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Research Output 1997 2020

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Article
2015

Recurrent ETNK1 mutations in atypical chronic myeloid leukemia

Gambacorti-Passerini, C. B., Donadoni, C., Parmiani, A., Pirola, A., Redaelli, S., Signore, G., Piazza, V., Malcovati, L., Fontana, D., Spinelli, R., Magistroni, V., Gaipa, G., Peronaci, M., Morotti, A., Panuzzo, C., Saglio, G., Usala, E., Kim, D. W., Rea, D., Zervakis, K. & 12 others, Viniou, N., Symeonidis, A., Becker, H., Boultwood, J., Campiotti, L., Carrabba, M., Elli, E., Bignell, G. R., Papaemmanuil, E., Campbell, P. J., Cazzola, M. & Piazza, R., Jan 15 2015, In : Blood. 125, 3, p. 499-503 5 p.

Research output: Contribution to journalArticle

Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative
Phosphorylcholine
Mutation
Catalyst activity
Phosphotransferases

SF3B1 mutation identifies a distinct subset of myelodysplastic syndrome with ring sideroblasts

Malcovati, L., Karimi, M., Papaemmanuil, E., Ambaglio, I., Jädersten, M., Jansson, M., Elena, C., Gallì, A., Walldin, G., Porta, M. G. D., Raaschou-Jensen, K., Travaglino, E., Kallenbach, K., Pietra, D., Ljungström, V., Conte, S., Boveri, E., Invernizzi, R., Rosenquist, R., Campbell, P. J. & 2 others, Cazzola, M. & Lindberg, E. H., Jul 9 2015, In : Blood. 126, 2, p. 233-241 9 p.

Research output: Contribution to journalArticle

Myelodysplastic Syndromes
Refractory materials
Mutation
Refractory Anemia
Hazards

The genomic landscape of myeloid neoplasms with myelodysplasia and its clinical implications

Malcovati, L., Ambaglio, I. & Elena, C., Oct 9 2015, In : Current Opinion in Oncology. 27, 6, p. 551-559 9 p.

Research output: Contribution to journalArticle

Clone Cells
Neoplasms
Mutation
Histone Code
Multipotent Stem Cells

Validation of the revised international prognostic scoring system (IPSS-R) in patients with lower-risk myelodysplastic syndromes: a report from the prospective European LeukaemiaNet MDS (EUMDS) registry

de Swart, L., Smith, A., Johnston, T. W., Haase, D., Droste, J., Fenaux, P., Symeonidis, A., Sanz, G., Hellström-Lindberg, E., Cermák, J., Germing, U., Stauder, R., Georgescu, O., MacKenzie, M., Malcovati, L., Holm, M. S., Almeida, A. M., Mądry, K., Slama, B., Guerci-Bresler, A. & 5 others, Sanhes, L., Beyne-Rauzy, O., Luño, E., Bowen, D. & de Witte, T., Aug 1 2015, In : British Journal of Haematology. 170, 3, p. 372-383 12 p.

Research output: Contribution to journalArticle

Myelodysplastic Syndromes
Registries
Chelation Therapy
Erythrocyte Transfusion
Survival

Validation of WHO classification-based Prognostic Scoring System (WPSS) for myelodysplastic syndromes and comparison with the revised International Prognostic Scoring System (IPSS-R). A study of the International Working Group for Prognosis in Myelodysplasia (IWG-PM)

Della Porta, M. G., Tuechler, H., Malcovati, L., Schanz, J., Sanz, G., Garcia-Manero, G., Solé, F., Bennett, J. M., Bowen, D., Fenaux, P., Dreyfus, F., Kantarjian, H., Kuendgen, A., Levis, A., Cermak, J., Fonatsch, C., Le Beau, M. M., Slovak, M. L., Krieger, O., Luebbert, M. & 15 others, Maciejewski, J., Magalhaes, S. M. M., Miyazaki, Y., Pfeilstöcker, M., Sekeres, M. A., Sperr, W. R., Stauder, R., Tauro, S., Valent, P., Vallespi, T., Van De Loosdrecht, A. A., Germing, U., Haase, D., Greenberg, P. L. & Cazzola, M., Jul 13 2015, In : Leukemia. 29, 7, p. 1502-1513 12 p.

