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Research Output 1991 2019

2019

A global scientific strategy to cure hepatitis B

Members of the ICE-HBV Working Groups, ICE-HBV Stakeholders Group Chairs, ICE-HBV Senior Advisors, Revill, P. A., Chisari, F. V., Block, J. M., Dandri, M., Gehring, A. J., Guo, H., Hu, J., Kramvis, A., Lampertico, P., Janssen, H. L. A., Levrero, M., Li, W., Liang, T. J., Lim, S. G., Lu, F., Penicaud, M. C., Tavis, J. E. & 33 others, Thimme, R., Arbuthnot, P., Boonstra, A., Chang, K. M., Chen, P. J., Glebe, D., Guidotti, L. G., Fellay, J., Ferrari, C., Jansen, L., Lau, D. T. Y., Lok, A. S., Maini, M. K., Mason, W., Matthews, G., Paraskevis, D., Petersen, J., Rehermann, B., Shin, E. C., Thompson, A., van Bömmel, F., Wang, F. S., Watashi, K., Yang, H. C., Yuan, Z., Yuen, M. F., Block, T., Miller, V., Protzer, U., Bréchot, C., Locarnini, S., Peters, M. G. & Schinazi, R. F., Jul 1 2019, In : The Lancet Gastroenterology and Hepatology. 4, 7, p. 545-558 14 p.

Research output: Contribution to journalComment/debate

Hepatitis B
Hepatitis B virus
Virus Diseases
Chronic Hepatitis B
Circular DNA

Update of the statements on biology and clinical impact of occult hepatitis B virus infection

Taormina Workshop on Occult HBV Infection Faculty Members, Aug 1 2019, In : Journal of Hepatology. 71, 2, p. 397-408 12 p.

Research output: Contribution to journalReview article

Open Access
Virus Diseases
Hepatitis B virus
Education
2017

Effector CD8+ T cell-derived interleukin-10 enhances acute liver immunopathology

Fioravanti, J., Di Lucia, P., Magini, D., Moalli, F., Boni, C., Benechet, AP., Fumagalli, V., Inverso, D., Vecchi, A., Fiocchi, A., Wieland, S., Purcell, R., Ferrari, C., Chisari, FV., Guidotti, LG. & Iannacone, M., 2017, In : Journal of Hepatology. 67, 3, p. 543-548 6 p.

Research output: Contribution to journalArticle

Interleukin-10
T-Lymphocytes
Hepatitis B virus
Liver
Cytokines

Microcirculation in the murine liver: A computational fluid dynamic model based on 3D reconstruction from in vivo microscopy

Piergiovanni, M., Bianchi, E., Capitani, G., Li Piani, I., Ganzer, L., Guidotti, LG., Iannacone, M. & Dubini, G., 2017, In : Journal of Biomechanics. 63, 12, p. 125-134 10 p.

Research output: Contribution to journalArticle

Microcirculation
Hydrodynamics
Liver
Dynamic models
Computational fluid dynamics

Pathogen-specific B-cell receptors drive chronic lymphocytic leukemia by light-chain-dependent cross-reaction with autoantigens

Jiménez de Oya, N., De Giovanni, M., Fioravanti, J., Übelhart, R., Di Lucia, P., Fiocchi, A., Iacovelli, S., Efremov, DG., Caligaris-Cappio, F., Jumaa, H., Ghia, P., Guidotti, LG. & Iannacone, M., 2017, In : EMBO Molecular Medicine. 9, 11, p. 1482-1490 9 p.

Research output: Contribution to journalArticle

Cross Reactions
Autoantigens
B-Cell Chronic Lymphocytic Leukemia
B-Lymphocytes
Light
2016

IFNα gene/cell therapy curbs colorectal cancer colonization of the liver by acting on the hepatic microenvironment

Catarinella, M., Monestiroli, A., Escobar, G., Fiocchi, A., Tran, N. L., Aiolfi, R., Marra, P., Esposito, A., Cipriani, F., Aldrighetti, L., Iannacone, M., Naldini, L., Guidotti, L. G. & Sitia, G., Feb 1 2016, In : EMBO Molecular Medicine. 8, 2, p. 155-170 16 p.

