1987 …2019

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2019

Dual CCR5/CCR2 targeting: opportunities for the cure of complex disorders

Fantuzzi, L., Tagliamonte, M., Gauzzi, M. C. & Lopalco, L., Dec 1 2019, In : Cellular and Molecular Life Sciences. 76, 24, p. 4869-4886 18 p.

Research output: Contribution to journalArticle

Short Communication: Decreased Plasma Calcitonin Gene-Related Peptide as a Novel Biomarker for HIV-1 Disease Progression

Bomsel, M., Lopalco, L., Uberti-Foppa, C., Siracusano, G. & Ganor, Y., Jan 2019, In : AIDS Research and Human Retroviruses. 35, 1, p. 52-55 4 p.

Research output: Contribution to journalArticle

2018

The abrogation of phosphorylation plays a relevant role in the CCR5 signalosome formation with natural antibodies to CCR5

Venuti, A., Pastori, C., Siracusano, G., Pennisi, R., Riva, A., Tommasino, M., Sciortino, MT. & Lopalco, L., 2018, In : Viruses. 10, 1, 9.

Research output: Contribution to journalArticle

2017

Diazabicyclo analogues of maraviroc: synthesis, modeling, NMR studies and antiviral activity

Legnani, L., Colombo, D., Venuti, A., Pastori, C., Lopalco, L., Toma, L., Mori, M., Grazioso, G. & Villa, S., 2017, In : MedChemComm. 8, 2, p. 422-433 12 p.

Research output: Contribution to journalArticle

Induction of antihuman C-C chemokine receptor type 5 antibodies by a bovine herpesvirus type-4 based vector

Verna, AE., Franceschi, V., Tebaldi, G., Macchi, F., Menozzi, V., Pastori, C., Lopalco, L., Ottonello, S., Cavirani, S. & Donofrio, G., 2017, In : Frontiers in Immunology. 8, 52, 1402.

Research output: Contribution to journalArticle

M48U1 and Tenofovir combination synergistically inhibits HIV infection in activated PBMCs and human cervicovaginal histocultures

Musumeci, G., Bon, I., Lembo, D., Cagno, V., Re, MC., Signoretto, C., Diani, E., Lopalco, L., Pastori, C., Martin, L., Ponchel, G., Gibellini, D. & Bouchemal, K., 2017, In : Scientific Reports. 7, 10, 41018.

Research output: Contribution to journalArticle

The role of natural antibodies to CC chemokine receptor 5 in HIV infection

Venuti, A., Pastori, C. & Lopalco, L., 2017, In : Frontiers in Immunology. 8, 5, 1358.

Research output: Contribution to journalArticle

2016

Class B β-arrestin2-dependent CCR5 signalosome retention with natural antibodies to CCR5

Venuti, A., Pastori, C., Pennisi, R., Riva, A., Sciortino, M. T. & Lopalco, L., Dec 23 2016, In : Scientific Reports. 6, 39382.

Research output: Contribution to journalArticle

Dysfunctions in the migratory phenotype and properties of circulating immature transitional B cells during HIV-1 infection

Amu, S., Fievez, V., Nozza, S., Lopalco, L. & Chiodi, F., 2016, In : AIDS. 30, 14, p. 2169 - 2177 9 p.

Research output: Contribution to journalArticle

Dysfunctions in the migratory phenotype and properties of circulating immature transitional B cells during HIV-1 Infection

Amu, S., Fievez, V., Nozza, S., Lopalco, L. & Chiodi, F., Jun 8 2016, (Accepted/In press) In : AIDS.

Research output: Contribution to journalArticle

GM-3 Lactone Mimetic Interacts with CD4 and HIV-1 Env Proteins, Hampering HIV-1 Infection without Inducing a Histopathological Alteration

Richichi, B., Pastori, C., Gherardi, S., Venuti, A., Cerreto, A., Sanvito, F., Toma, L., Lopalco, L. & Nativi, C., Aug 12 2016, In : ACS Infectious Diseases. 2, 8, p. 564-571 8 p.

Research output: Contribution to journalArticle

High-efficiency antibody discovery achieved with multiplexed microscopy

Izquierdo, S. M., Varela, S., Park, M., Collarini, E. J., Lu, D., Pramanick, S., Rucker, J., Lopalco, L., Etches, R. & Harriman, W., Aug 1 2016, In : Microscopy (Oxford, England). 65, 4, p. 341-352 12 p.

