• 13052 Citations
  • 54 h-Index
19972019
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Research Output 1997 2019

  • 13052 Citations
  • 54 h-Index
  • 176 Article
  • 4 Review article
  • 1 Conference contribution
  • 1 Editorial
2019

A rule-based expert system for automatic implementation of somatic variant clinical interpretation guidelines

Nicora, G., Limongelli, I., Cova, R., Della Porta, M. G., Malcovati, L., Cazzola, M. & Bellazzi, R., Jan 1 2019, Artificial Intelligence in Medicine - 17th Conference on Artificial Intelligence in Medicine, AIME 2019, Proceedings. Wilk, S., ten Teije, A. & Riaño, D. (eds.). Springer Verlag, p. 114-119 6 p. (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); vol. 11526 LNAI).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Rule-based Systems
Expert System
Expert systems
Oncology
Biomarkers

ClinGen Myeloid Malignancy Variant Curation Expert Panel recommendations for germline RUNX1 variants

Luo, X., Feurstein, S., Mohan, S., Porter, C. C., Jackson, S. A., Keel, S., Chicka, M., Brown, A. L., Kesserwan, C., Agarwal, A., Luo, M., Li, Z., Ross, J. E., Baliakas, P., Pineda-Alvarez, D., DiNardo, C. D., Bertuch, A. A., Mehta, N., Vulliamy, T., Wang, Y. & 14 others, Nichols, K. E., Malcovati, L., Walsh, M. F., Rawlings, L. H., McWeeney, S. K., Soulier, J., Raimbault, A., Routbort, M. J., Zhang, L., Ryan, G., Speck, N. A., Plon, S. E., Wu, D. & Godley, L. A., Oct 22 2019, In : Blood advances. 3, 20, p. 2962-2979 18 p.

Research output: Contribution to journalArticle

Open Access
Molecular Pathology
Genomics
Medical Genetics
Genome
Blood Platelets
2 Citations (Scopus)

Clinical, histopathological and molecular characterization of hypoplastic myelodysplastic syndrome

Bono, E., McLornan, D., Travaglino, E., Gandhi, S., Gallì, A., Khan, A. A., Kulasekararaj, A. G., Boveri, E., Raj, K., Elena, C., Ireland, R. M., Bianchessi, A., Jiang, J., Todisco, G., Ferretti, V. V., Cazzola, M., Marsh, J. C. W., Malcovati, L. & Mufti, G. J., Jan 1 2019, In : Leukemia.

Research output: Contribution to journalArticle

Myelodysplastic Syndromes
Bone Marrow
Aplastic Anemia
Chromosome Aberrations
Differential Diagnosis

Disclosing the Impact of Carcinogenic SF3b Mutations on Pre-mRNA Recognition Via All-Atom Simulations

Borišek, J., Saltalamacchia, A., Gallì, A., Palermo, G., Molteni, E., Malcovati, L. & Magistrato, A., Oct 21 2019, In : Biomolecules. 9, 10

Research output: Contribution to journalArticle

Open Access
Spliceosomes
RNA Splice Sites
RNA Precursors
RNA Splicing
Atoms
1 Citation (Scopus)

Distinct and convergent consequences of splice factor mutations in myelodysplastic syndromes

Madan, V., Li, J., Zhou, S., Teoh, W. W., Han, L., Meggendorfer, M., Malcovati, L., Cazzola, M., Ogawa, S., Haferlach, T., Yang, H. & Koeffler, H. P., Jan 1 2019, (Accepted/In press) In : American Journal of Hematology.

Research output: Contribution to journalArticle

Myelodysplastic Syndromes
Spliceosomes
Mutation
RNA Splicing
Recombinant DNA

Prognostic impact of eosinophils in mastocytosis: analysis of 2350 patients collected in the ECNM Registry

Kluin-Nelemans, H. C., Reiter, A., Illerhaus, A., van Anrooij, B., Hartmann, K., Span, L. F. R., Gorska, A., Niedoszytko, M., Lange, M., Scaffidi, L., Zanotti, R., Bonadonna, P., Perkins, C., Elena, C., Malcovati, L., Shoumariyeh, K., von Bubnoff, N., Parente, R., Triggiani, M., Schwaab, J. & 26 others, Jawhar, M., Caroppo, F., Fortina, A. B., Brockow, K., Zink, A., Fuchs, D., Kilbertus, A., Yavuz, A. S., Doubek, M., Mattsson, M., Hagglund, H., Panse, J., Sabato, V., Aberer, E., Niederwieser, D., Breynaert, C., Várkonyi, J., Kennedy, V., Lortholary, O., Jakob, T., Hermine, O., Rossignol, J., Arock, M., Gotlib, J., Valent, P. & Sperr, W. R., Jan 1 2019, (Accepted/In press) In : Leukemia.