Research output: Contribution to journalArticle

Liver Neoplasms
Cell- and Tissue-Based Therapy
Interferon-alpha
Genetic Therapy
Colorectal Neoplasms
2015

Editorial overview: Viral pathogenesis

Guidotti, L. G. & Iannacone, M., May 31 2015, In : Current Opinion in Virology. 11, p. v-vii 461.

Research output: Contribution to journalArticle

Editorial overview: Viral pathogenesis

Guidotti, L. G. & Iannacone, M., Apr 1 2015, In : Current Opinion in Virology. 11, p. v-vii

Research output: Contribution to journalEditorial

Eukaryotic translation initiation factor 6 is a novel regulator of reactive oxygen species-dependent megakaryocyte maturation

Ricciardi, S., Miluzio, A., Brina, D., Clarke, K., Bonomo, M., Aiolfi, R., Guidotti, L. G., Falciani, F. & Biffo, S., Nov 1 2015, In : Journal of Thrombosis and Haemostasis. 13, 11, p. 2108-2118 11 p.

Research output: Contribution to journalArticle

Eukaryotic Initiation Factors
Megakaryocytes
Reactive Oxygen Species
Bone Marrow
eIF-6

Host-virus interactions in hepatitis B virus infection

Guidotti, L. G., Isogawa, M. & Chisari, F. V., Oct 1 2015, In : Current Opinion in Immunology. 36, p. 61-66 6 p.

Research output: Contribution to journalArticle

Virus Diseases
Hepatitis B virus
Viruses
DNA Viruses
Chronic Hepatitis B

Immunosurveillance of the liver by intravascular effector CD8+ T cells

Guidotti, L. G., Inverso, D., Sironi, L., Di Lucia, P., Fioravanti, J., Ganzer, L., Fiocchi, A., Vacca, M., Aiolfi, R., Sammicheli, S., Mainetti, M., Cataudella, T., Raimondi, A., Gonzalez-Aseguinolaza, G., Protzer, U., Ruggeri, Z. M., Chisari, F. V., Isogawa, M., Sitia, G. & Iannacone, M., Apr 23 2015, In : Cell. 161, 3, p. 486-500 15 p.

Research output: Contribution to journalArticle

Immunologic Monitoring
T-cells
Liver
T-Lymphocytes
Antigens

Mouse models of hepatitis B virus pathogenesis

Iannacone, M. & Guidotti, L. G., Nov 1 2015, In : Cold Spring Harbor perspectives in medicine. 5, 11, a021477.

Research output: Contribution to journalArticle

Viruses
Hepatitis B virus
Pan troglodytes
Virus Diseases
Duck Hepatitis Virus
2014

In vivo flow mapping in complex vessel networks by single image correlation

Sironi, L., Bouzin, M., Inverso, D., D'Alfonso, L., Pozzi, P., Cotelli, F., Guidotti, L. G., Iannacone, M., Collini, M. & Chirico, G., 2014, In : Scientific Reports. 4, 7341.

Research output: Contribution to journalArticle

Photons
Microscopy
Spectrum Analysis
Fluorescence
Liver

The COP9 signalosome is a repressor of replicative stress responses and polyploidization in the regenerating liver

Panattoni, M., Maiorino, L., Lukacs, A., Zentilin, L., Mazza, D., Sanvito, F., Sitia, G., Guidotti, L. G. & Pardi, R., 2014, In : Hepatology. 59, 6, p. 2331-2343 13 p.

Research output: Contribution to journalArticle

Liver
Ligases
Cell Cycle Checkpoints
DNA Replication
Proto-Oncogene Proteins
2013
Hepatitis B virus
Hepatocellular Carcinoma
Blood Platelets
Viruses
clopidogrel

Bisphosphonates Target B Cells to Enhance Humoral Immune Responses

Tonti, E., JiménezdeOya, N., Galliverti, G., Moseman, E. A., DiLucia, P., Amabile, A., Sammicheli, S., DeGiovanni, M., Sironi, L., Chevrier, N., Sitia, G., Gennari, L., Guidotti, L., VonAndrian, U. & Iannacone, M., 2013, In : Cell Reports. 5, 2, p. 323-330 8 p.

