1993 …2019

Research output per year

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Research Output

2014

NOTCH3 signaling regulates MUSASHI-1 expression in metastatic colorectal cancer cells

Pastó, A., Serafin, V., Pilotto, G., Lago, C., Bellio, C., Trusolino, L., Bertotti, A., Hoey, T., Plateroti, M., Esposito, G., Pinazza, M., Agostini, M., Nitti, D., Amadori, A. & Indraccolo, S., Apr 1 2014, In : Cancer Research. 74, 7, p. 2106-2118 13 p.

Research output: Contribution to journalArticle

Patient-derived Xenograft models: An emerging platform for translational cancer research

Hidalgo, M., Amant, F., Biankin, A. V., Budinská, E., Byrne, A. T., Caldas, C., Clarke, R. B., de Jong, S., Jonkers, J., Mælandsmo, G. M., Roman-Roman, S., Seoane, J., Trusolino, L. & Villanueva, A., 2014, In : Cancer Discovery. 4, 9, p. 998-1013 16 p.

Research output: Contribution to journalArticle

Targeting the MET gene for the treatment of non-small-cell lung cancer

Gelsomino, F., Facchinetti, F., Haspinger, E. R., Garassino, M. C., Trusolino, L., De Braud, F. & Tiseo, M., Feb 2014, In : Critical Reviews in Oncology/Hematology. 89, 2, p. 284-299 16 p.

Research output: Contribution to journalArticle

The ROR1 pseudokinase diversifies signaling outputs in MET-addicted cancer cells

Gentile, A., Lazzari, L., Benvenuti, S., Trusolino, L. & Comoglio, P. M., Nov 15 2014, In : International Journal of Cancer. 135, 10, p. 2305-2316 12 p.

Research output: Contribution to journalArticle

2013

Amplification of the MET receptor drives resistance to anti-EGFR therapies in colorectal cancer

Bardelli, A., Corso, S., Bertotti, A., Hobor, S., Valtorta, E., Siravegna, G., Sartore-Bianchi, A., Scala, E., Cassingena, A., Zecchin, D., Apicella, M., Migliardi, G., Galimi, F., Lauricella, C., Zanon, C., Perera, T., Veronese, S., Corti, G., Amatu, A., Gambacorta, M. & 8 others, Diaz, L. A., Sausen, M., Velculescu, V. E., Comoglio, P., Trusolino, L., Di Nicolantonio, F., Giordano, S. & Siena, S., 2013, In : Cancer Discovery. 3, 6, p. 658-673 16 p.

Research output: Contribution to journalArticle

Animal research: Temper Italy's strict lab-animal law

Trusolino, L. & Bertotti, A., 2013, In : Nature. 501, 7465, p. 33 1 p.

Research output: Contribution to journalArticle

Erratum: Sema3E-Plexin D1 signaling drives human cancer cell invasiveness and metastatic spreading in mice (Journal of Clinical Investigation (2010) 120:8 (2684-2698) DOI: 10.1172/JCI42118)

Casazza, A., Finisguerra, V., Capparuccia, L., Camperi, A., Swiercz, J. M., Rizzolio, S., Rolny, C., Christensen, C., Bertotti, A., Sarotto, I., Risio, M., Trusolino, L., Weitz, J., Schneider, M., Mazzone, M., Comoglio, P. M. & Tamagnone, L., Dec 2 2013, In : Journal of Clinical Investigation. 123, 12, p. 5411 1 p.

Research output: Contribution to journalArticle

Met signaling regulates growth, repopulating potential and basal cell-fate commitment of mammary luminal progenitors: Implications for basal-like breast cancer

Gastaldi, S., Sassi, F., Accornero, P., Torti, D., Galimi, F., Migliardi, G., Molyneux, G., Perera, T., Comoglio, P. M., Boccaccio, C., Smalley, M. J., Bertotti, A. & Trusolino, L., Mar 14 2013, In : Oncogene. 32, 11, p. 1428-1440 13 p.

