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Research Output 1999 2019

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2019

Analysis of determinants for in vitro resistance to the small molecule deubiquitinase inhibitor b-AP15

Mofers, A., Perego, P., Selvaraju, K., Gatti, L., Gullbo, J., Linder, S. & D’Arcy, P., Jan 1 2019, In : PLoS One. 14, 10, e0223807.

Research output: Contribution to journalArticle

Open Access
drugs
Molecules
proteasome endopeptidase complex
ubiquitin
resistance mechanisms

Axl downstream targeting unravels synergistic drug combinations in ovarian carcinoma cells

Alampi, D. M., Ciusani, E., Carenini, N., Corna, E., Gatti, L. & Corno, C., Jan 1 2019, In : Anticancer Research. 39, 7, p. 3803-3808 6 p.

Research output: Contribution to journalArticle

Drug Combinations
Cisplatin
Carcinoma
Receptor Protein-Tyrosine Kinases
STAT3 Transcription Factor

Microfragmented human fat tissue is a natural scaffold for drug delivery: Potential application in cancer chemotherapy

Alessandri, G., Coccè, V., Pastorino, F., Paroni, R., Dei Cas, M., Restelli, F., Pollo, B., Gatti, L., Tremolada, C., Berenzi, A., Parati, E., Brini, A. T., Bondiolotti, G., Ponzoni, M. & Pessina, A., May 28 2019, In : Journal of Controlled Release. 302, p. 2-18 17 p.

Research output: Contribution to journalArticle

Fats
Drug Therapy
Paclitaxel
Pharmaceutical Preparations
Adipose Tissue
2018

The impact of overdiagnosis on thyroid cancer epidemic in Italy,1998–2012

Dal Maso, L., Panato, C., Franceschi, S., Serraino, D., Buzzoni, C., Busco, S., Ferretti, S., Torrisi, A., Falcini, F., Zorzi, M., Cirilli, C., Mazzucco, W., Magoni, M., Collarile, P., Pannozzo, F., Caiazzo, A. L., Russo, A. G., Gili, A., Caldarella, A., Zanetti, R. & 54 others, Michiara, M., Mangone, L., Filiberti, R. A., Fusco, M., Gasparini, F., Tagliabue, G., Cesaraccio, R., Tumino, R., Gatti, L., Tisano, F., Piffer, S., Sini, G. M., Mazzoleni, G., Rosso, S., Fanetti, A. C., Vaccarella, S., Fedeli, U., Varvarà, M., Ravaioli, A., Pennelli, G., Valla, K., Cusimano, R., Gasparotti, C., Taborelli, M., Iannelli, A., Leite, S., Manneschi, G., Patriarca, S., Sgargi, P., Vicentini, M., Puppo, A., Vitale, M. F., Barigelletti, G., Pirino, D. R., Spata, E., Ricci, P., Madeddu, A., Rizzello, R., Usala, M., Bulatko, A., Vercellino, P. C., Cometti, I., Cuccaro, F., Sampietro, G., Scalzi, S., Gola, G., Guarda, L., Melcarne, A., d'Oro, L. C., Borciani, E., Carone, S., Candela, G., Stoppa, G. & group, F. AIRTUM. W., 2018, In : European journal of cancer. 94, p. 6-15 10 p.

Research output: Contribution to journalArticle

The impact of overdiagnosis on thyroid cancer epidemic in Italy,1998–2012

Dal Maso, L., Panato, C., Franceschi, S., Serraino, D., Buzzoni, C., Busco, S., Ferretti, S., Torrisi, A., Falcini, F., Zorzi, M., Cirilli, C., Mazzucco, W., Magoni, M., Collarile, P., Pannozzo, F., Caiazzo, A. L., Russo, A. G., Gili, A., Caldarella, A., Zanetti, R. & 54 others, Michiara, M., Mangone, L., Filiberti, R. A., Fusco, M., Gasparini, F., Tagliabue, G., Cesaraccio, R., Tumino, R., Gatti, L., Tisano, F., Piffer, S., Sini, G. M., Mazzoleni, G., Rosso, S., Fanetti, A. C., Vaccarella, S., Fedeli, U., Varvarà, M., Ravaioli, A., Pennelli, G., Valla, K., Cusimano, R., Gasparotti, C., Taborelli, M., Iannelli, A., Leite, S., Manneschi, G., Patriarca, S., Sgargi, P., Vicentini, M., Puppo, A., Vitale, M. F., Barigelletti, G., Pirino, D. R., Spata, E., Ricci, P., Madeddu, A., Rizzello, R., Usala, M., Bulatko, A., Vercellino, P. C., Cometti, I., Cuccaro, F., Sampietro, G., Scalzi, S., Gola, G., Guarda, L., Melcarne, A., d'Oro, L. C., Borciani, E., Carone, S., Candela, G., Stoppa, G. & group, F. AIRTUM. W., 2018, In : European journal of cancer. 94, p. 6-15 10 p.