Research output: Contribution to journalArticle

Myelodysplastic Syndromes
Cytogenetics
Anemia
Bone Marrow
Weights and Measures
2014

Driver somatic mutations identify distinct disease entities within myeloid neoplasms with myelodysplasia

Malcovati, L., Papaemmanuil, E., Ambaglio, I., Elena, C., Gallì, A., Della Porta, M. G., Travaglino, E., Pietra, D., Pascutto, C., Ubezio, M., Bono, E., Da Vià, M. C., Brisci, A., Bruno, F., Cremonesi, L., Ferrari, M., Boveri, E., Invernizzi, R., Campbell, P. J. & Cazzola, M., Aug 28 2014, In : Blood. 124, 9, p. 1513-1521 9 p.

Research output: Contribution to journalArticle

Myelodysplastic Syndromes
Mutation
Genes
Neoplasms
Statistical methods

Erratum to Myelodysplastic syndromes are propagated by rare and distinct human cancer stem cells in vivo [Cancer Cell, 25 (2014) 794-808]

Woll, P. S., Kjällquist, U., Chowdhury, O., Doolittle, H., Wedge, D. C., Thongjuea, S., Erlandsson, R., Ngara, M., Anderson, K., Deng, Q., Mead, A. J., Stenson, L., Giustacchini, A., Duarte, S., Giannoulatou, E., Taylor, S., Karimi, M., Scharenberg, C., Mortera-Blanco, T., Macaulay, I. C. & 28 others, Clark, S. A., Dybedal, I., Josefsen, D., Fenaux, P., Hokland, P., Holm, M. S., Cazzola, M., Malcovati, L., Tauro, S., Bowen, D., Boultwood, J., Pellagatti, A., Pimanda, J. E., Unnikrishnan, A., Vyas, P., Göhring, G., Schlegelberger, B., Tobiasson, M., Kvalheim, G., Constantinescu, S. N., Nerlov, C., Nilsson, L., Campbell, P. J., Sandberg, R., Papaemmanuil, E., Hellström-Lindberg, E., Linnarsson, S. & Jacobsen, S. W., Jun 16 2014, In : Cancer Cell. 25, 6, p. 861 1 p.

Research output: Contribution to journalArticle

Myelodysplastic syndromes are propagated by rare and distinct human cancer stem cells in vivo

Woll, P. S., Kjällquist, U., Chowdhury, O., Doolittle, H., Wedge, D. C., Thongjuea, S., Erlandsson, R., Ngara, M., Anderson, K., Deng, Q., Mead, A. J., Stenson, L., Giustacchini, A., Duarte, S., Giannoulatou, E., Taylor, S., Karimi, M., Scharenberg, C., Mortera-Blanco, T., Macaulay, I. C. & 28 others, Clark, S. A., Dybedal, I., Josefsen, D., Fenaux, P., Hokland, P., Holm, M. S., Cazzola, M., Malcovati, L., Tauro, S., Bowen, D., Boultwood, J., Pellagatti, A., Pimanda, J. E., Unnikrishnan, A., Vyas, P., Göhring, G., Schlegelberger, B., Tobiasson, M., Kvalheim, G., Constantinescu, S. N., Nerlov, C., Nilsson, L., Campbell, P. J., Sandberg, R., Papaemmanuil, E., Hellström-Lindberg, E., Linnarsson, S. & Jacobsen, S. E. W., Jun 16 2014, In : Cancer Cell. 25, 6, p. 794-808 15 p.

Research output: Contribution to journalArticle

Neoplastic Stem Cells
Myelodysplastic Syndromes
Molecular Evolution
Stem Cells

Predictive factors for the outcome of allogeneic transplantation in patients with MDS stratified according to the revised IPSS-R

Della Porta, M. G., Alessandrino, E. P., Bacigalupo, A., Van Lint, M. T., Malcovati, L., Pascutto, C., Falda, M., Bernardi, M., Onida, F., Guidi, S., Iori, A. P., Cerretti, R., Marenco, P., Pioltelli, P., Angelucci, E., Oneto, R., Ripamonti, F., Bernasconi, P., Bosi, A., Cazzola, M. & 1 others, Rambaldi, A., Apr 10 2014, In : Blood. 123, 15, p. 2333-2342 10 p.

