1993 …2019

Research output per year

If you made any changes in Pure these will be visible here soon.

Research Output

Activation of HER family members in gastric carcinoma cells mediates resistance to MET inhibition

Corso, S., Ghiso, E., Cepero, V., Sierra, J. R., Migliore, C., Bertotti, A., Trusolino, L., Comoglio, P. M. & Giordano, S., May 26 2010, In : Molecular Cancer. 9, 121.

Research output: Contribution to journalArticle

Adaptive mutability of colorectal cancers in response to targeted therapies

Russo, M., Crisafulli, G., Sogari, A., Reilly, N. M., Arena, S., Lamba, S., Bartolini, A., Amodio, V., Magrì, A., Novara, L., Sarotto, I., Nagel, Z. D., Piett, C. G., Amatu, A., Sartore-Bianchi, A., Siena, S., Bertotti, A., Trusolino, L., Corigliano, M., Gherardi, M. & 3 others, Lagomarsino, M. C., Di Nicolantonio, F. & Bardelli, A., Dec 20 2019, In : Science. 366, 6472, p. 1473-1480 8 p.

Research output: Contribution to journalArticle

Adhesion properties and integrin expression of cultured human osteoclast-like cells

Grano, M., Zigrino, P., Colucci, S., Zambonin, G., Trusolino, L., Serra, M., Baldini, N., Teti, A., Marchisio, P. C. & Zallone, A. Z., 1994, In : Experimental Cell Research. 212, 2, p. 209-218 10 p.

Research output: Contribution to journalArticle

A diphtheria toxin resistance marker for in vitro and in vivo selection of stably transduced human cells

Picco, G., Petti, C., Trusolino, L., Bertotti, A. & Medico, E., Sep 30 2015, In : Scientific Reports. 5, 14721.

Research output: Contribution to journalArticle

Altered expression of α6 integrin subunit in oral squamous cell carcinoma and oral potentially malignant lesions

Garzino-Demo, P., Carrozzo, M., Trusolino, L., Savoia, P., Gandolfo, S. & Marchisio, P. C., May 1998, In : Oral Oncology. 34, 3, p. 204-210 7 p.

Research output: Contribution to journalArticle

A module of inflammatory cytokines defines resistance of colorectal cancer to EGFR inhibitors

Gelfo, V., Rodia, M. T., Pucci, M., Dall'Ora, M., Santi, S., Solmi, R., Roth, L., Lindzen, M., Bonafè, M., Bertotti, A., Caramelli, E., Lollini, P. L., Trusolino, L., Yarden, Y., D'Uva, G. & Lauriola, M., 2016, In : Oncotarget. 7, 44, p. 72167-72183 17 p.

Research output: Contribution to journalArticle

A module of inflammatory cytokines defines resistance of colorectal cancer to EGFR inhibitors

Gelfo, V., Rodia, M. T., Pucci, M., Dall'Ora, M., Santi, S., Solmi, R., Roth, L., Lindzen, M., Bonafè, M., Bertotti, A., Caramelli, E., Lollini, P. L., Trusolino, L., Yarden, Y., D'Uva, G. & Lauriola, M., 2016, In : Oncotarget. 7, 44, p. 72167-72183 17 p.

Research output: Contribution to journalArticle

A molecularly annotated model of patient-Derived colon cancer stem–Like cells to assess genetic and nongenetic mechanisms of resistance to anti- EGFR therapy

Luraghi, P., Bigatto, V., Cipriano, E., Reato, G., Orzan, F., Sassi, F., De Bacco, F., Isella, C., Bellomo, S. E., Medico, E., Comoglio, P. M., Bertotti, A., Trusolino, L. & Boccaccio, C., Feb 15 2018, In : Clinical Cancer Research. 24, 4, p. 807-820 14 p.

Research output: Contribution to journalArticle

A Molecularly Annotated Model of Patient-Derived Colon Cancer Stem-Like Cells to Assess Genetic and Nongenetic Mechanisms of Resistance to Anti-EGFR Therapy.

Luraghi, P., Bigatto, V., Cipriano, E., Reato, G., Orzan, F., Sassi, F., De Bacco, F., Isella, C., Bellomo, S. E., Medico, E., Comoglio, P. M., Bertotti, A., Trusolino, L. & Boccaccio, C., Oct 1 2017, In : Clinical Cancer Research.

