• 682 Citations
  • 10 h-Index
20042016
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Research Output 2004 2016

  • 682 Citations
  • 10 h-Index
  • 12 Article
2016
16 Citations (Scopus)
Iduronidase
Mucopolysaccharidosis I
Toxicology
Hematopoietic Stem Cells
Genetic Therapy
2011
5 Citations (Scopus)

Maintenance of a functional hematopoietic stem cell niche through galactocerebrosidase and other enzymes

Visigalli, I. & Biffi, A., Jul 2011, In : Current Opinion in Hematology. 18, 4, p. 214-219 6 p.

Research output: Contribution to journalArticle

Galactosylceramidase
Stem Cell Niche
Hematopoietic Stem Cells
Maintenance
Enzymes
2010
95 Citations (Scopus)

Gene therapy augments the efficacy of hematopoietic cell transplantation and fully corrects mucopolysaccharidosis type I phenotype in the mouse model

Visigalli, I., Delai, S., Politi, L. S., Di Domenico, C., Cerri, F., Mrak, E., D'Isa, R., Ungaro, D., Stok, M., Sanvito, F., Mariani, E., Staszewsky, L., Godi, C., Russo, I., Cecere, F., Del Carro, U., Rubinacci, A., Brambilla, R., Quattrini, A., Di Natale, P. & 3 others, Ponder, K., Naldini, L. & Biffi, A., Dec 9 2010, In : Blood. 116, 24, p. 5130-5139 10 p.

Research output: Contribution to journalArticle

Mucopolysaccharidosis I
Gene therapy
Cell Transplantation
Genetic Therapy
Stem cells
143 Citations (Scopus)

Identification of hematopoietic stem cell-specific miRNAs enables gene therapy of globoid cell leukodystrophy

Gentner, B., Visigalli, I., Hiramatsu, H., Lechman, E., Ungari, S., Giustacchini, A., Schira, G., Amendola, M., Quattrini, A., Martino, S., Orlacchio, A., Dick, J. E., Biffi, A. & Naldini, L., Nov 17 2010, In : Science Translational Medicine. 2, 58, 58ra84.

Research output: Contribution to journalArticle

Galactosylceramidase
Globoid Cell Leukodystrophy
Hematopoietic Stem Cells
MicroRNAs
Genetic Therapy
13 Citations (Scopus)

Sulfatase modifying factor 1-mediated fibroblast growth factor signaling primes hematopoietic multilineage development

Buono, M., Visigalli, I., Bergamasco, R., Biffi, A. & Cosma, M. P., Aug 2 2010, In : Journal of Experimental Medicine. 207, 8, p. 1647-1660 14 p.

Research output: Contribution to journalArticle

Sulfatases
Fibroblast Growth Factor 1
Hematopoietic Stem Cells
Fibroblast Growth Factors
Heparan Sulfate Proteoglycans
30 Citations (Scopus)

The galactocerebrosidase enzyme contributes to the maintenance of a functional hematopoietic stem cell niche

Visigalli, I., Ungari, S., Martino, S., Park, H., Cesani, M., Gentner, B., Sergi, L. S., Orlacchio, A., Naldini, L. & Biffi, A., Sep 16 2010, In : Blood. 116, 11, p. 1857-1866 10 p.

Research output: Contribution to journalArticle

Galactosylceramidase
Stem Cell Niche
Sphingolipids
Hematopoietic Stem Cells
Stem cells
2009
13 Citations (Scopus)

Development and maturation of invariant NKT cells in the presence of lysosomal engulfment

Plati, T., Visigalli, I., Capotondo, A., Buono, M., Naldini, L., Cosma, M. P. & Biffi, A., Oct 2009, In : European Journal of Immunology. 39, 10, p. 2748-2754 7 p.

Research output: Contribution to journalArticle

Natural Killer T-Cells
Glycosphingolipids
Ligands
Lipids
Multiple Sulfatase Deficiency Disease
70 Citations (Scopus)

Dlg1, Sec8, and Mtmr2 regulate membrane homeostasis in Schwann cell myelination

Bolis, A., Coviello, S., Visigalli, I., Taveggia, C., Bachi, A., Chishti, A. H., Hanada, T., Quattrini, A., Previtali, S. C., Biffi, A. & Bolino, A., Jul 8 2009, In : Journal of Neuroscience. 29, 27, p. 8858-8870 13 p.

Research output: Contribution to journalArticle

Schwann Cells
Homeostasis
Membranes
Myelin Sheath
Kinesin
7 Citations (Scopus)

Monitoring disease evolution and treatment response in lysosomal disorders by the peripheral benzodiazepine receptor ligand PK11195

Visigalli, I., Moresco, R. M., Belloli, S., Politi, L. S., Gritti, A., Ungaro, D., Matarrese, M., Turolla, E., Falini, A., Scotti, G., Naldini, L., Fazio, F. & Biffi, A., Apr 2009, In : Neurobiology of Disease. 34, 1, p. 51-62 12 p.

Research output: Contribution to journalArticle

Microglia
GABA-A Receptors
Hematopoietic Stem Cell Transplantation
Ligands
Central Nervous System Diseases
30 Citations (Scopus)

Specific determination of β-galactocerebrosidase activity via competitive inhibition of β-galactosidase

Martino, S., Tiribuzi, R., Tortori, A., Conti, D., Visigalli, I., Lattanzi, A., Biffi, A., Gritti, A. & Orlacchio, A., Mar 1 2009, In : Clinical Chemistry. 55, 3, p. 541-548 8 p.

Research output: Contribution to journalArticle

Galactosylceramidase
Galactosidases
Assays
Stem cells
Hymecromone
2007
43 Citations (Scopus)

SUMF1 enhances sulfatase activities in vivo in five sulfatase deficiencies

Fraldi, A., Biffi, A., Lombardi, A., Visigalli, I., Pepe, S., Settembre, C., Nusco, E., Auricchio, A., Naldini, L., Ballabio, A. & Cosma, M. P., Apr 15 2007, In : Biochemical Journal. 403, 2, p. 305-312 8 p.

Research output: Contribution to journalArticle

Sulfatases
Dependovirus
Genes
Glycosaminoglycans
Viruses
2004
217 Citations (Scopus)

Correction of metachromatic leukodystrophy in the mouse model by transplantation of genetically modified hematopoietic stem cells

Biffi, A., De Palma, M., Quattrini, A., Del Carro, U., Amadio, S., Visigalli, I., Sessa, M., Fasano, S., Brambilla, R., Marchesini, S., Bordignon, C. & Naldini, L., Apr 2004, In : Journal of Clinical Investigation. 113, 8, p. 1118-1129 12 p.

Research output: Contribution to journalArticle

Metachromatic Leukodystrophy
Hematopoietic Stem Cells
Transplantation
Peripheral Nervous System
Genes