Research output: Contribution to journalArticle

2012

A preclinical algorithm of soluble surrogate biomarkers that correlate with therapeutic inhibition of the MET oncogene in gastric tumors

Torti, D., Sassi, F., Galimi, F., Gastaldi, S., Perera, T., Comoglio, P. M., Trusolino, L. & Bertotti, A., Mar 15 2012, In : International Journal of Cancer. 130, 6, p. 1357-1366 10 p.

Research output: Contribution to journalArticle

Inhibition of MEK and PI3K/mTOR suppresses tumor growth but does not cause tumor regression in patient-derived xenografts of RAS-mutant colorectal carcinomas

Migliardi, G., Sassi, F., Torti, D., Galimi, F., Zanella, E. R., Buscarino, M., Ribero, D., Muratore, A., Massucco, P., Pisacane, A., Risio, M., Capussotti, L., Marsoni, S., Di Nicolantonio, F., Bardelli, A., Comoglio, P. M., Trusolino, L. & Bertotti, A., May 1 2012, In : Clinical Cancer Research. 18, 9, p. 2515-2525 11 p.

Research output: Contribution to journalArticle

2011

A molecularly annotated platform of patient- derived xenografts ("xenopatients") identifies HER2 as an effective therapeutic target in cetuximab-resistant colorectal cancer

Bertotti, A., Migliardi, G., Galimi, F., Sassi, F., Torti, D., Isella, C., Corà, D., di Nicolantonio, F., Buscarino, M., Petti, C., Ribero, D., Russolillo, N., Muratore, A., Massucco, P., Pisacane, A., Molinaro, L., Valtorta, E., Sartore-Bianchi, A., Risio, M., Capussotti, L. & 8 others, Gambacorta, M., Siena, S., Medico, E., Sapino, A., Marsoni, S., Comoglio, P. M., Bardelli, A. & Trusolino, L., Nov 2011, In : Cancer Discovery. 1, 6, p. 508-523 16 p.

Research output: Contribution to journalArticle

Genetic and expression analysis of MET, MACC1, and HGF in metastatic colorectal cancer: Response to Met inhibition in patient xenografts and pathologic correlations

Galimi, F., Torti, D., Sassi, F., Isella, C., Corà, D., Gastaldi, S., Ribero, D., Muratore, A., Massucco, P., Siatis, D., Paraluppi, G., Gonella, F., Maione, F., Pisacane, A., David, E., Torchio, B., Risio, M., Salizzoni, M., Capussotti, L., Perera, T. & 5 others, Medico, E., Di Renzo, M. F., Comoglio, P. M., Trusolino, L. & Bertotti, A., May 15 2011, In : Clinical Cancer Research. 17, 10, p. 3146-3156 11 p.

Research output: Contribution to journalArticle

Oncogene addiction as a foundational rationale for targeted anti-cancer therapy: Promises and perils

Torti, D. & Trusolino, L., Nov 2011, In : EMBO Molecular Medicine. 3, 11, p. 623-636 14 p.

Research output: Contribution to journalArticle

Ror1 is a pseudokinase that is crucial for met-driven tumorigenesis

Gentile, A., Lazzari, L., Benvenuti, S., Trusolino, L. & Comoglio, P. M., Apr 15 2011, In : Cancer Research. 71, 8, p. 3132-3141 10 p.

Research output: Contribution to journalArticle

Sema3E - Plexin D1 signaling drives human cancer cell invasiveness and metastatic spreading in mice (The Journal of Clinical Investigation (2010) 120, 8, (2684-26980) DOI: 10.1172/JCI42118)

Casazza, A., Finisguerra, V., Capparuccia, L., Camperi, A., Swiercz, J. M., Rizzolio, S., Rolny, C., Christensen, C., Bertotti, A., Sarotto, I., Risio, M., Trusolino, L., Weitz, J., Schneider, M., Mazzone, M., Comoglio, P. M. & Tamagnone, L., Jul 2011, In : Journal of Clinical Investigation. 121, 7, p. 2945 1 p.