Research output: Contribution to journalArticle

Mastocytosis
Eosinophils
Registries
Eosinophilia
Systemic Mastocytosis

Proposals for revised IWG 2018 hematological response criteria in patients with MDS included in clinical trials

Platzbecker, U., Fenaux, P., Adès, L., Giagounidis, A., Santini, V., van de Loosdrecht, A. A., Bowen, D., de Witte, T., Garcia-Manero, G., Hellström-Lindberg, E., Germing, U., Stauder, R., Malcovati, L., Sekeres, M. A., Steensma, D. P. & Gloaguen, S., 2019, In : Blood. 133, 10, p. 1020-1030 11 p.

Research output: Contribution to journalArticle

Proposals for revised IWG 2018 hematological response criteria in patients with MDS included in clinical trials

Platzbecker, U., Fenaux, P., Adès, L., Giagounidis, A., Santini, V., Van De Loosdrecht, A. A., Bowen, D., De Witte, T., Garcia-Manero, G., Hellström-Lindberg, E., Germing, U., Stauder, R., Malcovati, L., Sekeres, M. A., Steensma, D. P. & Gloaguen, S., 2019, In : Blood. 133, 10, p. 1020-1030 11 p.

Research output: Contribution to journalArticle

Myelodysplastic Syndromes
Clinical Trials
Therapeutics

Proposals for revised IWG 2018 hematological response criteria in patients with MDS included in clinical trials

Platzbecker, U., Fenaux, P., Adès, L., Giagounidis, A., Santini, V., van de Loosdrecht, A. A., Bowen, D., de Witte, T., Garcia-Manero, G., Hellström-Lindberg, E., Germing, U., Stauder, R., Malcovati, L., Sekeres, M. A., Steensma, D. P. & Gloaguen, S., Mar 7 2019, In : Blood. 133, 10

Research output: Contribution to journalArticle

Myelodysplastic Syndromes
Clinical Trials
Therapeutics
8 Citations (Scopus)

Proposed diagnostic criteria for classical chronic myelomonocytic leukemia (CMML), CMML variants and pre-CMML conditions

Valent, P., Orazi, A., Savona, M. R., Patnaik, M. M., Onida, F., Van De Loosdrecht, A. A., Haase, D., Haferlach, T., Elena, C., Pleyer, L., Kern, W., Pemovska, T., Vladimer, G. I., Schanz, J., Keller, A., Lübbert, M., Lion, T., Sotlar, K., Reiter, A., De Witte, T. & 10 others, Pfeilstöcker, M., Geissler, K., Padron, E., Deininger, M., Orfao, A., Horny, H. P., Greenberg, P. L., Arber, D. A., Malcovati, L. & Bennett, J. M., Jan 1 2019, In : Haematologica. 104, 10, p. 1935-1949 15 p.

Research output: Contribution to journalReview article

Open Access
Leukemia, Myelomonocytic, Chronic
Systemic Mastocytosis
Hematology
11 Citations (Scopus)

TP53 mutation status divides myelodysplastic syndromes with complex karyotypes into distinct prognostic subgroups

for the International Working Group for MDS Molecular Prognostic Committee, Jan 1 2019, (Accepted/In press) In : Leukemia.

Research output: Contribution to journalArticle

Myelodysplastic Syndromes
Karyotype
Mutation
Chromosome Aberrations
Critical Care
2018
20 Citations (Scopus)

Aberrant splicing and defective mRNA production induced by somatic spliceosome mutations in myelodysplasia

Shiozawa, Y., Malcovati, L., Gallì, A., Sato-Otsubo, A., Kataoka, K., Sato, Y., Watatani, Y., Suzuki, H., Yoshizato, T., Yoshida, K., Sanada, M., Makishima, H., Shiraishi, Y., Chiba, K., Hellström-Lindberg, E., Miyano, S., Ogawa, S. & Cazzola, M., Dec 1 2018, In : Nature Communications. 9, 1, 3649.

Research output: Contribution to journalArticle

Spliceosomes
splicing
mutations
Genes
Messenger RNA
2 Citations (Scopus)

appreci8: a pipeline for precise variant calling integrating 8 tools

Sandmann, S., Karimi, M., de Graaf, A. O., Rohde, C., Göllner, S., Varghese, J., Ernsting, J., Walldin, G., van der Reijden, B. A., Müller-Tidow, C., Malcovati, L., Hellström-Lindberg, E., Jansen, J. H. & Dugas, M., Dec 15 2018, In : Bioinformatics (Oxford, England). 34, 24, p. 4205-4212 8 p.

Research output: Contribution to journalArticle

Sequencing
Pipelines
Information Storage and Retrieval
Myelodysplastic Syndromes
Computational Biology

Cannibalism by erythroleukaemic blasts

Travaglino, E. & Malcovati, L., 2018, In : British Journal of Haematology. 183, 1, p. 14

Research output: Contribution to journalArticle

1 Citation (Scopus)

Differing clinical features between Japanese and Caucasian patients with myelodysplastic syndromes: Analysis from the International Working Group for Prognosis of MDS

Miyazaki, Y., Tuechler, H., Sanz, G., Schanz, J., Garcia-Manero, G., Solé, F., Bennett, J. M., Bowen, D., Fenaux, P., Dreyfus, F., Kantarjian, H., Kuendgen, A., Malcovati, L., Cazzola, M., Cermak, J., Fonatsch, C., Le Beau, M. M., Slovak, M. L., Santini, V., Lübbert, M. & 14 others, Maciejewski, J., Machherndl-Spandl, S., Magalhaes, S. M. M., Pfeilstöcker, M., Sekeres, M. A., Sperr, W. R., Stauder, R., Tauro, S., Valent, P., Vallespi, T., van de Loosdrecht, A. A., Germing, U., Haase, D. & Greenberg, P. L., Oct 1 2018, In : Leukemia Research. 73, p. 51-57 7 p.