Research output: Contribution to journalArticle

2017
Platinum
Cisplatin
Cells
Carcinoma
Pharmaceutical Preparations

PKC-alpha modulation by miR-483-3p in platinum-resistant ovarian carcinoma cells

Arrighetti, N., Cossa, G., De Cecco, L., Stucchi, S., Carenini, N., Corna, E., Gandellini, P., Zaffaroni, N., Perego, P. & Gatti, L., Nov 1 2016, In : Toxicology and Applied Pharmacology. 310, p. 9-19 11 p.

Research output: Contribution to journalArticle

Platinum
MicroRNAs
Cells
Modulation
Platinum Compounds

Targeting peptidyl-prolyl isomerase pin1 to inhibit tumor cell aggressiveness

Beretta, G. L., De Cesare, M., Albano, L., Magnifico, A., Carenini, N., Corna, E., Perego, P. & Gatti, L., Mar 1 2016, In : Tumori. 102, 2, p. 144-149 6 p.

Research output: Contribution to journalArticle

Peptidylprolyl Isomerase
Neoplasms
Nude Mice
Neoplastic Stem Cells
Phosphoproteins
2015

Drug combinations with HDAC inhibitors in antitumor therapy

Arrighetti, N., Corno, C. & Gatti, L., 2015, In : Critical Reviews in Oncogenesis. 20, 1-2, p. 83-117 35 p.

Research output: Contribution to journalArticle

Histone Deacetylase Inhibitors
Drug Combinations
Neoplasms
Therapeutics
Clinical Trials

Microenvironment-modulated metastatic CD133+/CXCR4+/EpCAM-lung cancer-initiating cells sustain tumor dissemination and correlate with poor prognosis

Bertolini, G., D'Amico, L., Moro, M., Landoni, E., Perego, P., Miceli, R., Gatti, L., Andriani, F., Wong, D., Caserini, R., Tortoreto, M., Milione, M., Ferracini, R., Mariani, L., Pastorino, U., Roato, I., Sozzi, G. & Roz, L., Sep 1 2015, In : Cancer Research. 75, 17, p. 3636-3649 14 p.

Research output: Contribution to journalArticle

Neoplastic Stem Cells
Lung Neoplasms
Neoplasms
Neoplasm Metastasis
Heterografts
Platinum Compounds
Drug Resistance
Platinum
DNA
Pharmaceutical Preparations

Nucleolar targeting by platinum: P53-independent apoptosis follows rRNA inhibition, cell-cycle arrest, and DNA compaction

Peterson, E. J., Menon, V. R., Gatti, L., Kipping, R., Dewasinghe, D., Perego, P., Povirk, L. F. & Farrell, N. P., Jan 5 2015, In : Molecular Pharmaceutics. 12, 1, p. 287-297 11 p.

Research output: Contribution to journalArticle

Cell Cycle Checkpoints
Platinum
Apoptosis
DNA
Mitosis

Orchestration of DSB repair: a novel BRCA2 connection

Gatti, L. & Perego, P., Jan 1 2015, In : Cell Cycle. 14, 14, p. 2195-2196 2 p.

Research output: Contribution to journalArticle

Targeting the invasive phenotype of cisplatin-resistant Non-Small Cell Lung Cancer cells by a novel histone deacetylase inhibitor

Zuco, V., Cassinelli, G., Cossa, G., Gatti, L., Favini, E., Tortoreto, M., Cominetti, D., Scanziani, E., Castiglioni, V., Cincinelli, R., Giannini, G., Zunino, F., Zaffaroni, N., Lanzi, C. & Perego, P., Mar 15 2015, In : Biochemical Pharmacology. 94, 2, p. 79-90 12 p.

