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20002019
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Research Output 2000 2019

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Article
2014

Interaction between PNPLA3 I148M variant and age at infection in determining fibrosis progression in chronic hepatitis C

De Nicola, S., Dongiovanni, P., Aghemo, A., Cheroni, C., D'Ambrosio, R., Pedrazzini, M., Marabita, F., Donnici, L., Maggioni, M., Fargion, S., Colombo, M., De Francesco, R. & Valenti, L., Aug 29 2014, In : PLoS One. 9, 8, e106022.

Research output: Contribution to journalArticle

chronic hepatitis C
Chronic Hepatitis C
Medical problems
fibrosis
Fibrosis

Interleukin 28B genotype and insulin resistance in chronic hepatitis C patients

Degasperi, E., Valenti, L., Aghemo, A., De Francesco, R., Rumi, M., Soffredini, R., Donnici, L., Cheroni, C., Fargion, S., Zanoni, V., Orsi, E. & Colombo, M., 2014, In : Antiviral Therapy. 19, 8, p. 747-753 7 p.

Research output: Contribution to journalArticle

Interleukins
Chronic Hepatitis C
Insulin Resistance
Genotype
Ribavirin
Iron
Iron Overload
beta-Thalassemia
Mutation
compound A 12

PNPLA3 has retinyl-palmitate lipase activity in human hepatic stellate cells

Pirazzi, C., Valenti, L., Motta, B. M., Pingitore, P., Hedfalk, K., Mancina, R. M., Burza, M. A., Indiveri, C., Ferro, Y., Montalcini, T., Maglio, C., Dongiovanni, P., Fargion, S., Rametta, R., Pujia, A., Andersson, L., Ghosal, S., Levin, M., Wiklund, O., Iacovino, M. & 2 others, Borén, J. & Romeo, S., 2014, In : Human Molecular Genetics. 23, 15, p. 4077-4085 9 p., ddu121.

Research output: Contribution to journalArticle

Hepatic Stellate Cells
Phospholipases
Lipase
Human Activities
Vitamin A
Thrombin
Thrombomodulin
Coagulants
Fatty Liver
Fibrosis

Reply

Romeo, S., Valenti, L., Trépo, E., Moreno, C., Nahon, P. & Deltenre, P., 2014, In : Hepatology. 60, 3, p. 1111-1112 2 p.

Research output: Contribution to journalArticle

Risk of obstructive sleep apnea with daytime sleepiness is associated with liver damage in non-morbidly obese patients with nonalcoholic fatty liver disease

Pulixi, E. A., Tobaldini, E., Battezzati, P. M., D'Ingianna, P., Borroni, V., Fracanzani, A. L., Maggioni, M., Pelusi, S., Bulgheroni, M., Zuin, M., Fargion, S., Montano, N. & Valenti, L., Apr 24 2014, In : PLoS One. 9, 4, e96349.

Research output: Contribution to journalArticle

sleep apnea
fatty liver
Obstructive Sleep Apnea
Liver
liver

Role of iron in hepatocellular carcinoma

Fargion, S., Valenti, L. & Fracanzani, A. L., 2014, In : Clinical Liver Disease. 3, 5, p. 108-110 3 p.

Research output: Contribution to journalArticle

The PNPLA3 I148M variant and chronic liver disease: When a genetic mutation meets nutrients

Maglio, C., Pirazzi, C., Pujia, A., Valenti, L. & Romeo, S., 2014, In : Food Research International. 63, p. 239-243 5 p.

Research output: Contribution to journalArticle

liver diseases
Liver Diseases
Chronic Disease
mutation
Food

Triple therapy with first-generation Protease Inhibitors for patients with genotype 1 chronic hepatitis C: Recommendations of the Italian Association for the Study of the Liver (AISF)

Coco, B., Caraceni, P., Aghemo, A., Bitetto, D., Bruno, R., Ciancio, A., Marzioni, M., Petta, S., Rendina, M. & Valenti, L., Jan 2014, In : Digestive and Liver Disease. 46, 1, p. 18-24 7 p.