Research output: Contribution to journalArticle

Myelodysplastic Syndromes
Cytogenetics
Survival
Intrinsic Factor
Acute Myeloid Leukemia
7 Citations (Scopus)

Health-related quality of life in lower-risk MDS patients compared with age- and sex-matched reference populations: A European LeukemiaNet study

Stauder, R., Yu, G., Koinig, K. A., Bagguley, T., Fenaux, P., Symeonidis, A., Sanz, G., Cermak, J., Mittelman, M., Hellström-Lindberg, E., Langemeijer, S., Holm, M. S., Madry, K., Malcovati, L., Tatic, A., Germing, U., Savic, A., Van Marrewijk, C., Guerci-Bresler, A., Luño, E. & 5 others, Droste, J., Efficace, F., Smith, A., Bowen, D. & De Witte, T., Jun 1 2018, In : Leukemia. 32, 6, p. 1380-1392 13 p.

Research output: Contribution to journalArticle

Myelodysplastic Syndromes
Quality of Life
Population
Anxiety
Depression
27 Citations (Scopus)

Impact of spliceosome mutations on RNA splicing in myelodysplasia: Dysregulated genes/pathways and clinical associations

Pellagatti, A., Armstrong, R. N., Steeples, V., Sharma, E., Repapi, E., Singh, S., Sanchi, A., Radujkovic, A., Horn, P., Dolatshad, H., Roy, S., Broxholme, J., Lockstone, H., Taylor, S., Giagounidis, A., Vyas, P., Schuh, A., Hamblin, A., Papaemmanuil, E., Killick, S. & 10 others, Malcovati, L., Hennrich, M. L., Gavin, A. C., Ho, A. D., Luft, T., Hellström-Lindberg, E., Cazzola, M., Smith, C. W. J., Smith, S. & Boultwood, J., Sep 20 2018, In : Blood. 132, 12, p. 1225-1240 16 p.

Research output: Contribution to journalArticle

Spliceosomes
RNA Splicing
Critical Pathways
Myelodysplastic Syndromes
Recombinant DNA
5 Citations (Scopus)

Infection perturbs Bach2- and Bach1-dependent erythroid lineage ‘choice’ to cause anemia

Kato, H., Itoh-Nakadai, A., Matsumoto, M., Ishii, Y., Watanabe-Matsui, M., Ikeda, M., Ebina-Shibuya, R., Sato, Y., Kobayashi, M., Nishizawa, H., Suzuki, K., Muto, A., Fujiwara, T., Nannya, Y., Malcovati, L., Cazzola, M., Ogawa, S., Harigae, H. & Igarashi, K., Oct 1 2018, In : Nature Immunology. 19, 10, p. 1059-1070 12 p.

Research output: Contribution to journalArticle

Hematopoietic Stem Cells
Anemia
Transcription Factors
Infection
Myelopoiesis
2 Citations (Scopus)

Prognostic impact of a suboptimal number of analyzed metaphases in normal karyotype lower-risk MDS

de Swart, L., Smith, A., Haase, D., Fenaux, P., Symeonidis, A., Cermak, J., Sanz, G., Stauder, R., Mittelman, M., Hellström-Lindberg, E., Malcovati, L., Langemeijer, S., Skov-Holm, M., Mądry, K., Germing, U., Almeida, A. M., Tatic, A., Savic, A., Šimec, N. G., van Marrewijk, C. & 9 others, Guerci-Bresler, A., Sanhes, L., Luño, E., Culligan, D., Beyne-Rauzy, O., Burgstaller, S., Blijlevens, N., Bowen, D. & de Witte, T., Apr 1 2018, In : Leukemia Research. 67, p. 21-26 6 p.

Research output: Contribution to journalArticle

Metaphase
Karyotype
Abnormal Karyotype
General Practice
Disease-Free Survival

Proposals for revised IWG 2018 hematological response criteria in patients with MDS included in clinical trials

Platzbecker, U., Fenaux, P., Adès, L., Giagounidis, A., Santini, V., van de Loosdrecht, A. A., Bowen, D., de Witte, T., Garcia-Manero, G., Hellström-Lindberg, E., Germing, U., Stauder, R., Malcovati, L., Sekeres, M., Steensma, D. P. & Gloaguen, S., Nov 7 2018, In : Blood.

