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20002019
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Research Output 2000 2019

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Article
2011
37 Citations (Scopus)

Glucagon-like peptide 1 inhibits the sirtuin deacetylase SirT1 to stimulate pancreatic β-cell mass expansion

Bastien-Dionne, P. O., Valenti, L., Kon, N., Gu, W. & Buteau, J., Dec 2011, In : Diabetes. 60, 12, p. 3217-3222 6 p.

Research output: Contribution to journalArticle

Glucagon-Like Peptide 1
NAD
Acetylation
Transgenic Mice
Hormones
160 Citations (Scopus)
Fatty Liver
Iron Overload
Iron
Insulin Resistance
Cardiovascular Diseases
192 Citations (Scopus)

Patatin-Like phospholipase domain-containing 3 I148M polymorphism, steatosis, and liver damage in chronic hepatitis C

Valenti, L., Rumi, M., Galmozzi, E., Aghemo, A., Del Menico, B., De Nicola, S., Dongiovanni, P., Maggioni, M., Fracanzani, A. L., Rametta, R., Colombo, M. & Fargion, S., Mar 2011, In : Hepatology. 53, 3, p. 791-799 9 p.

Research output: Contribution to journalArticle

Phospholipases
Chronic Hepatitis C
Fatty Liver
Genotype
Odds Ratio
5 Citations (Scopus)
5 Citations (Scopus)
2 Citations (Scopus)

PNPLA3 I148M polymorphism and liver damage in obese children

Valenti, L. & Nobili, V., Nov 2011, In : Journal of Pediatrics. 159, 5, p. 876 1 p.

Research output: Contribution to journalArticle

62 Citations (Scopus)

Risk of nonalcoholic steatohepatitis and fibrosis in patients with nonalcoholic fatty liver disease and low visceral adiposity

Fracanzani, A. L., Valenti, L., Bugianesi, E., Vanni, E., Grieco, A., Miele, L., Consonni, D., Fatta, E., Lombardi, R., Marchesini, G. & Fargion, S., Jun 2011, In : Journal of Hepatology. 54, 6, p. 1244-1249 6 p.

Research output: Contribution to journalArticle

Adiposity
Waist Circumference
Fibrosis
Abdominal Obesity
Fatty Liver
58 Citations (Scopus)

Serum ferritin levels are associated with vascular damage in patients with nonalcoholic fatty liver disease

Valenti, L., Swinkels, D. W., Burdick, L., Dongiovanni, P., Tjalsma, H., Motta, B. M., Bertelli, C., Fatta, E., Bignamini, D., Rametta, R., Fargion, S. & Fracanzani, A. L., Aug 2011, In : Nutrition, Metabolism and Cardiovascular Diseases. 21, 8, p. 568-575 8 p.

Research output: Contribution to journalArticle

Ferritins
Blood Vessels
Iron
Hepcidins
Serum
66 Citations (Scopus)

Serum hepcidin and macrophage iron correlate with MCP-1 release and vascular damage in patients with metabolic syndrome alterations

Valenti, L., Dongiovanni, P., Motta, B. M., Swinkels, D. W., Bonara, P., Rametta, R., Burdick, L., Frugoni, C., Fracanzani, A. L. & Fargion, S., Mar 2011, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 31, 3, p. 683-690 8 p.

Research output: Contribution to journalArticle

Hepcidins
Chemokine CCL2
Blood Vessels
Iron
Macrophages
55 Citations (Scopus)

The APOC3 T-455C and C-482T promoter region polymorphisms are not associated with the severity of liver damage independently of PNPLA3 I148M genotype in patients with nonalcoholic fatty liver

Valenti, L., Nobili, V., Al-Serri, A., Rametta, R., Leathart, J. B. S., Zappa, M. A., Dongiovanni, P., Fracanzani, A. L., Alterio, A., Roviaro, G., Daly, A. K., Fargion, S. & Day, C. P., Dec 2011, In : Journal of Hepatology. 55, 6, p. 1409-1414 6 p.

Research output: Contribution to journalArticle

Genetic Promoter Regions
Genotype
Single Nucleotide Polymorphism
Liver
Insulin Resistance
39 Citations (Scopus)

Venesection for non-alcoholic fatty liver disease unresponsive to lifestyle counselling-a propensity score-adjusted observational study

Valenti, L., Moscatiello, S., Vanni, E., Fracanzani, A. L., Bugianesi, E., Fargion, S. & Marchesini, G., Feb 2011, In : QJM. 104, 2, p. 141-149 9 p., hcq170.

