1993 …2019

Research output per year

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Research Output

2019

Adaptive mutability of colorectal cancers in response to targeted therapies

Russo, M., Crisafulli, G., Sogari, A., Reilly, N. M., Arena, S., Lamba, S., Bartolini, A., Amodio, V., Magrì, A., Novara, L., Sarotto, I., Nagel, Z. D., Piett, C. G., Amatu, A., Sartore-Bianchi, A., Siena, S., Bertotti, A., Trusolino, L., Corigliano, M., Gherardi, M. & 3 others, Lagomarsino, M. C., Di Nicolantonio, F. & Bardelli, A., Dec 20 2019, In : Science. 366, 6472, p. 1473-1480 8 p.

Research output: Contribution to journalArticle

Combined blockade of MEK and PI3KCA as an effective antitumor strategy in HER2 gene amplified human colorectal cancer models

Belli, V., Matrone, N., Napolitano, S., Migliardi, G., Cottino, F., Bertotti, A., Trusolino, L., Martinelli, E., Morgillo, F., Ciardiello, D., De Falco, V., Giunta, E. F., Bracale, U., Ciardiello, F. & Troiani, T., Jun 4 2019, In : Journal of experimental & clinical cancer research : CR. 38, 1, p. 236

Research output: Contribution to journalArticle

Evolving neoantigen profiles in colorectal cancers with DNA repair defects

Rospo, G., Lorenzato, A., Amirouchene-Angelozzi, N., Magrì, A., Cancelliere, C., Corti, G., Negrino, C., Amodio, V., Montone, M., Bartolini, A., Barault, L., Novara, L., Isella, C., Medico, E., Bertotti, A., Trusolino, L., Germano, G., Di Nicolantonio, F. & Bardelli, A., Jun 28 2019, In : Genome Medicine. 11, 1, p. 42

Research output: Contribution to journalArticle

HER2 Positivity Predicts Unresponsiveness to EGFR-Targeted Treatment in Metastatic Colorectal Cancer

Sartore-Bianchi, A., Amatu, A., Porcu, L., Ghezzi, S., Lonardi, S., Leone, F., Bergamo, F., Fenocchio, E., Martinelli, E., Borelli, B., Tosi, F., Racca, P., Valtorta, E., Bonoldi, E., Martino, C., Vaghi, C., Marrapese, G., Ciardiello, F., Zagonel, V., Bardelli, A. & 4 others, Trusolino, L., Torri, V., Marsoni, S. & Siena, S., Oct 2019, In : The oncologist. 24, 10, p. 1395-1402 8 p.

Research output: Contribution to journalArticle

HER2 Positivity Predicts Unresponsiveness to EGFR-Targeted Treatment in Metastatic Colorectal Cancer

Sartore-Bianchi, A., Amatu, A., Porcu, L., Ghezzi, S., Lonardi, S., Leone, F., Bergamo, F., Fenocchio, E., Martinelli, E., Borelli, B., Tosi, F., Racca, P., Valtorta, E., Bonoldi, E., Martino, C., Vaghi, C., Marrapese, G., Ciardiello, F., Zagonel, V., Bardelli, A. & 4 others, Trusolino, L., Torri, V., Marsoni, S. & Siena, S., Oct 2019, In : Oncologist. 24, 10, p. 1395-1402 8 p.

Research output: Contribution to journalArticle

Immunogenomics of Colorectal Tumors: Facts and Hypotheses on an Evolving Saga

Catalano, I., Grassi, E., Bertotti, A. & Trusolino, L., Dec 2019, In : Trends in Cancer. 5, 12, p. 779-788 10 p.

Research output: Contribution to journalReview article

INKA, an integrative data analysis pipeline for phosphoproteomic inference of active kinases.

Beekhof, R., van Alphen, C., Henneman, A. A., Knol, J. C., Pham, T. V., Rolfs, F., Labots, M., Henneberry, E., Le Large, T. Y., de Haas, R. R., Piersma, S. R., Vurchio, V., Bertotti, A., Trusolino, L., Verheul, H. M. & Jimenez, C. R., Apr 1 2019, In : Molecular Systems Biology. 15, p. e8250

Research output: Contribution to journalArticle

Patient-Derived Xenografts and Matched Cell Lines Identify Pharmacogenomic Vulnerabilities in Colorectal Cancer

Lazzari, L., Corti, G., Picco, G., Isella, C., Montone, M., Arcella, P., Durinikova, E., Zanella, E. R., Novara, L., Barbosa, F., Cassingena, A., Cancelliere, C., Medico, E., Sartore-Bianchi, A., Siena, S., Garnett, M. J., Bertotti, A., Trusolino, L., Di Nicolantonio, F., Linnebacher, M. & 2 others, Bardelli, A. & Arena, S., Oct 15 2019, In : Clin. Cancer Res.. 25, 20, p. 6243-6259 17 p.