Research output: Contribution to journalArticle

Myelodysplastic Syndromes
Clinical Trials
Therapeutics
6 Citations (Scopus)

The Data Registry of the European Competence Network on Mastocytosis (ECNM): Set Up, Projects, and Perspectives

Study Group of the European Competence Network on Mastocytosis (ECNM), Jan 1 2018, (Accepted/In press) In : Journal of Allergy and Clinical Immunology: In Practice.

Research output: Contribution to journalArticle

Systemic Mastocytosis
Mastocytosis
Mental Competency
Registries
Cutaneous Mastocytosis
2017
64 Citations (Scopus)

Allogeneic hematopoietic stem cell transplantation for MDS and CMML: Recommendations from an international expert panel

De Witte, T., Bowen, D., Robin, M., Malcovati, L., Niederwieser, D., Yakoub-Agha, I., Mufti, G. J., Fenaux, P., Sanz, G., Martino, R., Alessandrino, E. P., Onida, F., Symeonidis, A., Passweg, J., Kobbe, G., Ganser, A., Platzbecker, U., Finke, J., Van Gelder, M., Van De Loosdrecht, A. A. & 10 others, Ljungman, P., Stauder, R., Volin, L., Deeg, H. J., Cutler, C., Saber, W., Champlin, R., Giralt, S., Anasetti, C. & Kröger, N., Mar 30 2017, In : Blood. 129, 13, p. 1753-1762 10 p.

Research output: Contribution to journalReview article

Leukemia, Myelomonocytic, Chronic
Hematopoietic Stem Cell Transplantation
Myelodysplastic Syndromes
Stem cells
Comorbidity
64 Citations (Scopus)

Allogeneic hematopoietic stem cell transplantation for MDS and CMML: recommendations from an international expert panel

Witte, T. D., Bowen, D., Robin, M., Malcovati, L., Niederwieser, D., Yakoub-Agha, I., Mufti, G. J., Fenaux, P., Sanz, G., Martino, R., Alessandrino, E. P., Onida, F., Symeonidis, A., Passweg, J., Kobbe, G., Ganser, A., Platzbecker, U., Finke, J., Gelder, M. V., Loosdrecht, A. A. V. D. & 10 others, Ljungman, P., Stauder, R., Volin, L., Deeg, H. J., Cutler, C., Saber, W., Champlin, R., Giralt, S., Anasetti, C. & Kroger, N., Mar 30 2017, In : Blood. 129, 13, p. 1753-1762 10 p.

Research output: Contribution to journalArticle

Leukemia, Myelomonocytic, Chronic
Hematopoietic Stem Cell Transplantation
Myelodysplastic Syndromes
Stem cells
Comorbidity
104 Citations (Scopus)

Clinical significance of somatic mutation in unexplained blood cytopenia

Malcovati, L., Gallì, A., Travaglino, E., Ambaglio, I., Rizzo, E., Molteni, E., Elena, C., Ferretti, VV., Catricalà, S., Bono, E., Todisco, G., Bianchessi, A., Rumi, E., Zibellini, S., Pietra, D., Boveri, E., Camaschella, C., Toniolo, D., Papaemmanuil, E., Ogawa, S. & 1 others, Cazzola, M., 2017, In : Blood. 129, 25, p. 3371-3378 8 p.

Research output: Contribution to journalArticle

Blood
Genes
Mutation
Neoplasms
Hazards
104 Citations (Scopus)

Clinical significance of somatic mutation in unexplained blood cytopenia

Malcovati, L., Gallì, A., Travaglino, E., Ambaglio, I., Rizzo, E., Molteni, E., Elena, C., Ferretti, V. V., Catricalà, S., Bono, E., Todisco, G., Bianchessi, A., Rumi, E., Zibellini, S., Pietra, D., Boveri, E., Camaschella, C., Toniolo, D., Papaemmanuil, E., Ogawa, S. & 1 others, Cazzola, M., Jun 22 2017, In : Blood. 129, 25, p. 3371-3378 8 p.

Research output: Contribution to journalArticle

Blood
Genes
Mutation
Neoplasms
Hazards
8 Citations (Scopus)

Cytomorphology review of 100 newly diagnosed lower-risk MDS patients in the European LeukemiaNet MDS (EUMDS) registry reveals a high inter-observer concordance

de Swart, L., Smith, A., MacKenzie, M., Symeonidis, A., Neukirchen, J., Mikulenková, D., Vallespí, T., Zini, G., Paszkowska-Kowalewska, M., Kruger, A., Saft, L., Fenaux, P., Bowen, D., Hellström-Lindberg, E., Čermák, J., Stauder, R., Tatic, A., Holm, M. S., Malcovati, L., Mądry, K. & 4 others, Droste, J., Blijlevens, N., de Witte, T. & Germing, U., Jul 1 2017, In : Annals of Hematology. 96, 7, p. 1105-1112 8 p.