Research output: Contribution to journalArticle

Diphosphonates
Humoral Immunity
B-Lymphocytes
Cells
Antibody Formation

Effector CD8 T cell trafficking within the liver

Guidotti, L. G. & Iannacone, M., Aug 2013, In : Molecular Immunology. 55, 1, p. 94-99 6 p.

Research output: Contribution to journalArticle

T-Lymphocytes
Liver
Leukocytes
Vascular Endothelium
Venules

Nkx2-5+islet1+ mesenchymal precursors generate distinct spleen stromal cell subsets and participate in restoring stromal network integrity

Castagnaro, L., Lenti, E., Maruzzelli, S., Spinardi, L., Migliori, E., Farinello, D., Sitia, G., Harrelson, Z., Evans, S. M., Guidotti, L. G., Harvey, R. P. & Brendolan, A., Apr 18 2013, In : Immunity. 38, 4, p. 782-791 10 p.

Research output: Contribution to journalArticle

Stromal Cells
Spleen
Follicular Dendritic Cells
Lymphoid Tissue
Virus Diseases

TIE2-expressing monocytes/macrophages regulate revascularization of the ischemic limb

Patel, A. S., Smith, A., Nucera, S., Biziato, D., Saha, P., Attia, R. Q., Humphries, J., Mattock, K., Grover, S. P., Lyons, O. T., Guidotti, L. G., Siow, R., Ivetic, A., Egginton, S., Waltham, M., Naldini, L., De Palma, M. & Modarai, B., Jun 2013, In : EMBO Molecular Medicine. 5, 6, p. 858-869 12 p.

Research output: Contribution to journalArticle

Monocytes
Ischemia
Extremities
Macrophages
Muscles
2012

Antiplatelet therapy prevents hepatocellular carcinoma and improves survival in a mouse model of chronic hepatitis B

Sitia, G., Aiolfi, R., Di Lucia, P., Mainetti, M., Fiocchi, A., Mingozzi, F., Esposito, A., Ruggeri, Z. M., Chisari, F. V., Iannacone, M. & Guidotti, L. G., Aug 7 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 32

Research output: Contribution to journalArticle

Chronic Hepatitis B
Hepatocellular Carcinoma
Hepatitis B virus
Blood Platelets
clopidogrel

Follicular helper NKT cells induce limited B cell responses and germinal center formation in the absence of CD4 + T cell help

Tonti, E., Fedeli, M., Napolitano, A., Iannacone, M., Von Andrian, U. H., Guidotti, L. G., Abrignani, S., Casorati, G. & Dellabona, P., Apr 1 2012, In : Journal of Immunology. 188, 7, p. 3217-3222 6 p.

Research output: Contribution to journalArticle

Natural Killer T-Cells
Germinal Center
Helper-Inducer T-Lymphocytes
Galactosylceramides
B-Lymphocytes
2011

Kupffer cells hasten resolution of liver immunopathology in mouse models of viral hepatitis

Sitia, G., Iannacone, M., Aiolfi, R., Isogawa, M., van Rooijen, N., Scozzesi, C., Bianchi, M. E., von Andrian, U. H., Chisari, F. V. & Guidotti, L. G., Jun 2011, In : PLoS Pathogens. 7, 6, e1002061.

Research output: Contribution to journalArticle

Kupffer Cells
Hepatitis
Liver
Hepatocytes
HMGB1 Protein
2010

Modulation of early inflammatory reactions to promote engraftment and function of transplanted pancreatic islets in autoimmune diabetes

Piemonti, L., Guidotti, L. G. & Battaglia, M., 2010, Advances in Experimental Medicine and Biology. Vol. 654. p. 725-747 23 p. (Advances in Experimental Medicine and Biology; vol. 654).