Research output: Contribution to journalArticle

Propensity Score
Phlebotomy
Observational Studies
Life Style
Counseling
2010
2 Citations (Scopus)
23 Citations (Scopus)

A promoter polymorphism in the liver-specific fatty acid transport protein 5 is associated with features of the metabolic syndrome and steatosis

Auinger, A., Valenti, L., Pfeuffer, M., Helwig, U., Herrmann, J., Fracanzani, A. L., Dongiovanni, P., Fargion, S., Schrezenmeir, J. & Rubin, D., 2010, In : Hormone and Metabolic Research. 42, 12, p. 854-859 6 p.

Research output: Contribution to journalArticle

Fatty Acid Transport Proteins
Polymorphism
Liver
Alleles
Insulin
40 Citations (Scopus)
Siderosis
beta-Globins
Fibrosis
Iron
beta-Thalassemia
85 Citations (Scopus)

Genetic variants regulating insulin receptor signalling are associated with the severity of liver damage in patients with non-alcoholic fatty liver disease

Dongiovanni, P., Valenti, L., Rametta, R., Daly, A. K., Nobili, V., Mozzi, E., Leathart, J. B. S., Pietrobattista, A., Burt, A. D., Maggioni, M., Fracanzani, A. L., Lattuada, E., Zappa, M. A., Roviaro, G., Marchesini, G., Day, C. P. & Fargion, S., Feb 2010, In : Gut. 59, 2, p. 267-273 7 p.

Research output: Contribution to journalArticle

Insulin Receptor
Phosphoric Diester Hydrolases
Insulin Receptor Substrate Proteins
Nucleotides
Liver
21 Citations (Scopus)
31 Citations (Scopus)

Hemochromatosis in Italy in the last 30 years: Role of genetic and acquired factors

Fracanzani, A. L., Piperno, A., Valenti, L., Fraquelli, M., Coletti, S., Maraschi, A., Consonni, D., Coviello, E., Conte, D. & Fargion, S., Feb 2010, In : Hepatology. 51, 2, p. 501-510 10 p.

Research output: Contribution to journalArticle

Hemochromatosis
Italy
Iron Overload
Hepacivirus
Fibrosis
171 Citations (Scopus)

HFE Genotype, Parenchymal Iron Accumulation, and Liver Fibrosis in Patients With Nonalcoholic Fatty Liver Disease

Valenti, L., Fracanzani, A. L., Bugianesi, E., Dongiovanni, P., Galmozzi, E., Vanni, E., Canavesi, E., Lattuada, E., Roviaro, G., Marchesini, G. & Fargion, S., Mar 2010, In : Gastroenterology. 138, 3, p. 905-912 8 p.

Research output: Contribution to journalArticle

Liver Cirrhosis
Iron
Genotype
Siderosis
Mutation
374 Citations (Scopus)

Homozygosity for the patatin-like phospholipase-3/adiponutrin i148m polymorphism influences liver fibrosis in patients with nonalcoholic fatty liver disease

Valenti, L., Al-Serri, A., Daly, A. K., Enrico Galmozzi, G., Rametta, R., Dongiovanni, P., Nobili, V., Mozzi, E., Roviaro, G., Vanni, E., Bugianesi, E., Maggioni, M., LudovicaFracanzani, A., Fargion, S. & Day, C. P., Apr 2010, In : Hepatology. 51, 4, p. 1209-1217 9 p.

Research output: Contribution to journalArticle

Phospholipases
Liver Cirrhosis
Genotype
Odds Ratio
Confidence Intervals
183 Citations (Scopus)

I148M patatin-like phospholipase domain-containing 3 gene variant and severity of pediatric nonalcoholic fatty liver disease.

Valenti, L., Alisi, A., Galmozzi, E., Bartuli, A., Del Menico, B., Alterio, A., Dongiovanni, P., Fargion, S. & Nobili, V., Oct 2010, In : Hepatology. 52, 4, p. 1274-1280 7 p.

Research output: Contribution to journalArticle

Phospholipases
Pediatrics
Genes
Alleles
Fibrosis
37 Citations (Scopus)

Iron-dependent regulation of MDM2 influences p53 activity and hepatic carcinogenesis

Dongiovanni, P., Fracanzani, A. L., Cairo, G., Megazzini, C. P., Gatti, S., Rametta, R., Fargion, S. & Valenti, L., Feb 2010, In : American Journal of Pathology. 176, 2, p. 1006-1017 12 p.

Research output: Contribution to journalArticle

Carcinogenesis
Iron
Liver
Genes
Deferoxamine
43 Citations (Scopus)
PPAR alpha
Peroxisome Proliferator-Activated Receptors
Case-Control Studies
Alleles
Liver
42 Citations (Scopus)

Plasma chromogranin a response to octreotide test: Prognostic value for clinical outcome in endocrine digestive tumors

Massironi, S., Conte, D., Sciola, V., Spampatti, M. P., Ciafardini, C., Valenti, L., Rossi, R. E. & Peracchi, M., Sep 2010, In : American Journal of Gastroenterology. 105, 9, p. 2072-2078 7 p.