Research output: Contribution to journalArticle

Myelodysplastic Syndromes
Registries
Bone Marrow
Myelopoiesis
Observer Variation
11 Citations (Scopus)

Decision analysis of allogeneic hematopoietic stem cell transplantation for patients with myelodysplastic syndrome stratified according to the revised International Prognostic Scoring System

della Porta, M. G., Jackson, C. H., Alessandrino, E. P., Rossi, M., Bacigalupo, A., van Lint, M. T., Bernardi, M., Allione, B., Bosi, A., Guidi, S., Santini, V., Malcovati, L., Ubezio, M., Milanesi, C., Todisco, E., Voso, M. T., Musto, P., Onida, F., Iori, A. P., Cerretti, R. & 13 others, Grillo, G., Molteni, A., Pioltelli, P., Borin, L., Angelucci, E., Oldani, E., Sica, S., Pascutto, C., Ferretti, V., Santoro, A., Bonifazi, F., Cazzola, M. & Rambaldi, A., 2017, In : Leukemia. 31, 11, p. 2449-2457

Research output: Contribution to journalArticle

Decision Support Techniques
Hematopoietic Stem Cell Transplantation
Myelodysplastic Syndromes
Life Expectancy
Transplantation
11 Citations (Scopus)

Decision analysis of allogeneic hematopoietic stem cell transplantation for patients with myelodysplastic syndrome stratified according to the revised International Prognostic Scoring System

Porta, M. G. D., Jackson, C. H., Alessandrino, E. P., Rossi, M., Bacigalupo, A., Lint, M. T. V., Bernardi, M., Allione, B., Bosi, A., Guidi, S., Santini, V., Malcovati, L., Ubezio, M., Milanesi, C., Todisco, E., Voso, M. T., Musto, P., Onida, F., Iori, A. P., Cerretti, R. & 13 others, Grillo, G., Molteni, A., Pioltelli, P., Borin, L., Angelucci, E., Oldani, E., Sica, S., Pascutto, C., Ferretti, V., Santoro, A., Bonifazi, F., Cazzola, M. & Rambaldi, A., Nov 1 2017, In : Leukemia. 31, 11, p. 2449-2457 9 p.

Research output: Contribution to journalArticle

Decision Support Techniques
Hematopoietic Stem Cell Transplantation
Myelodysplastic Syndromes
Life Expectancy
Transplantation
11 Citations (Scopus)

Decision analysis of allogeneic hematopoietic stem cell transplantation for patients with myelodysplastic syndrome stratified according to the revised International Prognostic Scoring System

della Porta, M. G., Jackson, C. H., Alessandrino, E. P., Rossi, M., Bacigalupo, A., van Lint, M. T., Bernardi, M., Allione, B., Bosi, A., Guidi, S., Santini, V., Malcovati, L., Ubezio, M., Milanesi, C., Todisco, E., Voso, M. T., Musto, P., Onida, F., Iori, A. P., Cerretti, R. & 13 others, Grillo, G., Molteni, A., Pioltelli, P., Borin, L., Angelucci, E., Oldani, E., Sica, S., Pascutto, C., Ferretti, V., Santoro, A., Bonifazi, F., Cazzola, M. & Rambaldi, A., 2017, In : Leukemia. 31, 11, p. 2449-2457 9 p.

Research output: Contribution to journalArticle

Decision Support Techniques
Hematopoietic Stem Cell Transplantation
Myelodysplastic Syndromes
Life Expectancy
Transplantation
11 Citations (Scopus)

Decision analysis of allogeneic hematopoietic stem cell transplantation for patients with myelodysplastic syndrome stratified according to the revised international prognostic scoring system (IPSS-R)

Della Porta, M. G., Jackson, C. H., Alessandrino, E. P., Rossi, M., Bacigalupo, A., van Lint, M. T., Bernardi, M., Allione, B., Bosi, A., Guidi, S., Santini, V., Malcovati, L., Ubezio, M. C., Milanesi, C., Todisco, E., Voso, M. T., Musto, P., Onida, F., Iori, A. P., Cerretti, R. & 13 others, Grillo, G., Molteni, A., Pioltelli, P., Borin, L., Angelucci, E., Oldani, E., Sica, G. S., Pascutto, C., Ferretti, V., Santoro, A., Bonifazi, F., Cazzola, M. & Rambaldi, A., Mar 21 2017, In : Leukemia.

Research output: Contribution to journalArticle

Decision Support Techniques
Hematopoietic Stem Cell Transplantation
Myelodysplastic Syndromes
Life Expectancy
Transplantation
11 Citations (Scopus)

Decision analysis of allogeneic hematopoietic stem cell transplantation for patients with myelodysplastic syndrome stratified according to the revised international prognostic scoring system (IPSS-R)

Della Porta, M. G., Jackson, C. H., Alessandrino, E. P., Rossi, M., Bacigalupo, A., van Lint, M. T., Bernardi, M., Allione, B., Bosi, A., Guidi, S., Santini, V., Malcovati, L., Ubezio, M. C., Milanesi, C., Todisco, E., Voso, M. T., Musto, P., Onida, F., Iori, A. P., Cerretti, R. & 13 others, Grillo, G., Molteni, A., Pioltelli, P., Borin, L., Angelucci, E., Oldani, E., Sica, G. S., Pascutto, C., Ferretti, V., Santoro, A., Bonifazi, F., Cazzola, M. & Rambaldi, A., Mar 21 2017, In : Leukemia.

