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Research Output

2019
Open Access

DNA methylation dynamic of bone marrow hematopoietic stem cells after allogeneic transplantation

Trino, S., Zoppoli, P., Carella, A. M., Laurenzana, I., Weisz, A., Memoli, D., Calice, G., La Rocca, F., Simeon, V., Savino, L., Del Vecchio, L., Musto, P., Caivano, A. & De Luca, L., May 20 2019, In : Stem cell research & therapy. 10, 1, 1 p.

Research output: Contribution to journalArticle

Open Access

DNA methylation dynamic of bone marrow hematopoietic stem cells after allogeneic transplantation

Trino, S., Zoppoli, P., Carella, A. M., Laurenzana, I., Weisz, A., Memoli, D., Calice, G., Rocca, F. L., Simeon, V., Savino, L., Vecchio, L. D., Musto, P., Caivano, A. & De Luca, L., 2019, In : Stem Cell Research and Therapy. 10, 1

Research output: Contribution to journalArticle

In Vitro Antiproliferative Evaluation of Synthetic Meroterpenes Inspired by Marine Natural Products

Imperatore, C., Della Sala, G., Casertano, M., Luciano, P., Aiello, A., Laurenzana, I., Piccoli, C. & Menna, M., Dec 5 2019, In : Marine Drugs. 17, 12

Research output: Contribution to journalArticle

2018

Extracellular Vesicles: A New Prospective in Crosstalk between Microenvironment and Stem Cells in Hematological Malignancies

Laurenzana, I., Lamorte, D., Trino, S., De Luca, L., Ambrosino, C., Zoppoli, P., Ruggieri, V., Vecchio, L. D., Musto, P., Caivano, A. & Falco, G., Jan 1 2018, In : Stem Cells International. 2018, 9863194.

Research output: Contribution to journalReview article

Future in the Past: Azorella glabra Wedd. as a Source of New Natural Compounds with Antiproliferative and Cytotoxic Activity on Multiple Myeloma Cells

Lamorte, D., Faraone, I., Laurenzana, I., Milella, L., Trino, S., De Luca, L., Del Vecchio, L., Armentano, M. F., Sinisgalli, C., Chiummiento, L., Russo, D., Bisaccia, F., Musto, P. & Caivano, A., Oct 26 2018, In : International Journal of Molecular Sciences. 19, 11

Research output: Contribution to journalArticle

Micrornas as new biomarkers for diagnosis and prognosis, and as potential therapeutic targets in acute myeloid leukemia

Trino, S., Lamorte, D., Caivano, A., Laurenzana, I., Tagliaferri, D., Falco, G., Vecchio, L. D., Musto, P. & De Luca, L., Feb 3 2018, In : International Journal of Molecular Sciences. 19, 2, 460.

Research output: Contribution to journalReview article

Smenamide a analogues. Synthesis and biological activity on multiple myeloma cells

Caso, A., Laurenzana, I., Lamorte, D., Trino, S., Esposito, G., Piccialli, V. & Costantino, V., Jun 1 2018, In : Marine Drugs. 16, 6, 206.

Research output: Contribution to journalArticle

2017

Epha3 acts as proangiogenic factor in multiple myeloma

Caivano, A., La Rocca, F., Laurenzana, I., Annese, T., Tamma, R., Famigliari, U., Simeon, V., Trino, S., Luca, L. D., Villani, O., Berardi, S., Basile, A., Vacca, A., Saglio, G., Del Vecchio, L., Musto, P. & Cilloni, D., 2017, In : Oncotarget. 8, 21, p. 34298-34309 12 p.

Research output: Contribution to journalArticle

EphA3 targeting reduces in vitro adhesion and invasion and in vivo growth and angiogenesis of multiple myeloma cells

la Rocca, F., Airoldi, I., Di Carlo, E., Marotta, P., Falco, G., Simeon, V., Laurenzana, I., Trino, S., de Luca, L., Todoerti, K., Villani, O., Lackmann, M., D’Auria, F., Frassoni, F., Neri, A., Del Vecchio, L., Musto, P., Cilloni, D. & Caivano, A., 2017, In : Cellular Oncology. 40, 5, p. 483-496 14 p.

Research output: Contribution to journalArticle

EphA3 targeting reduces in vitro adhesion and invasion and in vivo growth and angiogenesis of multiple myeloma cells

La Rocca, F., Airoldi, I., Di Carlo, E., Marotta, P., Falco, G., Simeon, V., Laurenzana, I., Trino, S., De Luca, L., Todoerti, K., Villani, O., Lackmann, M., D'Auria, F., Frassoni, F., Neri, A., Del Vecchio, L., Musto, P., Cilloni, D. & Caivano, A., Oct 2017, In : Cellular oncology (Dordrecht). 40, 5, p. 483-496 14 p.