Research output: Contribution to journalArticle

Transplants
Myelodysplastic Syndromes
Homologous Transplantation
Stem cells
Hematopoietic Stem Cell Transplantation

Prognostic significance of reproducible immunophenotypic markers of marrow dysplasia

Della Porta, M. G., Picone, C., Tenore, A., Yokose, N., Malcovati, L., Cazzola, M. & Ogata, K., Jan 1 2014, In : Haematologica. 99, 1, p. 8-10 3 p.

Research output: Contribution to journalArticle

Should patients with high-risk or transformed myelodysplastic syndrome proceed directly to allogeneic transplant without prior cytoreduction by remission-induction chemotherapy or hypomethylating agent therapy?

De Witte, T. M., Bowen, D., Robin, M., Malcovati, L., Mufti, G., Niederwieser, D., Yakoubagha, I. & Kröger, N., Sep 1 2014, In : Clinical Lymphoma, Myeloma and Leukemia. 14, p. S42-S45

Research output: Contribution to journalArticle

Remission Induction
Induction Chemotherapy
Myelodysplastic Syndromes
Hematopoietic Stem Cells
Transplants
2013

Biologic and clinical significance of somatic mutations of SF3B1 in myeloid and lymphoid neoplasms

Cazzola, M., Rossi, M. & Malcovati, L., Jan 10 2013, In : Blood. 121, 2, p. 260-269 10 p.

Research output: Contribution to journalArticle

Spliceosomes
Genes
RNA Precursors
Mutation
Myelodysplastic Syndromes

Clinical and biological implications of driver mutations in myelodysplastic syndromes

Papaemmanuil, E., Gerstung, M., Malcovati, L., Tauro, S., Gundem, G., Van Loo, P., Yoon, C. J., Ellis, P., Wedge, D. C., Pellagatti, A., Shlien, A., Groves, M. J., Forbes, S. A., Raine, K., Hinton, J., Mudie, L. J., McLaren, S., Hardy, C., Latimer, C., Della Porta, M. G. & 18 others, O'Meara, S., Ambaglio, I., Galli, A., Butler, A. P., Walldin, G., Teague, J. W., Quek, L., Sternberg, A., Gambacorti-Passerini, C., Cross, N. C. P., Green, A. R., Boultwood, J., Vyas, P., Hellstrom-Lindberg, E., Bowen, D., Cazzola, M., Stratton, M. R. & Campbell, P. J., Nov 21 2013, In : Blood. 122, 22, p. 3616-3627 12 p.

Research output: Contribution to journalArticle

Myelodysplastic Syndromes
Genes
Mutation
RNA Splicing
RNA

Complex Patterns of Chromosome 11 Aberrations in Myeloid Malignancies Target CBL, MLL, DDB1 and LMO2

Klampfl, T., Milosevic, J. D., Puda, A., Schönegger, A., Bagienski, K., Berg, T., Harutyunyan, A. S., Gisslinger, B., Rumi, E., Malcovati, L., Pietra, D., Elena, C., Della Porta, M. G., Pieri, L., Guglielmelli, P., Bock, C., Doubek, M., Dvorakova, D., Suvajdzic, N., Tomin, D. & 8 others, Tosic, N., Racil, Z., Steurer, M., Pavlovic, S., Vannucchi, A. M., Cazzola, M., Gisslinger, H. & Kralovics, R., Oct 16 2013, In : PLoS One. 8, 10, e77819.

Research output: Contribution to journalArticle

Chromosomes, Human, Pair 11
Chromosomes
Aberrations
Chromosome Aberrations
Exome

Development and validation of a prognostic scoring system for patients with chronic myelomonocytic leukemia

Such, E., Germing, U., Malcovati, L., Cervera, J., Kuendgen, A., Della Porta, M. G., Nomdedeu, B., Arenillas, L., Luño, E., Xicoy, B., Amigo, M. L., Valcarcel, D., Nachtkamp, K., Ambaglio, I., Hildebrandt, B., Lorenzo, I., Cazzola, M. & Sanz, G., Apr 11 2013, In : Blood. 121, 15, p. 3005-3015 11 p.

Research output: Contribution to journalArticle

Leukemia, Myelomonocytic, Chronic
Blood
Erythrocyte Transfusion
Acute Myeloid Leukemia
Cytogenetics

Development and validation of a prognostic scoring system for patients with chronic myelomonocytic leukemia

Such, E., Germing, U., Malcovati, L. & Hrodek, O., 2013, In : Transfuze a Hematologie Dnes. 19, 3, p. 191 1 p.

