Laura Di Blasio

2018

MRCKα is activated by caspase cleavage to assemble an apical actin ring for epithelial cell extrusion

Gagliardi, P. A., Somale, D., Puliafito, A., Chiaverina, G., di Blasio, L., Oneto, M., Bianchini, P., Bussolino, F. & Primo, L., Jan 1 2018, In : Journal of Cell Biology. 217, 1, p. 231-249 19 p.

Research output: Contribution to journal › Article

Myotonic Dystrophy

Caspases

Actins

Phosphotransferases

Epithelial Cells

16 Citations (Scopus)

PI3K/mTOR inhibition promotes the regression of experimental vascular malformations driven by PIK3CA-activating mutations article

Di Blasio, L., Puliafito, A., Gagliardi, P. A., Comunanza, V., Somale, D., Chiaverina, G., Bussolino, F. & Primo, L., Feb 1 2018, In : Cell Death and Disease. 9, 2, 45.

Research output: Contribution to journal › Article

Vascular Malformations

Phosphatidylinositol 3-Kinases

Endothelial Cells

Mutation

Klippel-Trenaunay-Weber Syndrome

2017

20 Citations (Scopus)

Serine/threonine kinase 3-phosphoinositide-dependent protein kinase-1 (PDK1) as a key regulator of cell migration and cancer dissemination

Di Blasio, L., Gagliardi, P. A., Puliafito, A. & Primo, L., Jan 1 2017, In : Cancers. 9, 3, 25.

Research output: Contribution to journal › Review article

3-Phosphoinositide-Dependent Protein Kinases

Protein-Serine-Threonine Kinases

Cell Movement

Neoplasms

Phosphatidylinositol 3-Kinase

2 Citations (Scopus)

The AGMA1 polyamidoamine mediates the efficient delivery of siRNA

Cavalli, R., Primo, L., Sessa, R., Chiaverina, G., di Blasio, L., Alongi, J., Manfredi, A., Ranucci, E. & Ferruti, P., Nov 26 2017, In : Journal of Drug Targeting. 25, 9-10, p. 891-898 8 p.

Research output: Contribution to journal › Article

Small Interfering RNA

Transfection

Guanidine

Gene Silencing

HeLa Cells

2016

Dasatinib modulates sensitivity to pemetrexed in malignant pleural mesothelioma cell lines

Monica, V., Lo Iacono, M., Bracco, E., Busso, S., Di Blasio, L., Primo, L., Peracino, B., Papotti, M. & Vittorio Scagliotti, G., 2016, In : Oncotarget.

Research output: Contribution to journal › Article

2015

48 Citations (Scopus)

PDK1: A signaling hub for cell migration and tumor invasion

Gagliardi, P. A., di Blasio, L. & Primo, L., Dec 1 2015, In : Biochimica et Biophysica Acta - Reviews on Cancer. 1856, 2, p. 178-188 11 p.

Research output: Contribution to journal › Article

Cell Movement

Neoplasms

Aptitude

Transducers

Physiological Phenomena

14 Citations (Scopus)

PDK1 regulates focal adhesion disassembly by modulating endocytosis of αvβ3 integrin

di Blasio, L., Gagliardi, P. A., Puliafito, A., Sessa, R., Seano, G., Bussolino, F. & Primo, L., 2015, In : Journal of Cell Science. 128, 5, p. 863-877 15 p.

Research output: Contribution to journal › Article

Focal Adhesions

Phosphatidylinositols

Endocytosis

Integrins

Protein Kinases

14 Citations (Scopus)

Real-time monitoring of cell protrusion dynamics by impedance responses

Gagliardi, P. A., Puliafito, A., Di Blasio, L., Chianale, F., Somale, D., Seano, G., Bussolino, F. & Primo, L., May 15 2015, In : Scientific Reports. 5, 10206.

Research output: Contribution to journal › Article

Electric Impedance

Intercellular Signaling Peptides and Proteins

Myosins

Microscopy

Cell Surface Extensions

Three-dimensional in vitro assay of endothelial cell invasion and capillary tube morphogenesis

Di Blasio, L., Bussolino, F. & Primo, L., 2015, In : Methods in molecular biology (Clifton, N.J.). 1214, p. 41-47 7 p.

Research output: Contribution to journal › Article

Morphogenesis

Endothelial Cells

Gels

Blood Vessels

Pathologic Neovascularization

2014

64 Citations (Scopus)

Endothelial podosome rosettes regulate vascular branching in tumour angiogenesis

Seano, G., Chiaverina, G., Gagliardi, P. A., Di Blasio, L., Puliafito, A., Bouvard, C., Sessa, R., Tarone, G., Sorokin, L., Helley, D., Jain, R. K., Serini, G., Bussolino, F. & Primo, L., Jan 1 2014, In : Nature Cell Biology. 16, 10, p. 931-941 11 p.