Research output: Contribution to journalArticle

Histone Deacetylase Inhibitors
Non-Small Cell Lung Carcinoma
Cisplatin
Cells
Conditioned Culture Medium
2014

Antitumor activity of a novel homodimeric SMAC mimetic in ovarian carcinoma

Gatti, L., De Cesare, M., Ciusani, E., Corna, E., Arrighetti, N., Cominetti, D., Belvisi, L., Potenza, D., Moroni, E., Vasile, F., Lecis, D., Delia, D., Castiglioni, V., Scanziani, E., Seneci, P., Zaffaroni, N. & Perego, P., Jan 6 2014, In : Molecular Pharmaceutics. 11, 1, p. 283-293 11 p.

Research output: Contribution to journalArticle

TNF-Related Apoptosis-Inducing Ligand
Caspases
Mitochondria
Carcinoma
Tumor Necrosis Factor-alpha

Differential outcome of MEK1/2 inhibitor-platinum combinations in platinum-sensitive and -resistant ovarian carcinoma cells

Cossa, G., Lanzi, C., Cassinelli, G., Carenini, N., Arrighetti, N., Gatti, L., Corna, E., Zunino, F., Zaffaroni, N. & Perego, P., Jun 1 2014, In : Cancer Letters. 347, 2, p. 212-224 13 p.

Research output: Contribution to journalArticle

Platinum
Carcinoma
oxaliplatin
Platinum Compounds
Apoptosis

Histone deacetylase inhibitor-temozolomide co-treatment inhibits melanoma growth through suppression of Chemokine (C-C motif) ligand 2-driven signals

Gatti, L., Sevko, A., de Cesare, M., Arrighetti, N., Manenti, G., Ciusani, E., Verderio, P., Ciniselli, C. M., Cominetti, D., Carenini, N., Corna, E., Zaffaroni, N., Rodolfo, M., Rivoltini, L., Umansky, V. & Perego, P., 2014, In : Oncotarget. 5, 12, p. 4516-4528 13 p.

Research output: Contribution to journalArticle

temozolomide
Histone Deacetylase Inhibitors
Chemokine CCL2
Melanoma
Phosphotransferases

Improved apoptotic cell death in drug-resistant non-small-cell lung cancer cells by tumor necrosis factor-related apoptosis-inducing ligand-based treatments

Gatti, L., Cossa, G., Tinelli, S., Carenini, N., Arrighetti, N., Pennati, M., Cominetti, D., De Cesare, M., Zunino, F., Zaffaroni, N. & Perego, P., Mar 2014, In : Journal of Pharmacology and Experimental Therapeutics. 348, 3, p. 360-371 12 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Cell Death
Tumor Necrosis Factor-alpha
Apoptosis
Ligands
2013

Camptothecin resistance in cancer: Insights into the molecular mechanisms of a DNA-damaging drug

Beretta, G. L., Gatti, L., Perego, P. & Zaffaroni, N., Apr 2013, In : Current Medicinal Chemistry. 20, 12, p. 1541-1565 25 p.

Research output: Contribution to journalArticle

Camptothecin
DNA
Tumors
Pharmaceutical Preparations
Neoplasms

Clinicopathological impact of ABCC1/MRP1 and ABCC4/MRP4 in epithelial ovarian carcinoma

Bagnoli, M., Beretta, G. L., Gatti, L., Pilotti, S., Alberti, P., Tarantino, E., Barbareschi, M., Canevari, S., Mezzanzanica, D. & Perego, P., 2013, In : BioMed Research International. 2013, 143202.

Research output: Contribution to journalArticle

Platinum
Tumors
Carcinoma
ATP-Binding Cassette Transporters
Chemotherapy

Drug combinations with proteasome inhibitors in antitumor therapy

Gatti, L., Zuco, V., Zaffaroni, N. & Perego, P., 2013, In : Current Pharmaceutical Design. 19, 22, p. 4094-4114 21 p.

Research output: Contribution to journalArticle

Proteasome Inhibitors
Drug Combinations
Cytotoxins
Proteasome Endopeptidase Complex
Multiple Myeloma

Modulation of sensitivity to antitumor agents by targeting the MAPK survival pathway

Cossa, G., Gatti, L., Cassinelli, G., Lanzi, C., Zaffaroni, N. & Perego, P., 2013, In : Current Pharmaceutical Design. 19, 5, p. 883-894 12 p.

