19972020

Research output per year

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Research Output

2020

Discovering the Italian phenotype of cerebral amyloid angiopathy (CAA): the SENECA project

on behalf of SENECA project, Jan 1 2020, (Accepted/In press) In : Neurological Sciences.

Research output: Contribution to journalArticle

Plasma neurofilament light chain: an early biomarker for hereditary ATTR amyloid polyneuropathy

Maia, L. F., Maceski, A., Conceição, I., Obici, L., Magalhães, R., Cortese, A., Leppert, D., Merlini, G., Kuhle, J. & Saraiva, M. J., Jan 1 2020, (Accepted/In press) In : Amyloid.

Research output: Contribution to journalArticle

Quality of life outcomes in APOLLO, the phase 3 trial of the RNAi therapeutic patisiran in patients with hereditary transthyretin-mediated amyloidosis

Obici, L., Berk, J. L., González-Duarte, A., Coelho, T., Gillmore, J., Schmidt, H. H. J., Schilling, M., Yamashita, T., Labeyrie, C., Brannagan, T. H., Ajroud-Driss, S., Gorevic, P., Kristen, A. V., Franklin, J., Chen, J., Sweetser, M. T., Wang, J. J. & Adams, D., Jan 1 2020, (Accepted/In press) In : Amyloid.

Research output: Contribution to journalArticle

Open Access

Understanding the pathophysiology of cerebral amyloid angiopathy

Gatti, L., Tinelli, F., Scelzo, E., Arioli, F., Di Fede, G., Obici, L., Pantoni, L., Giaccone, G., Caroppo, P., Parati, E. A. & Bersano, A., May 2 2020, In : International Journal of Molecular Sciences. 21, 10, 3435.

Research output: Contribution to journalReview article

Open Access
2019

Amyloidosis in Heart Failure

Ihne, S., Morbach, C., Obici, L., Palladini, G. & Störk, S., Jan 1 2019, (Accepted/In press) In : Current Heart Failure Reports.

Research output: Contribution to journalReview article

An International Delphi Survey for the Definition of New Classification Criteria for Familial Mediterranean Fever, Mevalonate Kinase Deficiency, TNF Receptortextendashassociated Periodic Fever Syndromes, and Cryopyrin-associated Periodic Syndrome

Federici, S., Vanoni, F., Ben-Chetrit, E., Cantarini, L., Frenkel, J., Goldbach-Mansky, R., Gul, A., Hoffman, H., Koné-Paut, I., Kuemmerle-Deschner, J., Lachmann, H. J., Martini, A., Obici, L., Ozen, S., Simon, A., Hofer, M., Ruperto, N. & Gattorno, M., 2019, In : The Journal of rheumatology. 46, 4, p. 429-436 8 p.

Research output: Contribution to journalArticle

A novel knock-in mouse model of cryopyrin-associated periodic syndromes with development of amyloidosis: Therapeutic efficacy of proton pump inhibitors

Bertoni, A., Carta, S., Baldovini, C., Penco, F., Balza, E., Borghini, S., Di Duca, M., Ognio, E., Signori, A., Nozza, P., Schena, F., Castellani, P., Pastorino, C., Perrone, C., Obici, L., Martini, A., Ceccherini, I., Gattorno, M., Rubartelli, A. & Chiesa, S., Jan 1 2019, In : Journal of Allergy and Clinical Immunology.

Research output: Contribution to journalArticle

Assessment of patients with hereditary transthyretin amyloidosis–understanding the impact of management and disease progression

Conceição, I., Coelho, T., Rapezzi, C., Parman, Y., Obici, L., Galán, L. & Rousseau, A., Jul 3 2019, In : Amyloid. 26, 3, p. 103-111 9 p.

Research output: Contribution to journalReview article

Open Access

Burden of hereditary transthyretin amyloidosis on quality of life

Yarlas, A., Gertz, M. A., Dasgupta, N. R., Obici, L., Pollock, M., Ackermann, E. J., Lovley, A., Kessler, A. S., Patel, P. A., White, M. K. & Guthrie, S. D., Aug 1 2019, In : Muscle and Nerve. 60, 2, p. 169-175 7 p.