Research output: Contribution to journalArticle

Chronic Hepatitis C
Protease Inhibitors
Genotype
Liver
Therapeutics
2013

A 360-degree overview of paediatric NAFLD: Recent insights

Nobili, V., Svegliati-Baroni, G., Alisi, A., Miele, L., Valenti, L. & Vajro, P., Jun 2013, In : Journal of Hepatology. 58, 6, p. 1218-1229 12 p.

Research output: Contribution to journalArticle

Pediatrics
Obesity
Sedentary Lifestyle
Liver
Fatty Liver

A novel alpha1-antitrypsin null variant (PiQ0Milano)

Rametta, R., Nebbia, G., Dongiovanni, P., Farallo, M., Fargion, S. & Valenti, L., 2013, In : World Journal of Hepatology. 5, 8, p. 458-461 4 p.

Research output: Contribution to journalArticle

Pulmonary Emphysema
Incidental Findings
Protein Stability
Lung Diseases
Genes

Cirrhosis and rapid virological response to peginterferon plus ribavirin determine treatment outcome in HCV-1 IL28B rs12979860 CC patients

Aghemo, A., Degasperi, E., Rumi, M. G., Galmozzi, E., Valenti, L., De Francesco, R., De Nicola, S., Cheroni, C., Grassi, E. & Colombo, M., 2013, In : BioMed Research International. 2013, 580796.

Research output: Contribution to journalArticle

Ribavirin
Interleukin-1
Viruses
Hepacivirus
Fibrosis

Cobalamin as a regulator of serum and cerebrospinal fluid levels of normal prions

Scalabrino, G., Veber, D., Briani, C., Milani, S., Terralavoro, A., Brenna, S., Valenti, L., Silani, V., Morelli, C. & Peracchi, M., Jan 2013, In : Journal of Clinical Neuroscience. 20, 1, p. 134-138 5 p.

Research output: Contribution to journalArticle

Prions
Vitamin B 12
Cerebrospinal Fluid
Serum
Subacute Combined Degeneration

Dietary anthocyanins as nutritional therapy for nonalcoholic fatty liver disease

Valenti, L., Riso, P., Mazzocchi, A., Porrini, M., Fargion, S. & Agostoni, C., 2013, In : Oxidative Medicine and Cellular Longevity. 145421.

Research output: Contribution to journalArticle

Anthocyanins
Liver
Fatty Liver
Therapeutics
Lipids

Dietary iron overload induces visceral adipose tissue insulin resistance

Dongiovanni, P., Ruscica, M., Rametta, R., Recalcati, S., Steffani, L., Gatti, S., Girelli, D., Cairo, G., Magni, P., Fargion, S. & Valenti, L., Jun 2013, In : American Journal of Pathology. 182, 6, p. 2254-2263 10 p.

Research output: Contribution to journalArticle

Dietary Iron
Iron Overload
Intra-Abdominal Fat
Insulin Resistance
Iron

Genetic predisposition in NAFLD and NASH: Impact on severity of liver disease and response to treatment

Dongiovanni, P., Anstee, Q. M. & Valenti, L., 2013, In : Current Pharmaceutical Design. 19, 29, p. 5219-5238 20 p.

Research output: Contribution to journalArticle

Fatty Liver
Genetic Predisposition to Disease
Liver Diseases
Liver
Insulin Resistance

Hepatic notch signaling correlates with insulin resistance and nonalcoholic fatty liver disease

Valenti, L., Mendoza, R. M., Rametta, R., Maggioni, M., Kitajewski, C., Shawber, C. J. & Pajvani, U. B., Dec 2013, In : Diabetes. 62, 12, p. 4052-4062 11 p.

Research output: Contribution to journalArticle

Insulin Resistance
Liver
Hyperglycemia
Notch Receptors
Biopsy

IL28B rs12979860 polymorphism influences serum TNFalpha levels in chronic hepatitis C

Motta, B. M., Dongiovanni, P., Fargion, S. & Valenti, L., Apr 2013, In : Digestive and Liver Disease. 45, 4, p. 348-349 2 p.

