1989 …2019

Research output per year

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Research Output

2019

Bioprofiling TS/A Murine Mammary Cancer for a Functional Precision Experimental Model

De Giovanni, C., Nicoletti, G., Landuzzi, L., Palladini, A., Lollini, P-L. & Nanni, P., Nov 27 2019, In : Cancers. 11, 12, p. 1-20 20 p.

Research output: Contribution to journalReview article

Bone sarcoma patient-derived xenografts are faithful and stable preclinical models for molecular and therapeutic investigations

Nanni, P., Landuzzi, L., Manara, M. C., Righi, A., Nicoletti, G., Cristalli, C., Pasello, M., Parra, A., Carrabotta, M., Ferracin, M., Palladini, A., Ianzano, M. L., Giusti, V., Ruzzi, F., Magnani, M., Donati, D. M., Picci, P., Lollini, P-L. & Scotlandi, K., Aug 21 2019, In : Scientific Reports. 9, 1, p. 1-12 12 p.

Research output: Contribution to journalArticle

Cancer vaccines co-targeting HER2/NEU and IGF1R

De Giovanni, C., Landuzzi, L., Palladini, A., Ianzano, M. L., Nicoletti, G., Ruzzi, F., Amici, A., Croci, S., Nanni, P. & Lollini, P. L., Apr 11 2019, In : Cancers. 11, 4, 517.

Research output: Contribution to journalArticle

Open Access

Cancer Vaccines Co-Targeting HER2/Neu and IGF1R

De Giovanni, C., Landuzzi, L., Palladini, A., Ianzano, M. L., Nicoletti, G., Ruzzi, F., Amici, A., Croci, S., Nanni, P. & Lollini, P-L., Apr 11 2019, In : Cancers. 11, 4, p. 1-12 12 p.

Research output: Contribution to journalArticle

Immune targeting of autocrine IGF2 hampers rhabdomyosarcoma growth and metastasis

De Giovanni, C., Nanni, P., Landuzzi, L., Ianzano, M. L., Nicoletti, G., Croci, S., Palladini, A. & Lollini, P-L., Feb 7 2019, In : BMC Cancer. 19, 1, 7 p., 126.

Research output: Contribution to journalArticle

Immune targeting of autocrine IGF2 hampers rhabdomyosarcoma growth and metastasis

De Giovanni, C., Nanni, P., Landuzzi, L., Ianzano, M. L., Nicoletti, G., Croci, S., Palladini, A. & Lollini, P-L., Feb 7 2019, In : BMC Cancer. 19, 1, p. 1-7 7 p.

Research output: Contribution to journalArticle

ROCK2 deprivation leads to the inhibition of tumor growth and metastatic potential in osteosarcoma cells through the modulation of YAP activity

Zucchini, C., Manara, M. C., Cristalli, C., Carrabotta, M., Greco, S., Pinca, R. S., Ferrari, C., Landuzzi, L., Pasello, M., Lollini, P-L., Gambarotti, M., Donati, D. M. & Scotlandi, K., Dec 26 2019, In : Journal of experimental & clinical cancer research : CR. 38, 1, p. 1-14 14 p.

Research output: Contribution to journalArticle

2018

A quinoline-based DNA methyltransferase inhibitor as a possible adjuvant in osteosarcoma therapy

Manara, M. C., Valente, S., Cristalli, C., Nicoletti, G., Landuzzi, L., Zwergel, C., Mazzone, R., Stazi, G., Arimondo, P. B., Pasello, M., Guerzoni, C., Picci, P., Nanni, P., Lollini, P. L., Mai, A. & Scotlandi, K., Sep 2018, In : Molecular Cancer Therapeutics. 17, 9, p. 1881-1892 12 p.

Research output: Contribution to journalArticle

Cancer immunoprevention: From mice to early clinical trials

Palladini, A., Landuzzi, L., Lollini, P. L. & Nanni, P., Jun 15 2018, In : BMC Immunology. 19, 1, p. 1-6 6 p., 16.

