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2015

International genome-wide meta-analysis identifies new primary biliary cirrhosis risk loci and targetable pathogenic pathways

Cordell, H. J., Han, Y., Mells, G. F., Li, Y., Hirschfield, G. M., Greene, C. S., Xie, G., Juran, B. D., Zhu, D., Qian, D. C., Floyd, J. A. B., Morley, K. I., Prati, D., Lleo, A., Cusi, D., Gershwin, M. E., Anderson, C. A., Lazaridis, K. N., Invernizzi, P., Seldin, M. F. & 441 others, Sandford, R. N., Amos, C. I., Siminovitch, K. A., Schlicht, E. M., Lammert, C., Atkinson, E. J., Chan, L. L., De Andrade, M., Balschun, T., Mason, A. L., Myers, R. P., Zhang, J., Milkiewicz, P., Qu, J., Odin, J. A., Luketic, V. A., Bacon, B. R., Bodenheimer, H. C., Liakina, V., Vincent, C., Levy, C., Gregersen, P. K., Almasio, P. L., Alvaro, D., Andreone, P., Andriulli, A., Barlassina, C., Battezzati, P. M., Benedetti, A., Bernuzzi, F., Bianchi, I., Bragazzi, M. C., Brunetto, M., Bruno, S., Casella, G., Coco, B., Colli, A., Colombo, M., Colombo, S., Cursaro, C., Crocè, L. S., Crosignani, A., Donato, M. F., Elia, G., Fabris, L., Ferrari, C., Floreani, A., Foglieni, B., Fontana, R., Galli, A., Lazzari, R., Macaluso, F., Malinverno, F., Marra, F., Marzioni, M., Mattalia, A., Montanari, R., Morini, L., Morisco, F., Mousa Hani, S., Muratori, L., Muratori, P., Niro, G. A., Palmieri, V. O., Picciotto, A., Podda, M., Portincasa, P., Ronca, V., Rosina, F., Rossi, S., Sogno, I., Spinzi, G., Spreafico, M., Strazzabosco, M., Tarallo, S., Tarocchi, M., Tiribelli, C., Toniutto, P., Vinci, M., Zuin, M., Ch'Ng, C. L., Rahman, M., Yapp, T., Sturgess, R., Healey, C., Czajkowski, M., Gunasekera, A., Gyawali, P., Premchand, P., Kapur, K., Marley, R., Foster, G., Watson, A., Dias, A., Subhani, J., Harvey, R., McCorry, R., Ramanaden, D., Gasem, J., Evans, R., Mathialahan, T., Shorrock, C., Lipscomb, G., Southern, P., Tibble, J., Gorard, D., Palegwala, A., Jones, S., Carbone, M., Dawwas, M., Alexander, G., Dolwani, S., Prince, M., Foxton, M., Elphick, D., Mitchison, H., Gooding, I., Karmo, M., Saksena, S., Mendall, M., Patel, M., Ede, R., Austin, A., Sayer, J., Hankey, L., Hovell, C., Fisher, N., Carter, M., Koss, K., Piotrowicz, A., Grimley, C., Neal, D., Lim, G., Levi, S., Ala, A., Broad, A., Saeed, A., Wood, G., Brown, J., Wilkinson, M., Gordon, H., Ramage, J., Ridpath, J., Ngatchu, T., Grover, B., Shaukat, S., Shidrawi, R., Abouda, G., Ali, F., Rees, I., Salam, I., Narain, M., Brown, A., Taylor-Robinson, S., Williams, S., Grellier, L., Banim, P., Das, D., Chilton, A., Heneghan, M., Curtis, H., Gess, M., Drake, I., Aldersley, M., Davies, M., Jones, R., McNair, A., Srirajaskanthan, R., Pitcher, M., Sen, S., Bird, G., Barnardo, A., Kitchen, P., Yoong, K., Chirag, O., Sivaramakrishnan, N., MacFaul, G., Jones, D., Shah, A., Evans, C., Saha, S., Pollock, K., Bramley, P., Mukhopadhya, A., Fraser, A., Mills, P., Shallcross, C., Campbell, S., Bathgate, A., Shepherd, A., Dillon, J., Rushbrook, S., Przemioslo, R., Macdonald, C., Metcalf, J., Shmueli, U., Davis, A., Naqvi, A., Lee, T., Stephen, D., Collier, J., Klass, H., Ninkovic, M., Cramp, M., Sharer, N., Aspinall, R., Goggin, P., Ghosh, D., Douds, A., Hoeroldt, B., Booth, J., Williams, E., Hussaini, H., Stableforth, W., Ayres, R., Thorburn, D., Marshall, E., Burroughs, A., Mann, S., Lombard, M., Richardson, P., Patanwala, I., Maltby, J., Brookes, M., Mathew, R., Vyas, S., Singhal, S., Gleeson, D., Misra, S., Butterworth, J., George, K., Harding, T., Douglass, A., Panter, S., Shearman, J., Bray, G., Butcher, G., Forton, D., McLindon, J., Cowan, M., Whatley, G., Mandal, A., Gupta, H., Sanghi, P., Jain, S., Pereira, S., Prasad, G., Watts, G., Wright, M., Neuberger, J., Gordon, F., Unitt, E., Grant, A., Delahooke, T., Higham, A., Brind, A., Cox, M., Ramakrishnan, S., King, A., Collins, C., Whalley, S., Li, A., Fraser, J., Bell, A., Wong, V. S., Singhal, A., Gee, I., Ang, Y., Ransford, R., Gotto, J., Millson, C., Bowles, J., Thomas, C., Harrison, M., Galaska, R., Kendall, J., Whiteman, J., Lawlor, C., Gray, C., Elliott, K., Mulvaney-Jones, C., Hobson, L., Van Duyvenvoorde, G., Loftus, A., Seward, K., Penn, R., Maiden, J., Damant, R., Hails, J., Cloudsdale, R., Silvestre, V., Glenn, S., Dungca, E., Wheatley, N., Doyle, H., Kent, M., Hamilton, C., Braim, D., Wooldridge, H., Abrahams, R., Paton, A., Lancaster, N., Gibbins, A., Hogben, K., Desousa, P., Muscariu, F., Musselwhite, J., McKay, A., Tan, L., Foale, C., Brighton, J., Flahive, K., Nambela, E., Townshend, P., Ford, C., Holder, S., Palmer, C., Featherstone, J., Nasseri, M., Sadeghian, J., Williams, B., Thomas, C., Rolls, S. A., Hynes, A., Duggan, C., Jones, S., Crossey, M., Stansfield, G., MacNicol, C., Wilkins, J., Wilhelmsen, E., Raymode, P., Lee, H. J., Durant, E., Bishop, R., Ncube, N., Tripoli, S., Casey, R., Cowley, C., Miller, R., Houghton, K., Ducker, S., Wright, F., Bird, B., Baxter, G., Keggans, J., Hughes, M., Grieve, E., Young, K., Williams, D., Ocker, K., Hines, F., Martin, K., Innes, C., Valliani, T., Fairlamb, H., Thornthwaite, S., Eastick, A., Tanqueray, E., Morrison, J., Holbrook, B., Browning, J., Walker, K., Congreave, S., Verheyden, J., Slininger, S., Stafford, L., O'Donnell, D., Ainsworth, M., Lord, S., Kent, L., March, L., Dickson, C., Simpson, D., Longhurst, B., Hayes, M., Shpuza, E., White, N., Besley, S., Pearson, S., Wright, A., Jones, L., Gunter, E., Dewhurst, H., Fouracres, A., Farrington, L., Graves, L., Marriott, S., Leoni, M., Tyrer, D., Martin, K., Dali-Kemmery, L., Lambourne, V., Green, M., Sirdefield, D., Amor, K., Colley, J., Shinder, B., Jones, J., Mills, M., Carnahan, M., Taylor, N., Boulton, K., Tregonning, J., Brown, C., Clifford, G., Archer, E., Hamilton, M., Curtis, J., Shewan, T., Walsh, S., Warner, K., Netherton, K., Mupudzi, M., Gunson, B., Gitahi, J., Gocher, D., Batham, S., Pateman, H., Desmennu, S., Conder, J., Clement, D., Gallagher, S., Orpe, J., Chan, P., Currie, L., O'Donohoe, L., Oblak, M., Morgan, L., Quinn, M., Amey, I., Baird, Y., Cotterill, D., Cumlat, L., Winter, L., Greer, S., Spurdle, K., Allison, J., Dyer, S., Sweeting, H. & Kordula, J., Sep 22 2015, In : Nature Communications. 6, 8019.