Research output: Chapter in Book/Report/Conference proceedingChapter

Medical problems
Type 1 Diabetes Mellitus
Islets of Langerhans
Liver
Modulation

Role of CCL2/MCP-1 in islet transplantation

Melzi, R., Mercalli, A., Sordi, V., Cantarelli, E., Nano, R., Maffi, P., Sitia, G., Guidotti, L. G., Secchi, A., Bonifacio, E. & Piemonti, L., 2010, In : Cell Transplantation. 19, 8, p. 1031-1046 16 p.

Research output: Contribution to journalArticle

Islets of Langerhans Transplantation
Transplants
Grafts
Transplantation (surgical)
Medical problems

Subcapsular sinus macrophages prevent CNS invasion on peripheral infection with a neurotropic virus

Iannacone, M., Moseman, E. A., Tonti, E., Bosurgi, L., Junt, T., Henrickson, S. E., Whelan, S. P., Guidotti, L. G. & Von Andrian, U. H., Jun 24 2010, In : Nature. 465, 7301, p. 1079-1083 5 p.

Research output: Contribution to journalArticle

Vesicular Stomatitis
Central Nervous System
Macrophages
Viruses
Infection
2009

Bone marrow as an alternative site for islet transplantation

Cantarelli, E., Melzi, R., Mercalli, A., Sordi, V., Ferrari, G., Lederer, C. W., Mrak, E., Rubinacci, A., Ponzoni, M., Sitia, G., Guidotti, L. G., Bonifacio, E. & Piemonti, L., Nov 12 2009, In : Blood. 114, 20, p. 4566-4574 9 p.

Research output: Contribution to journalArticle

Islets of Langerhans Transplantation
Bone
Bone Marrow
Liver
Transplantation

On the role of platelets in the pathogenesis of viral hepatitis

Iannacone, M., Sitia, G. & Guidotti, L. G., Sep 2009, In : Journal of Hepatology. 51, 3, p. 599-600 2 p.

Research output: Contribution to journalArticle

2008

Platelets prevent IFN-α/β-induced lethal hemorrhage promoting CTL-dependent clearance of lymphocytic choriomeningitis virus

Iannacone, M., Sitia, G., Isogawa, M., Whitmire, J. K., Marchese, P., Chisari, F. V., Ruggeri, Z. M. & Guidotti, L. G., Jan 15 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 2, p. 629-634 6 p.

Research output: Contribution to journalArticle

Lymphocytic choriomeningitis virus
Cytotoxic T-Lymphocytes
Anemia
CD40 Ligand
Blood Platelets

Tumor-Targeted Interferon-α Delivery by Tie2-Expressing Monocytes Inhibits Tumor Growth and Metastasis

De Palma, M., Mazzieri, R., Politi, L. S., Pucci, F., Zonari, E., Sitia, G., Mazzoleni, S., Moi, D., Venneri, M. A., Indraccolo, S., Falini, A., Guidotti, L. G., Galli, R. & Naldini, L., Oct 7 2008, In : Cancer Cell. 14, 4, p. 299-311 13 p.

Research output: Contribution to journalArticle

Interferons
Monocytes
Neoplasm Metastasis
Growth
Neoplasms
2007
clopidogrel
Drug therapy
Platelet Aggregation Inhibitors
Adenoviridae
Liver

HBV pathogenesis in animal models: Recent advances on the role of platelets

Iannacone, M., Sitia, G., Ruggeri, Z. M. & Guidotti, L. G., Apr 2007, In : Journal of Hepatology. 46, 4, p. 719-726 8 p.

Research output: Contribution to journalArticle

Hepatitis B virus
Blood Platelets
Animal Models
Liver Diseases
Cytotoxic T-Lymphocytes

In vivo administration of lentiviral vectors triggers a type I interferon response that restricts hepatocyte gene transfer and promotes vector clearance

Brown, B. D., Sitia, G., Annoni, A., Hauben, E., Sergi, L. S., Zingale, A., Roncarolo, M. G., Guidotti, L. G. & Naldini, L., Apr 1 2007, In : Blood. 109, 7, p. 2797-2805 9 p.