Research output: Contribution to journalArticle

Open Access

Classification criteria for autoinflammatory recurrent fevers

Gattorno, M., Hofer, M., Federici, S., Vanoni, F., Bovis, F., Aksentijevich, I., Anton, J., Arostegui, J. I., Barron, K., Ben-Cherit, E., Brogan, P. A., Cantarini, L., Ceccherini, I., De Benedetti, F., Dedeoglu, F., Demirkaya, E., Frenkel, J., Goldbach-Mansky, R., Gul, A., Hentgen, V. & 23 others, Hoffman, H., Kallinich, T., Kone-Paut, I., Kuemmerle-Deschner, J., Lachmann, H. J., Laxer, R. M., Livneh, A., Obici, L., Ozen, S., Rowczenio, D., Russo, R., Shinar, Y., Simon, A., Toplak, N., Touitou, I., Uziel, Y., van Gijn, M., Foell, D., Garassino, C., Kastner, D., Martini, A., Sormani, M. P. & Ruperto, N., Apr 24 2019, In : Annals of the Rheumatic Diseases.

Research output: Contribution to journalArticle

Classification criteria for autoinflammatory recurrent fevers

Gattorno, M., Hofer, M., Federici, S., Vanoni, F., Bovis, F., Aksentijevich, I., Anton, J., Arostegui, J. I., Barron, K., Ben-Cherit, E., Brogan, P. A., Cantarini, L., Ceccherini, I., De Benedetti, F., Dedeoglu, F., Demirkaya, E., Frenkel, J., Goldbach-Mansky, R., Gul, A., Hentgen, V. & 23 others, Hoffman, H., Kallinich, T., Kone-Paut, I., Kuemmerle-Deschner, J., Lachmann, H. J., Laxer, R. M., Livneh, A., Obici, L., Ozen, S., Rowczenio, D., Russo, R., Shinar, Y., Simon, A., Toplak, N., Touitou, I., Uziel, Y., Van Gijn, M., Foell, D., Garassino, C., Kastner, D., Martini, A., Sormani, M. P. & Ruperto, N., Aug 1 2019, In : Annals of the Rheumatic Diseases. 78, 8, p. 1025-1032 8 p.

Research output: Contribution to journalArticle

Open Access

Classification criteria for autoinflammatory recurrent fevers

Gattorno, M., Hofer, M., Federici, S., Vanoni, F., Bovis, F., Aksentijevich, I., Anton, J., Arostegui, J. I., Barron, K., Ben-Cherit, E., Brogan, P. A., Cantarini, L., Ceccherini, I., De Benedetti, F., Dedeoglu, F., Demirkaya, E., Frenkel, J., Goldbach-Mansky, R., Gul, A., Hentgen, V. & 24 others, Hoffman, H., Kallinich, T., Kone-Paut, I., Kuemmerle-Deschner, J., Lachmann, H. J., Laxer, R. M., Livneh, A., Obici, L., Ozen, S., Rowczenio, D., Russo, R., Shinar, Y., Simon, A., Toplak, N., Touitou, I., Uziel, Y., van Gijn, M., Foell, D., Garassino, C., Kastner, D., Martini, A., Sormani, M. P., Ruperto, N. & (PRINTO), E. R. A. T. P. R. I. T. O., Aug 2019, In : Annals of the Rheumatic Diseases. 78, 8, p. 1025-1032 8 p.

Research output: Contribution to journalArticle

Development of measures of polyneuropathy impairment in hATTR amyloidosis: From NIS to mNIS + 7

Dyck, P. J. B., González-Duarte, A., Obici, L., Polydefkis, M., Wiesman, J. F., Antonino, I., Litchy, W. J. & Dyck, P. J., Oct 15 2019, In : Journal of the Neurological Sciences. 405, 116424.

