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Research Output 2009 2019

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Article
2019
Artificial Intelligence
Melanoma
L-Lactate Dehydrogenase
Neutrophils
Lymphocytes

Combination of Immunotherapy and Brain Radiotherapy in Metastatic Melanoma: A Retrospective Analysis

Galli, G., Cavalieri, S., Di Guardo, L., Cimminiello, C., Nichetti, F., Corti, F., Garcia, M. A., Pappalardi, B., Fallai, C., De Braud, F., Platania, M. & Del Vecchio, M., Apr 1 2019, In : Oncology Research and Treatment. 42, 4, p. 182-188 7 p.

Research output: Contribution to journalArticle

Immunotherapy
Melanoma
Radiotherapy
Brain
Survival

Developing a score system to predict therapeutic outcomes to anti-PD-1 immunotherapy in metastatic melanoma

Indini, A., Di Guardo, L., Cimminiello, C., Prisciandaro, M., Randon, G., De Braud, F. & Del Vecchio, M., Jan 1 2019, (Accepted/In press) In : Tumori.

Research output: Contribution to journalArticle

Immunotherapy
Melanoma
Lymphocyte Count
L-Lactate Dehydrogenase
Survival

Immune-related adverse events correlate with improved survival in patients undergoing anti-PD1 immunotherapy for metastatic melanoma

Indini, A., Di Guardo, L., Cimminiello, C., Prisciandaro, M., Randon, G., De Braud, F. & Del Vecchio, M., Feb 13 2019, In : Journal of Cancer Research and Clinical Oncology. 145, 2, p. 511-521 11 p.

Research output: Contribution to journalArticle

Immunotherapy
Melanoma
Survival
Vitiligo
Programmed Cell Death 1 Receptor
Open Access
Immunotherapy
Melanoma
CTLA-4 Antigen
Cell Death
Vulva

Pembrolizumab in the treatment of advanced/metastatic melanoma: A single-center institution experience

Cimminiello, C., Indini, A., Di Guardo, L., Prisciandaro, M., Randon, G., Tolomio, E., De Braud, F. & Del Vecchio, M., Jun 1 2019, In : Melanoma Research. 29, 3, p. 289-294 6 p.

Research output: Contribution to journalArticle

Melanoma
Confidence Intervals
Therapeutics
Proportional Hazards Models
Disease-Free Survival
Tissue Distribution
Melanoma
Catenins
Myeloid Cells
Immunity

The density and spatial tissue distribution of CD8+ and CD163+ immune cells predict response and outcome in melanoma patients receiving MAPK inhibitors

Intergroup, I. M., Massi, D., Rulli, E., Cossa, M., Valeri, B., Rodolfo, M., Merelli, B., De Logu, F., Nassini, R., Del Vecchio, M., Di Guardo, L., De Penni, R., Guida, M., Sileni, V. C., Di Giacomo, A. M., Tucci, M., Occelli, M., Portelli, F., Vallacchi, V., Consoli, F. & 9 others, Quaglino, P., Queirolo, P., Baroni, G., Carnevale-Schianca, F., Cattaneo, L., Minisini, A., Palmieri, G., Rivoltini, L. & Mandalà, M., Nov 15 2019, In : Journal for ImmunoTherapy of Cancer. 7, 1

Research output: Contribution to journalArticle

The density and spatial tissue distribution of CD8+ and CD163+ immune cells predict response and outcome in melanoma patients receiving MAPK inhibitors

Massi, D., Rulli, E., Cossa, M., Valeri, B., Rodolfo, M., Merelli, B., De Logu, F., Nassini, R., Del Vecchio, M., Di Guardo, L., De Penni, R., Guida, M., Sileni, V. C., Di Giacomo, A. M., Tucci, M., Occelli, M., Portelli, F., Vallacchi, V., Consoli, F., Quaglino, P. & 10 others, Queirolo, P., Baroni, G., Carnevale-Schianca, F., Cattaneo, L., Minisini, A., Palmieri, G., Rivoltini, L., Mandalà, M., Simi, S. & Galli, F., 2019, In : Journal for ImmunoTherapy of Cancer. 7, 1

Research output: Contribution to journalArticle

The density and spatial tissue distribution of CD8+ and CD163+ immune cells predict response and outcome in melanoma patients receiving MAPK inhibitors.

