• 8305 Citations
  • 48 h-Index
20002019
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Research Output 2000 2019

2019
2 Citations (Scopus)

Accuracy of imaging methods for steatohepatitis diagnosis in non-alcoholic fatty liver disease patients: A systematic review

Besutti, G., Valenti, L., Ligabue, G., Bassi, M. C., Pattacini, P., Guaraldi, G. & Giorgi Rossi, P., Jan 1 2019, In : Liver International. 39, 8, p. 1521-1534

Research output: Contribution to journalArticle

Fatty Liver
Elasticity Imaging Techniques
Magnetic Resonance Spectroscopy
Acoustics
MEDLINE
1 Citation (Scopus)

Association between Helicobacter pylori infection and risk of nonalcoholic fatty liver disease: An updated meta-analysis

Mantovani, A., Turino, T., Altomari, A., Lonardo, A., Zoppini, G., Valenti, L., Tilg, H., Byrne, C. D. & Targher, G., Jul 1 2019, In : Metabolism: Clinical and Experimental. 96, p. 56-65 10 p.

Research output: Contribution to journalArticle

Helicobacter Infections
Helicobacter pylori
Meta-Analysis
Publication Bias
Longitudinal Studies
6 Citations (Scopus)

Association between PNPLA3rs738409 polymorphism decreased kidney function in postmenopausal type 2 diabetic women with or without non-alcoholic fatty liver disease

Mantovani, A., Zusi, C., Sani, E., Colecchia, A., Lippi, G., Zaza, G. L., Valenti, L., Byrne, C. D., Maffeis, C., Bonora, E. & Targher, G., Jan 1 2019, In : Diabetes and Metabolism. 45, 5, p. 480-487

Research output: Contribution to journalArticle

Chronic Renal Insufficiency
Kidney
Genotype
Albuminuria
Non-alcoholic Fatty Liver Disease
2 Citations (Scopus)

Beyond fat accumulation, NAFLD genetics converges on lipid droplet biology

Baselli, G. & Valenti, L., Jan 1 2019, In : Journal of Lipid Research. 60, 1, p. 7-8 2 p.

Research output: Contribution to journalComment/debate

Building mass to prevent non-alcoholic fatty liver disease?

Pelusi, S. & Valenti, L., Apr 2019, In : Hepatobiliary surgery and nutrition. 8, 2, p. 173-176 4 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Contribution of a genetic risk score to clinical prediction of hepatic steatosis in obese children and adolescents

Zusi, C., Mantovani, A., Olivieri, F., Morandi, A., Corradi, M., Miraglia Del Giudice, E., Dauriz, M., Valenti, L., Byrne, C. D., Targher, G. & Maffeis, C., Jan 1 2019, In : Digestive and Liver Disease. 51, 11, p. 1586-1592

Research output: Contribution to journalArticle

Liver
Single Nucleotide Polymorphism
Non-alcoholic Fatty Liver Disease
Genetic Loci
Lipid Metabolism
13 Citations (Scopus)

Does nonalcoholic fatty liver disease cause cardiovascular disease? Current knowledge and gaps

Santos, R. D., Valenti, L. & Romeo, S., Mar 1 2019, In : Atherosclerosis. 282, p. 110-120 11 p.

Research output: Contribution to journalReview article

Cardiovascular Diseases
Fibrosis
Non-alcoholic Fatty Liver Disease
Fatty Liver
Dyslipidemias
5 Citations (Scopus)

Hepatic fat as clinical outcome and therapeutic target for nonalcoholic fatty liver disease

Pelusi, S. & Valenti, L., 2019, In : Liver International. 39, 2, p. 250-256

Research output: Contribution to journalArticle

Fats
Liver
Lipids
Therapeutics
Inflammation

Impact of natural neuromedin-B receptor variants on iron metabolism

Rametta, R., Dongiovanni, P., Baselli, G. A., Pelusi, S., Meroni, M., Fracanzani, A. L., Busti, F., Castagna, A., Scarlini, S., Corradini, E., Pietrangelo, A., Girelli, D., Fargion, S. & Valenti, L., Jan 1 2019, (Accepted/In press) In : American Journal of Hematology.