Research output: Contribution to journalReview article

Open Access

Diagnosis and treatment of gastrointestinal dysfunction in hereditary TTR amyloidosis

Obici, L. & Suhr, O. B., Jan 1 2019, In : Clinical Autonomic Research.

Research output: Contribution to journalReview article

Differential serum levels of interleukin-37 in patients with tumour necrosis factor receptor-associated periodic syndrome (TRAPS)

Lucherini, O. M., Vitale, A., Obici, L., Sota, J., Frediani, B., Merlini, G., Rigante, D. & Cantarini, L., Nov 1 2019, In : Clinical and Experimental Rheumatology. 37, 6, p. 159-160 2 p.

Research output: Contribution to journalLetter

Inotersen for the treatment of adults with polyneuropathy caused by hereditary transthyretin-mediated amyloidosis

Gertz, M. A., Scheinberg, M., Waddington-Cruz, M., Heitner, S. B., Karam, C., Drachman, B., Khella, S., Whelan, C. & Obici, L., Jan 1 2019, In : Expert Review of Clinical Pharmacology.

Research output: Contribution to journalArticle

Open Access

Inotersen preserves or improves quality of life in hereditary transthyretin amyloidosis

Coelho, T., Yarlas, A., Waddington-Cruz, M., White, M. K., Sikora Kessler, A., Lovley, A., Pollock, M., Guthrie, S., Ackermann, E. J., Hughes, S. G., Karam, C., Khella, S., Gertz, M., Merlini, G., Obici, L., Schmidt, H. H., Polydefkis, M., Dyck, P. J. B., Brannagan, T. H., Conceição, I. & 2 others, Benson, M. D. & Berk, J. L., Jan 1 2019, (Accepted/In press) In : Journal of Neurology.

Research output: Contribution to journalArticle

Open Access

Light Chains With Heavy Effects

Obici, L. & Merlini, G., Jan 1 2019, (Accepted/In press) In : American Journal of Kidney Diseases.

Research output: Contribution to journalEditorial

Patisiran, an RNAi therapeutic for the treatment of hereditary transthyretin-mediated amyloidosis

Kristen, A. V., Ajroud-Driss, S., Conceição, I., Gorevic, P., Kyriakides, T. & Obici, L., Feb 1 2019, In : Neurodegenerative disease management. 9, 1, p. 5-23 19 p.

Research output: Contribution to journalArticle

Screening for Transthyretin Amyloid Cardiomyopathy in Everyday Practice

Witteles, R. M., Bokhari, S., Damy, T., Elliott, P. M., Falk, R. H., Fine, N. M., Gospodinova, M., Obici, L., Rapezzi, C. & Garcia-Pavia, P., Aug 1 2019, In : JACC: Heart Failure. 7, 8, p. 709-716 8 p.

Research output: Contribution to journalReview article

Open Access

Simple, reliable detection of amyloid in fat aspirates using the fluorescent dye FSB: prospective study in 206 patients

Tasaki, M., Milani, P., Foli, A., Verga, L., Obici, L., Basset, M., Bozzola, M., Ferraro, G., Nuvolone, M., Morbini, P., Capello, G., Ueda, M., Obayashi, K., Paulli, M., Ando, Y., Merlini, G., Palladini, G. & Lavatelli, F., Jul 18 2019, In : Blood. 134, 3, p. 320-323 4 p.

Research output: Contribution to journalLetter

Transthyretin deposition in the eye in the era of effective therapy for hereditary ATTRV30M amyloidosis

Buxbaum, J. N., Brannagan, T., Buades-Reinés, J., Cisneros, E., Conceicao, I., Kyriakides, T., Merlini, G., Obici, L., Plante-Bordeneuve, V., Rousseau, A., Sekijima, Y., Imai, A., Waddington Cruz, M. & Yamada, M., Jan 2 2019, In : Amyloid. 26, 1, p. 10-14 5 p.

