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Research Output 2005 2019

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2019

Effects of Macuprev® Supplementation in Age-Related Macular Degeneration: A Double-Blind Randomized Morpho-Functional Study Along 6 Months of Follow-Up

Parravano, M., Tedeschi, M., Manca, D., Costanzo, E., Di Renzo, A., Giorno, P., Barbano, L., Ziccardi, L., Varano, M. & Parisi, V., Sep 1 2019, In : Advances in Therapy. 36, 9, p. 2493-2505 13 p.

Research output: Contribution to journalArticle

Open Access
Macular Degeneration
Optical Coherence Tomography
Italy
Meals
Stomach
Cytidine Diphosphate Choline
Visual Pathways
Ophthalmic Solutions
Open Angle Glaucoma
Neural Conduction

Functional Changes of Retinal Ganglion Cells and Visual Pathways in Patients with Chronic Leber's Hereditary Optic Neuropathy during One Year of Follow-up

Parisi, V., Ziccardi, L., Sadun, F., De Negri, A. M., La Morgia, C., Barbano, L., Carelli, V. & Barboni, P., Jul 1 2019, In : Ophthalmology. 126, 7, p. 1033-1044 12 p.

Research output: Contribution to journalArticle

Leber's Hereditary Optic Atrophy
Visual Pathways
Retinal Ganglion Cells
Visual Evoked Potentials
Analysis of Variance

Mutation profile of BBS genes in patients with Bardet-Biedl syndrome: an Italian study

Manara, E., Paolacci, S., D'Esposito, F., Abeshi, A., Ziccardi, L., Falsini, B., Colombo, L., Iarossi, G., Pilotta, A., Boccone, L., Guerri, G., Monica, M., Marta, B., Maltese, P. E., Buzzonetti, L., Rossetti, L. & Bertelli, M., Jun 13 2019, In : Italian Journal of Pediatrics. 45, 1, p. 72

Research output: Contribution to journalArticle

Bardet-Biedl Syndrome
Mutation
Genes
Multifactorial Inheritance
Chaperonins

Mutation profile of BBS genes in patients with Bardet-Biedl syndrome: an Italian study

Manara, E., Paolacci, S., D'Esposito, F., Abeshi, A., Ziccardi, L., Falsini, B., Colombo, L., Iarossi, G., Pilotta, A., Boccone, L., Guerri, G., Monica, M., Marta, B., Maltese, P. E., Buzzonetti, L., Rossetti, L. & Bertelli, M., Jun 13 2019, In : Ital. J. Pediatr.. 45, 1

Research output: Contribution to journalArticle

Bardet-Biedl Syndrome
Mutation
Genes
Multifactorial Inheritance
Chaperonins

Neuroenhancement and neuroprotection by oral solution citicoline in non-arteritic ischemic optic neuropathy as a model of neurodegeneration: A randomized pilot study

Parisi, V., Barbano, L., Di Renzo, A., Coppola, G. & Ziccardi, L., Jan 1 2019, In : PLoS One. 14, 7, e0220435.

Research output: Contribution to journalArticle

Open Access
Cytidine Diphosphate Choline
Ischemic Optic Neuropathy
peripheral nervous system diseases
optics
Visual Evoked Potentials

Pathogenicity of new BEST1 variants identified in Italian patients with best vitelliform macular dystrophy assessed by computational structural biology

Frecer, V., Iarossi, G., Salvetti, A. P., Maltese, P. E., Delledonne, G., Oldani, M., Staurenghi, G., Falsini, B., Minnella, A. M., Ziccardi, L., Magli, A., Colombo, L., D'Esposito, F., Miertus, J., Viola, F., Attanasio, M., Maggio, E. & Bertelli, M., Oct 1 2019, In : Journal of Translational Medicine. 17, 1

Research output: Contribution to journalArticle

Vitelliform Macular Dystrophy
Computational Biology
Virulence
Amino Acids
Visual Acuity

Pathogenicity of new BEST1 variants identified in Italian patients with best vitelliform macular dystrophy assessed by computational structural biology

Frecer, V., Iarossi, G., Salvetti, A. P., Maltese, P. E., Delledonne, G., Oldani, M., Staurenghi, G., Falsini, B., Minnella, A. M., Ziccardi, L., Magli, A., Colombo, L., D'Esposito, F., Miertus, J., Viola, F., Attanasio, M., Maggio, E. & Bertelli, M., Oct 1 2019, In : Journal of Translational Medicine. 17, 1, 330.

Research output: Contribution to journalArticle

Open Access
Vitelliform Macular Dystrophy
Computational Biology
Virulence
Amino Acids
Visual Acuity
2018
Obesity
Genetic Testing
Genes
Phenotype
Delayed Diagnosis

A novel p.(Glu111Val) missense mutation in GUCA1A associated with cone-rod dystrophy leads to impaired calcium sensing and perturbed second messenger homeostasis in photoreceptors

Marino, V., Dal Cortivo, G., Oppici, E., Maltese, P. E., D'Esposito, F., Manara, E., Ziccardi, L., Falsini, B., Magli, A., Bertelli, M. & Dell'Orco, D., Dec 15 2018, In : Human Molecular Genetics. 27, 24, p. 4204-4217 14 p.