Research output: Contribution to journalReview article

OX40 triggering concomitant to IL12-engineered cell vaccine hampers the immunoprevention of HER2/neu-driven mammary carcinogenesis

Nanni, P., De Giovanni, C., Burocchi, A., Nicoletti, G., Landuzzi, L., Palladini, A., Ianzano, M. L., Arioli, I., Colombo, M. P. & Lollini, P. L., Jun 11 2018, In : OncoImmunology. 7, 8, p. 1-7 7 p.

Research output: Contribution to journalArticle

OX40 triggering concomitant to IL12-engineered cell vaccine hampers the immunoprevention of HER2/neu-driven mammary carcinogenesis

Nanni, P., De Giovanni, C., Burocchi, A., Nicoletti, G., Landuzzi, L., Palladini, A., Ianzano, M. L., Arioli, I., Colombo, M. P. & Lollini, P-L., 2018, In : OncoImmunology. 7, 8, p. e1465164

Research output: Contribution to journalArticle

Virus-like particle display of HER2 induces potent anti-cancer responses

Palladini, A., Thrane, S., Janitzek, C. M., Pihl, J., Clemmensen, S. B., de Jongh, W. A., Clausen, T. M., Nicoletti, G., Landuzzi, L., Penichet, M. L., Balboni, T., Ianzano, M. L., Giusti, V., Theander, T. G., Nielsen, M. A., Salanti, A., Lollini, P. L., Nanni, P. & Sander, A. F., Mar 4 2018, In : OncoImmunology. 7, 3, p. 1-13 13 p.

Research output: Contribution to journalArticle

2017

HER2 isoforms co-expression differently tunes mammary tumor phenotypes affecting onset, vasculature and therapeutic response

Palladini, A., Nicoletti, G., Lamolinara, A., Dall'Ora, M., Balboni, T., Ianzano, M. L., Laranga, R., Landuzzi, L., Giusti, V., Ceccarelli, C., Santini, D., Taffurelli, M., Oto, E. D., Asioli, S., Amici, A., Pupa, S. M., De Giovanni, C., Tagliabue, E., Iezzi, M., Nanni, P. & 1 others, Lollini, P. L., Jan 1 2017, In : Oncotarget. 8, 33, p. 54444-54458 15 p.

Research output: Contribution to journalArticle

HER2 isoforms co-expression differently tunes mammary tumor phenotypes affecting onset, vasculature and therapeutic response

Palladini, A., Nicoletti, G., Lamolinara, A., Dall'Ora, M., Balboni, T., Ianzano, M. L., Laranga, R., Landuzzi, L., Giusti, V., Ceccarelli, C., Santini, D., Taffurelli, M., Di Oto, E., Asioli, S., Amici, A., Pupa, S., De Giovanni, C., Tagliabue, E., Iezzi, M., Nanni, P. & 1 others, Lollini, P. L., Apr 13 2017, In : Oncotarget. 8, 33, p. 54444-54458 15 p.

Research output: Contribution to journalArticle

2015

Interleukin-15 is required for immunosurveillance and immunoprevention of HER2/neu-driven mammary carcinogenesis

Croci, S., Nanni, P., Palladini, A., Nicoletti, G., Grosso, V., Benegiamo, G., Landuzzi, L., Lamolinara, A., Ianzano, M. L., Ranieri, D., Dall'Ora, M., Iezzi, M., De Giovanni, C. & Lollini, P. L., May 22 2015, In : Breast Cancer Research. 17, 1, 70.

Research output: Contribution to journalArticle

Interleukin-15 is required for immunosurveillance and immunoprevention of HER2/neu-driven mammary carcinogenesis

Croci, S., Nanni, P., Palladini, A., Nicoletti, G., Grosso, V., Benegiamo, G., Landuzzi, L., Lamolinara, A., Ianzano, M. L., Ranieri, D., Dall'Ora, M., Iezzi, M., De Giovanni, C. & Lollini, P. L., Dec 14 2015, In : Breast Cancer Research. 17, 1, 70.

Research output: Contribution to journalArticle

2014

An aza-macrocycle containing maltolic side-arms (maltonis) as potential drug against human pediatric sarcomas

Guerzoni, C., Amatori, S., Giorgi, L., Manara, M. C., Landuzzi, L., Lollini, P. L., Tassoni, A., Balducci, M., Manfrini, M., Pratelli, L., Serra, M., Picci, P., Magnani, M., Fusi, V., Fanelli, M. & Scotlandi, K., Feb 27 2014, In : BMC Cancer. 14, 1, 137.