Research output: Contribution to journalArticle

2018

Autoinflammatory diseases as a cause of acute abdominal pain in the emergency department

Maconi, G., Obici, L., Carmagnola, S. & Guzzetti, S., Jan 1 2018, In : Clinical and Experimental Rheumatology. 36, 1, p. 39-43 5 p.

Research output: Contribution to journalReview article

Becoming familiar with hereditary transthyretin amyloidosis, a treatable neuropathy

Obici, L., Sep 1 2018, In : Arquivos de Neuro-Psiquiatria. 76, p. 573 - 574

Research output: Contribution to journalArticle

Canakinumab for the treatment of autoinflammatory recurrent fever syndromes

De Benedetti, F., Gattorno, M., Anton, J., Eldad, B. C., Frenkel, J., Hoffman, H. M., Isabelle, K. P., Lachmann, H. J., Ozen, S., Simon, A., Zeft, A., Penades, I. C., Moutschen, M., Quartier, P., Kasapcopur, O., Shcherbina, A., Hofer, M., Hashkes, P. J., Van der Hilst, J., Hara, R. & 10 others, Segundo, B. R., Constantin, T., Gul, A., Livneh, A., Brogan, P., Cattalini, M., Obici, L., Lheritier, K., Speziale, A. & Junge, G., May 17 2018, In : New England Journal of Medicine. 378, 20, p. 1908-1919 12 p.

Research output: Contribution to journalArticle

Canakinumab for the treatment of autoinflammatory recurrent fever syndromes

De Benedetti, F., Gattorno, M., Anton, J., Eldad, B-C., Frenkel, J., Hoffman, H. M., Isabelle, K-P., Lachmann, H. J., Ozen, S., Simon, A., Zeft, A., Penades, I. C., Moutschen, M., Quartier, P., Kasapcopur, O., Shcherbina, A., Hofer, M., Hashkes, P. J., Van der Hilst, J., Hara, R. & 10 others, Segundo, B-R., Constantin, T., Gul, A., Livneh, A., Brogan, P., Cattalini, M., Obici, L., Lheritier, K., Speziale, A. & Junge, G., 2018, In : New England Journal of Medicine. 378, 20, p. 1908-1919 12 p.

Research output: Contribution to journalArticle

Canakinumab for the treatment of autoinflammatory recurrent fever syndromes

De Benedetti, F., Gattorno, M., Anton, J., Eldad, B. C., Frenkel, J., Hoffman, H. M., Isabelle, K. P., Lachmann, H. J., Ozen, S., Simon, A., Zeft, A., Penades, I. C., Moutschen, M., Quartier, P., Kasapcopur, O., Shcherbina, A., Hofer, M., Hashkes, P. J., Van der Hilst, J., Hara, R. & 10 others, Segundo, B. R., Constantin, T., Gul, A., Livneh, A., Brogan, P., Cattalini, M., Obici, L., Lheritier, K., Speziale, A. & Junge, G., May 17 2018, In : New England Journal of Medicine. 378, 20, p. 1908-1919 12 p.

Research output: Contribution to journalArticle

Conhecendo melhor a amiloidose transtirretina hereditária, uma neuropatia tratável

Translated title of the contribution: Becoming familiar with hereditary transthyretin amyloidosis, a treatable neuropathyObici, L., Sep 1 2018, In : Arquivos de Neuro-Psiquiatria. 76, 9, p. 573-574 2 p.

Research output: Contribution to journalEditorial

Inotersen treatment for patients with Hereditary transthyretin amyloidosis

Benson, M. D., Waddington-Cruz, M., Berk, J. L., Polydefkis, M., Dyck, P. J., Wang, A. K., Planté-Bordeneuve, V., Barroso, F. A., Merlini, G., Obici, L., Scheinberg, M., Brannagan, T. H., Litchy, W. J., Whelan, C., Drachman, B. M., Adams, D., Heitner, S. B., Conceição, I., Schmidt, H. H., Vita, G. & 15 others, Campistol, J. M., Gamez, J., Gorevic, P. D., Gane, E., Shah, A. M., Solomon, S. D., Monia, B. P., Hughes, S. G., Jesse Kwoh, T., McEvoy, B. W., Jung, S. W., Baker, B. F., Ackermann, E. J., Gertz, M. A. & Coelho, T., Jul 5 2018, In : New England Journal of Medicine. 379, 1, p. 22-31 10 p.