Research output: Contribution to journalArticle

Extracellular vesicles in hematological malignancies: From biology to therapy

Caivano, A., La Rocca, F., Laurenzana, I., Trino, S., De Luca, L., Lamorte, D., Del Vecchio, L. & Musto, P., Jun 2 2017, In : International Journal of Molecular Sciences. 18, 6, 1183.

Research output: Contribution to journalReview article

Knockdown of miR-128a induces Lin28a expression and reverts myeloid differentiation blockage in acute myeloid leukemia

De Luca, L., Trino, S., Laurenzana, I., Tagliaferri, D., Falco, G., Grieco, V., Bianchino, G., Nozza, F., Campia, V., D'Alessio, F., La Rocca, F., Caivano, A., Villani, O., Cilloni, D., Musto, P. & Del Vecchio, L., 2017, In : Cell Death and Disease. 8, 6, e2849.

Research output: Contribution to journalArticle

Mesenchymal stem cell derived extracellular vesicles: A role in hematopoietic transplantation?

De Luca, L., Trino, S., Laurenzana, I., Lamorte, D., Caivano, A., Del Vecchio, L. & Musto, P., May 9 2017, In : International Journal of Molecular Sciences. 18, 5, 1022.

Research output: Contribution to journalReview article

Rewiring carbohydrate catabolism differentially affects survival of pancreatic cancer cell lines with diverse metabolic profiles

Tataranni, T., Agriesti, F., Ruggieri, V., Mazzoccoli, C., Simeon, V., Laurenzana, I., Scrima, R., Pazienza, V., Capitanio, N. & Piccoli, C., Jun 20 2017, In : Oncotarget. 8, 25, p. 41265-41281 17 p.

Research output: Contribution to journalArticle

Rewiring carbohydrate catabolism differentially affects survival of pancreatic cancer cell lines with diverse metabolic profiles

Tataranni, T., Agriesti, F., Ruggieri, V., Mazzoccoli, C., Simeon, V., Laurenzana, I., Scrima, R., Pazienza, V., Capitanio, N. & Piccoli, C., 2017, In : Oncotarget. 8, 25, p. 41265-41281 17 p.

Research output: Contribution to journalArticle

The multifunctional polydnavirus TnBVANK1 protein: Impact on host apoptotic pathway

Salvia, R., Grossi, G., Amoresano, A., Scieuzo, C., Nardiello, M., Giangrande, C., Laurenzana, I., Ruggieri, V., Bufo, S. A., Vinson, S. B., Carmosino, M., Neunemann, D., Vogel, H., Pucci, P. & Falabella, P., Dec 1 2017, In : Scientific Reports. 7, 1, 11775.

Research output: Contribution to journalArticle

2016

A Pyrazolo[3,4-d]pyrimidine compound inhibits Fyn phosphorylation and induces apoptosis in natural killer cell leukemia

Laurenzana, I., Caivano, A., Trino, S., De Luca, L., La Rocca, F., Simeon, V., Tintori, C., D'Alessio, F., Teramo, A., Zambello, R., Traficante, A., Maietti, M., Semenzato, G., Schenone, S., Botta, M., Musto, P. & Del Vecchio, L., 2016, In : Oncotarget. 7, 40, p. 65171-65184 14 p.

Research output: Contribution to journalArticle

A pyrazolo[3,4-d]pyrimidine compound reduces cell viability and induces apoptosis in different hematological malignancies

Laurenzana, I., Caivano, A., La Rocca, F., Trino, S., De Luca, L., D'Alessio, F., Schenone, S., Falco, G., Botta, M., Del Vecchio, L. & Musto, P., Nov 7 2016, In : Frontiers in Pharmacology. 7, 416.

Research output: Contribution to journalArticle

Characterization and prognostic relevance of circulating microvesicles in chronic lymphocytic leukemia

De Luca, L., D’Arena, G., Simeon, V., Trino, S., Laurenzana, I., Caivano, A., La Rocca, F., Villani, O., Mansueto, G., Deaglio, S., Innocenti, I., Laurenti, L., Molica, S., Pietrantuono, G., De Stradis, A., Del Vecchio, L. & Musto, P., Oct 14 2016, (Accepted/In press) In : Leukemia and Lymphoma. p. 1-9 9 p.

Research output: Contribution to journalArticle

MicroRNA-155 in serum-derived extracellular vesicles as a potential biomarker for hematologic malignancies - a short report

Caivano, A., la Rocca, F., Simeon, V., Girasole, M., Dinarelli, S., Laurenzana, I., de Stradis, A., de Luca, L., Trino, S., Traficante, A., D’Arena, G., Mansueto, G., Villani, O., Pietrantuono, G., Laurenti, L., Del Vecchio, L. & Musto, P., Oct 19 2016, (Accepted/In press) In : Cellular Oncology. p. 1-7 7 p.

