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Research Output

2019

A new genetic variant of hereditary apolipoprotein A-I amyloidosis: a case-report followed by discussion of diagnostic challenges and therapeutic options

Moutafi, M., Ziogas, D. C., Michopoulos, S., Bagratuni, T., Vasileiou, V., Verga, L., Merlini, G., Palladini, G., Matsouka, C., Dimopoulos, M. A. & Kastritis, E., Jan 21 2019, In : BMC Medical Genetics. 20, 1, 1 p.

Research output: Contribution to journalArticle

Central nervous system fungal infections in allogeneic stem cell transplantation. Outcome of 24 recent cases and literature review

Candoni, A., Facchin, G., Busca, A., Lazzarotto, D., Cattaneo, C., Nadali, G., Klimko, N., Del Principe, M. I., Castagnola, C., Verga, L., Zannier, M. E., Calore, E., Capelli, D., Perruccio, K., Melillo, L., Fanin, R. & Pagano, L., Jan 1 2019, (Accepted/In press) In : European Journal of Haematology.

Research output: Contribution to journalLetter

Fungaemia in haematological malignancies: SEIFEM-2015 survey

the SEIFEM Group (Sorveglianza Epidemiologica Infezioni nelle Emopatie), Criscuolo, M., Marchesi, F., Candoni, A., Cattaneo, C., Nosari, A., Veggia, B., Verga, L., Fracchiolla, N., Vianelli, N., Del Principe, M. I., Picardi, M., Tumbarello, M., Aversa, F., Busca, A. & Pagano, L., Jan 1 2019, In : European Journal of Clinical Investigation. 49, 5, e13083.

Research output: Contribution to journalArticle

Fungal infections of the central nervous system and paranasal sinuses in onco-haematologic patients. Epidemiological study reporting the diagnostic-therapeutic approach and outcome in 89 cases

SEIFEM Group (Epidemiological Surveillance of Infections in Haematological Diseases), Jan 1 2019, (Accepted/In press) In : Mycoses.

Research output: Contribution to journalArticle

Fungal infections of the central nervous system and paranasal sinuses in onco-haematologic patients. Epidemiological study reporting the diagnostic-therapeutic approach and outcome in 89 cases

Candoni, A., Klimko, N., Busca, A., Di Blasi, R., Shadrivova, O., Cesaro, S., Zannier, M. E., Verga, L., Forghieri, F., Calore, E., Nadali, G., Simonetti, E., Muggeo, P., Quinto, A. M., Castagnola, C., Cellini, M., Del Principe, M. I., Fracchiolla, N., Melillo, L., Piedimonte, M. & 14 others, Zama, D., Farina, F., Giusti, D., Mosna, F., Capelli, D., Delia, M., Picardi, M., Decembrino, N., Perruccio, K., Vallero, S., Aversa, F., Fanin, R., Pagano, L. & Diseases), SEIFEM. G. E. S. O. I. I. H., 2019, In : Mycoses. 62, 3, p. 252-260

Research output: Contribution to journalArticle

Prenylated Curcumin Analogues as Multipotent Tools to Tackle Alzheimer's Disease

Bisceglia, F., Seghetti, F., Serra, M., Zusso, M., Gervasoni, S., Verga, L., Vistoli, G., Lanni, C., Catanzaro, M., De Lorenzi, E. & Belluti, F., Jan 1 2019, (Accepted/In press) In : ACS Chemical Neuroscience.

Research output: Contribution to journalArticle

Simple, reliable detection of amyloid in fat aspirates using the fluorescent dye FSB: prospective study in 206 patients

Tasaki, M., Milani, P., Foli, A., Verga, L., Obici, L., Basset, M., Bozzola, M., Ferraro, G., Nuvolone, M., Morbini, P., Capello, G., Ueda, M., Obayashi, K., Paulli, M., Ando, Y., Merlini, G., Palladini, G. & Lavatelli, F., Jul 18 2019, In : Blood. 134, 3, p. 320-323 4 p.

Research output: Contribution to journalLetter

The risk of neurodegeneration in REM sleep behavior disorder: A systematic review and meta-analysis of longitudinal studies

Galbiati, A., Verga, L., Giora, E., Zucconi, M. & Ferini-Strambi, L., Feb 2019, In : Sleep Medicine Reviews. 43, p. 37-46 10 p.