Research output: Contribution to journal › Article

Blood Vessels

Integrins

Neoplasms

Basement Membrane

Pathologic Neovascularization

44 Citations (Scopus)

Gelatin-based hydrogel for vascular endothelial growth factor release in peripheral nerve tissue engineering

Gnavi, S., di Blasio, L., Tonda-Turo, C., Mancardi, A., Primo, L., Ciardelli, G., Gambarotta, G., Geuna, S. & Perroteau, I., 2014, (Accepted/In press) In : Journal of Tissue Engineering and Regenerative Medicine.

Research output: Contribution to journal › Article

Nerve Tissue

Hydrogel

Gelatin

Tissue Engineering

Peripheral Nerves

22 Citations (Scopus)

PDK1-mediated activation of MRCKα regulates directional cell migration and lamellipodia retraction

Gagliardi, P. A., di Blasio, L., Puliafito, A., Seano, G., Sessa, R., Chianale, F., Leung, T., Bussolino, F. & Primo, L., 2014, In : Journal of Cell Biology. 206, 3, p. 415-434 20 p.

Research output: Contribution to journal › Article

Myotonic Dystrophy

Pseudopodia

1-Phosphatidylinositol 4-Kinase

Cell Movement

Phosphotransferases

2 Citations (Scopus)

Three-dimensional in vitro assay of endothelial cell invasion and capillary tube morphogenesis

Di Blasio, L., Bussolino, F. & Primo, L., Dec 2 2014, Vascular Morphogenesis: Methods and Protocols. Springer New York, p. 41-47 7 p.

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Capillary tubes

Endothelial cells

Morphogenesis

Assays

Endothelial Cells

2013

43 Citations (Scopus)

Modeling human tumor angiogenesis in a three-dimensional culture system.

Seano, G., Chiaverina, G., Gagliardi, P. A., di Blasio, L., Sessa, R., Bussolino, F. & Primo, L., May 23 2013, In : Blood. 121, 21

Research output: Contribution to journal › Article

Tumors

Assays

Neoplasms

Endothelial cells

Blood Vessels

2012

39 Citations (Scopus)

3-Phosphoinositide-dependent kinase 1 controls breast tumor growth in a kinase-dependent but Akt-independent manner

Gagliardi, P. A., di Blasio, L., Orso, F., Seano, G., Sessa, R., Taverna, D., Bussolino, F. & Primo, L., Aug 2012, In : Neoplasia (United States). 14, 8, p. 719-731 13 p.

Research output: Contribution to journal › Article

3-Phosphoinositide-Dependent Protein Kinases

Phosphotransferases

Breast Neoplasms

Growth

Phosphatidylinositol 3-Kinase

53 Citations (Scopus)

The miR-126 regulates Angiopoietin-1 signaling and vessel maturation by targeting p85β

Sessa, R., Seano, G., di Blasio, L., Gagliardi, P. A., Isella, C., Medico, E., Cotelli, F., Bussolino, F. & Primo, L., Oct 2012, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1823, 10, p. 1925-1935 11 p.

Research output: Contribution to journal › Article

Angiopoietin-1

Blood Vessels

Vascular Endothelial Growth Factor A

Class Ia Phosphatidylinositol 3-Kinase

Endothelial Cells

2010

32 Citations (Scopus)

Increased expression of α6 integrin in endothelial cells unveils a proangiogenic role for basement membrane

Primo, L., Seano, G., Roca, C., Maione, F., Gagliardi, P. A., Sessa, R., Martinelli, M., Giraudo, E., Di Blasio, L. & Bussolino, F., Jul 15 2010, In : Cancer Research. 70, 14, p. 5759-5769 11 p.

Research output: Contribution to journal › Article

Basement Membrane

Integrins

Endothelial Cells

Fibroblast Growth Factor 2

Vascular Endothelial Growth Factor A

32 Citations (Scopus)

Protein kinase D1 regulates VEGF-A-induced αvβ3 integrin trafficking and endothelial cell migration

di Blasio, L., Droetto, S., Norman, J., Bussolino, F. & Primo, L., Aug 2010, In : Traffic. 11, 8, p. 1107-1118 12 p.

Research output: Contribution to journal › Article

Endothelial cells

Integrins

Protein Kinases

Vascular Endothelial Growth Factor A

Cell Movement

2007

59 Citations (Scopus)

Essential role of PDK1 in regulating endothelial cell migration

Primo, L., Di Blasio, L., Roca, C., Droetto, S., Piva, R., Schaffhausen, B. & Bussolino, F., Mar 26 2007, In : Journal of Cell Biology. 176, 7, p. 1035-1047 13 p.

Research output: Contribution to journal › Article

1-Phosphatidylinositol 4-Kinase

Cell Movement

Endothelial Cells

Chemotaxis

Vascular Endothelial Growth Factor A

2005

63 Citations (Scopus)

Identification of CD36 molecular features required for its in vitro angiostatic activity

Primo, L., Ferrandi, C., Roca, C., Marchio, S., Di Blasio, L., Alessio, M. & Bussolino, F., Oct 2005, In : FASEB Journal. 19, 12, p. 1713-1715 3 p.

Research output: Contribution to journal › Article