Research output: Contribution to journalArticle

Cell Transdifferentiation
Hepatic Stellate Cells
insulin resistance
Insulin Resistance
Down-Regulation

NAFLD in children: new genes, new diagnostic modalities and new drugs

Nobili, V., Alisi, A., Valenti, L., Miele, L., Feldstein, A. E. & Alkhouri, N., Jul 5 2019, In : Nature Reviews Gastroenterology and Hepatology.

Research output: Contribution to journalReview article

Pharmaceutical Preparations
Genes
Fibrosis
Pediatrics
Elasticity Imaging Techniques
3 Citations (Scopus)

NAFLD in children: new genes, new diagnostic modalities and new drugs

Nobili, V., Alisi, A., Valenti, L., Miele, L., Feldstein, A. E. & Alkhouri, N., Jan 1 2019, In : Nature Reviews Gastroenterology and Hepatology. 16, 9, p. 517-530

Research output: Contribution to journalReview article

Pharmaceutical Preparations
Genes
Fibrosis
Pediatrics
Elasticity Imaging Techniques
1 Citation (Scopus)

Novel Insights into the Genetic Landscape of Nonalcoholic Fatty Liver Disease

Taliento, A. E., Dallio, M., Federico, A., Prati, D. & Valenti, L., Aug 1 2019, In : International Journal of Environmental Research and Public Health. 16, 15, E2755.

Research output: Contribution to journalReview article

Open Access
Vitamin A
Hepatocytes
Oxidative Stress
Liver
Lipid Metabolism

PCSK7 gene variation bridges atherogenic dyslipidemia with hepatic inflammation in NAFLD patients

Dongiovanni, P., Meroni, M., Baselli, G., Mancina, R. M., Ruscica, M., Longo, M., Rametta, R., Cespiati, A., Pelusi, S., Ferri, N., Ranzani, V., Nobili, V., Pihlajamaki, J., Fracanzani, A. L., Badiali, S., Petta, S., Fargion, S., Romeo, S., Kozlitina, J. & Valenti, L., Jan 1 2019, In : Journal of Lipid Research. 60, 6, p. 1144-1153 10 p.

Research output: Contribution to journalArticle

Proprotein Convertases
Subtilisin
Dyslipidemias
Liver
Genes
12 Citations (Scopus)

Pnpla3 silencing with antisense oligonucleotides ameliorates nonalcoholic steatohepatitis and fibrosis in Pnpla3 I148M knock-in mice

Lindén, D., Ahnmark, A., Pingitore, P., Ciociola, E., Ahlstedt, I., Andréasson, A. C., Sasidharan, K., Madeyski-Bengtson, K., Zurek, M., Mancina, R. M., Lindblom, A., Bjursell, M., Böttcher, G., Ståhlman, M., Bohlooly-Y, M., Haynes, W. G., Carlsson, B., Graham, M., Lee, R., Murray, S. & 4 others, Valenti, L., Bhanot, S., Åkerblad, P. & Romeo, S., Apr 1 2019, In : Molecular Metabolism. 22, p. 49-61 13 p.

Research output: Contribution to journalArticle

Open Access
Antisense Oligonucleotides
Fibrosis
Phospholipases
Fatty Liver
Liver

Post-transplant metabolic syndrome in children: Know better to cure better

Nobili, V., Pietrobattista, A., Valenti, L. & Spada, M., May 1 2019, In : Pediatric Transplantation. 23, 3, e13367.