Research output: Contribution to journalArticle

A molecularly annotated platform of patient- derived xenografts ("xenopatients") identifies HER2 as an effective therapeutic target in cetuximab-resistant colorectal cancer

Bertotti, A., Migliardi, G., Galimi, F., Sassi, F., Torti, D., Isella, C., Corà, D., di Nicolantonio, F., Buscarino, M., Petti, C., Ribero, D., Russolillo, N., Muratore, A., Massucco, P., Pisacane, A., Molinaro, L., Valtorta, E., Sartore-Bianchi, A., Risio, M., Capussotti, L. & 8 others, Gambacorta, M., Siena, S., Medico, E., Sapino, A., Marsoni, S., Comoglio, P. M., Bardelli, A. & Trusolino, L., Nov 2011, In : Cancer Discovery. 1, 6, p. 508-523 16 p.

Research output: Contribution to journalArticle

A monoclonal antibody identifies a novel GPI-anchored glycoprotein involved in epithelial intercellular adhesion

Rabino, M., Trusolino, L., Prat, M., Cremona, O., Savoia, P. & Marchisio, P. C., Jun 1994, In : Journal of Cell Science. 107, 6, p. 1413-1428 16 p.

Research output: Contribution to journalArticle

Amplification of the MET receptor drives resistance to anti-EGFR therapies in colorectal cancer

Bardelli, A., Corso, S., Bertotti, A., Hobor, S., Valtorta, E., Siravegna, G., Sartore-Bianchi, A., Scala, E., Cassingena, A., Zecchin, D., Apicella, M., Migliardi, G., Galimi, F., Lauricella, C., Zanon, C., Perera, T., Veronese, S., Corti, G., Amatu, A., Gambacorta, M. & 8 others, Diaz, L. A., Sausen, M., Velculescu, V. E., Comoglio, P., Trusolino, L., Di Nicolantonio, F., Giordano, S. & Siena, S., 2013, In : Cancer Discovery. 3, 6, p. 658-673 16 p.

Research output: Contribution to journalArticle

Animal research: Temper Italy's strict lab-animal law

Trusolino, L. & Bertotti, A., 2013, In : Nature. 501, 7465, p. 33 1 p.

Research output: Contribution to journalArticle

An 'in-cell trial' to assess the efficacy of a monovalent anti-MET antibody as monotherapy and in association with standard cytotoxics

Benvenuti, S., Gentile, A., Lazzari, L., Arnesano, A., Trusolino, L. & Comoglio, P. M., Mar 2014, In : Molecular Oncology. 8, 2, p. 378-388 11 p.

Research output: Contribution to journalArticle

A novel GPI-anchored glycoprotein shows properties of a coohterminus truncated cadherin involved in cell-cell contacts of cultured human epithelial cells

Trusolino, L., Rabino, M., Prat, M., Cremona, O., Savoia, P. & Marchisio, P. C., Jan 1993, In : Cytotechnology. 11, 1 Supplement

Research output: Contribution to journalArticle

Anti-cancer effect and gene modulation of ET-743 in human biliary tract carcinoma preclinical models

Peraldo-Neia, C., Cavalloni, G., Soster, M., Gammaitoni, L., Marchiò, S., Sassi, F., Trusolino, L., Bertotti, A., Medico, E., Capussotti, L., Aglietta, M. & Leone, F., Dec 5 2014, In : BMC Cancer. 14, 1, 918.

Research output: Contribution to journalArticle

A preclinical algorithm of soluble surrogate biomarkers that correlate with therapeutic inhibition of the MET oncogene in gastric tumors

Torti, D., Sassi, F., Galimi, F., Gastaldi, S., Perera, T., Comoglio, P. M., Trusolino, L. & Bertotti, A., Mar 15 2012, In : International Journal of Cancer. 130, 6, p. 1357-1366 10 p.

Research output: Contribution to journalArticle

A signaling adapter function for α6β4 integrin in the control of HGF-dependent invasive growth

Trusolino, L., Bertotti, A. & Comoglio, P. M., Nov 30 2001, In : Cell. 107, 5, p. 643-654 12 p.

Research output: Contribution to journalArticle

Autoantibodies against a 72-kDa ductal cell membrane glycoprotein in a patient affected by Sjögren's syndrome and gastric MALT lymphoma

Folli, F., Perego, L., Ponzoni, M., Girardi, A. M., Bosi, E., Ferreri, A. J. M., Bellone, M., Sabbadini, M. G., Marchisio, P. C., Vicari, A. M. & Trusolino, L., 2002, In : Annals of Hematology. 81, 10, p. 597-602 6 p.

Research output: Contribution to journalArticle

Cancer: The matrix is now in control

Comoglio, P. M. & Trusolino, L., Nov 2005, In : Nature Medicine. 11, 11, p. 1156-1159 4 p.