Research output: Contribution to journalArticle

Characterization of a genetic mouse model of lung cancer: a promise to identify Non-Small Cell Lung Cancer therapeutic targets and biomarkers

Riccardo, F., Arigoni, M., Buson, G., Zago, E., Iezzi, M., Longo, D., Carrara, M., Fiore, A., Nuzzo, S., Bicciato, S., Nanni, P., Landuzzi, L., Cavallo, F., Calogero, R. & Quaglino, E., 2014, In : BMC Genomics. 15, p. S1

Research output: Contribution to journalArticle

Genetic prevention of lymphoma in p53 knockout mice allows the early development of p53-related sarcomas

Landuzzi, L., Ianzano, M. L., Nicoletti, G., Palladini, A., Grosso, V., Ranieri, D., Dall'Ora, M., Raschi, E., Laranga, R., Gambarotti, M., Picci, P., de Giovanni, C., Nanni, P. & Lollini, P. L., 2014, In : Oncotarget. 5, 23, p. 11924-11938 15 p.

Research output: Contribution to journalArticle

Tumor suppressor genes promote rhabdomyosarcoma progression in p53 heterozygous, HER-2/neu transgenic mice

Ianzano, M. L., Croci, S., Nicoletti, G., Palladini, A., Landuzzi, L., Grosso, V., Ranieri, D., Dall'Ora, M., Santeramo, I., Urbini, M., De Giovanni, C., Lollini, P. L. & Nanni, P., 2014, In : Oncotarget. 5, 1, p. 108-119 12 p.

Research output: Contribution to journalArticle

Vaccines against human HER2 prevent mammary carcinoma in mice transgenic for human HER2

De Giovanni, C., Nicoletti, G., Quaglino, E., Landuzzi, L., Palladini, A., Ianzano, M. L., Dall'Ora, M., Grosso, V., Ranieri, D., Laranga, R., Croci, S., Amici, A., Penichet, M. L., Iezzi, M., Cavallo, F., Nanni, P. & Lollini, P. L., Jan 23 2014, In : Breast Cancer Research. 16, 1, R10.

Research output: Contribution to journalArticle

2013

Metformin as an adjuvant drug against pediatric sarcomas: Hypoxia limits therapeutic effects of the drug

Garofalo, C., Capristo, M., Manara, M. C., Mancarella, C., Landuzzi, L., Belfiore, A., Lollini, P. L., Picci, P. & Scotlandi, K., Dec 31 2013, In : PLoS One. 8, 12, e83832.

Research output: Contribution to journalArticle

Preclinical Therapy of Disseminated HER-2+ Ovarian and Breast Carcinomas with a HER-2-Retargeted Oncolytic Herpesvirus

Nanni, P., Gatta, V., Menotti, L., de Giovanni, C., Ianzano, M., Palladini, A., Grosso, V., Dall'Ora, M., Croci, S., Nicoletti, G., Landuzzi, L., Iezzi, M., Campadelli-Fiume, G. & Lollini, P. L., Jan 2013, In : PLoS Pathogens. 9, 1, e1003155.

Research output: Contribution to journalArticle

Preclinical validation of Aurora kinases-targeting drugs in osteosarcoma

Tavanti, E., Sero, V., Vella, S., Fanelli, M., Michelacci, F., Landuzzi, L., Magagnoli, G., Versteeg, R., Picci, P., Hattinger, C. M. & Serra, M., Nov 12 2013, In : British Journal of Cancer. 109, 10, p. 2607-2618 12 p.

Research output: Contribution to journalArticle

2012

Human responses against HER-2-positive cancer cells in human immune system-engrafted mice

De Giovanni, C., Nicoletti, G., Landuzzi, L., Romani, F., Croci, S., Palladini, A., Murgo, A., Antognoli, A., Ianzano, M. L., Stivani, V., Grosso, V., Iezzi, M., Stramucci, L., Barbieri, E., Lemoli, R. M., Nanni, P. & Lollini, P. L., Oct 9 2012, In : British Journal of Cancer. 107, 8, p. 1302-1309 8 p.