Research output: Contribution to journalArticle

Diagnosis and treatment of primary myelodysplastic syndromes in adults: Recommendations from the European LeukemiaNet

Malcovati, L., Hellström-Lindberg, E., Bowen, D., Adès, L., Cermak, J., Del Cañizo, C., Della Porta, M. G., Fenaux, P., Gattermann, N., Germing, U., Jansen, J. H., Mittelman, M., Mufti, G., Platzbecker, U., Sanz, G. F., Selleslag, D., Skov-Holm, M., Stauder, R., Symeonidis, A., Van De Loosdrecht, A. A. & 2 others, De Witte, T. & Cazzola, M., Oct 24 2013, In : Blood. 122, 17, p. 2943-2964 22 p.

Research output: Contribution to journalArticle

Myelodysplastic Syndromes
Health
Stem cells
Risk assessment
Comorbidity

Effects of mitochondrial ferritin overexpression in normal and sideroblastic erythroid progenitors

Invernizzi, R., Travaglino, E., Della Porta, M. G., Gallì, A., Malcovati, L., Rosti, V., Bergamaschi, G., Erba, B. G., Bellistri, F., Bastia, R., Santambrogio, P., Levi, S. & Cazzola, M., Jun 2013, In : British Journal of Haematology. 161, 5, p. 726-737 12 p.

Research output: Contribution to journalArticle

Erythropoiesis
Myelodysplastic Syndromes
Ferritins
Iron
Lentivirus

Identification of gene expression-based prognostic markers in the hematopoietic stem cells of patients with myelodysplastic syndromes.

Pellagatti, A., Benner, A., Mills, K. I., Cazzola, M., Giagounidis, A., Perry, J., Malcovati, L., Della Porta, M. G., Jädersten, M., Verma, A., McDonald, E. J., Killick, S., Hellström-Lindberg, E., Bullinger, L., Wainscoat, J. S. & Boultwood, J., Oct 1 2013, In : Journal of Clinical Oncology. 31, 28, p. 3557-3564 8 p.

Research output: Contribution to journalArticle

Myelodysplastic Syndromes
Hematopoietic Stem Cells
Gene Expression Profiling
Gene Expression
Bone Marrow Cells

Inappropriately low hepcidin levels in patients with myelodysplastic syndrome carrying a somatic mutation of SF3B1

Ambaglio, I., Malcovati, L., Papaemmanuil, E., Laarakkers, C. M., Della Porta, M. G., Gallì, A., Da Vià, M. C., Bono, E., Ubezio, M., Travaglino, E., Albertini, R., Campbell, P. J., Swinkels, D. W. & Cazzola, M., Mar 1 2013, In : Haematologica. 98, 3, p. 420-423 4 p.

Research output: Contribution to journalArticle

Hepcidins
Myelodysplastic Syndromes
Mutation
Growth Differentiation Factor 15
Erythroblasts

Management recommendations for chronic myelomonocytic leukemia: Consensus statements from the SIE, SIES, GITMO groups

Onida, F., Barosi, G., Leone, G., Malcovati, L., Morra, E., Santini, V., Specchia, G. & Tura, S., Sep 1 2013, In : Haematologica. 98, 9, p. 1344-1352 9 p.

Research output: Contribution to journalArticle

Leukemia, Myelomonocytic, Chronic
Bone Marrow
Therapeutics
Azacitidine
Stem Cell Transplantation

Optimal timing of allogeneic hematopoietic stem cell transplantation in patients with myelodysplastic syndrome

Alessandrino, E. P., Porta, M. G. D., Malcovati, L., Jackson, C. H., Pascutto, C., Bacigalupo, A., Teresa van Lint, M., Falda, M., Bernardi, M., Onida, F., Guidi, S., Iori, A. P., Cerretti, R., Marenco, P., Pioltelli, P., Angelucci, E., Oneto, R., Ripamonti, F., Rambaldi, A., Bosi, A. & 1 others, Cazzola, M., Jul 2013, In : American Journal of Hematology. 88, 7, p. 581-588 8 p.