Research output: Contribution to journalArticle

2015

ERK1-based pathway as a new selective mechanism to modulate CCR5 with natural antibodies

Venuti, A., Pastori, C., Siracusano, G., Riva, A., Sciortino, M. T. & Lopalco, L., Oct 1 2015, In : Journal of Immunology. 195, 7, p. 3045-3057 13 p.

Research output: Contribution to journalArticle

2014

Frequency and phenotype of B cell subpopulations in young and aged HIV-1 infected patients receiving ART

Amu, S., Lavy-Shahaf, G., Cagigi, A., Hejdeman, B., Nozza, S., Lopalco, L., Mehr, R. & Chiodi, F., Sep 11 2014, In : Retrovirology. 11, 1, 76.

Research output: Contribution to journalArticle

Induction of HIV-blocking anti-CCR5 IgA in peyers's patches without histopathological alterations

Pastori, C., Diomede, L., Venuti, A., Fisher, G., Jarvik, J., Bomsel, M., Sanvito, F. & Lopalco, L., 2014, In : Journal of Virology. 88, 7, p. 3623-3635 13 p.

Research output: Contribution to journalArticle

Induction of HIV-blocking anti-CCR5 IgA in peyers's patches without histopathological alterations

Pastori, C., Diomede, L., Venuti, A., Fisher, G., Jarvik, J., Bomsel, M., Sanvito, F. & Lopalco, L., Apr 1 2014, In : Journal of Virology. 88, 7, p. 3623-3635 13 p.

Research output: Contribution to journalArticle

Spontaneous control of HIV-1 viremia in a subject with protective HLA-B plus HLA-C alleles and HLA-C associated single nucleotide polymorphisms

Moroni, M., Ghezzi, S., Baroli, P., Heltai, S., De Battista, D., Pensieroso, S., Cavarelli, M., Dispinseri, S., Vanni, I., Pastori, C., Zerbi, P., Tosoni, A., Vicenzi, E., Nebuloni, M., Wong, K., Zhao, H., McHugh, S., Poli, G., Lopalco, L., Scarlatti, G. & 4 others, Biassoni, R., Mullins, J. I., Malnati, M. S. & Alfano, M., Dec 5 2014, In : Journal of Translational Medicine. 12, 1, 335.

Research output: Contribution to journalArticle

Synergy in monoclonal antibody neutralization of HIV-1 pseudoviruses and infectious molecular clones

Miglietta, R., Pastori, C., Venuti, A., Ochsenbauer, C. & Lopalco, L., 2014, In : Journal of Translational Medicine. 12, 1, 346.

Research output: Contribution to journalArticle

2013

A Nonparametric Procedure for Defining a New Humoral Immunologic Profile in a Pilot Study on HIV Infected Patients

Brombin, C., Diomede, L., Tudor, D., Drillet, A. S., Pastori, C., Poli, E., Riva, A., Uberti-Foppa, C., Galli, M., Di Serio, C., Bomsel, M. & Lopalco, L., Mar 22 2013, In : PLoS One. 8, 3, e58768.

Research output: Contribution to journalArticle

Calcitonin gene-related peptide inhibits langerhans cell-mediated HIV-1 transmission

Ganor, Y., Drillet-Dangeard, A. S., Lopalco, L., Tudor, D., Tambussi, G., Delongchamps, N. B., Zerbib, M. & Bomsel, M., Oct 2013, In : Journal of Experimental Medicine. 210, 11, p. 2161-2170 10 p.

Research output: Contribution to journalArticle

Investigational treatment suspension and enhanced cell-mediated immunity at rebound followed by drug-free remission of simian AIDS

Shytaj, I. L., Chirullo, B., Wagner, W., Ferrari, M. G., Sgarbanti, R., Corte, A. D., LaBranche, C., Lopalco, L., Palamara, A. T., Montefiori, D., Lewis, M. G., Garaci, E. & Savarino, A., Jul 16 2013, In : Retrovirology. 10, 1, 71.

Research output: Contribution to journalArticle

Randomized Phase I: Safety, Immunogenicity and Mucosal Antiviral Activity in Young Healthy Women Vaccinated with HIV-1 Gp41 P1 Peptide on Virosomes

Leroux-Roels, G., Maes, C., Clement, F., van Engelenburg, F., van den Dobbelsteen, M., Adler, M., Amacker, M., Lopalco, L., Bomsel, M., Chalifour, A. & Fleury, S., Feb 20 2013, In : PLoS One. 8, 2, e55438.