Research output: Contribution to journalArticle

Multiorgan metastasis of human HER-2+ breast cancer in Rag2-/-;Il2rg-/- mice and treatment with PI3K inhibitor

Nanni, P., Nicoletti, G., Palladini, A., Croci, S., Murgo, A., Ianzano, M. L., Grosso, V., Stivani, V., Antognoli, A., Lamolinara, A., Landuzzi, L., di Tomaso, E., Iezzi, M., de Giovanni, C. & Lollini, P. L., Jun 21 2012, In : PLoS One. 7, 6, e39626.

Research output: Contribution to journalArticle

2011

HER-2/neu tolerant and non-tolerant mice for fine assessment of antimetastatic potency of dendritic cell-tumor cell hybrid vaccines

Landuzzi, L., Antognoli, A., Nicoletti, G., Croci, S., Palladini, A., Ianzano, M. L., Murgo, A., Stivani, V., Grosso, V., Nanni, P., De Giovanni, C. & Lollini, P. L., Jun 24 2011, In : Vaccine. 29, 29-30, p. 4690-4697 8 p.

Research output: Contribution to journalArticle

Targeting Glutathione-S transferase enzymes in musculoskeletal sarcomas: A promising therapeutic strategy

Pasello, M., Manara, M. C., Michelacci, F., Fanelli, M., Hattinger, C. M., Nicoletti, G., Landuzzi, L., Lollini, P. L., Caccuri, A., Picci, P., Scotlandi, K. & Serra, M., 2011, In : Analytical Cellular Pathology. 34, 3, p. 131-145 15 p.

Research output: Contribution to journalArticle

TRAF6 regulates proliferation and differentiation of skeletal myoblasts

Mueck, T., Berger, F., Buechsler, I., Valchanova, R. S., Landuzzi, L., Lollini, P. L., Klingel, K. & Munz, B., Feb 2011, In : Differentiation. 81, 2, p. 99-106 8 p.

Research output: Contribution to journalArticle

Vaccines and other immunological approaches for cancer immunoprevention

Lollini, P. L., Nicoletti, G., Landuzzi, L., Cavallo, F., Forni, G., de Giovanni, C. & Nanni, P., Dec 2011, In : Current Drug Targets. 12, 13, p. 1957-1973 17 p.

Research output: Contribution to journalArticle

2010

Biological indicators of prognosis in Ewing's sarcoma: An emerging role for lectin galactoside-binding soluble 3 binding protein (LGALS3BP)

Zambelli, D., Zuntini, M., Nardi, F., Manara, M. C., Serra, M., Landuzzi, L., Lollini, P. L., Ferrari, S., Alberghini, M., Llombart-Bosch, A., Piccolo, E., Iacobelli, S., Picci, P. & Scotlandi, K., Jan 1 2010, In : International Journal of Cancer. 126, 1, p. 41-52 12 p.

Research output: Contribution to journalArticle

Evaluation of modified PEG-anilinoquinazoline derivatives as potential agents for EGFR imaging in cancer by small animal PET

Pantaleo, M. A., Mishani, E., Nanni, C., Landuzzi, L., Boschi, S., Nicoletti, G., Dissoki, S., Paterini, P., Piccaluga, P. P., Lodi, F., Lollini, P. L., Fanti, S. & Biasco, G., Dec 2010, In : Molecular Imaging and Biology. 12, 6, p. 616-625 10 p.

Research output: Contribution to journalArticle

High metastatic efficiency of human sarcoma cells in Rag2/γc double knockout mice provides a powerful test system for antimetastatic targeted therapy

Nanni, P., Nicoletti, G., Landuzzi, L., Croci, S., Murgo, A., Palladini, A., Antognoli, A., Ianzano, M. L., Stivani, V., Grosso, V., Maira, S. M., García-Echeverría, C., Scotlandi, K., De Giovanni, C. & Lollini, P. L., Feb 2010, In : European Journal of Cancer. 46, 3, p. 659-668 10 p.