Research output: Contribution to journalArticle

Hematopoietic Stem Cell Transplantation
Myelodysplastic Syndromes
Transplantation
Decision Support Techniques
Life Expectancy

Rationale for the clinical application of flow cytometry in patients with myelodysplastic syndromes: Position paper of an International Consortium and the European LeukemiaNet Working Group

Van De Loosdrecht, A. A., Ireland, R., Kern, W., Della Porta, M. G., Alhan, C., Balleisen, J. S., Bettelheim, P., Bowen, D. T., Burbury, K., Eidenschink, L., Cazzola, M., Chu, S. S. C., Cullen, M., Cutler, J. A., Dräger, A. M., Feuillard, J., Fenaux, P., Font, P., Germing, U., Haase, D. & 31 others, Hellström-Lindberg, E., Johansson, U., Kordasti, S., Loken, M. R., Malcovati, L., Te Marvelde, J. G., Matarraz, S., Milne, T., Moshaver, B., Mufti, G. J., Nikolova, V., Ogata, K., Oelschlaegel, U., Orfao, A., Ossenkoppele, G. J., Porwit, A., Platzbecker, U., Preijers, F., Psarra, K., Richards, S. J., Subirá, D., Seymour, J. F., Tindell, V., Vallespi, T., Valent, P., Van Der Velden, V. H. J., Wells, D. A., De Witte, T. M., Zettl, F., Béné, M. C. & Westers, T. M., Mar 2013, In : Leukemia and Lymphoma. 54, 3, p. 472-475 4 p.

Research output: Contribution to journalArticle

Myelodysplastic Syndromes
Flow Cytometry
Therapeutics

Refractory anemia with ring sideroblasts

Malcovati, L. & Cazzola, M., Dec 2013, In : Best Practice and Research: Clinical Haematology. 26, 4, p. 377-385 9 p.

Research output: Contribution to journalArticle

Refractory Anemia
Refractory materials
Myelodysplastic Syndromes
Mutation
Anemia

Refractory anemia with ring sideroblasts

Malcovati, L. & Cazzola, M., 2013, (Accepted/In press) In : Best Practice and Research: Clinical Haematology.

Research output: Contribution to journalArticle

Refractory Anemia
Refractory materials
Myelodysplastic Syndromes
Mutation
Anemia

Role of reduced-intensity conditioning allogeneic hematopoietic stem-cell transplantation in older patients with de novo myelodysplastic syndromes: an international collaborative decision analysis.

Koreth, J., Pidala, J., Perez, W. S., Deeg, H. J., Garcia-Manero, G., Malcovati, L., Cazzola, M., Park, S., Itzykson, R., Ades, L., Fenaux, P., Jadersten, M., Hellstrom-Lindberg, E., Gale, R. P., Beach, C. L., Lee, S. J., Horowitz, M. M., Greenberg, P. L., Tallman, M. S., DiPersio, J. F. & 3 others, Bunjes, D., Weisdorf, D. J. & Cutler, C., Jul 20 2013, In : Journal of Clinical Oncology. 31, 21, p. 2662-2670 9 p.

Research output: Contribution to journalArticle

Transplantation Conditioning
Decision Support Techniques
Hematopoietic Stem Cell Transplantation
Myelodysplastic Syndromes
Life Expectancy

Somatic mutations of calreticulin in myeloproliferative neoplasms

Klampfl, T., Gisslinger, H., Harutyunyan, A. S., Nivarthi, H., Rumi, E., Milosevic, J. D., Them, N. C. C., Berg, T., Gisslinger, B., Pietra, D., Chen, D., Vladimer, G. I., Bagienski, K., Milanesi, C., Casetti, I. C., Sant'Antonio, E., Ferretti, V., Elena, C., Schischlik, F., Cleary, C. & 9 others, Six, M., Schalling, M., Schon̈egger, A., Bock, C., Malcovati, L., Pascutto, C., Superti-Furga, G., Cazzola, M. & Kralovics, R., 2013, In : New England Journal of Medicine. 369, 25, p. 2379-2390 12 p.

Research output: Contribution to journalArticle

Calreticulin
Janus Kinase 2
Primary Myelofibrosis
Mutation
Essential Thrombocythemia

The genetic basis of myelodysplasia and its clinical relevance

Cazzola, M., Della Porta, M. G. & Malcovati, L., Dec 12 2013, In : Blood. 122, 25, p. 4021-4034 14 p.