Research output: Contribution to journalEditorial

Post-transplant metabolic syndrome in children: Know better to cure better

Nobili, V., Pietrobattista, A., Valenti, L. & Spada, M., Feb 21 2019, In : Pediatric Transplantation. p. e13367

Research output: Contribution to journalArticle

Open Access
Muscular Dystrophies
Controlled Clinical Trials
Flavonoids
Placebos
Safety
6 Citations (Scopus)

Prevalence and Risk Factors of Significant Fibrosis in Patients With Nonalcoholic Fatty Liver Without Steatohepatitis

Pelusi, S., Cespiati, A., Rametta, R., Pennisi, G., Mannisto, V., Rosso, C., Baselli, G., Dongiovanni, P., Fracanzani, A. L., Badiali, S., Maggioni, M., Craxi, A., Fargion, S., Prati, D., Nobili, V., Bugianesi, E., Romeo, S., Pihlajamaki, J., Petta, S. & Valenti, L., Oct 1 2019, In : Clinical Gastroenterology and Hepatology. 17, 11, p. 2310-2319.e6

Research output: Contribution to journalArticle

Fatty Liver
Fibrosis
Hyperglycemia
Inflammation
Fasting
4 Citations (Scopus)

Rare Pathogenic Variants Predispose to Hepatocellular Carcinoma in Nonalcoholic Fatty Liver Disease

Pelusi, S., Baselli, G., Pietrelli, A., Dongiovanni, P., Donati, B., McCain, M. V., Meroni, M., Fracanzani, A. L., Romagnoli, R., Petta, S., Grieco, A., Miele, L., Soardo, G., Bugianesi, E., Fargion, S., Aghemo, A., D’Ambrosio, R., Xing, C., Romeo, S., De Francesco, R. & 2 others, Reeves, H. L. & Valenti, L. V. C., Dec 1 2019, In : Scientific Reports. 9, 1, 3682.

Research output: Contribution to journalArticle

Open Access
Hepatocellular Carcinoma
Liver Neoplasms
Non-alcoholic Fatty Liver Disease
HDL Cholesterol
Genes
1 Citation (Scopus)

Serum coding and non-coding RNAs as biomarkers of NAFLD and fibrosis severity

Di Mauro, S., Scamporrino, A., Petta, S., Urbano, F., Filippello, A., Ragusa, M., Di Martino, M. T., Scionti, F., Grimaudo, S., Pipitone, R. M., Privitera, G., Di Pino, A., Scicali, R., Valenti, L., Dongiovanni, P., Fracanzani, A., Rabuazzo, A. M., Craxì, A., Purrello, M., Purrello, F. & 1 others, Piro, S., Sep 1 2019, In : Liver international : official journal of the International Association for the Study of the Liver. 39, 9, p. 1742-1754 13 p.

Research output: Contribution to journalArticle

Open Access
Untranslated RNA
Liver Cirrhosis
Biomarkers
Palmitates
Long Noncoding RNA

The TM6SF2 E167K genetic variant induces lipid biosynthesis and reduces apolipoprotein B secretion in human hepatic 3D spheroids

Prill, S., Caddeo, A., Baselli, G., Jamialahmadi, O., Dongiovanni, P., Rametta, R., Kanebratt, K. P., Pujia, A., Pingitore, P., Mancina, R. M., Lindén, D., Whatling, C., Janefeldt, A., Kozyra, M., Ingelman-Sundberg, M., Valenti, L., Andersson, T. B. & Romeo, S., Dec 1 2019, In : Scientific Reports. 9, 1, 11585.

Research output: Contribution to journalArticle

Open Access
Apolipoproteins B
Lipids
Liver
Hepatocytes
Medical Genetics

Uncovering occult hepatitis B in blood donations: a tale of two worlds

Prati, D. & Valenti, L., Nov 1 2019, In : Blood transfusion = Trasfusione del sangue. 17, 6, p. 399-400 2 p.

Research output: Contribution to journalEditorial

Whole exome sequencing for personalized hepatology: Expanding applications in adults and challenges

Valenti, L., Pelusi, S. & Baselli, G., Oct 1 2019, In : Journal of Hepatology. 71, 4, p. 849-850 2 p.

Research output: Contribution to journalLetter

β-Klotho gene variation is associated with liver damage in children with NAFLD

Dongiovanni, P., Crudele, A., Panera, N., Romito, I., Meroni, M., De Stefanis, C., Palma, A., Comparcola, D., Fracanzani, A. L., Miele, L., Valenti, L., Nobili, V. & Alisi, A., Jan 1 2019, (Accepted/In press) In : Journal of Hepatology.

