K-M., Chandel, N. S., Cheng, E. H., Chipuk, J. E., Cidlowski, J. A., Ciechanover, A., Cohen, G. M., Conrad, M., Cubillos-Ruiz, J. R., Czabotar, P. E., D'Angiolella, V., Dawson, T. M., Dawson, V. L., De Laurenzi, V., De Maria, R., Debatin, K-M., DeBerardinis, R. J., Deshmukh, M., Di Daniele, N., Di Virgilio, F., Dixit, V. M., Dixon, S. J., Duckett, C. S., Dynlacht, B. D., El-Deiry, W. S., Elrod, J. W., Fimia, G. M., Fulda, S., García-Sáez, A. J., Garg, A. D., Garrido, C., Gavathiotis, E., Golstein, P., Gottlieb, E., Green, D. R., Greene, L. A., Gronemeyer, H., Gross, A., Hajnoczky, G., Hardwick, J. M., Harris, I. S., Hengartner, M. O., Hetz, C., Ichijo, H., Jäättelä, M., Joseph, B., Jost, P. J., Juin, P. P., Kaiser, W. J., Karin, M., Kaufmann, T., Kepp, O., Kimchi, A., Kitsis, R. N., Klionsky, D. J., Knight, R. A., Kumar, S., Lee, S. W., Lemasters, J. J., Levine, B., Linkermann, A., Lipton, S. A., Lockshin, R. A., López-Otín, C., Lowe, S. W., Luedde, T., Lugli, E., MacFarlane, M., Madeo, F., Malewicz, M., Malorni, W., Manic, G., Marine, J-C., Martin, S. J., Martinou, J-C., Medema, J. P., Mehlen, P., Meier, P., Melino, S., Miao, E. A., Molkentin, J. D., Moll, U. M., Muñoz-Pinedo, C., Nagata, S., Nuñez, G., Oberst, A., Oren, M., Overholtzer, M., Pagano, M., Panaretakis, T., Pasparakis, M., Penninger, J. M., Pereira, D. M., Pervaiz, S., Peter, M. E., Piacentini, M., Pinton, P., Prehn, J. H. M., Puthalakath, H., Rabinovich, G. A., Rehm, M., Rizzuto, R., Rodrigues, C. M. P., Rubinsztein, D. C., Rudel, T., Ryan, K. M., Sayan, E., Scorrano, L., Shao, F., Shi, Y., Silke, J., Simon, H-U., Sistigu, A., Stockwell, B. R., Strasser, A., Szabadkai, G., Tait, S. W. G., Tang, D., Tavernarakis, N., Thorburn, A., Tsujimoto, Y., Turk, B., Vanden Berghe, T., Vandenabeele, P., Vander Heiden, M. G., Villunger, A., Virgin, H. W., Vousden, K. H., Vucic, D., Wagner, E. F., Walczak, H., Wallach, D., Wang, Y., Wells, J. A., Wood, W., Yuan, J., Zakeri, Z., Zhivotovsky, B., Zitvogel, L., Melino, G. & Kroemer, G., Mar 2018, In : Cell Death and Differentiation. 25, 3, p. 486-541 56 p.

Research output: Contribution to journalArticle

Terminology
Cell Death
Apoptosis
Cell Aging
Autophagy

Molecular mechanisms of cell death: Recommendations of the Nomenclature Committee on Cell Death 2018

Galluzzi, L., Vitale, I., Aaronson, S. A., Abrams, J. M., Adam, D., Agostinis, P., Alnemri, E. S., Altucci, L., Amelio, I., Andrews, D. W., Annicchiarico-Petruzzelli, M., Antonov, A. V., Arama, E., Baehrecke, E. H., Barlev, N. A., Bazan, N. G., Bernassola, F., Bertrand, M. J. M., Bianchi, K., Blagosklonny, M. V. & 30 others, Blomgren, K., Borner, C., Boya, P., Brenner, C., Campanella, M., Candi, E., Carmona-Gutierrez, D., Cecconi, F., Chan, FK-M., Chandel, N. S., Cheng, E. H., Chipuk, J. E., Cidlowski, J. A., Ciechanover, A., Cohen, G. M., Conrad, M., Cubillos-Ruiz, J. R., Czabotar, P. E., D'Angiolella, V., Dawson, T. M., De Maria, R., Fimia, G. M., Lugli, E., Malorni, W., Manic, G., Pagano, M., Piacentini, M., Sistigu, A., Tait, S. W. G. & Melino, G., 2018, In : Cell Death and Differentiation. 25, 3, p. 486-541 56 p.