Research output: Contribution to journalArticle

Genes
Myelodysplastic Syndromes
Mutation
Leukemia, Neutrophilic, Chronic
Signal transduction
2012

Clinical evaluation of extra-hematologic comorbidity in myelodysplastic syndromes: Ready-to-wear versus made-to-measure tool

Della Porta, M. G., Ambaglio, I., Ubezio, M., Travaglino, E., Pascutto, C. & Malcovati, L., Apr 1 2012, In : Haematologica. 97, 4, p. 631-632 2 p.

Research output: Contribution to journalArticle

Clinical features and course of refractory anemia with ring sideroblasts associated with marked thrombocytosis

Broseus, J., Florensa, L., Zipperer, E., Schnittger, S., Malcovati, L., Richebourg, S., Lippert, E., Cermak, J., Evans, J., Mounier, M., Raya, J. M., Bailly, F., Gattermann, N., Haferlach, T., Garand, R., Allou, K., Besses, C., Germing, U., Haferlach, C., Travaglino, E. & 14 others, Luno, E., Pinan, M. A., Arenillas, L., Rozman, M., Sirvent, M. L. P., Favre, B., Guy, J., Alonso, E., Ahwij, N., Jerez, A., Hermouet, S., Maynadié, M., Cazzola, M. & Girodon, F., Jul 1 2012, In : Haematologica. 97, 7, p. 1036-1041 6 p.

Research output: Contribution to journalArticle

Refractory Anemia
Thrombocytosis
Essential Thrombocythemia
Survival
Janus Kinase 2

Clinical significance of genetic aberrations in secondary acute myeloid leukemia

Milosevic, J. D., Puda, A., Malcovati, L., Berg, T., Hofbauer, M., Stukalov, A., Klampfl, T., Harutyunyan, A. S., Gisslinger, H., Gisslinger, B., Burjanivova, T., Rumi, E., Pietra, D., Elena, C., Vannucchi, A. M., Doubek, M., Dvorakova, D., Robesova, B., Wieser, R., Koller, E. & 9 others, Suvajdzic, N., Tomin, D., Tosic, N., Colinge, J., Racil, Z., Steurer, M., Pavlovic, S., Cazzola, M. & Kralovics, R., Nov 2012, In : American Journal of Hematology. 87, 11, p. 1010-1016 7 p.

Research output: Contribution to journalArticle

Acute Myeloid Leukemia
Karyotype
Mutation
Survival
Loss of Heterozygosity

Frequent deletions of JARID2 in leukemic transformation of chronic myeloid malignancies

Puda, A., Milosevic, J. D., Berg, T., Klampfl, T., Harutyunyan, A. S., Gisslinger, B., Rumi, E., Pietra, D., Malcovati, L., Elena, C., Doubek, M., Steurer, M., Tosic, N., Pavlovic, S., Guglielmelli, P., Pieri, L., Vannucchi, A. M., Gisslinger, H., Cazzola, M. & Kralovics, R., Mar 2012, In : American Journal of Hematology. 87, 3, p. 245-250 6 p.

Research output: Contribution to journalArticle

Polycomb Repressive Complex 2
Myelodysplastic Syndromes
Neoplasms
Acute Myeloid Leukemia
Exome

From perpetual haemosiderinuria to possible iron overload: Iron redistribution in paroxysmal nocturnal haemoglobinuria patients on eculizumab by magnetic resonance imaging

Risitano, A. M., Imbriaco, M., Marando, L., Seneca, E., Soscia, E., Malcovati, L., Iori, A. P., Pane, F., Notaro, R. & Matarazzo, M., Aug 2012, In : British Journal of Haematology. 158, 3, p. 415-418 4 p.

Research output: Contribution to journalArticle

Multicenter validation of a reproducible flow cytometric score for the diagnosis of low-grade myelodysplastic syndromes: Results of a European LeukemiaNET study

Porta, M. G. D., Picone, C., Pascutto, C., Malcovati, L., Tamura, H., Handa, H., Czader, M., Freeman, S., Vyas, P., Porwit, A., Saft, L., Westers, T. M., Alhan, C., Cali, C., van de Loosdrecht, A. A. & Ogata, K., Aug 1 2012, In : Haematologica. 97, 8, p. 1209-1217 9 p.