Research output: Contribution to journalArticle

2014

Genetics and epigenetics of primary biliary cirrhosis

Bianchi, I., Carbone, M., Lleo, A. & Invernizzi, P., 2014, In : Seminars in Liver Disease. 34, 3, p. 255-264 10 p.

Research output: Contribution to journalArticle

2013

Y chromosome loss in male patients with primary biliary cirrhosis

Lleo, A., Oertelt-Prigione, S., Bianchi, I., Caliari, L., Finelli, P., Miozzo, M., Lazzari, R., Floreani, A., Donato, F., Colombo, M., Gershwin, M. E., Podda, M. & Invernizzi, P., Mar 2013, In : Journal of Autoimmunity. 41, p. 87-91 5 p.

Research output: Contribution to journalArticle

2012

Geoepidemiology, gender and autoimmune disease

Moroni, L., Bianchi, I. & Lleo, A., May 2012, In : Autoimmunity Reviews. 11, 6-7

Research output: Contribution to journalArticle

Immunochip analyses identify a novel risk locus for primary biliary cirrhosis at 13q14, multiple independent associations at four established risk loci and epistasis between 1p31 and 7q32 risk Variants

Juran, B. D., Hirschfield, G. M., Invernizzi, P., Atkinson, E. J., Li, Y., Xie, G., Kosoy, R., Ransom, M., Sun, Y., Bianchi, I., Schlicht, E. M., Lleo, A., Coltescu, C., Bernuzzi, F., Podda, M., Lammert, C., Shigeta, R., Chan, L. L., Balschun, T., Marconi, M. & 21 others, Cusi, D., Heathcote, E. J., Mason, A. L., Myers, R. P., Milkiewicz, P., Odin, J. A., Luketic, V. A., Bacon, B. R., Bodenheimer, H. C., Liakina, V., Vincent, C., Levy, C., Franke, A., Gregersen, P. K., Bossa, F., Eric Gershwin, M., De Andrade, M., Amos, C. I., Lazaridis, K. N., Seldin, M. F. & Siminovitch, K. A., Dec 2012, In : Human Molecular Genetics. 21, 23, p. 5209-5221 13 p., dds359.

Research output: Contribution to journalArticle

Increased loss of the Y chromosome in peripheral blood cells in male patients with autoimmune thyroiditis

Persani, L., Bonomi, M., Lleo, A., Pasini, S., Civardi, F., Bianchi, I., Campi, I., Finelli, P., Miozzo, M., Castronovo, C., Sirchia, S., Gershwin, M. E. & Invernizzi, P., May 2012, In : Journal of Autoimmunity. 38, 2-3

Research output: Contribution to journalArticle

The X chromosome and immune associated genes

Bianchi, I., Lleo, A., Gershwin, M. E. & Invernizzi, P., May 2012, In : Journal of Autoimmunity. 38, 2-3

Research output: Contribution to journalArticle

The X-factor in primary biliary cirrhosis: Monosomy X and xenobiotics

Bianchi, I., Lleo, A., Bernuzzi, F., Caliari, L., Smyk, D. S. & Invernizzi, P., Dec 2012, In : Autoimmunity Highlights. 3, 3, p. 127-132 6 p.

Research output: Contribution to journalArticle

2011

Genetic association of Fc receptor-like 3 polymorphisms with susceptibility to primary biliary cirrhosis: Ethnic comparative study in Japanese and Italian patients

Tanaka, A., Ohira, H., Kikuchi, K., Nezu, S., Shibuya, A., Bianchi, I., Podda, M., Invernizzi, P. & Takikawa, H., Mar 2011, In : Tissue Antigens. 77, 3, p. 239-243 5 p.

Research output: Contribution to journalArticle

2010

A short version of a HRQoL questionnaire for Italian and Japanese patients with Primary Biliary Cirrhosis

Montali, L., Tanaka, A., Riva, P., Takahashi, H., Cocchi, C., Ueno, Y., Miglioretti, M., Takikawa, H., Vecchio, L., Frigerio, A., Bianchi, I., Jorgensen, R., Lindor, K. D., Podda, M. & Invernizzi, P., Oct 2010, In : Digestive and Liver Disease. 42, 10, p. 718-723 6 p.

Research output: Contribution to journalArticle

Genome-wide meta-analyses identify three loci associated with primary biliary cirrhosis

Liu, X., Invernizzi, P., Lu, Y., Kosoy, R., Lu, Y., Bianchi, I., Podda, M., Xu, C., Xie, G., MacCiardi, F., Selmi, C., Lupoli, S., Shigeta, R., Ransom, M., Lleo, A., Lee, A. T., Mason, A. L., Myers, R. P., Peltekian, K. M., Ghent, C. N. & 52 others, Bernuzzi, F., Zuin, M., Rosina, F., Borghesio, E., Floreani, A., Lazzari, R., Niro, G., Andriulli, A., Muratori, L., Muratori, P., Almasio, P. L., Andreone, P., Margotti, M., Brunetto, M., Coco, B., Alvaro, D., Bragazzi, M. C., Marra, F., Pisano, A., Rigamonti, C., Colombo, M., Marzioni, M., Benedetti, A., Fabris, L., Strazzabosco, M., Portincasa, P., Palmieri, V. O., Tiribelli, C., Croce, L., Bruno, S., Rossi, S., Vinci, M., Prisco, C., Mattalia, A., Toniutto, P., Picciotto, A., Galli, A., Ferrari, C., Colombo, S., Casella, G., Morini, L., Caporaso, N., Colli, A., Spinzi, G., Montanari, R., Gregersen, P. K., Heathcote, E. J., Hirschfield, G. M., Siminovitch, K. A., Amos, C. I., Gershwin, M. E. & Seldin, M. F., Aug 2010, In : Nature Genetics. 42, 8, p. 658-660 3 p.