Research output: Contribution to journalArticle

Open Access
2018
1 Citation (Scopus)

Acquired hepatocerebral degeneration (AHD): a peculiar neurological impairment in advanced chronic liver disease

Pigoni, A., Iuculano, F., Saetti, C., Airaghi, L., Burdick, L., Spreafico, S., Curioni, M., Lombardi, R., Valenti, L., Fracanzani, A. L. & Fargion, S., 2018, In : Metabolic Brain Disease. 33, 1, p. 347-352 6 p.

Research output: Contribution to journalArticle

Hepatolenticular Degeneration
Liver
Liver Diseases
Brain
Chronic Disease
40 Citations (Scopus)

Causal relationship of hepatic fat with liver damage and insulin resistance in nonalcoholic fatty liver

Dongiovanni, P., Stender, S., Pietrelli, A., Mancina, R. M., Cespiati, A., Petta, S., Pelusi, S., Pingitore, P., Badiali, S., Maggioni, M., Mannisto, V., Grimaudo, S., Pipitone, R. M., Pihlajamaki, J., Craxi, A., Taube, M., Carlsson, L. M. S., Fargion, S., Romeo, S., Kozlitina, J. & 1 others, Valenti, L., Apr 1 2018, In : Journal of Internal Medicine. 283, 4, p. 356-370 15 p.

Research output: Contribution to journalArticle

Insulin Resistance
Fats
Liver
Liver Cirrhosis
Biopsy
3 Citations (Scopus)

Digital liver biopsy: Bio-imaging of fatty liver for translational and clinical research

Mancini, M., Summers, P., Faita, F., Brunetto, M. R., Callea, F., De Nicola, A., Di Lascio, N., Farinati, F., Gastaldelli, A., Gridelli, B., Mirabelli, P., Neri, E., Salvadori, P. A., Rebelos, E., Tiribelli, C., Valenti, L., Salvatore, M. & Bonino, F., Feb 1 2018, In : World Journal of Hepatology. 10, 2, p. 231-245 15 p.

Research output: Contribution to journalReview article

Translational Medical Research
Fatty Liver
Biopsy
Liver
Public Opinion
2 Citations (Scopus)
alpha-2-HS-Glycoprotein
fetuins
Liver Circulation
liver
hepatocytes
alpha-2-HS-Glycoprotein
fetuins
Liver Circulation
liver
hepatocytes
94 Citations (Scopus)

Genetics and epigenetics of NAFLD and NASH: Clinical impact

Eslam, M., Valenti, L. & Romeo, S., 2018, In : Journal of Hepatology. 68, 2, p. 268-279

Research output: Contribution to journalArticle

Epigenomics
Disease Progression
Fibrosis
Precision Medicine
Genetic Association Studies
17 Citations (Scopus)

Hepatic iron is the major determinant of serum ferritin in NAFLD patients

Ryan, J. D., Armitage, A. E., Cobbold, J. F., Banerjee, R., Borsani, O., Dongiovanni, P., Neubauer, S., Morovat, R., Wang, L. M., Pasricha, S. R., Fargion, S., Collier, J., Barnes, E., Drakesmith, H., Valenti, L. & Pavlides, M., 2018, In : Liver International. 38, 1, p. 164-173

Research output: Contribution to journalArticle

Ferritins
Iron
Liver
Serum
Hepcidins
30 Citations (Scopus)

Hepatitis C virus eradication by direct-acting antiviral agents improves carotid atherosclerosis in patients with severe liver fibrosis

Petta, S., Adinolfi, L. E., Fracanzani, A. L., Rini, F., Caldarella, R., Calvaruso, V., Cammà, C., Ciaccio, M., Di Marco, V., Grimaudo, S., Licata, A., Marrone, A., Nevola, R., Pipitone, R. M., Pinto, A., Rinaldi, L., Torres, D., Tuttolomondo, A., Valenti, L., Fargion, S. & 1 others, Craxì, A., Jul 1 2018, In : Journal of Hepatology. 69, 1, p. 18-24 7 p.