Research output: Contribution to journalArticle

Granulocyte Precursor Cells
Myelodysplastic Syndromes
Granulocytes
Bone Marrow
Developmental Bone Disease

Revised international prognostic scoring system for myelodysplastic syndromes

Greenberg, P. L., Tuechler, H., Schanz, J., Sanz, G., Garcia-Manero, G., Solé, F., Bennett, J. M., Bowen, D., Fenaux, P., Dreyfus, F., Kantarjian, H., Kuendgen, A., Levis, A., Malcovati, L., Cazzola, M., Cermak, J., Fonatsch, C., Le Beau, M. M., Slovak, M. L., Krieger, O. & 14 others, Luebbert, M., Maciejewski, J., Magalhaes, S. M. M., Miyazaki, Y., Pfeilstöcker, M., Sekeres, M., Sperr, W. R., Stauder, R., Tauro, S., Valent, P., Vallespi, T., Van De Loosdrecht, A. A., Germing, U. & Haase, D., Sep 20 2012, In : Blood. 120, 12, p. 2454-2465 12 p.

Research output: Contribution to journalArticle

Myelodysplastic Syndromes
Cytogenetics
Ferritins
L-Lactate Dehydrogenase
Bone Marrow

Standardization of flow cytometry in myelodysplastic syndromes: A report from an international consortium and the European LeukemiaNet Working Group

Westers, T. M., Ireland, R., Kern, W., Alhan, C., Balleisen, J. S., Bettelheim, P., Burbury, K., Cullen, M., Cutler, J. A., Della Porta, M. G., Dräger, A. M., Feuillard, J., Font, P., Germing, U., Haase, D., Johansson, U., Kordasti, S., Loken, M. R., Malcovati, L., Te Marvelde, J. G. & 19 others, Matarraz, S., Milne, T., Moshaver, B., Mufti, G. J., Ogata, K., Orfao, A., Porwit, A., Psarra, K., Richards, S. J., Subirá, D., Tindell, V., Vallespi, T., Valent, P., Van Der Velden, V. H. J., De Witte, T. M., Wells, D. A., Zettl, F., Béné, M. C. & Van De Loosdrecht, A. A., Jul 2012, In : Leukemia. 26, 7, p. 1730-1741 12 p.

Research output: Contribution to journalArticle

Myelodysplastic Syndromes
Flow Cytometry
Education
2011

Aplastic Anemia & MDS International Foundation (AA&MDSIF): Bone Marrow Failure Disease Scientific Symposium 2010

Malcovati, L., de Latour, R. P. & Risitano, A., Mar 2011, In : Leukemia Research. 35, 3, p. 291-294 4 p.

Research output: Contribution to journalArticle

Bone Marrow Diseases
Aplastic Anemia
Myelodysplastic Syndromes
Nonprofit Organizations
Research Personnel

Classification and prognostic evaluation of Myelodysplastic syndromes

Cazzola, M., Della Porta, M. G., Travaglino, E. & Malcovati, L., Oct 2011, In : Seminars in Oncology. 38, 5, p. 627-634 8 p.

Research output: Contribution to journalArticle

Myelodysplastic Syndromes
Bone Marrow
Survival
Acute Myeloid Leukemia
Cytogenetics

Clinical significance of SF3B1 mutations in myelodysplastic syndromes and myelodysplastic/myeloproliferative neoplasms

Malcovati, L., Papaemmanuil, E., Bowen, D. T., Boultwood, J., Della Porta, M. G., Pascutto, C., Travaglino, E., Groves, M. J., Godfrey, A. L., Ambaglio, I., Gallì, A., Da Vià, M. C., Conte, S., Tauro, S., Keenan, N., Hyslop, A., Hinton, J., Mudie, L. J., Wainscoat, J. S., Futreal, P. A. & 4 others, Stratton, M. R., Campbell, P. J., Hellström-Lindberg, E. & Cazzola, M., Dec 8 2011, In : Blood. 118, 24, p. 6239-6246 8 p.

Research output: Contribution to journalArticle

Myelodysplastic Syndromes
Hazards
Mutation
Gene encoding
Risk assessment

Impact of the degree of anemia on the outcome of patients with myelodysplastic syndrome and its integration into the WHO classification-based prognostic scoring system (WPSS)

Malcovati, L., Porta, M. G. D., Strupp, C., Ambaglio, I., Kuendgen, A., Nachtkamp, K., Travaglino, E., Invernizzi, R., Pascutto, C., Lazzarino, M., Germing, U. & Cazzola, M., Oct 2011, In : Haematologica. 96, 10, p. 1433-1440 8 p.