Research output: Contribution to journalReview article

‘Real-life’ analysis of the role of antifungal prophylaxis in preventing invasive aspergillosis in AML patients undergoing consolidation therapy: Sorveglianza epidemiologica infezioni nelle Emopatie (SEIFEM) 2016 study

Del Principe, M. I., Dragonetti, G., Verga, L., Candoni, A., Marchesi, F., Cattaneo, C., Delia, M., Potenza, L., Farina, F., Ballanti, S., Decembrino, N., Castagnola, C., Nadali, G., Fanci, R., Orciulo, E., Veggia, B., Offidani, M., Melillo, L., Manetta, S., Tumbarello, M. & 5 others, Venditti, A., Busca, A., Aversa, F., Pagano, L. & Group, S. E. I. N. E. SEIFEM., 2019, In : Journal of Antimicrobial Chemotherapy. 74, 4, p. 1062-1068 7 p.

Research output: Contribution to journalArticle

2018

An integrated strategy to correlate aggregation state, structure and toxicity of Aß 1–42 oligomers

Bisceglia, F., Natalello, A., Serafini, M. M., Colombo, R., Verga, L., Lanni, C. & De Lorenzi, E., Oct 1 2018, In : Talanta. 188, p. 17-26 10 p.

Research output: Contribution to journalArticle

Early consolidation with high-dose therapy and autologous stem cell transplantation is a feasible and effective treatment option in HIV-associated non-Hodgkin lymphoma at high risk

Re, A., Gini, G., Rupolo, M., Levis, A., Bandera, A., Liberati, A. M., Tozzi, P., Cattaneo, C., Casari, S., Skert, C., Bocci, C., Spina, M., Allione, B., Verga, L., Michieli, M., Almici, C., Leali, P. F., Tirelli, U. & Rossi, G., Feb 1 2018, In : Bone Marrow Transplantation. 53, 2, p. 228-230 3 p.

Research output: Contribution to journalLetter

Fungal infections of the central nervous system and paranasal sinuses in onco-haematologic patients. Epidemiological study reporting the diagnostic-therapeutic approach and outcome in 89 cases

SEIFEM Group (Epidemiological Surveillance of Infections in Haematological Diseases), Dec 19 2018, In : Mycoses.

Research output: Contribution to journalArticle

SEIFEM 2017: from real life to an agreement on the use of granulocyte transfusions and colony-stimulating factors for prophylaxis and treatment of infectious complications in patients with hematologic malignant disorders

On behalf of the SEIFEM group (Sorveglianza Epidemiologica Infezioni Fungine in Ematologia), Feb 1 2018, In : Expert Review of Hematology. 11, 2, p. 155-168 14 p.

Research output: Contribution to journalReview article

SEIFEM 2017: from real life to an agreement on the use of granulocyte transfusions and colony-stimulating factors for prophylaxis and treatment of infectious complications in patients with hematologic malignant disorders

Busca, A., Cesaro, S., Teofili, L., Delia, M., Cattaneo, C., Criscuolo, M., Marchesi, F., Fracchiolla, N. S., Valentini, C. G., Farina, F., Di Blasi, R., Prezioso, L., Spolzino, A., Candoni, A., del Principe, M. I., Verga, L., Nosari, A., Aversa, F. & Pagano, L., 2018, In : Expert Review of Hematology. 11, 2, p. 155-168 14 p.

Research output: Contribution to journalArticle

2017

Cardiac Light Chain Amyloidosis: The Role of Metal Ions in Oxidative Stress and Mitochondrial Damage

Diomede, L., Romeo, M., Rognoni, P., Beeg, M., Foray, C., Ghibaudi, E., Palladini, G., Cherny, R. A., Verga, L., Capello, G. L., Perfetti, V., Fiordaliso, F., Merlini, G. & Salmona, M., Sep 20 2017, In : Antioxidants and Redox Signaling. 27, 9, p. 567-582 16 p.

Research output: Contribution to journalArticle

Cardiac Light Chain Amyloidosis: The Role of Metal Ions in Oxidative Stress and Mitochondrial Damage

Diomede, L., Romeo, M., Rognoni, P., Beeg, M., Foray, C., Ghibaudi, E., Palladini, G., Cherny, R. A., Verga, L., Capello, G. L., Perfetti, V., Fiordaliso, F., Merlini, G. & Salmona, M., Sep 20 2017, In : Antioxidants and Redox Signaling. 27, 9, p. 567-582 16 p.