Research output: Contribution to journalArticle

Plasma HER2 (ERBB2) Copy Number Predicts Response to HER2-targeted Therapy in Metastatic Colorectal Cancer

Siravegna, G., Sartore-Bianchi, A., Nagy, R. J., Raghav, K., Odegaard, J. I., Lanman, R. B., Trusolino, L., Marsoni, S., Siena, S. & Bardelli, A., May 15 2019, In : Clin. Cancer Res.. 25, 10, p. 3046-3053 8 p.

Research output: Contribution to journalArticle

Prioritization of cancer therapeutic targets using CRISPR–Cas9 screens

Behan, F. M., Iorio, F., Picco, G., Gonçalves, E., Beaver, C. M., Migliardi, G., Santos, R., Rao, Y., Sassi, F., Pinnelli, M., Ansari, R., Harper, S., Jackson, D. A., McRae, R., Pooley, R., Wilkinson, P., van der Meer, D., Dow, D., Buser-Doepner, C., Bertotti, A. & 5 others, Trusolino, L., Stronach, E. A., Saez-Rodriguez, J., Yusa, K. & Garnett, M. J., Apr 25 2019, In : Nature. 568, 7753, p. 511-516 6 p.

Research output: Contribution to journalArticle

The Stromal and Immune Landscape of Colorectal Cancer Progression during Anti-EGFR Therapy

Catalano, I. & Trusolino, L., Jul 8 2019, In : Cancer Cell. 36, 1, p. 1-3 3 p.

Research output: Contribution to journalArticle

2018

A molecularly annotated model of patient-Derived colon cancer stem–Like cells to assess genetic and nongenetic mechanisms of resistance to anti- EGFR therapy

Luraghi, P., Bigatto, V., Cipriano, E., Reato, G., Orzan, F., Sassi, F., De Bacco, F., Isella, C., Bellomo, S. E., Medico, E., Comoglio, P. M., Bertotti, A., Trusolino, L. & Boccaccio, C., Feb 15 2018, In : Clinical Cancer Research. 24, 4, p. 807-820 14 p.

Research output: Contribution to journalArticle

Known and novel roles of the MET oncogene in cancer: A coherent approach to targeted therapy

Comoglio, P. M., Trusolino, L. & Boccaccio, C., Jun 1 2018, In : Nature Reviews Cancer. 18, 6, p. 341-358 18 p.

Research output: Contribution to journalReview article

Radiologic and Genomic Evolution of Individual Metastases during HER2 Blockade in Colorectal Cancer

Siravegna, G., Lazzari, L., Crisafulli, G., Sartore-Bianchi, A., Mussolin, B., Cassingena, A., Martino, C., Lanman, R. B., Nagy, R. J., Fairclough, S., Rospo, G., Corti, G., Bartolini, A., Arcella, P., Montone, M., Lodi, F., Lorenzato, A., Vanzati, A., Valtorta, E., Cappello, G. & 17 others, Bertotti, A., Lonardi, S., Zagonel, V., Leone, F., Russo, M., Balsamo, A., Truini, M., Di Nicolantonio, F., Amatu, A., Bonazzina, E., Ghezzi, S., Regge, D., Vanzulli, A., Trusolino, L., Siena, S., Marsoni, S. & Bardelli, A., Jul 9 2018, In : Cancer Cell. 34, 1, p. 148-162.e7

Research output: Contribution to journalArticle

Radiologic and Genomic Evolution of Individual Metastases during HER2 Blockade in Colorectal Cancer