Research output: Contribution to journalArticle

Plasminogen activation triggers transthyretin amyloidogenesis in vitro

Mangione, P. P., Verona, G., Corazza, A., Marcoux, J., Canetti, D., Giorgetti, S., Raimondi, S., Stoppini, M., Esposito, M., Relini, A., Canale, C., Valli, M., Marchese, L., Faravelli, G., Obici, L., Hawkins, P. N., Taylor, G. W., Gillmore, J. D., Pepys, M. B. & Bellotti, V., Jan 1 2018, In : Journal of Biological Chemistry. 293, 37, p. 14192-14199 8 p.

Research output: Contribution to journalArticle

Progressive axonal polyneuropathy in a mitochondrial disorder: an uncommon association with familial amyloid neuropathy

Luigetti, M., Primiano, G., Bisogni, G., Cuccagna, C., Carrozzo, R., Obici, L., Bernardo, D., Sancricca, C. & Servidei, S., Jan 1 2018, (Accepted/In press) In : Amyloid.

Research output: Contribution to journalArticle

Progressive axonal polyneuropathy in a mitochondrial disorder: an uncommon association with familial amyloid neuropathy

Luigetti, M., Primiano, G., Bisogni, G., Cuccagna, C., Carrozzo, R., Obici, L., Bernardo, D., Sancricca, C. & Servidei, S., 2018, In : Amyloid. 25, 4, p. 261-262 2 p.

Research output: Contribution to journalArticle

Progressive axonal polyneuropathy in a mitochondrial disorder: an uncommon association with familial amyloid neuropathy

Luigetti, M., Primiano, G., Bisogni, G., Cuccagna, C., Carrozzo, R., Obici, L., Bernardo, D., Sancricca, C. & Servidei, S., 2018, In : Amyloid.

Research output: Contribution to journalArticle

Renal involvement in autoinflammatory diseases and inflammasome-mediated chronic kidney damage

Scarpioni, R. & Obici, L., Jan 1 2018, In : Clinical and Experimental Rheumatology. 36, 1, p. 54-60 7 p.

Research output: Contribution to journalReview article

Seek and You Shall Find: Is Subclinical Amyloid More Common Than Expected?

Obici, L. & Merlini, G., Nov 1 2018, In : Mayo Clinic Proceedings. 93, 11, p. 1546-1548 3 p.

Research output: Contribution to journalEditorial

The role of clinical and neuroimaging features in the diagnosis of CADASIL

on behalf of Lombardia GENS-group, 2018, In : Journal of Neurology. 265, 12, p. 2934-2943

Research output: Contribution to journalArticle

Updated overview of molecular pathways involved in the most common monogenic autoinflammatory diseases

Lucherini, O. M., Rigante, D., Sota, J., Fabiani, C., Obici, L., Cattalini, M., Gattorno, M. & Cantarini, L., Jan 1 2018, In : Clinical and Experimental Rheumatology. 36, 1, p. 3-9 7 p.

Research output: Contribution to journalArticle

Updated overview of molecular pathways involved in the most common monogenic autoinflammatory diseases

Lucherini, O. M., Rigante, D., Sota, J., Fabiani, C., Obici, L., Cattalini, M., Gattorno, M. & Cantarini, L., 2018, In : Clinical and Experimental Rheumatology. 36, p. S3-S9

Research output: Contribution to journalArticle

Updated overview of molecular pathways involved in the most common monogenic autoinflammatory diseases

Lucherini, O. M., Rigante, D., Sota, J., Fabiani, C., Obici, L., Cattalini, M., Gattorno, M. & Cantarini, L., Jan 1 2018, In : Clinical and Experimental Rheumatology. 36, 1, p. 3-9 7 p.