Research output: Contribution to journalArticle

Guanylate Cyclase-Activating Proteins
Second Messenger Systems
Missense Mutation
Homeostasis
Calcium

Association between Early Neuroretinal Dysfunction and Peripheral Motor Unit Loss in Patients with Type 1 Diabetes Mellitus

Picconi, F., Mataluni, G., Ziccardi, L., Parravano, M., Di Renzo, A., Ylli, D., Pasqualetti, P., Studer, V., Chioma, L., Marfia, G. A. & Frontoni, S., Oct 4 2018, In : Journal of Diabetes Research. 2018, p. 9763507 9 p.

Research output: Contribution to journalArticle

Type 1 Diabetes Mellitus
Hallux
Diabetic Neuropathies
Neural Conduction
Peripheral Nervous System Diseases

Central retina functional damage in usher syndrome type 2: 22 years of focal macular ERG analysis in a patient population from central and southern Italy

Galli-Resta, L., Placidi, G., Campagna, F., Ziccardi, L., Piccardi, M., Minnella, A., Abed, E., Iovine, S., Maltese, P., Bertelli, M. & Falsini, B., Aug 1 2018, In : Investigative Ophthalmology and Visual Science. 59, 10, p. 3827-3835 9 p.

Research output: Contribution to journalArticle

Usher Syndromes
Italy
Retina
Visual Field Tests
Population

Early and localized retinal dysfunction in patients with type 1 diabetes mellitus studied by multifocal electroretinogram

Ziccardi, L., Parisi, V., Picconi, F., Di Renzo, A., Lombardo, M., Frontoni, S. & Parravano, M., Nov 1 2018, In : Acta Diabetologica. 55, 11, p. 1191-1200 10 p.

Research output: Contribution to journalArticle

Type 1 Diabetes Mellitus
Glycosylated Hemoglobin A
Diabetic Retinopathy
Nose
Analysis of Variance

Multimodal Imaging in Autosomal Dominant Cone-Rod Dystrophy Caused by Novel CRX Variant

D'Esposito, F., Cennamo, G., De Crecchio, G., Maltese, P. E., Cecchin, S., Bertelli, M., Ziccardi, L., Esposito Veneruso, P., Magli, A., Cennamo, G. & Cordeiro, M. F., Oct 1 2018, In : Ophthalmic Research. 60, 3, p. 169-175 7 p.

Research output: Contribution to journalArticle

Multimodal Imaging
Vertebrate Photoreceptor Cells
Homeobox Genes
Angiography
Ocular Refraction

Retinal AAV8-RS1 Gene Therapy for X-Linked Retinoschisis: Initial Findings from a Phase I/IIa Trial by Intravitreal Delivery

Cukras, C., Wiley, H. E., Jeffrey, B. G., Sen, H. N., Turriff, A., Zeng, Y., Vijayasarathy, C., Marangoni, D., Ziccardi, L., Kjellstrom, S., Park, T. K., Hiriyanna, S., Wright, J. F., Colosi, P., Wu, Z., Bush, R. A., Wei, L. L. & Sieving, P. A., Sep 5 2018, In : Molecular Therapy. 26, 9, p. 2282-2294 13 p.

Research output: Contribution to journalArticle

Retinoschisis
Genetic Therapy
Genome
Retina
Safety

Retinal dysfunction characterizes subtypes of dominant optic atrophy

Cascavilla, M. L., Parisi, V., Triolo, G., Ziccardi, L., Borrelli, E., Di Renzo, A., Balducci, N., Lamperti, C., Bianchi Marzoli, S., Darvizeh, F., Sadun, A. A., Carelli, V., Bandello, F. & Barboni, P., 2018, In : Acta Ophthalmologica. 96, 2, p. e156-e163

Research output: Contribution to journalArticle

Autosomal Dominant Optic Atrophy
Mutation
Haploinsufficiency
Missense Mutation
Nose
2017
Obesity
Genetic Testing
Genes
Phenotype
Delayed Diagnosis

Corrigendum to "Genotype-Phenotype Characterization of Novel Variants in Six Italian Patients with Familial Exudative Vitreoretinopathy"

Iarossi, G., Bertelli, M., Maltese, P. E., Gusson, E., Marchini, G., Bruson, A., Benedetti, S., Volpetti, S., Catena, G., Buzzonetti, L. & Ziccardi, L., 2017, In : Journal of Ophthalmology. 2017, p. 7969364

Research output: Contribution to journalArticle

Genotype
Phenotype
corrigendum
Familial Exudative Vitreoretinopathy

Design and validation of a New MLPA-Based assay for the detection of RS1 gene deletions and application in a large family with X-linked juvenile retinoschisis

Nicoletti, A., Ziccardi, L., Maltese, P. E., Benedetti, S., Palumbo, O., Rendina, M., D'Agruma, L., Falsini, B., Wang, X. & Bertelli, M., Feb 1 2017, In : Genetic Testing and Molecular Biomarkers. 21, 2, p. 116-121 6 p.