Research output: Contribution to journalArticle

Immunoprevention and immunotherapy of mammary carcinoma

Lollini, P. L., Nicoletti, G., Landuzzi, L., De Giovanni, C. & Nanni, P., Sep 2010, In : Breast Journal. 16, SUPPL. 1

Research output: Contribution to journalArticle

In silico modeling and in vivo efficacy of cancer-preventive vaccinations

Palladini, A., Nicoletti, G., Pappalardo, F., Murgo, A., Grosso, V., Stivani, V., Ianzano, M. L., Antognoli, A., Croci, S., Landuzzi, L., De Giovanni, C., Nanni, P., Motta, S. & Lollini, P. L., Oct 15 2010, In : Cancer Research. 70, 20, p. 7755-7763 9 p.

Research output: Contribution to journalArticle

NVP-BEZ235 as a new therapeutic option for sarcomas

Manara, M. C., Nicoletti, G., Zambelli, D., Ventura, S., Guerzoni, C., Landuzzi, L., Lollini, P. L., Maira, S. M., García-Echeverría, C., Mercuri, M., Picci, P. & Scotlandi, K., Jan 15 2010, In : Clinical Cancer Research. 16, 2, p. 530-540 11 p.

Research output: Contribution to journalArticle

Preclinical evaluation of KIT/PDGFRA and mTOR inhibitors in gastrointestinal stromal tumors using small animal FDG PET

Pantaleo, M. A., Nicoletti, G., Nanni, C., Gnocchi, C., Landuzzi, L., Quarta, C., Boschi, S., Nannini, M., Di Battista, M., Castellucci, P., Fanti, S., Lollini, P. L., Bellan, E., Castelli, M., Rubello, D. & Biasco, G., 2010, In : Journal of Experimental and Clinical Cancer Research. 29, 1, 173.

Research output: Contribution to journalArticle

Proteomic and PROTEOMEX profiling of mammary cancer progression in a HER-2/neu oncogene-driven animal model system

Croci, S., Recktenwald, C. V., Lichtenfels, R., Nicoletti, G., Dressler, S. P., De Giovanni, C., Astolfi, A., Palladini, A., Shin-Ya, K., Landuzzi, L., Nanni, P., Lollini, P. L. & Seliger, B., Nov 2010, In : Proteomics. 10, 21, p. 3835-3853 19 p.

Research output: Contribution to journalArticle

Research trends for early cancer biomarker detection in Italy: An Integrated Program in Oncology (PIO) survey

Verderio, P., Mangia, A., Orlando, C., Belfiglio, M., Marchetti, A., Bertario, L., Chiappetta, G., Gion, M., Tonini, G. P., Podo, F., Vocaturo, A., Silvestrini, R., Lombardo, C., Paradiso, A., Pizzamiglio, S., Romani, M., Belloni, E., Cavallo, D., Ulivi, P., Tommasi, S. & 18 others, Steffan, A., Russo, A., Massimo, A., Calistri, D., Parrella, P., Broggini, M., Naccarato, A. G., Buttitta, F., Finocchiaro, G., Veronesi, G., Landuzzi, L., Benevolo, M., Mariani, L., De Marco, F., Venuti, A., Giannelli, G., Quaranta, M. & Trojano, V., Sep 2010, In : Tumori. 96, 5, p. 721-725 5 p.

Research output: Contribution to journalArticle

2009

Advances in preclinical therapeutics development using small animal imaging and molecular analyses: The gastrointestinal stromal tumors model

Pantaleo, M. A., Landuzzi, L., Nicoletti, G., Nanni, C., Boschi, S., Piazzi, G., Santini, D., Di Battista, M., Castellucci, P., Lodi, F., Fanti, S., Lollini, P. L. & Biasco, G., Sep 2009, In : Clinical and Experimental Medicine. 9, 3, p. 199-205 7 p.

Research output: Contribution to journalArticle

A multi-DNA preventive vaccine for p53/neu-driven cancer syndrome

De Giovanni, C., Nicoletti, G., Palladini, A., Croci, S., Landuzzi, L., Antognoli, A., Murgo, A., Astolfi, A., Ferrini, S., Fabbi, M., Orengo, A. M., Amici, A., Penichet, M. L., Aurisicchio, L., Iezzi, M., Musiani, P., Nanni, P. & Lollini, P. L., May 1 2009, In : Human Gene Therapy. 20, 5, p. 453-464 12 p.