Research output: Contribution to journalArticle

2010

Activation of HER family members in gastric carcinoma cells mediates resistance to MET inhibition

Corso, S., Ghiso, E., Cepero, V., Sierra, J. R., Migliore, C., Bertotti, A., Trusolino, L., Comoglio, P. M. & Giordano, S., May 26 2010, In : Molecular Cancer. 9, 121.

Research output: Contribution to journalArticle

Inhibition of Src impairs the growth of met-addicted gastric tumors

Bertotti, A., Bracco, C., Girolami, F., Torti, D., Gastaldi, S., Galimi, F., Medico, E., Elvin, P., Comoglio, P. M. & Trusolino, L., Aug 1 2010, In : Clinical Cancer Research. 16, 15, p. 3933-3943 11 p.

Research output: Contribution to journalArticle

MET signalling: Principles and functions in development, organ regeneration and cancer

Trusolino, L., Bertotti, A. & Comoglio, P. M., Dec 2010, In : Nature Reviews Molecular Cell Biology. 11, 12, p. 834-848 15 p.

Research output: Contribution to journalArticle

Sema3E-Plexin D1 signaling drives human cancer cell invasiveness and metastatic spreading in mice

Casazza, A., Finisguerra, V., Capparuccia, L., Camperi, A., Swiercz, J. M., Rizzolio, S., Rolny, C., Christensen, C., Bertotti, A., Sarotto, I., Risio, M., Trusolino, L., Weitz, J., Schneider, M., Mazzone, M., Comoglio, P. M. & Tamagnone, L., Aug 2 2010, In : Journal of Clinical Investigation. 120, 8, p. 2684-2698 15 p.

Research output: Contribution to journalArticle

The Met oncogene and basal-like breast cancer: another culprit to watch out for?

Gastaldi, S., Comoglio, P. M. & Trusolino, L., 2010, In : Breast Cancer Research. 12, 4, p. 208 1 p.

Research output: Contribution to journalArticle

The tetraspanin CD151 is required for Met-dependent signaling and tumor cell growth

Franco, M., Muratori, C., Corso, S., Tenaglia, E., Bertotti, A., Capparuccia, L., Trusolino, L., Comoglio, P. M. & Tamagnone, L., Dec 10 2010, In : Journal of Biological Chemistry. 285, 50, p. 38756-38764 9 p.

Research output: Contribution to journalArticle

2009

Erratum: Only a subset of met-activated pathways are required to sustain oncogene addiction (Science Signaling (2009) 2 (er11)

Bertotti, A., Burbridge, M. F., Gastaldi, S., Galimi, F., Torti, D., Medico, E., Giordano, S., Corso, S., Rolland-Valognes, G., Lockhart, B. P., Hickman, J. A., Comoglio, P. M. & Trusolino, L., Dec 22 2009, In : Science Signaling. 2, 102

Research output: Contribution to journalArticle

Only a subset of met-activated pathways are required to sustain oncogene addiction

Bertotti, A., Burbridge, M. F., Gastaldi, S., Galimi, F., Torti, D., Medico, E., Giordano, S., Corso, S., Rolland-Valognes, G., Lockhart, B. P., Hickman, J. A., Comoglio, P. M. & Trusolino, L., Dec 8 2009, In : Science Signaling. 2, 100

Research output: Contribution to journalArticle

Only a subset of Met-activated pathways are required to sustain oncogene addiction.

Bertotti, A., Burbridge, M. F., Gastaldi, S., Galimi, F., Torti, D., Medico, E., Giordano, S., Corso, S., Rolland-Valognes, G., Lockhart, B. P., Hickman, J. A., Comoglio, P. M. & Trusolino, L., 2009, In : Science Signaling. 2, 102

Research output: Contribution to journalArticle

The Slit/Robo system suppresses hepatocyte growth factor-dependent invasion and morphogenesis

Stella, M. C., Trusolino, L. & Comoglio, P. M., Jan 15 2009, In : Molecular Biology of the Cell. 20, 2, p. 642-657 16 p.