Research output: Contribution to journalArticle

Extracellular Signal-Regulated MAP Kinases
Mitogen-Activated Protein Kinases
Antineoplastic Agents
Survival
Drug Resistance

Targeting the akt kinase to modulate survival, invasiveness and drug resistance of cancer cells

Cassinelli, G., Zuco, V., Gatti, L., Lanzi, C., Zaffaroni, N., Colombo, D. & Perego, P., May 2013, In : Current Medicinal Chemistry. 20, 15, p. 1923-1945 23 p.

Research output: Contribution to journalArticle

Drug Resistance
Tumors
Phosphotransferases
Cells
Survival
2012

Role of tyrosyl-DNA phosphodiesterase 1 and inter-players in regulation of tumor cell sensitivity to topoisomerase i inhibition

Perego, P., Cossa, G., Tinelli, S., Corna, E., Carenini, N., Gatti, L., De Cesare, M., Ciusani, E., Zunino, F., Luison, E., Canevari, S., Zaffaroni, N. & Beretta, G. L., Jan 1 2012, In : Biochemical Pharmacology. 83, 1, p. 27-36 10 p.

Research output: Contribution to journalArticle

Tumors
Cells
Type I DNA Topoisomerase
Camptothecin
Neoplasms

Sensitization of tumor cells by targeting histone deacetylases

Perego, P., Zuco, V., Gatti, L. & Zunino, F., Apr 15 2012, In : Biochemical Pharmacology. 83, 8, p. 987-994 8 p.

Research output: Contribution to journalArticle

Histone Deacetylase Inhibitors
Histone Deacetylases
Antineoplastic Agents
Tumors
Cells

Synergistic interaction between the novel histone deacetylase inhibitor ST2782 and the proteasome inhibitor bortezomib in platinum-sensitive and resistant ovarian carcinoma cells

Gatti, L., Benedetti, V., De Cesare, M., Corna, E., Cincinelli, R., Zaffaroni, N., Zunino, F. & Perego, P., Aug 2012, In : Journal of Inorganic Biochemistry. 113, p. 94-101 8 p.

Research output: Contribution to journalArticle

Proteasome Inhibitors
Histone Deacetylase Inhibitors
Platinum
Cells
Carcinoma
2011

Novel insights into targeting ATP-binding cassette transporters for antitumor therapy

Gatti, L., Cossa, G., Beretta, G. L., Zaffaroni, N. & Perego, P., Sep 2011, In : Current Medicinal Chemistry. 18, 27, p. 4237-4249 13 p.

Research output: Contribution to journalArticle

ATP-Binding Cassette Transporters
Tumors
Neoplastic Stem Cells
Stem cells
Antineoplastic Agents

Ubiquitin-proteasome genes as targets for modulation of cisplatin sensitivity in fission yeast

Gatti, L., Hoe, K. L., Hayles, J., Righetti, S. C., Carenini, N., Bo, L. D., Kim, D. U., Park, H. O. & Perego, P., Jan 19 2011, In : BMC Genomics. 12, 44.

Research output: Contribution to journalArticle

Schizosaccharomyces
Proteasome Endopeptidase Complex
Ubiquitin
Cisplatin
Genes
2010

Increased levels and defective glycosylation of MRPs in ovarian carcinoma cells resistant to oxaliplatin

Beretta, G. L., Benedetti, V., Cossa, G., Assaraf, Y. G. A., Bram, E., Gatti, L., Corna, E., Carenini, N., Colangelo, D., Howell, S. B., Zunino, F. & Perego, P., Apr 2010, In : Biochemical Pharmacology. 79, 8, p. 1108-1117 10 p.

Research output: Contribution to journalArticle

oxaliplatin
Glycosylation
Cells
Carcinoma
Cisplatin

Novel bis-platinum complexes endowed with an improved pharmacological profile

Gatti, L., Perego, P., Leone, R., Apostoli, P., Carenini, N., Corna, E., Allievi, C., Bastrup, U., De Munari, S., Di Giovine, S., Nicoli, P., Grugni, M., Natangelo, M., Pardi, G., Pezzoni, G., Singer, J. W. & Zunino, F., Feb 1 2010, In : Molecular Pharmaceutics. 7, 1, p. 207-216 10 p.