Research output: Contribution to journalArticle

Randomized comparison of liposomal amphotericin B versus placebo to prevent invasive mycoses in acute lymphoblastic leukaemia

Cornely, O. A., Leguay, T., Maertens, J., Vehreschild, M. J. G. T., Anagnostopoulos, A., Castagnola, C., Verga, L., Rieger, C., Kondakci, M., Härter, G., Duarte, R. F., Allione, B., Cordonnier, C., Heussel, C. P., Morrissey, C. O., Agrawal, S. G., Peter Donnelly, J., Bresnik, M., Hawkins, M. J., Garner, W. & 31 others, Gökbuget, N., Jarchum, G., Dictar, M., Ramirez Borga, S., Valledor, A., Knoebl, P., Greil, R., Linkesch, W., Sill, H., De Prijck, B., Sonet, A., Theunissen, K., Selleslag, D., Maertens, J., Vargas Schwarzbold, A., Nucci, M. L. M., Lopes de Castro Lobo, C., Fogliatto, L., Bonmati, C., Turlure, P., Herbrecht, R., Thiebaut, A., Michallet, M., Leguay, T., Egerer, G., Gentile, G., Gobbi, M., Rossi, G., Verga, L., Castagnola, C. & behalf of the AmBiGuard Study Group, Aug 1 2017, In : Journal of Antimicrobial Chemotherapy. 72, 8, p. 2359-2367 9 p., dkx133.

Research output: Contribution to journalArticle

2015

A practical approach to the diagnosis of systemic amyloidoses

De Larrea, C. F., Verga, L., Morbini, P., Klersy, C., Lavatelli, F., Foli, A., Obici, L., Milani, P., Capello, G. L., Paulli, M., Palladini, G. & Merlini, G., Apr 2 2015, In : Blood. 125, 14, p. 2239-2244 6 p.

Research output: Contribution to journalArticle

2014

Disease-modifying anti-Alzheimer's drugs: Inhibitors of human cholinesterases interfering with β-amyloid aggregation

Brogi, S., Butini, S., Maramai, S., Colombo, R., Verga, L., Lanni, C., De Lorenzi, E., Lamponi, S., Andreassi, M., Bartolini, M., Andrisano, V., Novellino, E., Campiani, G., Brindisi, M. & Gemma, S., 2014, In : CNS Neuroscience and Therapeutics. 20, 7, p. 624-632 9 p.

Research output: Contribution to journalArticle

2013

A Strategy for Synthesis of Pathogenic Human Immunoglobulin Free Light Chains in E. coli

Rognoni, P., Lavatelli, F., Casarini, S., Palladini, G., Verga, L., Pedrazzoli, P., Valentini, G., Merlini, G. & Perfetti, V., Sep 27 2013, In : PLoS One. 8, 9, e76022.

Research output: Contribution to journalArticle

High 99mTc-DPD myocardial uptake in a patient with apolipoprotein AI-related amyloidotic cardiomyopathy

Quarta, C. C., Obici, L., Guidalotti, P. L., Pieroni, M., Longhi, S., Perlini, S., Verga, L., Merlini, G. & Rapezzi, C., Mar 2013, In : Amyloid. 20, 1, p. 48-51 4 p.

Research output: Contribution to journalArticle

How nature preserves fetuses

Adami, F., Fedrigo, M., Gervasi, M. T., Verga, L., Coccato, M., Lessi, F., Angelini, A. & Daliento, L., Mar 2013, In : Amyloid. 20, 1, p. 56-57 2 p.

Research output: Contribution to journalArticle

Multifunctional cholinesterase and amyloid beta fibrillization modulators. Synthesis and biological investigation

Butini, S., Brindisi, M., Brogi, S., Maramai, S., Guarino, E., Panico, A., Saxena, A., Chauhan, V., Colombo, R., Verga, L., De Lorenzi, E., Bartolini, M., Andrisano, V., Novellino, E., Campiani, G. & Gemma, S., Dec 12 2013, In : ACS Medicinal Chemistry Letters. 4, 12, p. 1178-1182 5 p.

Research output: Contribution to journalArticle

2012

Reliable typing of systemic amyloidoses through proteomic analysis of subcutaneous adipose tissue

Brambilla, F., Lavatelli, F., Di Silvestre, D., Valentini, V., Rossi, R., Palladini, G., Obici, L., Verga, L., Mauri, P. & Merlini, G., Feb 23 2012, In : Blood. 119, 8, p. 1844-1847 4 p.

Research output: Contribution to journalArticle

Sporadic transthyretin amyloidosis with a novel TTR gene mutation misdiagnosed as primary amyloidosis

Briani, C., Cavallaro, T., Ferrari, S., Taioli, F., Calamelli, S., Verga, L., Adami, F. & Fabrizi, G. M., Oct 2012, In : Journal of Neurology. 259, 10, p. 2226-2228 3 p.