Siravegna, G., Lazzari, L., Crisafulli, G., Sartore-Bianchi, A., Mussolin, B., Cassingena, A., Martino, C., Lanman, R. B., Nagy, R. J., Fairclough, S., Rospo, G., Corti, G., Bartolini, A., Arcella, P., Montone, M., Lodi, F., Lorenzato, A., Vanzati, A., Valtorta, E., Cappello, G. & 17 others, Bertotti, A., Lonardi, S., Zagonel, V., Leone, F., Russo, M., Balsamo, A., Truini, M., Di Nicolantonio, F., Amatu, A., Bonazzina, E., Ghezzi, S., Regge, D., Vanzulli, A., Trusolino, L., Siena, S., Marsoni, S. & Bardelli, A., Jul 9 2018, In : Cancer Cell. 34, 1, p. 148-162.e7

Research output: Contribution to journalArticle

RET fusions in a small subset of advanced colorectal cancers at risk of being neglected

Pietrantonio, F., Di Nicolantonio, F., Schrock, A. B., Lee, J., Morano, F., Fucà, G., Nikolinakos, P., Drilon, A., Hechtman, J. F., Christiansen, J., Gowen, K., Frampton, G. M., Gasparini, P., Rossini, D., Gigliotti, C., Kim, S. T., Prisciandaro, M., Hodgson, J., Zaniboni, A., Chiu, V. K. & 16 others, Milione, M., Patel, R., Miller, V., Bardelli, A., Novara, L., Wang, L., Pupa, S. M., Sozzi, G., Ross, J., Di Bartolomeo, M., Bertotti, A., Ali, S., Trusolino, L., Falcone, A., de Braud, F. & Cremolini, C., Jun 1 2018, In : Annals of Oncology. 29, 6, p. 1394-1401 8 p.

Research output: Contribution to journalArticle

RET fusions in a small subset of advanced colorectal cancers at risk of being neglected

Pietrantonio, F., Di Nicolantonio, F., Schrock, A. B., Lee, J., Morano, F., Fuca, G., Nikolinakos, P., Drilon, A., Hechtman, J. F., Christiansen, J., Gowen, K., Frampton, G. M., Gasparini, P., Rossini, D., Gigliotti, C., Kim, S. T., Prisciandaro, M., Hodgson, J., Zaniboni, A., Chiu, V. K. & 16 others, Milione, M., Patel, R., Miller, V., Bardelli, A., Novara, L., Wang, L., Pupa, S. M., Sozzi, G., Ross, J., Di Bartolomeo, M., Bertotti, A., Ali, S., Trusolino, L., Falcone, A., de Braud, F. & Cremolini, C., Jun 1 2018, In : Annals of oncology : official journal of the European Society for Medical Oncology. 29, 6, p. 1394-1401 8 p.

Research output: Contribution to journalArticle

Targeting the human epidermal growth factor receptor 2 (HER2) oncogene in colorectal cancer

Siena, S., Sartore-Bianchi, A., Marsoni, S., Hurwitz, H. I., McCall, S. J., Penault-Llorca, F., Srock, S., Bardelli, A. & Trusolino, L., May 1 2018, In : Annals of Oncology. 29, 5, p. 1108-1119 12 p.

Research output: Contribution to journalReview article

2017

A Molecularly Annotated Model of Patient-Derived Colon Cancer Stem-Like Cells to Assess Genetic and Nongenetic Mechanisms of Resistance to Anti-EGFR Therapy.

Luraghi, P., Bigatto, V., Cipriano, E., Reato, G., Orzan, F., Sassi, F., De Bacco, F., Isella, C., Bellomo, S. E., Medico, E., Comoglio, P. M., Bertotti, A., Trusolino, L. & Boccaccio, C., Oct 1 2017, In : Clinical Cancer Research.

Research output: Contribution to journalArticle

Interrogating open issues in cancer precision medicine with patient-derived xenografts

Byrne, A. T., Alférez, D. G., Amant, F., Annibali, D., Arribas, J., Biankin, A. V., Bruna, A., Budinská, E., Caldas, C., Chang, D. K., Clarke, R. B., Clevers, H., Coukos, G., Dangles-Marie, V., Gail Eckhardt, S., Gonzalez-Suarez, E., Hermans, E., Hidalgo, M., Jarzabek, M. A., De Jong, S. & 22 others, Jonkers, J., Kemper, K., Lanfrancone, L., Mælandsmo, G. M., Marangoni, E., Marine, J. C., Medico, E., Norum, J. H., Palmer, H. G., Peeper, D. S., Pelicci, P. G., Piris-Gimenez, A., Roman-Roman, S., Rueda, O. M., Seoane, J., Serra, V., Soucek, L., Vanhecke, D., Villanueva, A., Vinolo, E., Bertotti, A. & Trusolino, L., Apr 1 2017, In : Nature Reviews Cancer. 17, 4, p. 254-268 15 p.