Research output: Contribution to journalArticle

2008

Drug development of MET inhibitors: Targeting oncogene addiction and expedience

Comoglio, P. M., Giordano, S. & Trusolino, L., Jun 2008, In : Nature Reviews Drug Discovery. 7, 6, p. 504-516 13 p.

Research output: Contribution to journalArticle

The Met tyrosine kinase receptor in development and cancer

Gentile, A., Trusolino, L. & Comoglio, P. M., Mar 2008, In : CANCER AND METASTASIS REVIEW. 27, 1, p. 85-94 10 p.

Research output: Contribution to journalArticle

2007

Scatter factor-dependent branching morphogenesis: Structural and histological features

Comoglio, P. M., Trusolino, L. & Boccaccio, C., 2007, In : European journal of histochemistry : EJH. 51, SUPPL.1, p. 79-92 14 p.

Research output: Contribution to journalArticle

2006

β4 integrin activates a Shp2-Src signaling pathway that sustains HGF-induced anchorage-independent growth

Bertotti, A., Comoglio, P. M. & Trusolino, L., Dec 18 2006, In : Journal of Cell Biology. 175, 6, p. 993-1003 11 p.

Research output: Contribution to journalArticle

2005

Cancer: The matrix is now in control

Comoglio, P. M. & Trusolino, L., Nov 2005, In : Nature Medicine. 11, 11, p. 1156-1159 4 p.

Research output: Contribution to journalArticle

Negative feedback regulation of met-dependent invasive growth by Notch

Stella, M. C., Trusolino, L., Pennacchietti, S. & Comoglio, P. M., May 2005, In : Molecular and Cellular Biology. 25, 10, p. 3982-3996 15 p.

Research output: Contribution to journalArticle

β4 integrin is a transforming molecule that unleashes Met tyrosine kinase tumorigenesis

Bertotti, A., Comoglio, P. M. & Trusolino, L., Dec 1 2005, In : Cancer Research. 65, 23, p. 10674-10679 6 p.

Research output: Contribution to journalArticle

2003

Erratum: Autoantibodies against a 72-kDa ductal cell membrane glycoprotein in a patient affected by Sjögren's syndrome and gastric MALT lymphoma (Annals of Hematology (2002) vol. 81 (597-602))

Folli, F., Perego, L., Ponzoni, M., Girardi, A. M., Bosi, E., Ferreri, A. J. M., Bellone, M., Sabbadini, M. G., Marchisio, P. C., Vicari, A. M. & Trusolino, L., Mar 1 2003, In : Annals of Hematology. 82, 3, p. 203 1 p.

Research output: Contribution to journalArticle

Interactions between growth factor receptors and adhesion molecules: Breaking the rules

Comoglio, P. M., Boccaccio, C. & Trusolino, L., Oct 2003, In : Current Opinion in Cell Biology. 15, 5, p. 565-571 7 p.

Research output: Contribution to journalArticle

Role of the MET/HGF receptor in proliferation and invasive behavior of osteosarcoma.

Coltella, N., Manara, M. C., Cerisano, V., Trusolino, L., Di Renzo, M. F., Scotlandi, K. & Ferracini, R., 2003, In : FASEB Journal. 17, 9, p. 1162-1164 3 p.

Research output: Contribution to journalArticle

2002

Autoantibodies against a 72-kDa ductal cell membrane glycoprotein in a patient affected by Sjögren's syndrome and gastric MALT lymphoma

Folli, F., Perego, L., Ponzoni, M., Girardi, A. M., Bosi, E., Ferreri, A. J. M., Bellone, M., Sabbadini, M. G., Marchisio, P. C., Vicari, A. M. & Trusolino, L., 2002, In : Annals of Hematology. 81, 10, p. 597-602 6 p.