Massi, D., Rulli, E., Cossa, M., Valeri, B., Rodolfo, M., Merelli, B., De Logu, F., Nassini, R., Del Vecchio, M., Di Guardo, L., De Penni, R., Guida, M., Sileni, V. C., Di Giacomo, A. M., Tucci, M., Occelli, M., Portelli, F., Vallacchi, V., Consoli, F., Quaglino, P. & 9 others, Queirolo, P., Baroni, G., Carnevale-Schianca, F., Cattaneo, L., Minisini, A., Palmieri, G., Rivoltini, L., Mandalà, M. & Intergroup, I. M., Nov 1 2019, In : Journal for ImmunoTherapy of Cancer. 7, p. 308 1 p.

Research output: Contribution to journalArticle

2018

Current status and perspectives in immunotherapy for metastatic melanoma

Marconcini, R., Spagnolo, F., Stucci, L. S., Ribero, S., Marra, E., de Rosa, F. D., Picasso, V., di Guardo, L. D., Cimminiello, C., Cavalieri, S., Orgiano, L., Tanda, E., Spano, L., Falcone, A., Queirolo, P., Palmieri, G., Stanganelli, I., Mandalà, M., Quaglino, P., Botti, G. & 3 others, Caracò, C., Sileni, V. C. & di Giacomo, A. M., 2018, In : Oncotarget. 9, 15, p. 12452-12470 19 p.

Research output: Contribution to journalArticle

Current status and perspectives in immunotherapy for metastatic melanoma

Marconcini, R., Spagnolo, F., Stucci, L. S., Ribero, S., Marra, E., de Rosa, F. D., Picasso, V., di Guardo, L. D., Cimminiello, C., Cavalieri, S., Orgiano, L., Tanda, E., Spano, L., Falcone, A., Queirolo, P., Palmieri, G., Stanganelli, I., Mandalà, M., Quaglino, P., Botti, G. & 3 others, Caracò, C., Sileni, V. C. & di Giacomo, A. M., Jan 1 2018, In : Oncotarget. 9, 15, p. 12452-12470 19 p.

Research output: Contribution to journalArticle

Immunotherapy
Melanoma
Immune System Diseases
Drug Combinations
Pharmaceutical Preparations

Tumor-derived microRNAs induce myeloid suppressor cells and predict immunotherapy resistance in melanoma

Huber, V., Vallacchi, V., Fleming, V., Hu, X., Cova, A., Dugo, M., Shahaj, E., Sulsenti, R., Vergani, E., Filipazzi, P., De Laurentiis, A., Lalli, L., Di Guardo, L., Patuzzo, R., Vergani, B., Casiraghi, E., Cossa, M., Gualeni, A., Bollati, V., Arienti, F. & 7 others, De Braud, F., Mariani, L., Villa, A., Altevogt, P., Umansky, V., Rodolfo, M. & Rivoltini, L., Dec 3 2018, In : Journal of Clinical Investigation. 128, 12, p. 5505-5516 12 p.