Research output: Contribution to journalArticle

Decision Support Techniques
Hematopoietic Stem Cell Transplantation
Myelodysplastic Syndromes
Life Expectancy
Transplantation
11 Citations (Scopus)

Erythropoiesis-stimulating agents significantly delay the onset of a regular transfusion need in nontransfused patients with lower-risk myelodysplastic syndrome

Garelius, H. K. G., Johnston, W. T., Smith, A. G., Park, S., de Swart, L., Fenaux, P., Symeonidis, A., Sanz, G., Čermák, J., Stauder, R., Malcovati, L., Mittelman, M., van de Loosdrecht, A. A., van Marrewijk, C. J., Bowen, D., Crouch, S., de Witte, T. J. M. & Hellström-Lindberg, E., Mar 1 2017, In : Journal of Internal Medicine. 281, 3, p. 284-299 16 p.

Research output: Contribution to journalArticle

Hematinics
Myelodysplastic Syndromes
Registries
Therapeutics
Proportional Hazards Models
14 Citations (Scopus)

Gene expression and risk of leukemic transformation in myelodysplasia

Shiozawa, Y., Malcovati, L., Gallì, A., Pellagatti, A., Karimi, M., Sato-Otsubo, A., Sato, Y., Suzuki, H., Yoshizato, T., Yoshida, K., Shiraishi, Y., Chiba, K., Makishima, H., Boultwood, J., Hellström-Lindberg, E., Miyano, S., Cazzola, M. & Ogawa, S., Dec 14 2017, In : Blood. 130, 24, p. 2642-2653 12 p.

Research output: Contribution to journalArticle

Gene expression
Genes
Bone Marrow Cells
Gene Expression
Bone

Introduction

Malcovati, L., Jul 1 2017, In : Seminars in Hematology. 54, 3, p. 129-132 4 p.

Research output: Contribution to journalEditorial

15 Citations (Scopus)

Pattern of somatic mutations in patients with Waldenström macroglobulinemia or IgM monoclonal gammopathy of undetermined significance

Varettoni, M., Zibellini, S., Defrancesco, I., Ferretti, V. V., Rizzo, E., Malcovati, L., Gallì, A., Della Porta, M. G., Boveri, E., Arcaini, L., Candido, C., Paulli, M. & Cazzola, M., Nov 30 2017, In : Haematologica. 102, 12, p. 2077-2085 9 p.

Research output: Contribution to journalArticle

Monoclonal Gammopathy of Undetermined Significance
Waldenstrom Macroglobulinemia
Immunoglobulin M
Mutation
TNF Receptor-Associated Factor 3
12 Citations (Scopus)

Recognition of familial myeloid neoplasia in adults

Brown, A. L., Churpek, J. E., Malcovati, L., Döhner, H. & Godley, L. A., Apr 1 2017, In : Seminars in Hematology. 54, 2, p. 60-68 9 p.

Research output: Contribution to journalReview article

Hematologic Neoplasms
Neoplasms
Gene Rearrangement
Genetic Counseling
Genetic Testing
26 Citations (Scopus)

The U2AF1S34F mutation induces lineage-specific splicing alterations in myelodysplastic syndromes

Yip, B. H., Steeples, V., Repapi, E., Armstrong, R. N., Llorian, M., Roy, S., Shaw, J., Dolatshad, H., Taylor, S., Verma, A., Bartenstein, M., Vyas, P., Cross, N. C. P., Malcovati, L., Cazzola, M., Hellström-Lindberg, E., Ogawa, S., Smith, C. W. J., Pellagatti, A. & Boultwood, J., Jun 1 2017, In : Journal of Clinical Investigation. 127, 6, p. 2206-2221 16 p.

Research output: Contribution to journalArticle

Myelodysplastic Syndromes
Mutation
Erythroid Cells
Protein Isoforms
RNA Sequence Analysis
2016
5 Citations (Scopus)

GFI136N as a therapeutic and prognostic marker for myelodysplastic syndrome

Botezatu, L., Michel, L. C., Makishima, H., Schroeder, T., Germing, U., Haas, R., Van der Reijden, B., Marneth, A. E., Bergevoet, S. M., Jansen, J. H., Przychodzen, B., Wlodarski, M., Niemeyer, C., Platzbecker, U., Ehninger, G., Unnikrishnan, A., Beck, D., Pimanda, J., Hellström-Lindberg, E., Malcovati, L. & 10 others, Boultwood, J., Pellagatti, A., Papaemmanuil, E., Le Coutre, P., Kaeda, J., Opalka, B., Möröy, T., Dührsen, U., Maciejewski, J. & Khandanpour, C., Jul 1 2016, In : Experimental Hematology. 44, 7, p. 590-595.e1