Research output: Contribution to journalArticle

Increased insulin receptor substrate 2 expression is associated with steatohepatitis and altered lipid metabolism in obese subjects

Rametta, R., Mozzi, E., Dongiovanni, P., Motta, B. M., Milano, M., Roviaro, G., Fargion, S. & Valenti, L., Jul 2013, In : International Journal of Obesity. 37, 7, p. 986-992 7 p.

Research output: Contribution to journalArticle

Insulin Receptor Substrate Proteins
Lipogenesis
Fatty Liver
Lipid Metabolism
Insulin
Telomerase
Liver Transplantation
Hepatocellular Carcinoma
Mutation
Liver Diseases

Patatin-like phospholipase domain-containing 3 I148M affects liver steatosis in patients with chronic hepatitis B

Viganò, M., Valenti, L., Lampertico, P., Facchetti, F., Motta, B. M., D'Ambrosio, R., Romagnoli, S., Dongiovanni, P., Donati, B., Fargion, S. & Colombo, M., Oct 2013, In : Hepatology. 58, 4, p. 1245-1252 8 p.

Research output: Contribution to journalArticle

Phospholipases
Chronic Hepatitis B
Fatty Liver
Odds Ratio
Confidence Intervals
Peroxisome Proliferator-Activated Receptors
Disease Susceptibility
Genetic Polymorphisms
Lipid Metabolism
Lipids

PNPLA3 GG Genotype and Carotid Atherosclerosis in Patients with Non-Alcoholic Fatty Liver Disease

Petta, S., Valenti, L., Marchesini, G., Di Marco, V., Licata, A., Cammà, C., Barcellona, M. R., Cabibi, D., Donati, B., Fracanzani, A., Grimaudo, S., Parrinello, G., Pipitone, R. M., Torres, D., Fargion, S., Licata, G. & Craxì, A., Sep 16 2013, In : PLoS One. 8, 9, e74089.

Research output: Contribution to journalArticle

Carotid Artery Diseases
fatty liver
atherosclerosis
Polymorphism
Liver
hepatoma
Polymorphism
Hepatocellular Carcinoma
genetic polymorphism
Liver

PNPLA3 I148M polymorphism and progressive liver disease

Dongiovanni, P., Donati, B., Fares, R., Lombardi, R., Mancina, R. M., Romeo, S. & Valenti, L., Nov 7 2013, In : World Journal of Gastroenterology. 19, 41, p. 6969-6978 10 p.

Research output: Contribution to journalArticle

Phospholipases
Liver Diseases
Fatty Liver
Liver
Fibrosis

PNPLA3 I148M variant and hepatocellular carcinoma: A common genetic variant for a rare disease

Valenti, L., Dongiovanni, P., Ginanni Corradini, S., Burza, M. A. & Romeo, S., Aug 2013, In : Digestive and Liver Disease. 45, 8, p. 619-624 6 p.

Research output: Contribution to journalArticle

Rare Diseases
Hepatocellular Carcinoma
Liver Diseases
Inborn Genetic Diseases
Phospholipases

The A736V TMPRSS6 polymorphism influences hepcidin and iron metabolism in chronic hemodialysis patients: TMPRSS6 and hepcidin in hemodialysis

Pelusi, S., Girelli, D., Rametta, R., Campostrini, N., Alfieri, C., Traglia, M., Dongiovanni, P., Como, G., Toniolo, D., Camaschella, C., Messa, P., Fargion, S. & Valenti, L., 2013, In : BMC Nephrology. 14, 1, 48.

Research output: Contribution to journalArticle

Hepcidins
Renal Dialysis
Iron
Erythropoiesis
Genotype

The I148M variant of PNPLA3 reduces the response to docosahexaenoic acid in children with non-Alcoholic fatty liver disease

Nobili, V., Bedogni, G., Donati, B., Alisi, A. & Valenti, L., Oct 1 2013, In : Journal of Medicinal Food. 16, 10, p. 957-960 4 p.

Research output: Contribution to journalArticle

Docosahexaenoic Acids
Phospholipases
Confidence Intervals
Alleles
Genotype
2012
Ferritins
Liver
Iron
Therapeutics
Insulin Resistance

Effect of the A736V TMPRSS6 polymorphism on the penetrance and clinical expression of hereditary hemochromatosis

Valenti, L., Fracanzani, A. L., Rametta, R., Fraquelli, M., Soverini, G., Pelusi, S., Dongiovanni, P., Conte, D. & Fargion, S., Dec 2012, In : Journal of Hepatology. 57, 6, p. 1319-1325 7 p.