Research output: Contribution to journalArticle

2012

Isotype modulates epitope specificity, affinity, and antiviral activities of anti-HIV-1 human broadly neutralizing 2F5 antibody

Tudor, D., Yu, H., Maupetit, J., Drillet, A. S., Bouceba, T., Schwartz-Cornil, I., Lopalco, L., Tuffery, P. & Bomsel, M., Jul 31 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 31, p. 12680-12685 6 p.

Research output: Contribution to journalArticle

Passively transmitted gp41 antibodies in babies born from HIV-1 subtype C-seropositive Women: Correlation between fine specificity and protection

Diomede, L., Nyoka, S., Pastori, C., Scotti, L., Zambon, A., Sherman, G., Gray, C. M., Sarzotti-Kelsoe, M. & Lopalco, L., Apr 2012, In : Journal of Virology. 86, 8, p. 4129-4138 10 p.

Research output: Contribution to journalArticle

Stable changes in CD4 + T lymphocyte miRNA expression after exposure to HIV-1

Bignami, F., Pilotti, E., Bertoncelli, L., Ronzi, P., Gulli, M., Marmiroli, N., Magnani, G., Pinti, M., Lopalco, L., Mussini, C., Ruotolo, R., Galli, M., Cossarizza, A. & Casoli, C., Jun 28 2012, In : Blood. 119, 26, p. 6259-6267 9 p.

Research output: Contribution to journalArticle

Virus like particle based strategy to elicit HIV-protective antibodies to the alpha-helic regions of gp41

Pastori, C., Tudor, D., Diomede, L., Drillet, A. S., Jegerlehner, A., Röhn, T. A., Bomsel, M. & Lopalco, L., Sep 15 2012, In : Virology. 431, 1-2, p. 1-11 11 p.

Research output: Contribution to journalArticle

2011

Broad-spectrum inhibition of HIV-1 by a monoclonal antibody directed against a gp120-induced epitope of CD4

Burastero, S. E., Frigerio, B., Lopalco, L., Sironi, F., Breda, D., Longhi, R., Scarlatti, G., Canevari, S., Figini, M. & Lusso, P., 2011, In : PLoS One. 6, 7, e22081.

Research output: Contribution to journalArticle

Generation of HIV-1 Virus-Like Particles expressing different HIV-1 glycoproteins

Visciano, M. L., Diomede, L., Tagliamonte, M., Tornesello, M. L., Asti, V., Bomsel, M., Buonaguro, F. M., Lopalco, L. & Buonaguro, L., Jul 12 2011, In : Vaccine. 29, 31, p. 4903-4912 10 p.

Research output: Contribution to journalArticle

Immunization with HIV-1 gp41 Subunit Virosomes Induces Mucosal Antibodies Protecting Nonhuman Primates against Vaginal SHIV Challenges

Bomsel, M., Tudor, D., Drillet, A. S., Alfsen, A., Ganor, Y., Roger, M. G., Mouz, N., Amacker, M., Chalifour, A., Diomede, L., Devillier, G., Cong, Z., Wei, Q., Gao, H., Qin, C., Yang, G. B., Zurbriggen, R., Lopalco, L. & Fleury, S., Feb 25 2011, In : Immunity. 34, 2, p. 269-280 12 p.

Research output: Contribution to journalArticle

Modeling and spectroscopic studies of synthetic diazabicyclo analogs of the HIV-1 inhibitor BMS-378806 and evaluation of their antiviral activity

Legnani, L., Colombo, D., Cocchi, E., Solano, L., Villa, S., Lopalco, L., Asti, V., Diomede, L., Marinone Albini, F. & Toma, L., Jan 2011, In : European Journal of Organic Chemistry. 2, p. 287-294 8 p.

Research output: Contribution to journalArticle

Protecting the initial site of viral entry: An alternative HIV vaccine target

Lopalco, L. & Bomsel, M., Sep 2011, In : Expert Review of Vaccines. 10, 9, p. 1253-1256 4 p.