Research output: Contribution to journalArticle

Chromogranins
Chromogranin A
Octreotide
Somatostatin
Neoplasms
2 Citations (Scopus)

Reply

Fracanzani, A. L., Piperno, A., Valenti, L. & Fargion, S., Apr 2010, In : Hepatology. 51, 4, p. 1474 1 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)
Hyaluronic Acid
Liver
Screening
Fibrosis
Serum

To the editor

Valenti, L., Nobili, V. & Fargion, S., Jul 8 2010, In : New England Journal of Medicine. 363, 2, p. 194 1 p.

Research output: Contribution to journalArticle

2009
89 Citations (Scopus)

Association between iron overload and osteoporosis in patients with hereditary hemochromatosis

Valenti, L., Varenna, M., Fracanzani, A. L., Rossi, V., Fargion, S. & Sinigaglia, L., Apr 2009, In : Osteoporosis International. 20, 4, p. 549-555 7 p.

Research output: Contribution to journalArticle

Iron Overload
Hemochromatosis
Osteoporosis
Hypogonadism
Spine
2 Citations (Scopus)
2 Citations (Scopus)
Iron Overload
Liver Transplantation
Recurrence
Liver
Siderosis
27 Citations (Scopus)

HFE mutations modulate the effect of iron on serum hepcidin-25 in chronic hemodialysis patients

Valenti, L., Girelli, D., Valenti, G. F., Castagna, A., Como, G., Campostrini, N., Rametta, R., Dongiovanni, P., Messa, P. & Fargion, S., 2009, In : Clinical Journal of the American Society of Nephrology. 4, 8, p. 1331-1337 7 p.

Research output: Contribution to journalArticle

Hepcidins
Renal Dialysis
Iron
Mutation
Serum

Reply

Fracanzani, A. L., Valenti, L. & Fargion, S., 2009, In : Hepatology. 49, 2, p. 697 1 p.

Research output: Contribution to journalArticle

52 Citations (Scopus)
Alcoholic Fatty Liver
Liver Diseases
Immune System
Alcoholic Liver Diseases
Lipogenesis
154 Citations (Scopus)

Carotid Artery Intima-media Thickness in Nonalcoholic Fatty Liver Disease

Fracanzani, A. L., Burdick, L., Raselli, S., Pedotti, P., Grigore, L., Santorelli, G., Valenti, L., Maraschi, A., Catapano, A. & Fargion, S., Jan 2008, In : American Journal of Medicine. 121, 1, p. 72-78 7 p.

Research output: Contribution to journalArticle

Carotid Intima-Media Thickness
Carotid Arteries
Liver Function Tests
Blood Vessels
Case-Control Studies
8 Citations (Scopus)

HFE genotype influences erythropoiesis support requirement in hemodialysis patients: A prospective study

Valenti, L., Valenti, G., Como, G., Santorelli, G., Dongiovanni, P., Rametta, R., Fracanzani, A. L., Tavazzi, D., Messa, P. G. & Fargion, S., Jan 2008, In : American Journal of Nephrology. 28, 2, p. 311-316 6 p.

Research output: Contribution to journalArticle

Erythropoiesis
Renal Dialysis
Iron
Genotype
Prospective Studies
13 Citations (Scopus)

HFE mutations in nonalcoholic fatty liver disease

Valenti, L., Dongiovanni, P., Fracanzani, A. L. & Fargion, S., May 2008, In : Hepatology. 47, 5, p. 1794-1795 2 p.

Research output: Contribution to journalArticle

98 Citations (Scopus)

Increased expression and activity of the transcription factor FOXO1 in nonalcoholic steatohepatitis

Valenti, L., Rametta, R., Dongiovanni, P., Maggioni, M., Fracanzani, A. L., Zappa, M., Lattuada, E., Roviaro, G. & Fargion, S., May 2008, In : Diabetes. 57, 5, p. 1355-1362 8 p.

Research output: Contribution to journalArticle

Fatty Liver
Transcription Factors
Insulin Resistance
Glucose-6-Phosphatase
Catalytic Domain
113 Citations (Scopus)
Deferoxamine
Hepatocellular Carcinoma
Up-Regulation
Iron
Hypoxia-Inducible Factor 1
3 Citations (Scopus)

Iron genes, dysmetabolism and fibrosis in chronic hepatitis C

Valenti, L., Dongiovanni, P., Fargion, S. & Fracanzani, A. L., Mar 2008, In : Journal of Hepatology. 48, 3, p. 513-514 2 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Reply

Fracanzani, A. L., Valenti, L. & Fargion, S., 2008, In : Hepatology. 48, 6, p. 2088 1 p.