Research output: Contribution to journalArticle

2009

Keratin variants are overrepresented in primary biliary cirrhosis and associate with disease severity

Zhong, B., Strnad, P., Selmi, C., Invernizzi, P., Tao, G. Z., Caleffi, A., Chen, M., Bianchi, I., Podda, M., Pietrangelo, A., Gershwin, M. E. & Omary, M. B., 2009, In : Hepatology. 50, 2, p. 546-554 9 p.

Research output: Contribution to journalArticle

Vitamin D receptor polymorphisms are associated with increased susceptibility to primary biliary cirrhosis in Japanese and Italian populations

Tanaka, A., Nezu, S., Uegaki, S., Kikuchi, K., Shibuya, A., Miyakawa, H., Takahashi, S. I., Bianchi, I., Zermiani, P., Podda, M., Ohira, H., Invernizzi, P. & Takikawa, H., Jun 2009, In : Journal of Hepatology. 50, 6, p. 1202-1209 8 p.

Research output: Contribution to journalArticle

2008

Cytokines in autoimmune liver diseases

Invernizzi, P., Bianchi, I., Bemuzzi, F., Caliari, L. & Locati, M., 2008, In : Research Journal of Medical Sciences. 2, 3, p. 145-154 10 p.

Research output: Contribution to journalArticle

Human leukocyte antigen polymorphisms in Italian primary biliary cirrhosis: A multicenter study of 664 patients and 1992 healthy controls

Invernizzi, P., Selmi, C., Poli, F., Frison, S., Floreani, A., Alvaro, D., Almasio, P., Rosina, F., Marzioni, M., Fabris, L., Muratori, L., Qi, L., Seldin, M. F., Gershwin, M. E., Podda, M., Andreoletti, M., Andriulli, A., Baldini, V., Battezzati, P. M., Benedetti, A. & 42 others, Bernuzzi, F., Bianchi, F. B., Bianchi, I., Bignotto, M., Bragazzi, M. C., Brunetto, M., Caimi, M., Caliari, L., Caporaso, N., Casella, G., Casiraghi, A., Colli, A., Colombo, M., Conte, D., Croce, L., Crosignani, A., Dottorini, L., Ferrari, C., Fraquelli, M., Frati, C. E., Galli, A., Lleo, A., Mancino, M. G., Mandelli, G., Marra, F., Montanari, R., Monti, V., Morini, L., Morisco, F., Niro, G., Palasciano, G., Calmieri, V. O., Pasini, S., Picciotto, A., Portincasa, P., Pozzoli, V., Spinzi, G., Strazzabosco, M., Tiribelli, C., Toniutto, P., Zerminai, P. & Zuin, M., 2008, In : Hepatology. 48, 6, p. 1906-1912 7 p.

Research output: Contribution to journalArticle

2004

Antibodies to soluble liver antigen and α-enolase in patients with autoimmune hepatitis

Bogdanos, D. P., Gilbert, D., Bianchi, I., Leoni, S., Mitry, R. R., Ma, Y., Mieli-Vergani, G. & Vergani, D., Nov 19 2004, In : Journal of Autoimmune Diseases. 1, 4.

Research output: Contribution to journalArticle

Frequency of monosomy X in women with primary biliary cirrhosis

Invernizzi, P., Miozzo, M., Battezzati, P. M., Bianchi, I., Grati, F. R., Simoni, G., Selmi, C., Watnik, M., Gershwin, M. E. & Podda, M., Feb 14 2004, In : Lancet. 363, 9408, p. 533-535 3 p.

Research output: Contribution to journalArticle

Targets of Antibodies to Soluble Liver Antigen in Patients with Autoimmune Hepatitis [5] (multiple letters)

Bogdanos, D. P., Bianchi, I., Ma, Y., Mitry, R. R., Mieli-Vergani, G., Vergani, D., Ballot, E., Bruneel, A. & Johanet, C., Mar 2004, In : Clinical Chemistry. 50, 3, p. 682-684 3 p.

Research output: Contribution to journalArticle