Research output: Contribution to journalArticle

Scarcity or absence of humoral immune responses in the plasma and cervicovaginal lavage fluids of heavily HIV-1-exposed but persistently seronegative women

Mestecky, J., Wright, P. F., Lopalco, L., Staats, H. F., Kozlowski, P. A., Moldoveanu, Z., Alexander, R. C., Kulhavy, R., Pastori, C., Maboko, L., Riedner, G., Zhu, Y., Wrinn, T. & Hoelscher, M., May 1 2011, In : AIDS Research and Human Retroviruses. 27, 5, p. 469-486 18 p.

Research output: Contribution to journalArticle

2010

CCR5: From natural resistance to a new anti-HIV strategy

Lopalco, L., Feb 2010, In : Viruses. 2, 2, p. 574-600 27 p.

Research output: Contribution to journalArticle

HLA-C is necessary for optimal human immunodeficiency virus type 1 infection of human peripheral blood CD4 lymphocytes

Baroni, M., Matucci, A., Scarlatti, G., Soprana, E., Rossolillo, P., Lopalco, L., Zipeto, D., Siccardi, A. G. & De Santis, C., 2010, In : Journal of General Virology. 91, 1, p. 235-241 7 p.

Research output: Contribution to journalArticle

Natural anti-CCR5 antibodies in HIV-infection and -exposure

Lopalco, L., Jan 27 2010, In : Journal of Translational Medicine. 9, SUPPL. 1, S4.

Research output: Contribution to journalArticle

Orally exposed uninfected individuals have systemic anti-HIV responses associating with partners' viral load

Hasselrot, K., Bratt, G., Hirbod, T., Säberg, P., Ehnlund, M., Lopalco, L., Sandström, E. & Broliden, K., Jan 2010, In : AIDS (London, England). 24, 1, p. 35-43 9 p.

Research output: Contribution to journalArticle

Setting of methods for analysis of mucosal antibodies in seminal and vaginal fluids of HIV seropositive subjects from Cambodian and Italian cohorts

Donadoni, C., Bisighini, C., Scotti, L., Diomede, L., Ngyen, M., Nouhin, J., DeSantis, L., Zambon, A., Ferrari, D., Gallotta, G., Corrao, G., Pancino, G. & Lopalco, L., 2010, In : PLoS One. 5, 3, e9920.

Research output: Contribution to journalArticle

The role of IL-1β in reduced IL-7 production by stromal and epithelial cells: A model for impaired T-cell numbers in the gut during HIV-1 infection

Thang, P. H., Ruffin, N., Brodin, D., Rethi, B., Cam, P. D., Hien, N. T., Lopalco, L., Vivar, N. & Chiodi, F., Aug 2010, In : Journal of Internal Medicine. 268, 2, p. 181-193 13 p.

Research output: Contribution to journalArticle

2009

Abundant and superficial expression of C-type lectin receptors in ectocervix of women at risk of HIV infection

Hirbod, T., Kaldensjö, T., Lopalco, L., Klareskog, E., Andersson, S., Uberti-Foppa, C., Ferrari, D., Manghi, M., Andersson, J., Loré, K. & Broliden, K., Jul 2009, In : Journal of Acquired Immune Deficiency Syndromes. 51, 3, p. 239-247 9 p.

Research output: Contribution to journalArticle

HIV-1 gp41-specific monoclonal mucosal IgAs derived from highly exposed but IgG-seronegative individuals block HIV-1 epithelial transcytosis and neutralize CD4+ cell infection: An IgA gene and functional analysis

Tudor, D., Derrien, M., Diomede, L., Drillet, A. S., Houimel, M., Moog, C., Reynes, J. M., Lopalco, L. & Bomsel, M., 2009, In : Mucosal Immunology. 2, 5, p. 412-426 15 p.

Research output: Contribution to journalArticle

P04-18. Comparison of HIV neutralization assays for use in vaccine research and clinical trials, phase II: Results from the NeutNet working group

Scarlatti, G., Alcami, J., Bongertz, V., Fenyö, E., Heath, A., Heyndrickx, L., Holmes, H., Jansson, M., Lopalco, L., Malnati, M., Montefiori, D., Moog, C., Morris, L., Osmanov, S., Polonis, V., Ramaswamy, M., Sattentau, Q., Schuitemaker, H. & Wrin, T., Oct 22 2009, In : Retrovirology. 6, SUPPL. 3, 1742.

Research output: Contribution to journalArticle

P11-13. Antigen presentation and immune priming of CCR5-ECL1 receptor in Peyer's patches B cells

Lopalco, L., Diomede, L., Pastori, C., Soprana, E. & Siccardi, A., Oct 22 2009, In : Retrovirology. 6, SUPPL. 3, 1742.