Research output: Contribution to journalArticle

389 Citations (Scopus)

Risk of severe liver disease in nonalcoholic fatty liver disease with normal aminotransferase levels: A role for insulin resistance and diabetes

Fracanzani, A. L., Valenti, L., Bugianesi, E., Andreoletti, M., Colli, A., Vanni, E., Bertelli, C., Fatta, E., Bignamini, D., Marchesini, G. & Fargion, S., Sep 2008, In : Hepatology. 48, 3, p. 792-798 7 p.

Research output: Contribution to journalArticle

Transaminases
Alanine Transaminase
Insulin Resistance
Liver Diseases
Odds Ratio
40 Citations (Scopus)

The hand arthropathy of hereditary hemochromatosis is strongly associated with iron overload

Valenti, L., Fracanzani, A. L., Rossi, V., Rampini, C., Pulixi, E., Varenna, M., Fargion, S. & Sinigaglia, L., Jan 2008, In : Journal of Rheumatology. 35, 1, p. 153-158 6 p.

Research output: Contribution to journalArticle

Iron Overload
Hemochromatosis
Joint Diseases
Hand
Ferritins
2007
14 Citations (Scopus)

HFE gene mutations and oxidative stress influence serum ferritin, associated with vascular damage, in hemodialysis patients

Valenti, L., Valenti, G., Como, G., Burdick, L., Santorelli, G., Dongiovanni, P., Rametta, R., Bamonti, F., Novembrino, C., Fracanzani, A. L., Messa, P. G. & Fargion, S., Mar 2007, In : American Journal of Nephrology. 27, 1, p. 101-107 7 p.

Research output: Contribution to journalArticle

Ferritins
Blood Vessels
Renal Dialysis
Oxidative Stress
Iron
211 Citations (Scopus)
Phlebotomy
Ferritins
Insulin Resistance
Case-Control Studies
Iron
52 Citations (Scopus)

Relative contribution of iron genes, dysmetabolism and hepatitis C virus (HCV) in the pathogenesis of altered iron regulation in HCV chronic hepatitis

Valenti, L., Pulixi, E. A., Arosio, P., Cremonesi, L., Biasiotto, G., Dongiovanni, P., Maggioni, M., Fargion, S. & Fracanzani, A. L., Aug 2007, In : Haematologica. 92, 8, p. 1037-1042 6 p.

Research output: Contribution to journalArticle

Chronic Hepatitis
Hepacivirus
Iron
Hepcidins
Mutation
2006
37 Citations (Scopus)

Circulating ghrelin levels in patients with inflammatory bowel disease [1]

Peracchi, M., Bardella, M. T., Caprioli, F., Massironi, S., Conte, D., Valenti, L., Ronchi, C., Beck-Peccoz, P., Arosio, M. & Piodi, L., Mar 2006, In : Gut. 55, 3, p. 432-433 2 p.

Research output: Contribution to journalArticle

58 Citations (Scopus)

α1-antitrypsin mutations in NAFLD: High prevalence and association with altered iron metabolism but not with liver damage

Valenti, L., Dongiovanni, P., Piperno, A., Fracanzani, A. L., Maggioni, M., Rametta, R., Loria, P., Casiraghi, M. A., Suigo, E., Ceriani, R., Remondini, E., Trombini, P. & Fargion, S., Oct 2006, In : Hepatology. 44, 4, p. 857-864 8 p.

Research output: Contribution to journalArticle

Iron
Mutation
Liver
Genotype
Ferritins
2005
20 Citations (Scopus)

Association between heterozygosity for HFE gene mutations and hepatitis viruses in hepatocellular carcinoma

Fracanzani, A. L., Fargion, S., Stazi, M. A., Valenti, L., Amoroso, P., Cariani, E., Sangiovanni, A., Tommasini, M., Rossini, A., Bertelli, C., Fatta, E., Patriarca, V., Brescianini, S. & Stroffolini, T., Jul 2005, In : Blood cells, molecules & diseases. 35, 1, p. 27-32 6 p.

Research output: Contribution to journalArticle

Hepatitis Viruses
Hepatocellular Carcinoma
Mutation
Hepatitis B virus
Hepacivirus

Erratum: Turning up the heat in the fat cell (Nature Medicine (2004) 10 (1168-1169))

Accili, D. & Valenti, L., Jun 2005, In : Nature Medicine. 11, 6, p. 690 1 p.

Research output: Contribution to journalArticle