Research output: Contribution to journalArticle

Gene transfer
Interferon Type I
Hepatocytes
Transgenes
Heterophile Antigens
HMGB1 Protein
Cytotoxic T-Lymphocytes
Hepatitis B virus
Transgenic Mice
Liver Diseases
2006

Defective Th1 cytokine gene transcription in CD4+ and CD8 + T cells from Wiskott-Aldrich syndrome patients

Trifari, S., Sitia, G., Aiuti, A., Scaramuzza, S., Marangoni, F., Guidotti, L. G., Martino, S., Saracco, P., Notarangelo, L. D., Roncarolo, M. G. & Dupré, L., Nov 15 2006, In : Journal of Immunology. 177, 10, p. 7451-7461 11 p.

Research output: Contribution to journalArticle

Wiskott-Aldrich Syndrome
Cytokines
T-Lymphocytes
Genes
Interleukin-2

Immunobiology and pathogenesis of viral hepatitis

Guidotti, L. G. & Chisari, F. V., 2006, In : Annual Review of Pathology. 1, p. 23-61 39 p.

Research output: Contribution to journalArticle

viral hepatitis
Hepatitis
Hepatitis C virus
Hepatitis B virus
pathogenesis

Naive HIV/HCV-coinfected patients have higher intrahepatic pro-inflammatory cytokines than coinfected patients treated with antiretroviral therapy

Sitia, G., De Bona, A., Bagaglio, S., Galli, L., Paties, C. T., Uberti-Foppa, C., Guidotti, L. G., Lazzarin, A. & Morsica, G., 2006, In : Antiviral Therapy. 11, 3, p. 385-389 5 p.

Research output: Contribution to journalArticle

Hepacivirus
HIV
Cytokines
Interleukin-10
Interferons

Reduced severity of liver ischemia/reperfusion injury following hepatic resection in humans is associated with enhanced intrahepatic expression of Th2 cytokines

Pulitanò, C., Sitia, G., Aldrighetti, L., Finazzi, R., Arru, M., Catena, M., Guidotti, L. G. & Ferla, G., Sep 2006, In : Hepatology Research. 36, 1, p. 20-26 7 p.

Research output: Contribution to journalArticle

Reperfusion Injury
Cytokines
Liver
Interleukin-4
Interleukin-10

Restauración de la inmunidad innata en pacientes con infección por VIH/SIDA después de inicio de terapia antirretroviral

Translated title of the contribution: Innate immunity restoration in patients with HIV/AIDS infection associated with antiretroviral therapyAfani S, A., Jiusán L, L., Raby A, P., Sitia, G., Puente P, J., Sepúlveda C, C., Miranda W, D., Cabrera C, R., Guidotti, L. & Lanza, P., 2006, In : Revista Medica de Chile. 134, 6, p. 689-696 8 p.

Research output: Contribution to journalArticle

Innate Immunity
HIV Infections
Acquired Immunodeficiency Syndrome
Highly Active Antiretroviral Therapy
Viral Load
2005

Immune tolerance split between hepatitis B virus precore and core proteins

Chen, M., Sällberg, M., Hughes, J., Jones, J., Guidotti, L. G., Chisari, F. V., Billaud, J. N. & Milich, D. R., Mar 2005, In : Journal of Virology. 79, 5, p. 3016-3027 12 p.

Research output: Contribution to journalArticle

Viral Core Proteins
Immune Tolerance
Hepatitis B e Antigens
Hepatitis B virus
immunosuppression

Platelets mediate cytotoxic T lymphocyte-induced liver damage

Iannacone, M., Sitia, G., Isogawa, M., Marchese, P., Castro, M. G., Lowenstein, P. R., Chisari, F. V., Ruggeri, Z. M. & Guidotti, L. G., Nov 2005, In : Nature Medicine. 11, 11, p. 1167-1169 3 p.

Research output: Contribution to journalArticle

T-cells
Cytotoxic T-Lymphocytes
Platelets
Liver
Blood Platelets
2004

A function of the hepatitis B virus precore protein is to regulate the immune response to the core antigen

Chen, M. T., Billaud, J. N., Sällberg, M., Guidotti, L. G., Chisari, F. V., Jones, J., Hughes, J. & Milich, D. R., Oct 12 2004, In : Proceedings of the National Academy of Sciences of the United States of America. 101, 41, p. 14913-14918 6 p.