Research output: Contribution to journalArticle

Invasive growth: From development to metastasis

Comoglio, P. M. & Trusolino, L., 2002, In : Journal of Clinical Investigation. 109, 7, p. 857-862 6 p.

Research output: Contribution to journalArticle

Scatter-factor and semaphorin receptors: Cell signalling for invasive growth

Trusolino, L. & Comoglio, P. M., Apr 2002, In : Nature Reviews Cancer. 2, 4, p. 289-300 12 p.

Research output: Contribution to journalArticle

2001

A signaling adapter function for α6β4 integrin in the control of HGF-dependent invasive growth

Trusolino, L., Bertotti, A. & Comoglio, P. M., Nov 30 2001, In : Cell. 107, 5, p. 643-654 12 p.

Research output: Contribution to journalArticle

Osteopontin is an autocrine mediator of hepatocyte growth factor-induced invasive growth

Medico, E., Gentile, A., Celso, C. L., Williams, T. A., Gambarotta, G., Trusolino, L. & Comoglio, P. M., Aug 1 2001, In : Cancer Research. 61, 15, p. 5861-5868 8 p.

Research output: Contribution to journalArticle

2000

HGF/scatter factor selectively promotes cell invasion by increasing integrin avidity

Trusolino, L., Cavassa, S., Angelini, P., Ando, M., Bertotti, A., Comoglio, P. M. & Boccaccio, C., 2000, In : FASEB Journal. 14, 11, p. 1629-1640 12 p.

Research output: Contribution to journalArticle

Integrin expression and IgA nephropathy: In vitro modulation by IgA with altered glycosylation and macromolecular IgA

Peruzzi, L., Amore, A., Cirina, P., Trusolino, L., Basso, G., Ricotti, E., Emancipator, S. N., Marchisio, P. C. & Coppo, R., 2000, In : Kidney International. 58, 6, p. 2331-2340 10 p.

Research output: Contribution to journalArticle

1999

Immunofluorescence of cultured cells.

Marchisio, P. C. & Trusolino, L., 1999, In : Methods in molecular biology (Clifton, N.J.). 96, p. 85-92 8 p.

Research output: Contribution to journalArticle

1998

Altered expression of α6 integrin subunit in oral squamous cell carcinoma and oral potentially malignant lesions

Garzino-Demo, P., Carrozzo, M., Trusolino, L., Savoia, P., Gandolfo, S. & Marchisio, P. C., May 1998, In : Oral Oncology. 34, 3, p. 204-210 7 p.

Research output: Contribution to journalArticle

Growth factor-dependent activation of αvβ3 integrin in normal epithelial cells: Implications for tumor invasion

Trusolino, L., Serini, G., Cecchini, G., Besati, C., Ambesi-Impiombato, F. S., Marchisio, P. C. & De Filippi, R., Aug 24 1998, In : Journal of Cell Biology. 142, 4, p. 1145-1156 12 p.

Research output: Contribution to journalArticle

Interactions between scatter factors and their receptors: Hints for therapeutic applications

Trusolino, L., Pugliese, L. & Comoglio, P. M., 1998, In : FASEB Journal. 12, 13, p. 1267-1280 14 p.

Research output: Contribution to journalArticle

1997

Le molecole di adesione nel carcinoma squamoso della laringe. Possibile significato prognostico.

Translated title of the contribution: Adhesion molecules in squamous cell carcinoma of the larynx: possible indication of prognosisPanizzut, B., Carlevato, M. T., Ferro, S., Cavalot, A. L., Gervasio, C. F., Ricci, E., Trusolino, L., Marchisio, P. C. & Cortesina, G., Oct 1997, In : Acta Otorhinolaryngologica Italica. 17, 5, p. 347-356 10 p.

Research output: Contribution to journalArticle