Research output: Contribution to journalArticle

Changes in integrin and E-cadherin expression in neoplastic versus normal thyroid tissue

Serini, G., Trusolino, L., Saggiorato, E., Cremona, O., De Rossi, M., Angeli, A., Orlandi, F. & Marchisio, P. C., Apr 3 1996, In : Journal of the National Cancer Institute. 88, 7, p. 442-449 8 p.

Research output: Contribution to journalArticle

C-met inhibition blocks bone metastasis development induced by renal cancer stem cells

D'Amico, L., Belisario, D., Migliardi, G., Grange, C., Bussolati, B., D'Amelio, P., Perera, T., Dalmasso, E., Carbonare, L. D., Godio, L., Comoglio, P., Trusolino, L., Ferracini, R. & Roato, I., 2016, In : Oncotarget. 7, 29, p. 45525-45537 13 p.

Research output: Contribution to journalArticle

Combined blockade of MEK and PI3KCA as an effective antitumor strategy in HER2 gene amplified human colorectal cancer models

Belli, V., Matrone, N., Napolitano, S., Migliardi, G., Cottino, F., Bertotti, A., Trusolino, L., Martinelli, E., Morgillo, F., Ciardiello, D., De Falco, V., Giunta, E. F., Bracale, U., Ciardiello, F. & Troiani, T., Jun 4 2019, In : Journal of experimental & clinical cancer research : CR. 38, 1, p. 236

Research output: Contribution to journalArticle

Differential integrin expression in thyroid and laryngeal carcinomas

Carlevato, M. T., Trusolino, L., Serini, G., Valente, G., Orlandi, F., Angeli, A., Cortesina, G. & Marchisio, P. C., Jul 1996, In : Anticancer Research. 16, 4 C, p. 2379-2384 6 p.

Research output: Contribution to journalArticle

Drug development of MET inhibitors: Targeting oncogene addiction and expedience

Comoglio, P. M., Giordano, S. & Trusolino, L., Jun 2008, In : Nature Reviews Drug Discovery. 7, 6, p. 504-516 13 p.

Research output: Contribution to journalArticle

Dual-targeted therapy with trastuzumab and lapatinib in treatment-refractory, KRAS codon 12/13 wild-type, HER2-positive metastatic colorectal cancer (HERACLES): A proof-of-concept, multicentre, open-label, phase 2 trial

Sartore-Bianchi, A., Trusolino, L., Martino, C., Bencardino, K., Lonardi, S., Bergamo, F., Zagonel, V., Leone, F., Depetris, I., Martinelli, E., Troiani, T., Ciardiello, F., Racca, P., Bertotti, A., Siravegna, G., Torri, V., Amatu, A., Ghezzi, S., Marrapese, G., Palmeri, L. & 10 others, Valtorta, E., Cassingena, A., Lauricella, C., Vanzulli, A., Regge, D., Veronese, S., Comoglio, P. M., Bardelli, A., Marsoni, S. & Siena, S., Jun 2016, In : The Lancet Oncology. 17, 6, p. 738-46 9 p.

Research output: Contribution to journalArticle

Dual-targeted therapy with trastuzumab and lapatinib in treatment-refractory, KRAS codon 12/13 wild-type, HER2-positive metastatic colorectal cancer (HERACLES): A proof-of-concept, multicentre, open-label, phase 2 trial

Sartore-Bianchi, A., Trusolino, L., Martino, C., Bencardino, K., Lonardi, S., Bergamo, F., Zagonel, V., Leone, F., Depetris, I., Martinelli, E., Troiani, T., Ciardiello, F., Racca, P., Bertotti, A., Siravegna, G., Torri, V., Amatu, A., Ghezzi, S., Marrapese, G., Palmeri, L. & 10 others, Valtorta, E., Cassingena, A., Lauricella, C., Vanzulli, A., Regge, D., Veronese, S., Comoglio, P. M., Bardelli, A., Marsoni, S. & Siena, S., 2016, In : The Lancet Oncology.

Research output: Contribution to journalArticle

Dual-targeted therapy with trastuzumab and lapatinib in treatment-refractory, KRAS codon 12/13 wild-type, HER2-positive metastatic colorectal cancer (HERACLES): A proof-of-concept, multicentre, open-label, phase 2 trial

Sartore-Bianchi, A., Trusolino, L., Martino, C., Bencardino, K., Lonardi, S., Bergamo, F., Zagonel, V., Leone, F., Depetris, I., Martinelli, E., Troiani, T., Ciardiello, F., Racca, P., Bertotti, A., Siravegna, G., Torri, V., Amatu, A., Ghezzi, S., Marrapese, G., Palmeri, L. & 10 others, Valtorta, E., Cassingena, A., Lauricella, C., Vanzulli, A., Regge, D., Veronese, S., Comoglio, P. M., Bardelli, A., Marsoni, S. & Siena, S., 2016, (Accepted/In press) In : The Lancet Oncology.