Research output: Contribution to journalArticle

MiRNAs and piRNAs from bone marrow mesenchymal stem cell extracellular vesicles induce cell survival and inhibit cell differentiation of cord blood hematopoietic stem cells: A new insight in transplantation

De Luca, L., Trino, S., Laurenzana, I., Simeon, V., Calice, G., Raimondo, S., Podesta, M., Santodirocco, M., Di Mauro, L., La Rocca, F., Caivano, A., Morano, A., Frassoni, F., Cilloni, D., Vecchio, L. D. & Musto, P., 2016, In : Oncotarget. 7, 6, p. 6676-6692 17 p.

Research output: Contribution to journalArticle

MiRNAs and piRNAs from bone marrow mesenchymal stem cell extracellular vesicles induce cell survival and inhibit cell differentiation of cord blood hematopoietic stem cells: A new insight in transplantation

De Luca, L., Trino, S., Laurenzana, I., Simeon, V., Calice, G., Raimondo, S., Podestà, M., Santodirocco, M., Di Mauro, L., La Rocca, F., Caivano, A., Morano, A., Frassoni, F., Cilloni, D., Vecchio, L. D. & Musto, P., 2016, In : Oncotarget. 7, 6, p. 6676-6692 17 p.

Research output: Contribution to journalArticle

N-acetylaspartate (NAA) induces neuronal differentiation of SH-SY5Y neuroblastoma cell line and sensitizes it to chemotherapeutic agents

Mazzoccoli, C., Ruggieri, V., Tataranni, T., Agriesti, F., Laurenzana, I., Fratello, A., Capitanio, N. & Piccoli, C., May 1 2016, In : Oncotarget. 7, 18, p. 26235-26246 12 p.

Research output: Contribution to journalArticle

P53-MDM2 Pathway: Evidences for A New Targeted Therapeutic Approach in B-Acute Lymphoblastic Leukemia

Trino, S., De Luca, L., Laurenzana, I., Caivano, A., Del Vecchio, L., Martinelli, G. & Musto, P., 2016, In : Frontiers in Pharmacology. 7, p. 491

Research output: Contribution to journalArticle

Targeting the p53-MDM2 interaction by the small-molecule MDM2 antagonist Nutlin-3a: A new challenged target therapy in adult Philadelphia positive acute lymphoblastic leukemia patients

Trino, S., Iacobucci, I., Erriquez, D., Laurenzana, I., De Luca, L., Ferrari, A., Di Rorà, A. G. L., Papayannidis, C., Derenzini, E., Simonetti, G., Lonetti, A., Venturi, C., Cattina, F., Ottaviani, E., Abbenante, M. C., Russo, D., Perini, G., Musto, P. & Martinelli, G., Mar 15 2016, In : Oncotarget. 7, 11, p. 12951-12961 11 p.

Research output: Contribution to journalArticle

TLR4 down-regulation identifies high risk HPV infection and integration in head and neck squamous cell carcinomas

Pannone, G., Bufo, P., Pace, M., Lepore, S., Russo, G. M., Rubini, C., Franco, R., Aquino, G., Santoro, A., Campisi, G., Rodolico, V., Bucci, E., Ilardi, G., Mascolo, M., Merolla, F., Lo Muzio, L., Natalicchio, I., Colella, G., Laurenzana, I., Trino, S. & 2 others, Leonardi, R. & Bucci, P., 2016, In : Frontiers in Bioscience - Elite. 8, p. 15-28 14 p.

Research output: Contribution to journalArticle

2015

Dichloroacetate, a selective mitochondria-targeting drug for oral squamous cell carcinoma: A metabolic perspective of treatment

Ruggieri, V., Agriesti, F., Scrima, R., Laurenzana, I., Perrone, D., Tataranni, T., Mazzoccoli, C., Muzio, L. L., Capitanio, N. & Piccoli, C., 2015, In : Oncotarget. 6, 2, p. 1217-1230 14 p.

Research output: Contribution to journalArticle

High serum levels of extracellular vesicles expressing malignancy-related markers are released in patients with various types of hematological neoplastic disorders

Caivano, A., Laurenzana, I., De Luca, L., La Rocca, F., Simeon, V., Trino, S., D’Auria, F., Traficante, A., Maietti, M., Izzo, T., D’Arena, G., Mansueto, G., Pietrantuono, G., Laurenti, L., Musto, P. & Del Vecchio, L., Dec 1 2015, In : Tumor Biology. 36, 12, p. 9739-9752 14 p.