Research output: Contribution to journalReview article

Interrogating open issues in cancer precision medicine with patient-derived xenografts

Byrne, A. T., Alférez, D. G., Amant, F., Annibali, D., Arribas, J., Biankin, A. V., Bruna, A., Budinská, E., Caldas, C., Chang, D. K., Clarke, R. B., Clevers, H., Coukos, G., Dangles-Marie, V., Gail Eckhardt, S., Gonzalez-Suarez, E., Hermans, E., Hidalgo, M., Jarzabek, M. A., De Jong, S. & 22 others, Jonkers, J., Kemper, K., Lanfrancone, L., Mælandsmo, G. M., Marangoni, E., Marine, J-C., Medico, E., Norum, J. H., Palmer, H. G., Peeper, D. S., Pelicci, P. G., Piris-Gimenez, A., Roman-Roman, S., Rueda, O. M., Seoane, J., Serra, V., Soucek, L., Vanhecke, D., Villanueva, A., Vinolo, E., Bertotti, A. & Trusolino, L., 2017, In : Nature Reviews Cancer. 17, 4, p. 254-268 15 p.

Research output: Contribution to journalArticle

PDX-MI: Minimal information for patient-derived tumor xenograft models

Meehan, T. F., Conte, N., Goldstein, T., Inghirami, G., Murakami, M. A., Brabetz, S., Gu, Z., Wiser, J. A., Dunn, P., Begley, D. A., Krupke, D. M., Bertotti, A., Bruna, A., Brush, M. H., Byrne, A. T., Caldas, C., Christie, A. L., Clark, D. A., Dowst, H., Dry, J. R. & 34 others, Doroshow, J. H., Duchamp, O., Evrard, Y. A., Ferretti, S., Frese, K. K., Goodwin, N. C., Greenawalt, D., Haendel, M. A., Hermans, E., Houghton, P. J., Jonkers, J., Kemper, K., Khor, T. O., Lewis, M. T., Lloyd, K. C. K., Mason, J., Medico, E., Neuhauser, S. B., Olson, J. M., Peeper, D. S., Rueda, O. M., Seong, J. K., Trusolino, L., Vinolo, E., Wechsler-Reya, R. J., Weinstock, D. M., Welm, A., Weroha, S. J., Amant, F., Pfister, S. M., Kool, M., Parkinson, H., Butte, A. J. & Bult, C. J., Nov 1 2017, In : Cancer Research. 77, 21, p. e62-e66

Research output: Contribution to journalArticle

Selective analysis of cancer-cell intrinsic transcriptional traits defines novel clinically relevant subtypes of colorectal cancer

Isella, C., Brundu, F., Bellomo, S. E., Galimi, F., Zanella, E., Porporato, R., Petti, C., Fiori, A., Orzan, F., Senetta, R., Boccaccio, C., Ficarra, E., Marchionni, L., Trusolino, L., Medico, E. & Bertotti, A., May 31 2017, In : Nature Communications. 8, 15107.

Research output: Contribution to journalArticle

2016

A module of inflammatory cytokines defines resistance of colorectal cancer to EGFR inhibitors

Gelfo, V., Rodia, M. T., Pucci, M., Dall'Ora, M., Santi, S., Solmi, R., Roth, L., Lindzen, M., Bonafè, M., Bertotti, A., Caramelli, E., Lollini, P. L., Trusolino, L., Yarden, Y., D'Uva, G. & Lauriola, M., 2016, In : Oncotarget. 7, 44, p. 72167-72183 17 p.

Research output: Contribution to journalArticle

A module of inflammatory cytokines defines resistance of colorectal cancer to EGFR inhibitors

Gelfo, V., Rodia, M. T., Pucci, M., Dall'Ora, M., Santi, S., Solmi, R., Roth, L., Lindzen, M., Bonafè, M., Bertotti, A., Caramelli, E., Lollini, P. L., Trusolino, L., Yarden, Y., D'Uva, G. & Lauriola, M., 2016, In : Oncotarget. 7, 44, p. 72167-72183 17 p.