Research output: Contribution to journalArticle

Myeloid Cells
MicroRNAs
Immunotherapy
Melanoma
Neoplasms
2017

Clinical features of serous retinopathy observed with cobimetinib in patients with BRAF-mutated melanoma treated in the randomized coBRIM study

de la Cruz-Merino, L., Di Guardo, L., Grob, J-J., Venosa, A., Larkin, J., McArthur, G. A., Ribas, A., Ascierto, P. A., Evans, J. T. R., Gomez-Escobar, A., Barteselli, G., Eng, S., Hsu, J. J., Uyei, A. & Dréno, B., Jun 24 2017, In : Journal of Translational Medicine. 15, 1, p. 146

Research output: Contribution to journalArticle

Melanoma
GDC-0973
Mitogen-Activated Protein Kinase Kinases
Photophobia
Screening
Melanoma
Radiotherapy
Neoplasm Metastasis
Disease-Free Survival
Survival
2016

Combined therapy with dabrafenib and trametinib in BRAF-mutated metastatic melanoma in a real-life setting: The INT Milan experience

Cavalieri, S., Di Guardo, L., Cimminiello, C., Bono, A., Tolomio, E., Colombetti, A., Valeri, B., Di Tolla, G., De Braud, F. & Del Vecchio, M., Sep 1 2016, In : Tumori. 102, 5, p. 501-507 7 p.

Research output: Contribution to journalArticle

Melanoma
Therapeutics
Disease Progression
Literature
Arthralgia

Overcoming melanoma resistance to vemurafenib by targeting CCL2-induced miR-34a, miR-100 and miR-125b

Vergani, E., Di Guardo, L., Dugo, M., Rigoletto, S., Tragni, G., Ruggeri, R., Perrone, F., Tamborini, E., Gloghini, A., Arienti, F., Vergani, B., Deho, P., De Cecco, L., Vallacchi, V., Frati, P., Shahaj, E., Villa, A., Santinami, M., De Braud, F., Rivoltini, L. & 1 others, Rodolfo, M., 2016, In : Oncotarget. 7, 4, p. 4428-4441 14 p.

Research output: Contribution to journalArticle

Melanoma
MicroRNAs
Apoptosis
Cell Proliferation
Cell Line
2015
Melanoma
Safety
Population
Disease-Free Survival
Survival
2014

Clinical experience with ipilimumab 3 mg/kg: Real-world efficacy and safety data from an expanded access programme cohort

Ascierto, P. A., Simeone, E., Sileni, V. C., Pigozzo, J., Maio, M., Altomonte, M., Del Vecchio, M., Di Guardo, L., Marchetti, P., Ridolfi, R., Cognetti, F., Testori, A., Bernengo, M. G., Guida, M., Marconcini, R., Mandalà, M., Cimminiello, C., Rinaldi, G., Aglietta, M. & Queirolo, P., May 7 2014, In : Journal of Translational Medicine. 12, 1, 116.

Research output: Contribution to journalArticle

Safety
Disease control
Melanoma
Clinical Trials
Survival

Efficacy and safety of ipilimumab 3 mg/kg in patients with pretreated, metastatic, mucosal melanoma

Del Vecchio, M., Di Guardo, L., Ascierto, P. A., Grimaldi, A. M., Sileni, V. C., Pigozzo, J., Ferraresi, V., Nuzzo, C., Rinaldi, G., Testori, A., Ferrucci, P. F., Marchetti, P., De Galitiis, F., Queirolo, P., Tornari, E., Marconcini, R., Calabrò, L. & Maio, M., Jan 2014, In : European Journal of Cancer. 50, 1, p. 121-127 7 p.

Research output: Contribution to journalArticle

Melanoma
Safety
Therapeutics
ipilimumab
Retreatment

Efficacy and safety of ipilimumab in elderly patients with pretreated advanced melanoma treated at Italian centres through the expanded access programme

Sileni, V. C., Pigozzo, J., Ascierto, P. A., Grimaldi, A. M., Maio, M., Di Guardo, L., Marchetti, P., De Rosa, F., Nuzzo, C., Testori, A., Cocorocchio, E., Bernengo, M. G., Guida, M., Marconcini, R., Merelli, B., Parmiani, G., Rinaldi, G., Aglietta, M., Grosso, M. & Queirolo, P., Apr 4 2014, In : Journal of Experimental and Clinical Cancer Research. 33, 1, 30.