Research output: Contribution to journalArticle

Carotid Artery Diseases
Hepacivirus
Liver Cirrhosis
Antiviral Agents
Fibrosis
7 Citations (Scopus)

Hepatocyte Notch activation induces liver fibrosis in nonalcoholic steatohepatitis

Zhu, C., Kim, K. J., Wang, X., Bartolome, A., Salomao, M., Dongiovanni, P., Meroni, M., Graham, M. J., Yates, K. P., Diehl, A. M., Schwabe, R. F., Tabas, I., Valenti, L., Lavine, J. E. & Pajvani, U. B., Nov 21 2018, In : Science Translational Medicine. 10, 468, at0344.

Research output: Contribution to journalArticle

Liver Cirrhosis
Hepatocytes
Fibrosis
Diet
Hepatic Stellate Cells

NGM282: a step forward in the nonalcoholic steatohepatitis treatment landscape?

Valenti, L. & Nobili, V., Dec 2018, In : Hepatobiliary surgery and nutrition. 7, 6, p. 484-486 3 p.

Research output: Contribution to journalArticle

Nonalcoholic Fatty Liver Disease in Children

Mann, J. P., Valenti, L., Scorletti, E., Byrne, C. D. & Nobili, V., Feb 2018, In : Seminars in Liver Disease. 38, 1, p. 1-13 13 p.

Research output: Contribution to journalReview article

Sedentary Lifestyle
Non-alcoholic Fatty Liver Disease
Life Style
Epidemiology
Fibrosis

Nonalcoholic Fatty Liver Disease in Children

Mann, J. P., Valenti, L., Scorletti, E., Byrne, C. D. & Nobili, V., 2018, In : Seminars in Liver Disease. 38, 1, p. 1-13 13 p.

Research output: Contribution to journalArticle

Protein phosphatase 1 regulatory subunit 3B gene variation protects against hepatic fat accumulation and fibrosis in individuals at high risk of nonalcoholic fatty liver disease

Dongiovanni, P., Meroni, M., Mancina, R. M., Baselli, G., Rametta, R., Pelusi, S., Männistö, V., Fracanzani, A. L., Badiali, S., Miele, L., Grimaudo, S., Petta, S., Bugianesi, E., Soardo, G., Fargion, S., Pihlajamäki, J., Romeo, S. & Valenti, L., 2018, In : Hepatology communications. 2, 6, p. 666-675 10 p.

Research output: Contribution to journalArticle

Protein Phosphatase 1
Fibrosis
Fats
Liver
Liver Diseases
2 Citations (Scopus)

Subclinical cerebrovascular disease in NAFLD without overt risk factors for atherosclerosis

Airaghi, L., Rango, M., Maira, D., Barbieri, V., Valenti, L., Lombardi, R., Biondetti, P., Fargion, S. & Fracanzani, A. L., Jan 1 2018, In : Atherosclerosis. 268, p. 27-31 5 p.

Research output: Contribution to journalArticle

Cerebrovascular Disorders
Atherosclerosis
Perfusion
Gyrus Cinguli
Brain
2017
103 Citations (Scopus)

AISF position paper on nonalcoholic fatty liver disease (NAFLD): Updates and future directions

Lonardo, A., Nascimbeni, F., Targher, G., Bernardi, M., Bonino, F., Bugianesi, E., Casini, A., Gastaldelli, A., Marchesini, G., Marra, F., Miele, L., Morisco, F., Petta, S., Piscaglia, F., Svegliati-Baroni, G., Valenti, L. & Bellentani, S., May 1 2017, In : Digestive and Liver Disease. 49, 5, p. 471-483 13 p.

Research output: Contribution to journalArticle

Liver Neoplasms
Fibrosis
Biomarkers
Liver
Metabolic Diseases
14 Citations (Scopus)

A nutrigenomic approach to non-alcoholic fatty liver disease

Dongiovanni, P. & Valenti, L., Jul 16 2017, In : International Journal of Molecular Sciences. 18, 7, 1534.