Research output: Contribution to journalArticle

Hepatitis B e Antigens
Hepatitis B virus
Antigens
T-Cell Antigen Receptor
Proteins

MMPs are required for recruitment of antigen-nonspecific mononuclear cells into the liver by CTLs

Sitia, G., Isogawa, M., Iannacone, M., Campbell, I. L., Chisari, F. V. & Guidotti, L. G., Apr 2004, In : Journal of Clinical Investigation. 113, 8, p. 1158-1167 10 p.

Research output: Contribution to journalArticle

Matrix Metalloproteinases
Antigens
Liver
Hepatitis B virus
Liver Diseases
2003

Pathogenesis of viral hepatitis

Guidotti, L. G., Apr 2003, In : Journal of Biological Regulators and Homeostatic Agents. 17, 2, p. 115-119 5 p.

Research output: Contribution to journalArticle

viral hepatitis
Hepatitis C virus
Hepatitis B virus
Virus Diseases
Hepatitis

Searching for interferon-induced genes that inhibit hepatitis B virus replication in transgenic mouse hepatocytes

Wieland, S. F., Vega, R. G., Müller, R., Evans, C. F., Hilbush, B., Guidotti, L. G., Sutcliffe, J. G., Schultz, P. G. & Chisari, F. V., Jan 2003, In : Journal of Virology. 77, 2, p. 1227-1236 10 p.

Research output: Contribution to journalArticle

Hepatitis B virus
interferons
Virus Replication
virus replication
Interferons
2002

Activated intrahepatic antigen-presenting cells inhibit hepatitis B virus replication in the liver of transgenic mice

Kimura, K., Kakimi, K., Wieland, S., Guidotti, L. G. & Chisari, F. V., Nov 1 2002, In : Journal of Immunology. 169, 9, p. 5188-5195 8 p.

Research output: Contribution to journalArticle

Antigen-Presenting Cells
Interleukin-12
Virus Replication
Hepatitis B virus
Natural Killer Cells
Neutrophil Infiltration
Cytotoxic T-Lymphocytes
Hepatitis B virus
Antiviral Agents
Neutrophils

Gene expression during the priming phase of liver regeneration after partial hepatectomy in mice

Su, A. I., Guidotti, L. G., Pezacki, J. P., Chisari, F. V. & Schultz, P. G., Aug 20 2002, In : Proceedings of the National Academy of Sciences of the United States of America. 99, 17, p. 11181-11186 6 p.

Research output: Contribution to journalArticle

Liver Regeneration
Hepatectomy
Gene Expression
Oligonucleotide Array Sequence Analysis
Extracellular Matrix

Interferon-regulated pathways that control hepatitis B virus replication in transgenic mice

Guidotti, L. G., Morris, A., Mendez, H., Koch, R., Silverman, R. H., Williams, B. R. G. & Chisari, F. V., 2002, In : Journal of Virology. 76, 6, p. 2617-2621 5 p.

Research output: Contribution to journalArticle

Hepatitis B virus
interferons
Virus Replication
virus replication
Interferons

The role of cytotoxic T cells and cytokines in the control of hepatitis B virus infection

Guidotti, L. G., Dec 19 2002, In : Vaccine. 20, SUPPL. 4

Research output: Contribution to journalArticle

Hepatitis B virus
Virus Diseases
cytokines
T-lymphocytes
Cytokines
2001

Blocking chemokine responsive to γ-2/interferon (IFN)-γ inducible protein and monokine induced by IFN-γ activity in vivo reduces the pathogenetic but not the antiviral potential of hepatitis B virus-specific cytotoxic T lymphocytes

Kakimi, K., Lane, T. E., Wieland, S., Asensio, V. C., Campbell, I. L., Chisari, F. V. & Guidotti, L. G., Dec 17 2001, In : Journal of Experimental Medicine. 194, 12, p. 1755-1766 12 p.

Research output: Contribution to journalArticle

Monokines
Cytotoxic T-Lymphocytes
Chemokines
Hepatitis B virus
Interferons