Research output: Contribution to journalArticle

Myelodysplastic Syndromes
Intercellular Signaling Peptides and Proteins
Gene Frequency
Asparagine
Belgium
67 Citations (Scopus)

Integrating clinical features and genetic lesions in the risk assessment of patients with chronic myelomonocytic leukemia

Elena, C., Gallì, A., Such, E., Meggendorfer, M., Germing, U., Rizzo, E., Cervera, J., Molteni, E., Fasan, A., Schuler, E., Ambaglio, I., Lopez-Pavia, M., Zibellini, S., Kuendgen, A., Travaglino, E., Sancho-Tello, R., Catricalà, S., Vicente, A. I., Haferlach, T., Haferlach, C. & 3 others, Sanz, G. F., Malcovati, L. & Cazzola, M., 2016, In : Blood. 128, 10, p. 1408-1417 10 p.

Research output: Contribution to journalArticle

Leukemia, Myelomonocytic, Chronic
Risk assessment
Mutation
Genes
Hazards
17 Citations (Scopus)

Recent advances in the understanding of myelodysplastic syndromes with ring sideroblasts

Malcovati, L. & Cazzola, M., Sep 1 2016, In : British Journal of Haematology. 174, 6, p. 847-858 12 p.

Research output: Contribution to journalReview article

Myelodysplastic Syndromes
Nonsense Mediated mRNA Decay
Mutation
Refractory Anemia
Haploinsufficiency

Tie2 expressing monocytes in the spleen of patients with primary myelofibrosis

Campanelli, R., Fois, G., Catarsi, P., Poletto, V., Villani, L., Erba, B. G., Maddaluno, L., Jemos, B., Salmoiraghi, S., Guglielmelli, P., Abbonante, V., Di Buduo, C. A., Balduini, A., Iurlo, A., Barosi, G., Rosti, V., Massa, M., Vannucchi, A. M., Balliu, M., Bartalucci, N. & 75 others, Bogani, C., Bosi, A., Calabresi, L., Corbizzi Fattori, G., Fanelli, T., Fjerza, R., Gesullo, F., Guglielmelli, P., Mannarelli, C., Merli, L., Pacilli, A., Pancrazzi, A., Paoli, C., Pieri, L., Rotunno, G., Sant'Antonio, E., Barosi, G., Abbonante, V., Balduini, A., Bonetti, E., Campanelli, R., Catarsi, P., Di Buduo, C. A., Fois, G., Massa, M., Poletto, V., Rosti, V., Villani, L., Cazzola, M., Ambaglio, I., Bernasconi, P., Casetti, C. I., Catricala, S., Elena, C., Fugazza, E., Gallì, A., Malcovati, L., Milanesi, C., Pascutto, C., Pietra, D., Ripamonti, F., Rossi, M., Rumi, E., Dejana, E., Breviario, F., Corada, M., Malinverno, M., Rambaldi, A., Chioda, G., Ferrari, M. L., Finazzi, G., Finazzi, M., Belotti, C., Boroni, C., Salmoiraghi, S., Amaru, A., Golay, J., Bortoluzzi, S., Bisognin, A., Coppe, A., Saccoman, C., Manfredini, R., Artuso, L., Bernardis, I., Bianchi, E., Montanari, M., Pennucci, V., Prudente, Z., Rontauroli, S., Rossi, C., Ruberti, S., Salati, S., Tagliafico, E., Tenedini, E. & Zini, R., Jun 1 2016, In : PLoS One. 11, 6, e0156990.

Research output: Contribution to journalArticle

Primary Myelofibrosis
monocytes
Monocytes
spleen
Spleen
1 Citation (Scopus)

Tie2 expressing monocytes in the spleen of patients with primary myelofibrosis

Campanelli, R., Fois, G., Catarsi, P., Poletto, V., Villani, L., Erba, B. G., Maddaluno, L., Jemos, B., Salmoiraghi, S., Guglielmelli, P., Abbonante, V., Di Buduo, C. A., Balduini, A., Iurlo, A., Barosi, G., Rosti, V., Massa, M., Vannucchi, A. M., Balliu, M., Bartalucci, N. & 31 others, Bogani, C., Bosi, A., Calabresi, L., Corbizzi Fattori, G., Fanelli, T., Fjerza, R., Gesullo, F., Guglielmelli, P., Mannarelli, C., Merli, L., Pacilli, A., Pancrazzi, A., Paoli, C., Pieri, L., Rotunno, G., Sant'Antonio, E., Barosi, G., Rosti, V., Cazzola, M., Ambaglio, I., Bernasconi, P., Catricalà, S., Elena, C., Fugazza, E., Malcovati, L., Milanesi, C., Pietra, D., Ripamonti, F., Rossi, M., Rumi, E. & AGIMM Investigators, Jun 1 2016, In : PLoS One. 11, 6, e0156990.