Research output: Contribution to journalArticle

Platinum
Pharmacology
oxaliplatin
Neoplasms
Drug Stability

Simultaneous confidence intervals to compare gene expression profiles using ABC transporter TaqMan microfluidic cards

Pizzamiglio, S., Cossa, G., Gatti, L., Beretta, G. L., Corna, E., Tinelli, S., Verderio, P. & Perego, P., Mar 2010, In : Oncology Reports. 23, 3, p. 853-860 8 p.

Research output: Contribution to journalArticle

ATP-Binding Cassette Transporters
Microfluidics
Transcriptome
Confidence Intervals
Gene Expression

The ABC of glycosylation

Perego, P., Gatti, L. & Beretta, G. L., Jul 2010, In : Nature Reviews Cancer. 10, 7, p. 523 1 p.

Research output: Contribution to journalArticle

The "stem" of chemoresistance

Bertolini, G., Gatti, L. & Roz, L., Feb 15 2010, In : Cell Cycle. 9, 4, p. 628-629 2 p.

Research output: Contribution to journalArticle

Tyrosyl-DNA phosphodiesterase 1 targeting for modulation of camptothecin-based treatment

Beretta, G. L., Cossa, G., Gatti, L., Zunino, F. & Perego, P., 2010, In : Current Medicinal Chemistry. 17, 15, p. 1500-1508 9 p.

Research output: Contribution to journalArticle

Camptothecin
Modulation
DNA
Repair
DNA Repair
2009

ABC transporters as potential targets for modulation of drug resistance

Gatti, L., Beretta, G. L., Cossa, G., Zunino, F. & Perego, P., 2009, In : Mini-Reviews in Medicinal Chemistry. 9, 9, p. 1102-1112 11 p.

Research output: Contribution to journalArticle

ATP-Binding Cassette Transporters
Drug Resistance
Neoplastic Stem Cells
Pharmaceutical Preparations
Antineoplastic Agents

Highly tumorigenic lung cancer CD133+ cells display stem-like features and are spared by cisplatin treatment

Bertolini, G., Roz, L., Perego, P., Tortoreto, M., Fontanella, E., Gatti, L., Pratesi, G., Fabbri, A., Andriani, F., Tinelli, S., Roz, E., Caserini, R., Lo Vullo, S., Camerini, T., Mariani, L., Delia, D., Calabrò, E., Pastorino, U. & Sozzi, G., Sep 22 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 38, p. 16281-16286 6 p.

Research output: Contribution to journalArticle

Cisplatin
Lung Neoplasms
Stem Cells
Lung
Neoplasms

Strategies to improve the efficacy of platinum compounds

Cossa, G., Gatti, L., Zunino, F. & Perego, P., 2009, In : Current Medicinal Chemistry. 16, 19, p. 2355-2365 11 p.

Research output: Contribution to journalArticle

Platinum Compounds
Platinum
Pharmaceutical Preparations
Tumors
Pharmacology
2008

A proteomic approach for evaluating the cell response to a novel histone deacetylase inhibitor in colon cancer cells

Milli, A., Cecconi, D., Campostrini, N., Timperio, A. M., Zolla, L., Righetti, S. C., Zunino, F., Perego, P., Benedetti, V., Gatti, L., Odreman, F., Vindigni, A. & Righetti, P. G., Nov 2008, In : Biochimica et Biophysica Acta - Proteins and Proteomics. 1784, 11, p. 1702-1710 9 p.

Research output: Contribution to journalArticle

Histone Deacetylase Inhibitors
Proteomics
Colonic Neoplasms
HCT116 Cells
Cells

Defining targets of modulation of human tumor cell response to cisplatin

Beretta, G. L., Gatti, L., Corna, E., Carenini, N., Zunino, F. & Perego, P., Jul 2008, In : Journal of Inorganic Biochemistry. 102, 7, p. 1406-1415 10 p.

Research output: Contribution to journalArticle

Cisplatin
Tumors
Cells
Modulation
Neoplasms

Eradication of ovarian tumor xenografts by locoregional administration of targeted immunotherapy

De Cesare, M., Calcaterra, C., Pratesi, G., Gatti, L., Zunino, F., Mènard, S. & Balsari, A., Sep 1 2008, In : Clinical Cancer Research. 14, 17, p. 5512-5518 7 p.