Research output: Contribution to journalArticle

2011

Mass spectrometry-based proteomics as a diagnostic tool when immunoelectron microscopy fails in typing amyloid deposits

Lavatelli, F., Valentini, V., Palladini, G., Verga, L., Russo, P., Foli, A., Obici, L., Sarais, G., Perfetti, V., Casarini, S. & Merlini, G., Jun 2011, In : Amyloid. 18, SUPPL. 1, p. 64-66 3 p.

Research output: Contribution to journalArticle

Mass spectrometry-based proteomics as a diagnostic tool when immunoelectron microscopy fails in typing amyloid deposits.

Lavatelli, F., Valentini, V., Palladini, G., Verga, L., Russo, P., Foli, A., Obici, L., Sarais, G., Perfetti, V., Casarini, S. & Merlini, G., Jun 2011, In : Amyloid. 18 Suppl 1, p. 59-61 3 p.

Research output: Contribution to journalArticle

The role of minor salivary gland biopsy in the diagnosis of systemic amyloidosis: Results of a prospective study in 62 patients

Foli, A., Palladini, G., Caporali, R., Verga, L., Morbini, P., Obici, L., Russo, P., Sarais, G., Donadei, S., Montecucco, C. & Merlini, G., Jun 2011, In : Amyloid. 18, SUPPL. 1, p. 80-82 3 p.

Research output: Contribution to journalArticle

2010

Folding and fibrillogenesis: Clues from β2-microglobulin

Rennella, E., Corazza, A., Giorgetti, S., Fogolari, F., Viglino, P., Porcari, R., Verga, L., Stoppini, M., Bellotti, V. & Esposito, G., Aug 2010, In : Journal of Molecular Biology. 401, 2, p. 286-297 12 p.

Research output: Contribution to journalArticle

2009

CE can identify small molecules that selectively target soluble oligomers of amyloid β protein and display antifibrillogenic activity

Colombo, R., Carotti, A., Catto, M., Racchi, M., Lanni, C., Verga, L., Caccialanza, G. & De Lorenzi, E., 2009, In : Electrophoresis. 30, 8, p. 1418-1429 12 p.

Research output: Contribution to journalArticle

Identification of amyloidogenic light chains requires the combination of serum-free light chain assay with immunofixation of serum and urine

Palladini, G., Russo, P., Bosoni, T., Verga, L., Sarais, G., Lavatelli, F., Nuvolone, M., Obici, L., Casarini, S., Donadei, S., Albertini, R., Righetti, G., Marini, M., Graziani, M. S., D'Eril, G. V. M., Moratti, R. & Merlini, G., Mar 1 2009, In : Clinical Chemistry. 55, 3, p. 499-504 6 p.

Research output: Contribution to journalArticle

2008

Heparin strongly enhances the formation of β2-microglobulin amyloid fibrils in the presence of type I collagen

Relini, A., De Stefano, S., Torrassa, S., Cavalleri, O., Rolandi, R., Gliozzi, A., Giorgetti, S., Raimondi, S., Marchese, L., Verga, L., Rossi, A., Stoppini, M. & Bellotti, V., Feb 22 2008, In : Journal of Biological Chemistry. 283, 8, p. 4912-4920 9 p.

Research output: Contribution to journalArticle

2005

Proteomics of β2-microglobulin amyloid fibrils

Stoppini, M., Mangione, P., Monti, M., Giorgetti, S., Marchese, L., Arcidiaco, P., Verga, L., Segagni, S., Pucci, P., Merlini, G. & Bellotti, V., Nov 10 2005, In : Biochimica et Biophysica Acta - Proteins and Proteomics. 1753, 1, p. 23-33 11 p.

Research output: Contribution to journalArticle

2004

Liver Biopsy Discloses a New Apolipoprotein A-I Hereditary Amyloidosis in Several Unrelated Italian Families

Obici, L., Palladini, G., Giorgetti, S., Bellotti, V., Gregorini, G., Arbustini, E., Verga, L., Marciano, S., Donadei, S., Perfetti, V., Calabresi, L., Bergonzi, C., Scolari, F. & Merlini, G., May 2004, In : Gastroenterology. 126, 5, p. 1416-1422 7 p.

Research output: Contribution to journalArticle

2003

Loss of lamin A/C expression revealed by immuno-electron microscopy in dilated cardiomyopathy with atrioventricular block caused by LMNA gene defects

Verga, L., Concardi, M., Pilotto, A., Bellini, O., Pasotti, M., Repetto, A., Tavazzi, L. & Arbustini, E., Nov 2003, In : Virchows Archiv. 443, 5, p. 664-671 8 p.