Research output: Contribution to journalReview article

2017

Canakinumab reverses overexpression of inflammatory response genes in tumour necrosis factor receptor-associated periodic syndrome

Torene, R., Nirmala, N., Obici, L., Cattalini, M., Tormey, V., Caorsi, R., Starck-Schwertz, S., Letzkus, M., Hartmann, N., Abrams, K., Lachmann, H. & Gattorno, M., Jan 1 2017, In : Annals of the Rheumatic Diseases. 76, 1, p. 303-309 7 p.

Research output: Contribution to journalArticle

Canakinumab treatment for patients with active recurrent or chronic TNF receptor-associated periodic syndrome (TRAPS): an open-label, phase II study

Gattorno, M., Obici, L., Cattalini, M., Tormey, V., Abrams, K., Davis, N., Speziale, A., Bhansali, S. G., Martini, A. & Lachmann, H. J., Jan 1 2017, In : Annals of the Rheumatic Diseases. 76, 1, p. 173-178 6 p.

Research output: Contribution to journalArticle

Circulating intercellular adhesion molecule 1 (sICAM-1) in tumour necrosis factor receptor-associated periodic syndrome (TRAPS)

Cantarini, L., Pucino, V., Vitale, A., Lucherini, O. M., Obici, L. & Matarese, G., Jan 1 2017, In : Clinical and Experimental Rheumatology. 35, p. 13-14 2 p.

Research output: Contribution to journalLetter

Cryopyrin-associated periodic syndromes in Italian Patients: Evaluation of the rate of somatic NLRP3 mosaicism and phenotypic characterization

Lasigliè, D., Mensa-Vilaro, A., Ferrera, D., Caorsi, R., Penco, F., Santamaria, G., Di Duca, M., Amico, G., Nakagawa, K., Antonini, F., Tommasini, A., Consolini, R., Insalaco, A., Cattalini, M., Obici, L., Gallizzi, R., Santarelli, F., Del Zotto, G., Severino, M., Rubartelli, A. & 7 others, Ravazzolo, R., Martini, A., Ceccherini, I., Nishikomori, R., Gattorno, M., Arostegui, J. I. & Borghini, S., Nov 1 2017, In : Journal of Rheumatology. 44, 11, p. 1667-1673 7 p.

Research output: Contribution to journalArticle

Cryopyrin-associated Periodic Syndromes in Italian Patients

Lasigliè, D., Mensa-Vilaro, A., Ferrera, D., Caorsi, R., Penco, F., Santamaria, G., Di Duca, M., Amico, G., Nakagawa, K., Antonini, F., Tommasini, A., Consolini, R., Insalaco, A., Cattalini, M., Obici, L., Gallizzi, R., Santarelli, F., Del Zotto, G., Severino, M., Rubartelli, A. & 7 others, Ravazzolo, R., Martini, A., Ceccherini, I., Nishikomori, R., Gattorno, M., Arostegui, J. I. & Borghini, S., Nov 2017, In : Journal of Rheumatology. 44, 11, p. 1667-1673 7 p.

Research output: Contribution to journalArticle

Cryopyrin-associated periodic syndromes in Italian Patients: Evaluation of the rate of somatic NLRP3 mosaicism and phenotypic characterization

Lasigliè, D., Mensa-Vilaro, A., Ferrera, D., Caorsi, R., Penco, F., Santamaria, G., Di Duca, M., Amico, G., Nakagawa, K., Antonini, F., Tommasini, A., Consolini, R., Insalaco, A., Cattalini, M., Obici, L., Gallizzi, R., Santarelli, F., Del Zotto, G., Severino, M., Rubartelli, A. & 7 others, Ravazzolo, R., Martini, A., Ceccherini, I., Nishikomori, R., Gattorno, M., Arostegui, J. I. & Borghini, S., 2017, In : Journal of Rheumatology. 44, 11, p. 1667-1673 7 p.

Research output: Contribution to journalArticle