Research output: Contribution to journalArticle

Primary Myelofibrosis
monocytes
Monocytes
spleen
Spleen
45 Citations (Scopus)

Time-dependent changes in mortality and transformation risk in MDS

Pfeilstöcker, M., Tuechler, H., Sanz, G., Schanz, J., Garcia-Manero, G., Solé, F., Bennett, J. M., Bowen, D., Fenaux, P., Dreyfus, F., Kantarjian, H., Kuendgen, A., Malcovati, L., Cazzola, M., Cermak, J., Fonatsch, C., Le Beau, M. M., Slovak, M. L., Levis, A., Luebbert, M. & 14 others, Maciejewski, J., Machherndl-Spandl, S., Magalhaes, S. M. M., Miyazaki, Y., Sekeres, M. A., Sperr, W. R., Stauder, R., Tauro, S., Valent, P., Vallespi, T., Van De Loosdrecht, A. A., Germing, U., Haase, D. & Greenberg, P. L., Aug 18 2016, In : Blood. 128, 7, p. 902-910 9 p.

Research output: Contribution to journalArticle

Myelodysplastic Syndromes
Mortality
Hazards
Survival
Acute Myeloid Leukemia
2015
66 Citations (Scopus)

An international consortium proposal of uniform response criteria for myelodysplastic/myeloproliferative neoplasms (MDS/MPN) in adults

Savona, M. R., Malcovati, L., Komrokji, R., Tiu, R. V., Mughal, T. I., Orazi, A., Kiladjian, J. J., Padron, E., Solary, E., Tibes, R., Itzykson, R., Cazzola, M., Mesa, R., Maciejewski, J., Fenaux, P., Garcia-Manero, G., Gerds, A., Sanz, G., Niemeyer, C. M., Cervantes, F. & 3 others, Germing, U., Cross, N. C. P. & List, A. F., Mar 19 2015, In : Blood. 125, 12, p. 1857-1865 9 p.

Research output: Contribution to journalArticle

Stem cells
Myelodysplastic Syndromes
Neoplasms
Stem Cells
Clinical Trials
52 Citations (Scopus)

An international MDS/MPN working group’s perspective and recommendations on molecular pathogenesis, diagnosis and clinical characterization of myelodysplastic/myeloproliferative neoplasms

Mughal, T. I., Cross, N. C. P., Padron, E., Tiu, R. V., Savona, M., Malcovati, L., Tibes, R., Komrokji, R. S., Kiladjian, J. J., Garcia-Manero, G., Orazi, A., Mesa, R., Maciejewski, J. P., Fenaux, P., Itzykson, R., Mufti, G., Solary, E. & List, A. F., Sep 7 2015, In : Haematologica. 100, 9, p. 1117-1130 14 p.

Research output: Contribution to journalArticle

Refractory Anemia
Thrombocytosis
Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative
Juvenile Myelomonocytic Leukemia
Leukemia, Myelomonocytic, Chronic
103 Citations (Scopus)

Combining gene mutation with gene expression data improves outcome prediction in myelodysplastic syndromes

Gerstung, M., Pellagatti, A., Malcovati, L., Giagounidis, A., Della Porta, M. G., Jädersten, M., Dolatshad, H., Verma, A., Cross, N. C. P., Vyas, P., Killick, S., Hellström-Lindberg, E., Cazzola, M., Papaemmanuil, E., Campbell, P. J. & Boultwood, J., Jan 9 2015, In : Nature Communications. 6, 5901.

Research output: Contribution to journalArticle

gene expression
Myelodysplastic Syndromes
mutations
Gene expression
genes
73 Citations (Scopus)

Disruption of SF3B1 results in deregulated expression and splicing of key genes and pathways in myelodysplastic syndrome hematopoietic stem and progenitor cells

Dolatshad, H., Pellagatti, A., Fernandez-Mercado, M., Yip, B. H., Malcovati, L., Attwood, M., Przychodzen, B., Sahgal, N., Kanapin, A. A., Lockstone, H., Scifo, L., Vandenberghe, P., Papaemmanuil, E., Smith, C. W. J., Campbell, P. J., Ogawa, S., Maciejewski, J. P., Cazzola, M., Savage, K. I. & Boultwood, J., May 11 2015, In : Leukemia. 29, 5, p. 1092-1103 12 p.

Research output: Contribution to journalArticle

Myelodysplastic Syndromes
Hematopoietic Stem Cells
Refractory Anemia
Genes
RNA
10 Citations (Scopus)

Erratum: Disruption of SF3B1 results in deregulated expression and splicing of key genes and pathways in myelodysplastic syndrome hematopoietic stem and progenitor cells (Leukemia (2015) 29 (1092-1103) 10.1038/leu.2014.331)

Dolatshad, H., Pellagatti, A., Fernandez-Mercado, M., Yip, B. H., Malcovati, L., Attwood, M., Przychodzen, B., Sahgal, N., Kanapin, A. A., Lockstone, H., Scifo, L., Vandenberghe, P., Papaemmanuil, E., Smith, C. W. J., Campbell, P. J., Ogawa, S., Maciejewski, J. P., Cazzola, M., Savage, K. I. & Boultwood, J., Aug 7 2015, In : Leukemia. 29, 8, p. 1798 1 p.

Research output: Contribution to journalArticle