Research output: Contribution to journalArticle

2002
1999

Infantile neuroaxonal dystrophy: Clinical spectrum and diagnostic criteria

Nardocci, N., Zorzi, G., Farina, L., Binelli, S., Scaioli, W., Ciano, C., Verga, L., Angelini, L., Savoiardo, M. & Bugiani, O., Apr 22 1999, In : Neurology. 52, 7, p. 1472-1478 7 p.

Research output: Contribution to journalArticle

Infantile neuroaxonal dystrophy: Neuroradiological studies in 11 patients

Farina, L., Nardocci, N., Bruzzone, M. G., D'Incerti, L., Zorzi, G., Verga, L., Morbin, M. & Savoiardo, M., May 1999, In : Neuroradiology. 41, 5, p. 376-380 5 p.

Research output: Contribution to journalArticle

The new apolipoprotein A-I variant Leu174 → Ser causes hereditary cardiac amyloidosis, and the amyloid fibrils are constituted by the 93- residue N-terminal polypeptide

Obici, L., Bellotti, V., Mangione, P., Stoppini, M., Arbustini, E., Verga, L., Zorzoli, I., Anesi, E., Zanotti, G., Campana, C., Vigano, M. & Merlini, G., 1999, In : American Journal of Pathology. 155, 3, p. 695-702 8 p.

Research output: Contribution to journalArticle

1998

Restrictive cardiomyopathy, atrioventricular block and mild to subclinical myopathy in patients with desmin-immunoreactive material deposits

Arbustini, E., Morbini, P., Grasso, M., Fasani, R., Verga, L., Bellini, O., Dal Bello, B., Campana, C., Piccolo, G., Febo, O., Opasich, C., Gavazzi, A. & Ferrans, V. J., 1998, In : Journal of the American College of Cardiology. 31, 3, p. 645-653 9 p.

Research output: Contribution to journalArticle

1997

Light and electron microscopy immunohistochemical characterization of amyloid deposits

Arbustini, E., Morbini, P., Verga, L., Concardi, M., Porcu, E., Pilotto, A., Zorzoli, I., Garini, P., Anesi, E. & Merlini, G., 1997, In : Amyloid. 4, 3, p. 157-170 14 p.

Research output: Contribution to journalArticle

1996

Human synovial mast cells: I. Ultrastructural in situ and in vitro immunologic characterization

De Paulis, A., Marinò, I., Ciccarelli, A., De Crescenzo, G., Concardi, M., Verga, L., Arbustini, E. & Marone, G., Jul 1996, In : Arthritis and Rheumatism. 39, 7, p. 1222-1233 12 p.

Research output: Contribution to journalArticle

βPP and tau interaction: A possible link between amyloid and neurofibrillary tangles in Alzheimer's disease

Giaccone, G., Pedrotti, B., Migheli, A., Verga, L., Perez, J., Racagni, G., Smith, M. A., Perry, G., De Gioia, L., Selvaggini, C., Salmona, M., Ghiso, J., Frangione, B., Islam, K., Bugiani, O. & Tagliavini, F., Jan 1996, In : American Journal of Pathology. 148, 1, p. 79-87 9 p.

Research output: Contribution to journalArticle

1995

Diffuse senile plaques: amorphous or fibrous?

Bugiani, O., Tagliavini, F., Giaccone, G., Verga, L., el-Hachimi, K., Foncin, J. F. & Frangione, B., Mar 1995, In : American Journal of Pathology. 146, 3, p. 777-779 3 p.

Research output: Contribution to journalArticle

1994

A neurotoxic prion protein fragment induces rat astroglial proliferation and hypertrophy

Forloni, G., Del Bo, R., Angeretti, N., Chiesa, R., Smiroldo, S., Doni, R., Ghibaudi, E., Salmona, M., Porro, M., Verga, L., Giaccone, G., Bugiani, O. & Tagliavini, F., 1994, In : European Journal of Neuroscience. 6, 9, p. 1415-1422 8 p.

Research output: Contribution to journalArticle

1993

A68 is a component of paired helical filaments of Gerstmann-Sträussler-Scheinker disease, Indiana kindred

Tagliavini, F., Giaccone, G., Prelli, F., Verga, L., Porro, M., Trojanowski, J. Q., Farlow, M. R., Frangione, B., Ghetti, B. & Bugiani, O., Jul 9 1993, In : Brain Research. 616, 1-2, p. 325-329 5 p.

Research output: Contribution to journalArticle

Apoptosis mediated neurotoxicity induced by chronic application of β amyloid fragment 25-35

Forloni, G., Chiesa, R., Smiroldo, S., Verga, L., Salmona, M., Tagliavini, F. & Angeretti, N., 1993, In : NeuroReport. 4, 5, p. 523-526 4 p.

Research output: Contribution to journalArticle