Research output: Contribution to journalArticle

2017

ATM kinase sustains breast cancer stem-like cells by promoting ATG4C expression and autophagy

Antonelli, M., Strappazzon, F., Arisi, I., Brandi, R., D'Onofrio, M., Sambucci, M., Manic, G., Vitale, I., Barilà, D. & Stagni, V., Jan 1 2017, In : Oncotarget. 8, 13, p. 21692-21709 18 p.

Research output: Contribution to journalArticle

Ataxia Telangiectasia
Neoplastic Stem Cells
Autophagy
Cysteine
Peptide Hydrolases

ATM kinase sustains breast cancer stem-like cells by promoting ATG4C expression and autophagy

Antonelli, M., Strappazzon, F., Arisi, I., Brandi, R., D'Onofrio, M., Sambucci, M., Manic, G., Vitale, I., Barila, D. & Stagni, V., Mar 28 2017, In : Oncotarget. 8, 13, p. 21692-21709 18 p.

Research output: Contribution to journalArticle

Ataxia Telangiectasia
Neoplastic Stem Cells
Autophagy
Cysteine
Peptide Hydrolases

CHK1-targeted therapy to deplete DNA replication-stressed, p53-deficient, hyperdiploid colorectal cancer stem cells

Manic, G., Signore, M., Sistigu, A., Russo, G., Corradi, F., Siteni, S., Musella, M., Vitale, S., De Angelis, M. L., Pallocca, M., Amoreo, C. A., Sperati, F., Di Franco, S., Barresi, S., Policicchio, E., De Luca, G., De Nicola, F., Mottolese, M., Zeuner, A., Fanciulli, M. & 6 others, Stassi, G., Maugeri-Saccà, M., Baiocchi, M., Tartaglia, M., Vitale, I. & De Maria, R., Apr 7 2017, In : Gut.

Research output: Contribution to journalArticle

Polyploidy
Neoplastic Stem Cells
DNA Replication
Colorectal Neoplasms
Protein Array Analysis
Epithelial-Mesenchymal Transition
Tumors
Cytokines
Neoplasms
Cells

DNA Damage in Stem Cells

Vitale, I., Manic, G., Maria, R. D., Kroemer, G. & Galluzzi, L., May 4 2017, In : Molecular Cell. 66, 3, p. 306-319 14 p.

Research output: Contribution to journalArticle

DNA Damage
Stem Cells
Genetic Drift
Pluripotent Stem Cells
Adult Stem Cells

Molecular Regulation of the Spindle Assembly Checkpoint by Kinases and Phosphatases

Manic, G., Corradi, F., Sistigu, A., Siteni, S. & Vitale, I., 2017, In : International Review of Cell and Molecular Biology. 328, p. 105-161 57 p.

Research output: Contribution to journalArticle

M Phase Cell Cycle Checkpoints
Kinetochores
Phosphoric Monoester Hydrolases
Phosphotransferases
Aurora Kinase B

Replication stress in colorectal cancer stem cells

Manic, G., Maria, R. D. & Vitale, I., Jun 7 2017, In : Oncotarget. 8, 53, p. 90606-90607

Research output: Contribution to journalArticle

Type-I-interferons in infection and cancer: Unanticipated dynamics with therapeutic implications

Musella, M., Manic, G., Maria, R. D., Vitale, I. & Sistigu, A., 2017, In : OncoImmunology. 6, 5, p. e1314424

Research output: Contribution to journalArticle

2016

Trial watch - inhibiting PARP enzymes for anticancer therapy

Sistigu, A., Manic, G., Obrist, F. & Vitale, I., Mar 2016, In : Molecular & cellular oncology. 3, 2, p. e1053594

Research output: Contribution to journalArticle

Enzyme Therapy
Poly(ADP-ribose) Polymerases
DNA Damage
Adenosine Diphosphate
Enzymes

Whole-genome duplication increases tumor cell sensitivity to MPS1 inhibition

Jemaà, M., Manic, G., Lledo, G., Lissa, D., Reynes, C., Morin, N., Chibon, F., Sistigu, A., Castedo, M., Vitale, I., Kroemer, G. & Abrieu, A., Jan 5 2016, In : Oncotarget. 7, 1, p. 885-901 17 p.

Research output: Contribution to journalArticle

Tetraploidy
Genome
M Phase Cell Cycle Checkpoints
Neoplasms
Diploidy