Research output: Contribution to journalArticle

Erratum: Only a subset of met-activated pathways are required to sustain oncogene addiction (Science Signaling (2009) 2 (er11)

Bertotti, A., Burbridge, M. F., Gastaldi, S., Galimi, F., Torti, D., Medico, E., Giordano, S., Corso, S., Rolland-Valognes, G., Lockhart, B. P., Hickman, J. A., Comoglio, P. M. & Trusolino, L., Dec 22 2009, In : Science Signaling. 2, 102

Research output: Contribution to journalArticle

Erratum: Sema3E-Plexin D1 signaling drives human cancer cell invasiveness and metastatic spreading in mice (Journal of Clinical Investigation (2010) 120:8 (2684-2698) DOI: 10.1172/JCI42118)

Casazza, A., Finisguerra, V., Capparuccia, L., Camperi, A., Swiercz, J. M., Rizzolio, S., Rolny, C., Christensen, C., Bertotti, A., Sarotto, I., Risio, M., Trusolino, L., Weitz, J., Schneider, M., Mazzone, M., Comoglio, P. M. & Tamagnone, L., Dec 2 2013, In : Journal of Clinical Investigation. 123, 12, p. 5411 1 p.

Research output: Contribution to journalArticle

Erratum: Autoantibodies against a 72-kDa ductal cell membrane glycoprotein in a patient affected by Sjögren's syndrome and gastric MALT lymphoma (Annals of Hematology (2002) vol. 81 (597-602))

Folli, F., Perego, L., Ponzoni, M., Girardi, A. M., Bosi, E., Ferreri, A. J. M., Bellone, M., Sabbadini, M. G., Marchisio, P. C., Vicari, A. M. & Trusolino, L., Mar 1 2003, In : Annals of Hematology. 82, 3, p. 203 1 p.

Research output: Contribution to journalArticle

Evolving neoantigen profiles in colorectal cancers with DNA repair defects

Rospo, G., Lorenzato, A., Amirouchene-Angelozzi, N., Magrì, A., Cancelliere, C., Corti, G., Negrino, C., Amodio, V., Montone, M., Bartolini, A., Barault, L., Novara, L., Isella, C., Medico, E., Bertotti, A., Trusolino, L., Germano, G., Di Nicolantonio, F. & Bardelli, A., Jun 28 2019, In : Genome Medicine. 11, 1, p. 42

Research output: Contribution to journalArticle

Genetic and expression analysis of MET, MACC1, and HGF in metastatic colorectal cancer: Response to Met inhibition in patient xenografts and pathologic correlations

Galimi, F., Torti, D., Sassi, F., Isella, C., Corà, D., Gastaldi, S., Ribero, D., Muratore, A., Massucco, P., Siatis, D., Paraluppi, G., Gonella, F., Maione, F., Pisacane, A., David, E., Torchio, B., Risio, M., Salizzoni, M., Capussotti, L., Perera, T. & 5 others, Medico, E., Di Renzo, M. F., Comoglio, P. M., Trusolino, L. & Bertotti, A., May 15 2011, In : Clinical Cancer Research. 17, 10, p. 3146-3156 11 p.

Research output: Contribution to journalArticle

Growth factor-dependent activation of αvβ3 integrin in normal epithelial cells: Implications for tumor invasion

Trusolino, L., Serini, G., Cecchini, G., Besati, C., Ambesi-Impiombato, F. S., Marchisio, P. C. & De Filippi, R., Aug 24 1998, In : Journal of Cell Biology. 142, 4, p. 1145-1156 12 p.

Research output: Contribution to journalArticle

HER2 activating mutations are targets for colorectal cancer treatment

Kavuri, S. M., Jain, N., Galimi, F., Cottino, F., Leto, S. M., Migliardi, G., Searleman, A. C., Shen, W., Monsey, J., Trusolino, L., Jacobs, S. A., Bertotti, A. & Bose, R., Aug 1 2015, In : Cancer Discovery. 5, 8, p. 832-841 10 p.