Research output: Contribution to journalArticle

Heterografts
Immunotherapy
Neoplasms
Adaptive Immunity
Keratinocytes

Small molecules targeting p53 to improve antitumor therapy

Beretta, G. L., Gatti, L., Benedetti, V., Perego, P. & Zunino, F., 2008, In : Mini-Reviews in Medicinal Chemistry. 8, 9, p. 856-868 13 p.

Research output: Contribution to journalArticle

Antineoplastic Agents
Molecules
Modulators
Therapeutics

The human homolog of fission yeast Rad17 is implicated in tumor growth

Beretta, G. L., Gatti, L., Cesare, M. D., Corna, E., Tinelli, S., Carenini, N., Zunino, F. & Perego, P., Aug 8 2008, In : Cancer Letters. 266, 2, p. 194-202 9 p.

Research output: Contribution to journalArticle

Schizosaccharomyces
Growth
Neoplasms
Exonucleases
ras Genes
2006

Cellular sensitivity to β-diketonato complexes of ruthenium(III), chromium(III) and rhodium(III)

Arandjelovic, S., Tesic, Z., Perego, P., Gatti, L., Carenini, N., Zunino, F., Leone, R., Apostoli, P. & Radulovic, S., May 2006, In : Medicinal Chemistry. 2, 3, p. 227-237 11 p.

Research output: Contribution to journalArticle

Rhodium
Ruthenium
Chromium
DNA
Apoptosis

Modulation of cell growth and cisplatin sensitivity by membrane γ-glutamyltransferase in melanoma cells

Franzini, M., Corti, A., Lorenzini, E., Paolicchi, A., Pompella, A., De Cesare, M., Perego, P., Gatti, L., Leone, R., Apostoli, P. & Zunino, F., Oct 2006, In : European Journal of Cancer. 42, 15, p. 2623-2630 8 p.

Research output: Contribution to journalArticle

Cisplatin
Melanoma
Membranes
Growth
Glutathione

Sensitization to gimatecan-induced apoptosis by tumor necrosis factor-related apoptosis inducing ligand in prostate carcinoma cells

Perego, P., Ciusani, E., Gatti, L., Carenini, N., Corna, E. & Zunino, F., Mar 14 2006, In : Biochemical Pharmacology. 71, 6, p. 791-798 8 p.

Research output: Contribution to journalArticle

Prostate
Tumor Necrosis Factor-alpha
Cells
Apoptosis
Ligands
2005

Overview of tumor cell chemoresistance mechanisms.

Gatti, L. & Zunino, F., 2005, In : Methods in molecular medicine. 111, p. 127-148 22 p.

Research output: Contribution to journalArticle

Neoplasms
Drug Resistance
R Factors
Treatment Failure
Drug Interactions
2004

Cellular pharmacology of cisplatin in relation to the expression of human copper transporter CTR1 in different pairs of cisplatin-sensitive and -resistant cells

Beretta, G. L., Gatti, L., Tinelli, S., Corna, E., Colangelo, D., Zunino, F. & Perego, P., Jul 15 2004, In : Biochemical Pharmacology. 68, 2, p. 283-291 9 p.

Research output: Contribution to journalArticle

Cisplatin
Copper
Pharmacology
Cells
Cell Line

Gene expression profiles in the cellular response to a multinuclear platinum complex

Gatti, L., Beretta, G. L., Carenini, N., Corna, E., Zunino, F. & Perego, P., Apr 2004, In : Cellular and Molecular Life Sciences. 61, 7-8, p. 973-981 9 p.

Research output: Contribution to journalArticle

Platinum
Transcriptome
Gene expression
Genes
Cells

Global gene expression of fission yeast in response to cisplatin

Gatti, L., Chen, D., Beretta, G. L., Rustici, G., Carenini, N., Corna, E., Colangelo, D., Zunino, F., Bähler, J. & Perego, P., Sep 2004, In : Cellular and Molecular Life Sciences. 61, 17, p. 2253-2263 11 p.

Research output: Contribution to journalArticle

Schizosaccharomyces
Gene expression
Yeast
Cisplatin
Gene Expression