Research output: Contribution to journalArticle

Melanoma
Safety
Italy
Disease-Free Survival
Survival

Efficacy and safety of ipilimumab in patients with advanced melanoma and brain metastases

Queirolo, P., Spagnolo, F., Ascierto, P. A., Simeone, E., Marchetti, P., Scoppola, A., Del Vecchio, M., Di Guardo, L., Maio, M., Di Giacomo, A. M., Antonuzzo, A., Cognetti, F., Ferraresi, V., Ridolfi, L., Guidoboni, M., Guida, M., Pigozzo, J. & Chiarion Sileni, V., 2014, In : Journal of Neuro-Oncology. 118, 1, p. 109-116 8 p.

Research output: Contribution to journalArticle

Melanoma
Neoplasm Metastasis
Safety
Brain
Clinical Trials

Ipilimumab retreatment in patients with pretreated advanced melanoma: The expanded access programme in Italy

Chiarion-Sileni, V., Pigozzo, J., Ascierto, P. A., Simeone, E., Maio, M., Calabrò, L., Marchetti, P., De Galitiis, F., Testori, A., Ferrucci, P. F., Queirolo, P., Spagnolo, F., Quaglino, P., Carnevale Schianca, F., Mandalà, M., Di Guardo, L. & Del Vecchio, M., Apr 1 2014, In : British Journal of Cancer. 110, 7, p. 1721-1726 6 p.

Research output: Contribution to journalArticle

Retreatment
Italy
Melanoma
Disease Progression
ipilimumab
2013

Efficacy and safety of ipilimumab in patients with pre-treated, uveal melanoma

Maio, M., Danielli, R., Chiarion-Sileni, V., Pigozzo, J., Parmiani, G., Ridolfi, R., De Rosa, F., Del Vecchio, M., Di Guardo, L., Queirolo, P., Picasso, V., Marchetti, P., De Galitiis, F., Mandalà, M., Guida, M., Simeone, E. & Ascierto, P. A., Nov 2013, In : Annals of Oncology. 24, 11, p. 2911-2915 5 p., mdt376.

Research output: Contribution to journalArticle

Safety
Disease-Free Survival
Melanoma
ipilimumab
Uveal melanoma
2011

T-cell activation and maturation at tumor site associated with objective response to ipilimumab in metastatic melanoma

Del Vecchio, M., Mortarini, R., Tragni, G., Di Guardo, L., Bersani, I., Di Tolla, G., Agustoni, F., Colonna, V., Weber, J. S. & Anichini, A., Nov 10 2011, In : Journal of Clinical Oncology. 29, 32

Research output: Contribution to journalArticle

2010

Bevacizumab plus fotemustine as first-line treatment in metastatic melanoma patients: Clinical activity and modulation of angiogenesis and lymphangiogenesis factors

Del Vecchio, M., Mortarini, R., Canova, S., Di Guardo, L., Pimpinelli, N., Sertoli, M. R., Bedognetti, D., Queirolo, P., Morosini, P., Perrone, T., Bajetta, E. & Anichini, A., Dec 1 2010, In : Clinical Cancer Research. 16, 23, p. 5862-5872 11 p.

Research output: Contribution to journalArticle

fotemustine
Lymphangiogenesis
Angiogenesis Inducing Agents
Melanoma
Vascular Endothelial Growth Factor C
2009

Pitfalls in the diagnosis of neuroendocrine tumors: Atypical clinical and radiological findings as cause of medical mistakes

Bajetta, E., Catena, L., Ducceschi, M., Pusceddu, S., Milione, M., Maccauro, M., Bajetta, R., Procopio, G., Buzzoni, R., Formisano, B., Di Guardo, L. & Platania, M., 2009, In : Tumori. 95, 4, p. 501-507 7 p.

Research output: Contribution to journalArticle

Medical Errors
Neuroendocrine Tumors
Enterochromaffin-like Cells
Atrophic Gastritis
Neuroendocrine Cells