Research output: Contribution to journalArticle

Hit Recycling: Discovery of a Potent Carbonic Anhydrase Inhibitor by in Silico Target Fishing

Mori, M., Cau, Y., Vignaroli, G., Laurenzana, I., Caivano, A., Vullo, D., Supuran, C. T. & Botta, M., Sep 18 2015, In : ACS Chemical Biology. 10, 9, p. 1964-1969 6 p.

Research output: Contribution to journalArticle

Inverse regulation of bridging integrator 1 and BCR-ABL1 in chronic myeloid leukemia

Trino, S., de Luca, L., Simeon, V., Laurenzana, I., Morano, A., Caivano, A., la Rocca, F., Pietrantuono, G., Bianchino, G., Grieco, V., Signorino, E., Fragasso, A., Bochicchio, M. T., Venturi, C., Rosti, G., Martinelli, G., Del Vecchio, L., Cilloni, D. & Musto, P., Jul 21 2015, (Accepted/In press) In : Tumor Biology.

Research output: Contribution to journalArticle

Relationship between CK19 expression, deregulation of normal keratinocyte differentiation pattern and high risk-human papilloma virus infection in oral and oropharyngeal squamous cell carcinoma

Santoro, A., Pannone, G., Ninivaggi, R., Petruzzi, M., Santarelli, A., Russo, G. M., Lepore, S., Pietrafesa, M., Laurenzana, I., Leonardi, R., Bucci, P., Natalicchio, M. I., Lucchese, A., Papagerakis, S. & Bufo, P., Dec 15 2015, In : Infectious Agents and Cancer. 10, 1, 41.

Research output: Contribution to journalArticle

Studies on the ATP Binding Site of Fyn Kinase for the Identification of New Inhibitors and Their Evaluation as Potential Agents against Tauopathies and Tumors

Tintori, C., La Sala, G., Vignaroli, G., Botta, L., Fallacara, A. L., Falchi, F., Radi, M., Zamperini, C., Dreassi, E., Dello Iacono, L., Orioli, D., Biamonti, G., Garbelli, M., Lossani, A., Gasparrini, F., Tuccinardi, T., Laurenzana, I., Angelucci, A., Maga, G., Schenone, S. & 5 others, Brullo, C., Musumeci, F., Desogus, A., Crespan, E. & Botta, M., Jun 11 2015, In : Journal of Medicinal Chemistry. 58, 11, p. 4590-4609 20 p.

Research output: Contribution to journalArticle

The iron chelator deferasirox affects redox signalling in haematopoietic stem/progenitor cells

Tataranni, T., Agriesti, F., Mazzoccoli, C., Ruggieri, V., Scrima, R., Laurenzana, I., D'Auria, F., Falzetti, F., Di Ianni, M., Musto, P., Capitanio, N. & Piccoli, C., Jul 1 2015, In : British Journal of Haematology. 170, 2, p. 236-246 11 p.

Research output: Contribution to journalArticle

2014

High-throughput docking for the identification of new influenza A virus polymerase inhibitors targeting the PA-PB1 protein-protein interaction

Tintori, C., Laurenzana, I., Fallacara, A. L., Kessler, U., Pilger, B., Stergiou, L. & Botta, M., Jan 1 2014, In : Bioorganic and Medicinal Chemistry Letters. 24, 1, p. 280-282 3 p.

Research output: Contribution to journalArticle

The fight against the influenza A virus H1N1: Synthesis, molecular modeling, and biological evaluation of benzofurazan derivatives as viral RNA polymerase inhibitors

Pagano, M., Castagnolo, D., Bernardini, M., Fallacara, A. L., Laurenzana, I., Deodato, D., Kessler, U., Pilger, B., Stergiou, L., Strunze, S., Tintori, C. & Botta, M., Jan 2014, In : ChemMedChem. 9, 1, p. 129-150 22 p.

Research output: Contribution to journalArticle

2013

Design, synthesis, and biological evaluation of pyrazolo[3,4-d]pyrimidines active in vivo on the Bcr-Abl T315I mutant

Radi, M., Tintori, C., Musumeci, F., Brullo, C., Zamperini, C., Dreassi, E., Fallacara, A. L., Vignaroli, G., Crespan, E., Zanoli, S., Laurenzana, I., Filippi, I., Maga, G., Schenone, S., Angelucci, A. & Botta, M., Jul 11 2013, In : Journal of Medicinal Chemistry. 56, 13, p. 5382-5394 13 p.

Research output: Contribution to journalArticle

Identification of Hck Inhibitors As Hits for the Development of Antileukemia and Anti-HIV Agents

Tintori, C., Laurenzana, I., LaRocca, F., Falchi, F., Carraro, F., Ruiz, A., Esté, J. A., Kissova, M., Crespan, E., Maga, G., Biava, M., Brullo, C., Schenone, S. & Botta, M., Aug 2013, In : ChemMedChem. 8, 8, p. 1353-1360 8 p.

Research output: Contribution to journalArticle