Research output: Contribution to journalArticle

APC10.1 cells as a model for assessing the efficacy of potential chemopreventive agents in the ApcMin mouse model in vivo

Sale, S., Fong, I. L., de Giovanni, C., Landuzzi, L., Brown, K., Steward, W. P. & Gescher, A. J., Nov 2009, In : European Journal of Cancer. 45, 16, p. 2731-2735 5 p.

Research output: Contribution to journalArticle

Experimental results and related clinical implications of PET detection of epidermal growth factor receptor (EGFr) in cancer

Pantaleo, M. A., Nannini, M., Maleddu, A., Fanti, S., Nanni, C., Boschi, S., Lodi, F., Nicoletti, G., Landuzzi, L., Lollini, P. L. & Biasco, G., 2009, In : Annals of Oncology. 20, 2, p. 213-226 14 p.

Research output: Contribution to journalArticle

Inhibition of human tumor growth in mice by an oncolytic herpes simplex virus designed to target solely HER-2-positive cells

Menotti, L., Nicoletti, G., Gatta, V., Croci, S., Landuzzi, L., De Giovanni, C., Nanni, P., Lollini, P. L. & Campadelli-Fiume, G., Jun 2 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 22, p. 9039-9044 6 p.

Research output: Contribution to journalArticle

Molecular and cellular biology of rhabdomyosarcoma

De Giovanni, C., Landuzzi, L., Nicoletti, G., Lollini, P. L. & Nanni, P., 2009, In : Future Oncology. 5, 9, p. 1449-1475 27 p.

Research output: Contribution to journalArticle

Opposing control of rhabdomyosarcoma growth and differentiation by myogenin and interleukin 4

Nanni, P., Nicoletti, G., Palladini, A., Astolfi, A., Rinella, P., Croci, S., Landuzzi, L., Monduzzi, G., Stivani, V., Antognoli, A., Murgo, A., Ianzano, M., De Giovanni, C. & Lollini, P. L., Apr 1 2009, In : Molecular Cancer Therapeutics. 8, 4, p. 754-761 8 p.

Research output: Contribution to journalArticle

Tamoxifen combined to anti-HER-2/neu cell vaccine does not hamper cancer immunopreventive efficacy

De Giovanni, C., Nicoletti, G., Landuzzi, L., Croci, S., Palladini, A., Antognoli, A., Murgo, A., Ianzano, M. L., Grosso, V., Stivani, V., Iezzi, M., Musiani, P., Nanni, P. & Lollini, P. L., Mar 23 2009, In : Vaccine. 27, 14, p. 2065-2069 5 p.

Research output: Contribution to journalArticle

2008

RIP2 regulates growth and differentiation of normal myoblasts and of rhabdomyosarcoma cells

Ehlers, S., Mueck, T., Adams, S., Landuzzi, L., Lollini, P. L. & Munz, B., Mar 17 2008, In : European Journal of Cell Biology. 87, 3, p. 163-172 10 p.

Research output: Contribution to journalArticle

Up-regulation of EphB and ephrin-B expression in rhabdomyosarcoma

Berardi, A. C., Marsilio, S., Rofani, C., Salvucci, O., Altavista, P., Perla, F. M., Diomedi-Camassei, F., Uccini, S., Kokai, G., Landuzzi, L., McDowell, H. P. & Dominici, C., Mar 2008, In : Anticancer Research. 28, 2 A, p. 763-769 7 p.

Research output: Contribution to journalArticle

2007

Antimetastatic activity of a preventive cancer vaccine

Nanni, P., Nicoletti, G., Palladini, A., Croci, S., Murgo, A., Antognoli, A., Landuzzi, L., Fabbi, M., Ferrini, S., Musiani, P., Iezzi, M., De Giovanni, C. & Lollini, P. L., Nov 15 2007, In : Cancer Research. 67, 22, p. 11037-11044 8 p.

Research output: Contribution to journalArticle