Research output: Contribution to journalArticle

Hemochromatosis
Penetrance
Hepcidins
Genotype
Iron

Gallstone disease is associated with more severe liver damage in patients with non-alcoholic fatty liver disease

Fracanzani, A. L., Valenti, L., Russello, M., Miele, L., Bertelli, C., Bellia, A., Masetti, C., Cefalo, C., Grieco, A., Marchesini, G. & Fargion, S., Jul 25 2012, In : PLoS One. 7, 7, e41183.

Research output: Contribution to journalArticle

cholelithiasis
fatty liver
Gallstones
Liver
liver

I148M PNPLA3 variant and progressive liver disease: A new paradigm in hepatology

Valenti, L., Alisi, A. & Nobili, V., Aug 2012, In : Hepatology. 56, 2, p. 791 1 p.

Research output: Contribution to journalArticle

I148M PNPLA3 variant and progressive liver disease: a new paradigm in hepatology.

Valenti, L., Alisi, A. & Nobili, V., Aug 2012, In : Hepatology. 56, 2, p. 1883-1889 7 p.

Research output: Contribution to journalArticle

IL28B, HCV core mutations, and hepatocellular carcinoma: Does host genetic make-up shape viral evolution in response to immunity?

Valenti, L., Pulixi, E. & La Spina, S., Jan 2012, In : Hepatology International. 6, 1, p. 356-359 4 p.

Research output: Contribution to journalArticle

Hepatocellular Carcinoma
Immunity
Genotype
Mutation
Chronic Hepatitis C

Implications of PNPLA3 polymorphism in chronic hepatitis C patients receiving peginterferon plus ribavirin

Valenti, L., Aghemo, A., Stättermayer, A. F., Maggioni, P., De Nicola, S., Motta, B. M., Rumi, M. G., Dongiovanni, P., Ferenci, P., Colombo, M. & Fargion, S., Jun 2012, In : Alimentary Pharmacology and Therapeutics. 35, 12, p. 1434-1442 9 p.

Research output: Contribution to journalArticle

Ribavirin
Chronic Hepatitis C
Genotype
Fibrosis
Interleukins

Interaction between IL28B and PNPLA3 genotypes in the pathogenesis of steatosis in chronic hepatitis C non genotype-3 patients

Valenti, L., Aghemo, A. & Stättermayer, A. F., May 2012, In : Journal of Hepatology. 56, 5, p. 1209-1210 2 p.

Research output: Contribution to journalArticle

Interleukin 28B polymorphism predicts pegylated interferon plus ribavirin treatment outcome in chronic hepatitis C genotype 4

De Nicola, S., Aghemo, A., Grazia Rumi, M., Galmozzi, E., Valenti, L., Soffredini, R., De Francesco, R., Prati, G. M., D'Ambrosio, R., Cheroni, C., Donato, M. F. & Colombo, M., Feb 2012, In : Hepatology. 55, 2, p. 336-342 7 p.

Research output: Contribution to journalArticle

Ribavirin
Interleukins
Chronic Hepatitis C
Interferons
Genotype

LPIN1 rs13412852 polymorphism in pediatric nonalcoholic fatty liver disease

Valenti, L., Motta, B. M., Alisi, A., Sartorelli, R., Buonaiuto, G., Dongiovanni, P., Rametta, R., Pelusi, S., Fargion, S. & Nobili, V., May 2012, In : Journal of Pediatric Gastroenterology and Nutrition. 54, 5, p. 588-593 6 p.

Research output: Contribution to journalArticle

Pediatrics
Odds Ratio
Genotype
Confidence Intervals
Liver Cirrhosis

Markers of activated inflammatory cells correlate with severity of liver damage in children with nonalcoholic fatty liver disease

De Vito, R., Alisi, A., Masotti, A., Ceccarelli, S., Panera, N., Citti, A., Salata, M., Valenti, L., Feldstein, A. E. & Nobili, V., Jul 2012, In : International Journal of Molecular Medicine. 30, 1, p. 49-56 8 p.