Research output: Contribution to journalArticle

HER2 Positivity Predicts Unresponsiveness to EGFR-Targeted Treatment in Metastatic Colorectal Cancer

Sartore-Bianchi, A., Amatu, A., Porcu, L., Ghezzi, S., Lonardi, S., Leone, F., Bergamo, F., Fenocchio, E., Martinelli, E., Borelli, B., Tosi, F., Racca, P., Valtorta, E., Bonoldi, E., Martino, C., Vaghi, C., Marrapese, G., Ciardiello, F., Zagonel, V., Bardelli, A. & 4 others, Trusolino, L., Torri, V., Marsoni, S. & Siena, S., Oct 2019, In : Oncologist. 24, 10, p. 1395-1402 8 p.

Research output: Contribution to journalArticle

HER2 Positivity Predicts Unresponsiveness to EGFR-Targeted Treatment in Metastatic Colorectal Cancer

Sartore-Bianchi, A., Amatu, A., Porcu, L., Ghezzi, S., Lonardi, S., Leone, F., Bergamo, F., Fenocchio, E., Martinelli, E., Borelli, B., Tosi, F., Racca, P., Valtorta, E., Bonoldi, E., Martino, C., Vaghi, C., Marrapese, G., Ciardiello, F., Zagonel, V., Bardelli, A. & 4 others, Trusolino, L., Torri, V., Marsoni, S. & Siena, S., Oct 2019, In : The oncologist. 24, 10, p. 1395-1402 8 p.

Research output: Contribution to journalArticle

HGF/scatter factor selectively promotes cell invasion by increasing integrin avidity

Trusolino, L., Cavassa, S., Angelini, P., Ando, M., Bertotti, A., Comoglio, P. M. & Boccaccio, C., 2000, In : FASEB Journal. 14, 11, p. 1629-1640 12 p.

Research output: Contribution to journalArticle

Hypertension-associated point mutations in the adducin α and β subunits affect actin cytoskeleton and ion transport

Tripodi, G., Valtorta, F., Torielli, L., Chieregatti, E., Salardi, S., Trusolino, L., Menegon, A., Ferrari, P., Marchisio, P. C. & Bianchi, G., Jun 15 1996, In : Journal of Clinical Investigation. 97, 12, p. 2815-2822 8 p.

Research output: Contribution to journalArticle

IGF2 is an actionable target that identifies a distinct subpopulation of colorectal cancer patients with marginal response to anti-EGFR therapies

Zanella, E. R., Galimi, F., Sassi, F., Migliardi, G., Cottino, F., Leto, S. M., Lupo, B., Erriquez, J., Isella, C., Comoglio, P. M., Medico, E., Tejpar, S., Budinská, E., Trusolino, L. & Bertotti, A., Jan 28 2015, In : Science Translational Medicine. 7, 272, 272ra12.

Research output: Contribution to journalArticle

Immunofluorescence of cultured cells.

Marchisio, P. C. & Trusolino, L., 1999, In : Methods in molecular biology (Clifton, N.J.). 96, p. 85-92 8 p.

Research output: Contribution to journalArticle

Immunogenomics of Colorectal Tumors: Facts and Hypotheses on an Evolving Saga

Catalano, I., Grassi, E., Bertotti, A. & Trusolino, L., Dec 2019, In : Trends in Cancer. 5, 12, p. 779-788 10 p.

Research output: Contribution to journalReview article

Inhibition of experimental IgA nephropathy by colchicine.

Amore, A., Peruzzi, L., Gianoglio, B., Cirina, P., Brusa, P., Cavallo, F., Trusolino, L., Sena, L. M., Marchisio, P. C. & Coppo, R., 1995, In : Contributions to Nephrology. 111, p. 155-160 6 p.

Research output: Contribution to journalArticle

Inhibition of MEK and PI3K/mTOR suppresses tumor growth but does not cause tumor regression in patient-derived xenografts of RAS-mutant colorectal carcinomas

Migliardi, G., Sassi, F., Torti, D., Galimi, F., Zanella, E. R., Buscarino, M., Ribero, D., Muratore, A., Massucco, P., Pisacane, A., Risio, M., Capussotti, L., Marsoni, S., Di Nicolantonio, F., Bardelli, A., Comoglio, P. M., Trusolino, L. & Bertotti, A., May 1 2012, In : Clinical Cancer Research. 18, 9, p. 2515-2525 11 p.

Research output: Contribution to journalArticle

Inhibition of Src impairs the growth of met-addicted gastric tumors

Bertotti, A., Bracco, C., Girolami, F., Torti, D., Gastaldi, S., Galimi, F., Medico, E., Elvin, P., Comoglio, P. M. & Trusolino, L., Aug 1 2010, In : Clinical Cancer Research. 16, 15, p. 3933-3943 11 p.

Research output: Contribution to journalArticle