Research output: Contribution to journalArticle

Myelodysplastic Syndromes
Anemia
Hemoglobins
Proportional Hazards Models
Italy

Marked down-regulation of nucleophosmin-1 is associated with advanced del(5q) myelodysplastic syndrome

Pellagatti, A., Cazzola, M., Giagounidis, A., Perry, J., Malcovati, L., Della Porta, M. G., Jädersten, M., Killick, S., Vyas, P., Hellström-Lindberg, E., Wainscoat, J. S. & Boultwood, J., Oct 2011, In : British Journal of Haematology. 155, 2, p. 272-274 3 p.

Research output: Contribution to journalArticle

Leukemia, Myelomonocytic, Chronic
Refractory Anemia
Thrombocytosis
Neoplasms
Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative

Myelodysplastic syndromes with bone marrow fibrosis

Porta, M. G. D. & Malcovati, L., Feb 2011, In : Haematologica. 96, 2, p. 180-183 4 p.

Research output: Contribution to journalArticle

Red blood cell transfusion-dependency implies a poor survival in primary myelofibrosis irrespective of IPSS and DIPSS

Elena, C., Passamonti, F., Rumi, E., Malcovati, L., Arcaini, L., Boveri, E., Merli, M., Pietra, D., Pascutto, C. & Lazzarin, M., Jan 2011, In : Haematologica. 96, 1, p. 167-170 4 p.

Research output: Contribution to journalArticle

Erythrocyte Transfusion
Primary Myelofibrosis
Survival
Erythrocytes

Risk stratification based on both disease status and extra-hematologic comorbidities in patients with myelodysplastic syndrome

della Porta, M. G., Malcovati, L., Strupp, C., Ambaglio, I., Kuendgen, A., Zipperer, E., Travaglino, E., Invernizzi, R., Pascutto, C., Lazzarino, M., Germing, U. & Cazzola, M., Mar 2011, In : Haematologica. 96, 3, p. 441-449 9 p.

Research output: Contribution to journalArticle

Myelodysplastic Syndromes
Comorbidity
Learning
Survival Analysis
Proportional Hazards Models

Somatic SF3B1 mutation in myelodysplasia with ring sideroblasts

Papaemmanuil, E., Cazzola, M., Boultwood, J., Malcovati, L., Vyas, P., Bowen, D., Pellagatti, A., Wainscoat, J. S., Hellstrom-Lindberg, E., Gambacorti-Passerini, C., Godfrey, A. L., Rapado, I., Cvejic, A., Rance, R., McGee, C., Ellis, P., Mudie, L. J., Stephens, P. J., McLaren, S., Massie, C. E. & 28 others, Tarpey, P. S., Varela, I., Nik-Zainal, S., Davies, H. R., Shlien, A., Jones, D., Raine, K., Hinton, J., Butler, A. P., Teague, J. W., Baxter, E. J., Score, J., Galli, A., Della Porta, M. G., Travaglino, E., Groves, M., Tauro, S., Munshi, N. C., Anderson, K. C., El-Naggar, A., Fischer, A., Mustonen, V., Warren, A. J., Cross, N. C. P., Green, A. R., Futreal, P. A., Stratton, M. R. & Campbell, P. J., Oct 13 2011, In : New England Journal of Medicine. 365, 15, p. 1384-1395 12 p.

Research output: Contribution to journalArticle

Mutation
Myelodysplastic Syndromes
Point Mutation
RNA Splicing
High-Throughput Nucleotide Sequencing
2010

Deregulated gene expression pathways in myelodysplastic syndrome hematopoietic stem cells

Pellagatti, A., Cazzola, M., Giagounidis, A., Perry, J., Malcovati, L., Della Porta, M. G., Jädersten, M., Killick, S., Verma, A., Norbury, C. J., Hellström-Lindberg, E., Wainscoat, J. S. & Boultwood, J., Apr 2010, In : Leukemia. 24, 4, p. 756-764 9 p.

Research output: Contribution to journalArticle

Myelodysplastic Syndromes
Hematopoietic Stem Cells
Gene Expression
Thrombopoietin
Gene Ontology