Research output: Contribution to journalArticle

C-met inhibition blocks bone metastasis development induced by renal cancer stem cells

D'Amico, L., Belisario, D., Migliardi, G., Grange, C., Bussolati, B., D'Amelio, P., Perera, T., Dalmasso, E., Carbonare, L. D., Godio, L., Comoglio, P., Trusolino, L., Ferracini, R. & Roato, I., 2016, In : Oncotarget. 7, 29, p. 45525-45537 13 p.

Research output: Contribution to journalArticle

Dual-targeted therapy with trastuzumab and lapatinib in treatment-refractory, KRAS codon 12/13 wild-type, HER2-positive metastatic colorectal cancer (HERACLES): A proof-of-concept, multicentre, open-label, phase 2 trial

Sartore-Bianchi, A., Trusolino, L., Martino, C., Bencardino, K., Lonardi, S., Bergamo, F., Zagonel, V., Leone, F., Depetris, I., Martinelli, E., Troiani, T., Ciardiello, F., Racca, P., Bertotti, A., Siravegna, G., Torri, V., Amatu, A., Ghezzi, S., Marrapese, G., Palmeri, L. & 10 others, Valtorta, E., Cassingena, A., Lauricella, C., Vanzulli, A., Regge, D., Veronese, S., Comoglio, P. M., Bardelli, A., Marsoni, S. & Siena, S., 2016, In : The Lancet Oncology.

Research output: Contribution to journalArticle

Dual-targeted therapy with trastuzumab and lapatinib in treatment-refractory, KRAS codon 12/13 wild-type, HER2-positive metastatic colorectal cancer (HERACLES): A proof-of-concept, multicentre, open-label, phase 2 trial

Sartore-Bianchi, A., Trusolino, L., Martino, C., Bencardino, K., Lonardi, S., Bergamo, F., Zagonel, V., Leone, F., Depetris, I., Martinelli, E., Troiani, T., Ciardiello, F., Racca, P., Bertotti, A., Siravegna, G., Torri, V., Amatu, A., Ghezzi, S., Marrapese, G., Palmeri, L. & 10 others, Valtorta, E., Cassingena, A., Lauricella, C., Vanzulli, A., Regge, D., Veronese, S., Comoglio, P. M., Bardelli, A., Marsoni, S. & Siena, S., Jun 2016, In : The Lancet Oncology. 17, 6, p. 738-46 9 p.

Research output: Contribution to journalArticle

Dual-targeted therapy with trastuzumab and lapatinib in treatment-refractory, KRAS codon 12/13 wild-type, HER2-positive metastatic colorectal cancer (HERACLES): A proof-of-concept, multicentre, open-label, phase 2 trial

Sartore-Bianchi, A., Trusolino, L., Martino, C., Bencardino, K., Lonardi, S., Bergamo, F., Zagonel, V., Leone, F., Depetris, I., Martinelli, E., Troiani, T., Ciardiello, F., Racca, P., Bertotti, A., Siravegna, G., Torri, V., Amatu, A., Ghezzi, S., Marrapese, G., Palmeri, L. & 10 others, Valtorta, E., Cassingena, A., Lauricella, C., Vanzulli, A., Regge, D., Veronese, S., Comoglio, P. M., Bardelli, A., Marsoni, S. & Siena, S., 2016, (Accepted/In press) In : The Lancet Oncology.

Research output: Contribution to journalArticle

Lenalidomide normalizes tumor vessels in colorectal cancer improving chemotherapy activity

Leuci, V., Maione, F., Rotolo, R., Giraudo, E., Sassi, F., Migliardi, G., Todorovic, M., Gammaitoni, L., Mesiano, G., Giraudo, L., Luraghi, P., Leone, F., Bussolino, F., Grignani, G., Aglietta, M., Trusolino, L., Bertotti, A. & Sangiolo, D., May 5 2016, In : Journal of Translational Medicine. 14, 1, 119.

Research output: Contribution to journalArticle

MM-151 overcomes acquired resistance to cetuximab and panitumumab in colorectal cancers harboring EGFR extracellular domain mutations

Arena, S., Siravegna, G., Mussolin, B., Kearns, J. D., Wolf, B. B., Misale, S., Lazzari, L., Bertotti, A., Trusolino, L., Adjei, A. A., Montagut, C., Di Nicolantonio, F., Nering, R. & Bardelli, A., Feb 3 2016, In : Science Translational Medicine. 8, 324, 324ra14.