Research output: Contribution to journalReview article

Nutrigenomics
liver
Liver
Nutrition
Sedentary Lifestyle
3 Citations (Scopus)

Degradation of PHLPP2 by KCTD17, via a Glucagon-Dependent Pathway, Promotes Hepatic Steatosis

Kim, K. J., Ryu, D., Dongiovanni, P., Ozcan, L., Nayak, S., Ueberheide, B., Valenti, L., Auwerx, J. & Pajvani, U. B., Dec 1 2017, In : Gastroenterology. 153, 6, p. 1568-1580.e10

Research output: Contribution to journalArticle

Protein Phosphatase 2
Glucagon
Liver
Obese Mice
Lipogenesis
12 Citations (Scopus)

Fibronectin type III domain-containing protein 5 rs3480 A>G polymorphism, irisin, and liver fibrosis in patients with nonalcoholic fatty liver disease

Petta, S., Valenti, L., Svegliati-Baroni, G., Ruscica, M., Pipitone, R. M., Dongiovanni, P., Rychlicki, C., Ferri, N., Cammà, C., Fracanzani, A. L., Pierantonelli, I., Di Marco, V., Meroni, M., Giordano, D., Grimaudo, S., Maggioni, M., Cabibi, D., Fargion, S. & Craxì, A., Aug 1 2017, In : Journal of Clinical Endocrinology and Metabolism. 102, 8, p. 2660-2669 10 p.

Research output: Contribution to journalArticle

Polymorphism
Fibronectins
Liver Cirrhosis
Liver
Fats
1 Citation (Scopus)

GNPAT p.D519G variant and iron metabolism during oral iron tolerance test

Rametta, R., Dongiovanni, P., Fargion, S. & Valenti, L., Jan 1 2017, In : Hepatology. 65, 1, p. 384-385 2 p.

Research output: Contribution to journalLetter

3 Citations (Scopus)

GNPAT rs11558492 is not a major modifier of iron status: Study of Italian hemochromatosis patients and blood donors

Greni, F., Valenti, L., Mariani, R., Pelloni, I., Rametta, R., Busti, F., Ravasi, G., Girelli, D., Fargion, S., Galimberti, S., Piperno, A. & Pelucchi, S., 2017, In : Annals of Hepatology. 16, 3, p. 451-456 6 p.

Research output: Contribution to journalArticle

Hemochromatosis
Blood Donors
Iron
Fibrosis
Gene Frequency
2 Citations (Scopus)

HFE mutations and iron in hemodialysis patients

Valenti, L. & Pelusi, S., Jul 1 2017, In : Hemodialysis International. 21, p. S47-S57

Research output: Contribution to journalReview article

Renal Dialysis
Iron
Mutation
Hepcidins
Hematinics
14 Citations (Scopus)

Insulin resistance promotes Lysyl Oxidase Like 2 induction and fibrosis accumulation in non-alcoholic fatty liver disease

Dongiovanni, P., Meroni, M., Baselli, G. A., Bassani, G. A., Rametta, R., Pietrelli, A., Maggioni, M., Facciotti, F., Trunzo, V., Badiali, S., Fargion, S., Gatti, S. & Valenti, L., Jun 1 2017, In : Clinical Science. 131, 12, p. 1301-1315 15 p.

Research output: Contribution to journalArticle

Protein-Lysine 6-Oxidase
Insulin Receptor
Hepatic Stellate Cells
Insulin Resistance
Fibrosis
21 Citations (Scopus)

Interferon lambda 4 rs368234815 TT>δG variant is associated with liver damage in patients with nonalcoholic fatty liver disease

Petta, S., Valenti, L., Tuttolomondo, A., Dongiovanni, P., Pipitone, R. M., Cammà, C., Cabibi, D., Di Marco, V., Fracanzani, A. L., Badiali, S., Nobili, V., Fargion, S., Grimaudo, S. & Craxì, A., Dec 2017, In : Hepatology. 66, 6, p. 1885-1893 9 p.

Research output: Contribution to journalArticle

Interferons
Fibrosis
Liver
Innate Immunity
Odds Ratio