Research output: Contribution to journalArticle

P11-14. Analysis of mucosal antibodies in genital fluids of HIV seropositive subjects from Cambodian and Italian cohorts

Lopalco, L., Scotti, L., Pastori, C., Ngyen, M., Nouhin, J., Ferrari, D. & Pancino, G., Oct 22 2009, In : Retrovirology. 6, SUPPL. 3, 1742.

Research output: Contribution to journalArticle

P11-20. HIV-1 gp41-specific mucosal IgAs from highly exposed but IgG seronegative women block HIV-1 epithelial transcytosis and neutralize CD4+ cell infection

Tudor, D., Derrien, M., Diomede, L., Houimel, M., Drillet, A., Moog, C., Reynes, J., Lopalco, L. & Bomsel, M., Oct 22 2009, In : Retrovirology. 6, SUPPL. 3, 1742.

Research output: Contribution to journalArticle

P19-02. High protection of female macaques from repeated intravaginal challenges with SHIV-162P3 upon mucosal vaccination with Gp41 subunits-virosomes

Bomsel, M., Drillet, A., Roger, M., Amacker, M., Mouz, N., Lopalco, L., Devillers, G., Zurbriggen, R. & Fleury, S., Oct 22 2009, In : Retrovirology. 6, SUPPL. 3, 1742.

Research output: Contribution to journalArticle

P19-34. Formal breaking of B cell tolerance to induce HIV blocking CCR5 specific antibodies in mouse model

Lopalco, L., Diomede, L. & Pastori, C., Oct 22 2009, In : Retrovirology. 6, SUPPL. 3, 1742.

Research output: Contribution to journalArticle

The′immunologic advantage′ of HIV-exposed seronegative individuals

Miyazawa, M., Lopalco, L., Mazzotta, F., Caputo, S. L., Veas, F. & Clerici, M., Jan 14 2009, In : AIDS (London, England). 23, 2, p. 161-175 15 p.

Research output: Contribution to journalArticle

Unsung hero Robert C. Gallo

Abbadessa, G., Accolla, R., Aiuti, F., Albini, A., Aldovini, A., Alfano, M., Antonelli, G., Bartholomew, C., Bentwich, Z., Bertazzoni, U., Berzofsky, J. A., Biberfeld, P., Boeri, E., Buonaguro, L., Buonaguro, F. M., Bukrinsky, M., Burny, A., Caruso, A., Cassol, S., Chandra, P. & 86 others, Ceccherini-Nelli, L., Chieco-Bianchi, L., Clerici, M., Colombini-Hatch, S., Morghen, C. D. G., De Maria, A., De Rossi, A., Dierich, M., Della-Favera, R., Dolei, A., Douek, D., Erfle, V., Felber, B., Fiorentini, S., Franchini, G., Gershoni, J. M., Gotch, F., Green, P., Greene, W. C., Hall, W., Haseltine, W., Jacobson, S., Kallings, L. O., Kalyanaraman, V. S., Katinger, H., Khalili, K., Klein, G., Klein, E., Klotman, M., Klotman, P., Kotler, M., Kurth, R., Lafeuillade, A., La Placa, M., Lewis, J., Lillo, F., Lisziewicz, J., Lomonico, A., Lopalco, L., Lori, F., Lusso, P., Macchi, B., Malim, M., Margolis, L., Markham, P. D., Mcclure, M., Miller, N., Mingari, M. C., Moretta, L., Noonan, D., O'Brien, S., Okamoto, T., Pal, R., Palese, P., Panet, A., Pantaleo, G., Pavlakis, G., Pistello, M., Plotkin, S., Poli, G., Pomerantz, R., Radaelli, A., Robert-Guroff, M., Roederer, M., Sarngadharan, M. G., Schols, D., Secchiero, P., Shearer, G., Siccardi, A., Stevenson, M., Svoboda, J., Tartaglia, J., Torelli, G., Tornesello, M. L., Tschachler, E., Vaccarezza, M., Vallbracht, A., Van Lunzen, J., Varnier, O., Vicenzi, E., Von Melchner, H., Witz, I., Zagury, D., Zagury, J. F., Zauli, G. & Zipeto, D., Jan 9 2009, In : Science. 323, 5911, p. 206-207 2 p.

Research output: Contribution to journalArticle