Research output: Contribution to journalArticle

Rebound effects caused by withdrawal of MET Kinase inhibitor are quenched by a MET Therapeutic antibody

Pupo, E., Ducano, N., Lupo, B., Vigna, E., Avanzato, D., Perera, T., Trusolino, L., Lanzetti, L. & Comoglio, P. M., Sep 1 2016, In : Cancer Research. 76, 17, p. 5019-5029 11 p.

Research output: Contribution to journalArticle

Tankyrase inhibition impairs directional migration and invasion of lung cancer cells by affecting microtubule dynamics and polarity signals

Lupo, B., Vialard, J., Sassi, F., Angibaud, P., Puliafito, A., Pupo, E., Lanzetti, L., Comoglio, P. M., Bertotti, A. & Trusolino, L., Jan 19 2016, In : BMC Biology. 14, 1, 5.

Research output: Contribution to journalArticle

2015

A diphtheria toxin resistance marker for in vitro and in vivo selection of stably transduced human cells

Picco, G., Petti, C., Trusolino, L., Bertotti, A. & Medico, E., Sep 30 2015, In : Scientific Reports. 5, 14721.

Research output: Contribution to journalArticle

HER2 activating mutations are targets for colorectal cancer treatment

Kavuri, S. M., Jain, N., Galimi, F., Cottino, F., Leto, S. M., Migliardi, G., Searleman, A. C., Shen, W., Monsey, J., Trusolino, L., Jacobs, S. A., Bertotti, A. & Bose, R., Aug 1 2015, In : Cancer Discovery. 5, 8, p. 832-841 10 p.

Research output: Contribution to journalArticle

IGF2 is an actionable target that identifies a distinct subpopulation of colorectal cancer patients with marginal response to anti-EGFR therapies

Zanella, E. R., Galimi, F., Sassi, F., Migliardi, G., Cottino, F., Leto, S. M., Lupo, B., Erriquez, J., Isella, C., Comoglio, P. M., Medico, E., Tejpar, S., Budinská, E., Trusolino, L. & Bertotti, A., Jan 28 2015, In : Science Translational Medicine. 7, 272, 272ra12.

Research output: Contribution to journalArticle

MEK plus PI3K/mTORC1/2 Therapeutic Efficacy Is Impacted by TP53 Mutation in Preclinical Models of Colorectal Cancer

García-García, C., Rivas, M. A., Ibrahim, Y. H., Calvo, M. T., Gris-Oliver, A., Rodríguez, O., Grueso, J., Antón, P., Guzmán, M., Aura, C., Nuciforo, P., Jessen, K., Argilés, G., Dienstmann, R., Bertotti, A., Trusolino, L., Matito, J., Vivancos, A., Chicote, I., Palmer, H. G. & 4 others, Tabernero, J., Scaltriti, M., Baselga, J. & Serra, V., Dec 15 2015, In : Clinical Cancer Research. 21, 24, p. 5499-5510 12 p.

Research output: Contribution to journalArticle

Stromal contribution to the colorectal cancer transcriptome

Isella, C., Terrasi, A., Bellomo, S. E., Petti, C., Galatola, G., Muratore, A., Mellano, A., Senetta, R., Cassenti, A., Sonetto, C., Inghirami, G., Trusolino, L., Fekete, Z., De Ridder, M., Cassoni, P., Storme, G., Bertotti, A. & Medico, E., Apr 28 2015, In : Nature Genetics. 47, 4, p. 312-319 8 p.

Research output: Contribution to journalArticle

Sustained Inhibition of HER3 and EGFR Is Necessary to Induce Regression of HER2-Amplified Gastrointestinal Carcinomas

Leto, S. M., Sassi, F., Catalano, I., Torri, V., Migliardi, G., Zanella, E. R., Throsby, M., Bertotti, A. & Trusolino, L., Dec 15 2015, In : Clinical Cancer Research. 21, 24, p. 5519-5531 13 p.