Research output: Contribution to journalArticle

Liver
Liver Diseases
Fibrosis
Kupffer Cells
Non-alcoholic Fatty Liver Disease

Patatin-like phospholipase domain containing-3 gene I148M polymorphism, steatosis, and liver damage in hereditary hemochromatosis

Valenti, L., Maggioni, P., Piperno, A., Rametta, R., Pelucchi, S., Mariani, R., Dongiovanni, P., Fracanzani, A. L. & Fargion, S., Jun 2012, In : World Journal of Gastroenterology. 18, 22, p. 2813-2820 8 p.

Research output: Contribution to journalArticle

Hemochromatosis
Phospholipases
Fatty Liver
Fibrosis
Genes

PNPLA3 Ile148Met variant and hepatocellular carcinoma: A matter of fat

Valenti, L., Dec 2012, In : Digestive and Liver Disease. 44, 12, p. 974-975 2 p.

Research output: Contribution to journalArticle

T-ARMS-PCR for the evaluation of rs12979860 IL28B genotype: An optimized protocol

Motta, B. M., Dongiovanni, P., Fargion, S. & Valenti, L., Mar 2012, In : Journal of Viral Hepatitis. 19, 3, p. 228 1 p.

Research output: Contribution to journalArticle

The A736V TMPRSS6 Polymorphism Influences Hepatic Iron Overload in Nonalcoholic Fatty Liver Disease

Valenti, L., Rametta, R., Dongiovanni, P., Motta, B. M., Canavesi, E., Pelusi, S., Pulixi, E. A., Fracanzani, A. L. & Fargion, S., Nov 5 2012, In : PLoS One. 7, 11, e48804.

Research output: Contribution to journalArticle

iron overload
Iron Overload
fatty liver
Polymorphism
Liver

The i148m Pnpla3 polymorphism influences serum adiponectin in patients with fatty liver and healthy controls

Valenti, L., Rametta, R., Ruscica, M., Dongiovanni, P., Steffani, L., Motta, B. M., Canavesi, E., Fracanzani, A. L., Mozzi, E., Roviaro, G., Magni, P. & Fargion, S., Aug 16 2012, In : BMC Gastroenterology. 12, 111.

Research output: Contribution to journalArticle

Adiponectin
Fatty Liver
Phospholipases
Serum
Chronic Hepatitis C

The SOD2 C47T polymorphism influences NAFLD fibrosis severity: Evidence from case-control and intra-familial allele association studies

Al-Serri, A., Anstee, Q. M., Valenti, L., Nobili, V., Leathart, J. B. S., Dongiovanni, P., Patch, J., Fracanzani, A., Fargion, S., Day, C. P. & Daly, A. K., Feb 2012, In : Journal of Hepatology. 56, 2, p. 448-454 7 p.

Research output: Contribution to journalArticle

Liver Cirrhosis
Alleles
Genotype
Superoxide Dismutase
Fibrosis
2011

A tetra-primer amplification refractory mutation system polymerase chain reaction for the evaluation of rs12979860 IL28B genotype

Galmozzi, E., Menico, B. D., Rametta, R., Dongiovanni, P., Fracanzani, A. L., Benedan, L., Borroni, V., Maggioni, P., Fargion, S. & Valenti, L., Sep 2011, In : Journal of Viral Hepatitis. 18, 9, p. 628-630 3 p.

Research output: Contribution to journalArticle

Interferons
Single Nucleotide Polymorphism
Genotype
Polymerase Chain Reaction
Mutation
Iron Overload
Hemochromatosis
Liver Diseases
Chronic Disease
Iron

Early interplay of intra-hepatic iron and insulin resistance in children with non-alcoholic fatty liver disease

Manco, M., Alisi, A., Real, J. M. F., Equitani, F., Devito, R., Valenti, L. & Nobili, V., Sep 2011, In : Journal of Hepatology. 55, 3, p. 647-653 7 p.

Research output: Contribution to journalArticle

Insulin Resistance
Iron
Liver
Siderosis
Mutation