1993 …2019

Research output per year

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Research Output

2018

Targeting the human epidermal growth factor receptor 2 (HER2) oncogene in colorectal cancer

Siena, S., Sartore-Bianchi, A., Marsoni, S., Hurwitz, H. I., McCall, S. J., Penault-Llorca, F., Srock, S., Bardelli, A. & Trusolino, L., May 1 2018, In : Annals of Oncology. 29, 5, p. 1108-1119 12 p.

Research output: Contribution to journalReview article

2019

Adaptive mutability of colorectal cancers in response to targeted therapies

Russo, M., Crisafulli, G., Sogari, A., Reilly, N. M., Arena, S., Lamba, S., Bartolini, A., Amodio, V., Magrì, A., Novara, L., Sarotto, I., Nagel, Z. D., Piett, C. G., Amatu, A., Sartore-Bianchi, A., Siena, S., Bertotti, A., Trusolino, L., Corigliano, M., Gherardi, M. & 3 others, Lagomarsino, M. C., Di Nicolantonio, F. & Bardelli, A., Dec 20 2019, In : Science. 366, 6472, p. 1473-1480 8 p.

Research output: Contribution to journalArticle

Combined blockade of MEK and PI3KCA as an effective antitumor strategy in HER2 gene amplified human colorectal cancer models

Belli, V., Matrone, N., Napolitano, S., Migliardi, G., Cottino, F., Bertotti, A., Trusolino, L., Martinelli, E., Morgillo, F., Ciardiello, D., De Falco, V., Giunta, E. F., Bracale, U., Ciardiello, F. & Troiani, T., Jun 4 2019, In : Journal of experimental & clinical cancer research : CR. 38, 1, p. 236

Research output: Contribution to journalArticle

Evolving neoantigen profiles in colorectal cancers with DNA repair defects

Rospo, G., Lorenzato, A., Amirouchene-Angelozzi, N., Magrì, A., Cancelliere, C., Corti, G., Negrino, C., Amodio, V., Montone, M., Bartolini, A., Barault, L., Novara, L., Isella, C., Medico, E., Bertotti, A., Trusolino, L., Germano, G., Di Nicolantonio, F. & Bardelli, A., Jun 28 2019, In : Genome Medicine. 11, 1, p. 42

Research output: Contribution to journalArticle

HER2 Positivity Predicts Unresponsiveness to EGFR-Targeted Treatment in Metastatic Colorectal Cancer

Sartore-Bianchi, A., Amatu, A., Porcu, L., Ghezzi, S., Lonardi, S., Leone, F., Bergamo, F., Fenocchio, E., Martinelli, E., Borelli, B., Tosi, F., Racca, P., Valtorta, E., Bonoldi, E., Martino, C., Vaghi, C., Marrapese, G., Ciardiello, F., Zagonel, V., Bardelli, A. & 4 others, Trusolino, L., Torri, V., Marsoni, S. & Siena, S., Oct 2019, In : The oncologist. 24, 10, p. 1395-1402 8 p.

Research output: Contribution to journalArticle

HER2 Positivity Predicts Unresponsiveness to EGFR-Targeted Treatment in Metastatic Colorectal Cancer

Sartore-Bianchi, A., Amatu, A., Porcu, L., Ghezzi, S., Lonardi, S., Leone, F., Bergamo, F., Fenocchio, E., Martinelli, E., Borelli, B., Tosi, F., Racca, P., Valtorta, E., Bonoldi, E., Martino, C., Vaghi, C., Marrapese, G., Ciardiello, F., Zagonel, V., Bardelli, A. & 4 others, Trusolino, L., Torri, V., Marsoni, S. & Siena, S., Oct 2019, In : Oncologist. 24, 10, p. 1395-1402 8 p.

Research output: Contribution to journalArticle

Immunogenomics of Colorectal Tumors: Facts and Hypotheses on an Evolving Saga

Catalano, I., Grassi, E., Bertotti, A. & Trusolino, L., Dec 2019, In : Trends in Cancer. 5, 12, p. 779-788 10 p.

Research output: Contribution to journalReview article

INKA, an integrative data analysis pipeline for phosphoproteomic inference of active kinases.

Beekhof, R., van Alphen, C., Henneman, A. A., Knol, J. C., Pham, T. V., Rolfs, F., Labots, M., Henneberry, E., Le Large, T. Y., de Haas, R. R., Piersma, S. R., Vurchio, V., Bertotti, A., Trusolino, L., Verheul, H. M. & Jimenez, C. R., Apr 1 2019, In : Molecular Systems Biology. 15, p. e8250

Research output: Contribution to journalArticle

Patient-Derived Xenografts and Matched Cell Lines Identify Pharmacogenomic Vulnerabilities in Colorectal Cancer

Lazzari, L., Corti, G., Picco, G., Isella, C., Montone, M., Arcella, P., Durinikova, E., Zanella, E. R., Novara, L., Barbosa, F., Cassingena, A., Cancelliere, C., Medico, E., Sartore-Bianchi, A., Siena, S., Garnett, M. J., Bertotti, A., Trusolino, L., Di Nicolantonio, F., Linnebacher, M. & 2 others, Bardelli, A. & Arena, S., Oct 15 2019, In : Clin. Cancer Res.. 25, 20, p. 6243-6259 17 p.

Research output: Contribution to journalArticle

Plasma HER2 (ERBB2) Copy Number Predicts Response to HER2-targeted Therapy in Metastatic Colorectal Cancer

Siravegna, G., Sartore-Bianchi, A., Nagy, R. J., Raghav, K., Odegaard, J. I., Lanman, R. B., Trusolino, L., Marsoni, S., Siena, S. & Bardelli, A., May 15 2019, In : Clin. Cancer Res.. 25, 10, p. 3046-3053 8 p.

Research output: Contribution to journalArticle

Prioritization of cancer therapeutic targets using CRISPR–Cas9 screens

Behan, F. M., Iorio, F., Picco, G., Gonçalves, E., Beaver, C. M., Migliardi, G., Santos, R., Rao, Y., Sassi, F., Pinnelli, M., Ansari, R., Harper, S., Jackson, D. A., McRae, R., Pooley, R., Wilkinson, P., van der Meer, D., Dow, D., Buser-Doepner, C., Bertotti, A. & 5 others, Trusolino, L., Stronach, E. A., Saez-Rodriguez, J., Yusa, K. & Garnett, M. J., Apr 25 2019, In : Nature. 568, 7753, p. 511-516 6 p.

Research output: Contribution to journalArticle

The Stromal and Immune Landscape of Colorectal Cancer Progression during Anti-EGFR Therapy

Catalano, I. & Trusolino, L., Jul 8 2019, In : Cancer Cell. 36, 1, p. 1-3 3 p.

Research output: Contribution to journalArticle