Research output: Contribution to journalArticle

The genomic landscape of response to EGFR blockade in colorectal cancer

Bertotti, A., Papp, E., Jones, S., Adleff, V., Anagnostou, V., Lupo, B., Sausen, M., Phallen, J., Hruban, C. A., Tokheim, C., Niknafs, N., Nesselbush, M., Lytle, K., Sassi, F., Cottino, F., Migliardi, G., Zanella, E. R., Ribero, D., Russolillo, N., Mellano, A. & 15 others, Muratore, A., Paraluppi, G., Salizzoni, M., Marsoni, S., Kragh, M., Lantto, J., Cassingena, A., Li, Q. K., Karchin, R., Scharpf, R., Sartore-Bianchi, A., Siena, S., Diaz, L. A., Trusolino, L. & Velculescu, V. E., Oct 8 2015, In : Nature. 526, 7572, p. 263-267 5 p.

Research output: Contribution to journalArticle

Vertical suppression of the EGFR pathway prevents onset of resistance in colorectal cancers

Misale, S., Bozic, I., Tong, J., Peraza-Penton, A., Lallo, A., Baldi, F., Lin, K. H., Truini, M., Trusolino, L., Bertotti, A., Di Nicolantonio, F., Nowak, M. A., Zhang, L., Wood, K. C. & Bardelli, A., Sep 22 2015, In : Nature Communications. 6, 8305.

Research output: Contribution to journalArticle

2014

An 'in-cell trial' to assess the efficacy of a monovalent anti-MET antibody as monotherapy and in association with standard cytotoxics

Benvenuti, S., Gentile, A., Lazzari, L., Arnesano, A., Trusolino, L. & Comoglio, P. M., Mar 2014, In : Molecular Oncology. 8, 2, p. 378-388 11 p.

Research output: Contribution to journalArticle

Anti-cancer effect and gene modulation of ET-743 in human biliary tract carcinoma preclinical models

Peraldo-Neia, C., Cavalloni, G., Soster, M., Gammaitoni, L., Marchiò, S., Sassi, F., Trusolino, L., Bertotti, A., Medico, E., Capussotti, L., Aglietta, M. & Leone, F., Dec 5 2014, In : BMC Cancer. 14, 1, 918.

Research output: Contribution to journalArticle

Intrinsic resistance to MEK inhibition in kras mutant lung and colon cancer through transcriptional induction of ERBB3

Sun, C., Hobor, S., Bertotti, A., Zecchin, D., Huang, S., Galimi, F., Cottino, F., Prahallad, A., Grernrum, W., Tzani, A., Schlicker, A., Wessels, L. F. A., Smit, E. F., Thunnissen, E., Halonen, P., Lieftink, C., Beijersbergen, R. L., DiNicolantonio, F., Bardelli, A., Trusolino, L. & 1 others, Bernards, R., Oct 4 2014, In : Cell Reports. 7, 1, p. 86-93 8 p.

Research output: Contribution to journalArticle

MET dysregulation is a hallmark of aggressive disease in multiple myeloma patients

Rocci, A., Gambella, M., Aschero, S., Baldi, I., Trusolino, L., Cavallo, F., Gay, F., Larocca, A., Magarotto, V., Omedè, P., Isaia, G., Bertotti, A., Liberati, A. M., Catalano, L., De Rosa, L., Musto, P., Vallone, R., Falcone, A., Drandi, D., Ladetto, M. & 3 others, Comoglio, P. M., Boccadoro, M. & Palumbo, A., Mar 2014, In : British Journal of Haematology. 164, 6, p. 841-850 10 p.

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MET signaling in colon cancer stem-like cells blunts the therapeutic response to EGFR inhibitors

Luraghi, P., Reato, G., Cipriano, E., Sassi, F., Orzan, F., Bigatto, V., De Bacco, F., Menietti, E., Han, M., Rideout, W. M., Perera, T., Bertotti, A., Trusolino, L., Comoglio, P. M. & Boccaccio, C., Mar 15 2014, In : Cancer Research. 74, 6, p. 1857-1869 13 p.

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Microenvironment-derived HGF overcomes genetically determined sensitivity to anti-MET drugs

Pennacchietti, S., Cazzanti, M., Bertotti, A., Rideout, W. M., Han, M., Gyuris, J., Perera, T., Comoglio, P. M., Trusolino, L. & Michieli, P., Nov 15 2014, In : Cancer Research. 74, 22, p. 6598-6609 12 p.

Research output: Contribution to journalArticle