Research output: Contribution to journalArticle

Retinoschisis
Multiplex Polymerase Chain Reaction
Gene Deletion
Exons
Genes

Design and Validation of a New MLPA-Based Assay for the Detection of RS1 Gene Deletions and Application in a Large Family with X-Linked Juvenile Retinoschisis.

Nicoletti, A., Ziccardi, L., Maltese, PE., Benedetti, S., Palumbo, O., Rendina, M., D'Agruma, L., Falsini, B., Wang, X. & Bertelli, M., Feb 2017, In : Genetic Testing and Molecular Biomarkers. 21, 2, p. 116-121 6 p., doi: 10.1089/gtmb.2016.0257.

Research output: Contribution to journalArticle

Retinoschisis
Multiplex Polymerase Chain Reaction
Gene Deletion
Exons
Genes

Developmental visual deprivation: long term effects on human cone driven retinal function

Esposito Veneruso, P., Ziccardi, L., Magli, G., Parisi, V., Falsini, B. & Magli, A., Dec 1 2017, In : Graefe's Archive for Clinical and Experimental Ophthalmology. 255, 12, p. 2481-2486 6 p.

Research output: Contribution to journalArticle

Retinal Cone Photoreceptor Cells
Cataract
Light
Retina
Healthy Volunteers

Early light deprivation effects on human cone-driven retinal function.

Esposito Veneruso, P., Ziccardi, L., Magli, G., Parisi, V., Falsini, B. & Magli, A., Mar 2017, In : Acta Ophthalmologica. 95, 2, p. 133-139 7 p., doi: 10.1111/aos.13191.

Research output: Contribution to journalArticle

Retinal Cone Photoreceptor Cells
Cataract
Light
Visual Acuity
Healthy Volunteers

Genotype-Phenotype Characterization of Novel Variants in Six Italian Patients with Familial Exudative Vitreoretinopathy

Iarossi, G., Bertelli, M., Maltese, P. E., Gusson, E., Marchini, G., Bruson, A., Benedetti, S., Volpetti, S., Catena, G., Buzzonetti, L. & Ziccardi, L., 2017, In : Journal of Ophthalmology. 2017, p. 3080245

Research output: Contribution to journalArticle

Genotype
Phenotype
Genetic Testing
Pedigree
Familial Exudative Vitreoretinopathy

Genotype-Phenotype Characterization of Novel Variants in Six Italian Patients with Familial Exudative Vitreoretinopathy

Iarossi, G., Bertelli, M., Maltese, P. E., Gusson, E., Marchini, G., Bruson, A., Benedetti, S., Volpetti, S., Catena, G., Buzzonetti, L. & Ziccardi, L., Jan 1 2017, In : Journal of Ophthalmology. 2017, 3080245.

Research output: Contribution to journalArticle

Genotype
Phenotype
Genetic Testing
Pedigree
Genes

Osteoporosis-pseudoglioma syndrome: Report of two cases and a manifesting carrier

Maltese, P., Ziccardi, L., Iarossi, G., Gusson, E., D’Agruma, L., Marchini, G., Buzzonetti, L., Nicoletti, A., Benedetti, S. & Bertelli, M., Sep 3 2017, In : Ophthalmic Genetics. 38, 5, p. 473-479 7 p.

Research output: Contribution to journalArticle

Parents
Eye Abnormalities
Genetic Testing
Rare Diseases
Italy

Osteoporosis-pseudoglioma syndrome

Maltese, P., Ziccardi, L., Iarossi, G., Gusson, E., D’Agruma, L., Marchini, G., Buzzonetti, L., Nicoletti, A., Benedetti, S. & Bertelli, M., Sep 3 2017, In : Ophthalmic Genetics. 38, 5, p. 473-479 7 p.

Research output: Contribution to journalArticle

Parents
Eye Abnormalities
Genetic Testing
Rare Diseases
Italy
2016

Bilateral symmetry of visual function loss in cone–rod dystrophies

Galli-Resta, L., Falsini, B., Rossi, G., Piccardi, M., Ziccardi, L., Fadda, A., Minnella, A., Marangoni, D., Placidi, G., Campagna, F., Abed, E., Bertelli, M., Zuntini, M. & Resta, G., Jul 1 2016, In : Investigative Ophthalmology and Visual Science. 57, 8, p. 3759-3768 10 p.

Research output: Contribution to journalArticle

Vision Disorders
Clinical Trials
Vertebrate Photoreceptor Cells
Ophthalmology
Visual Acuity

Early light deprivation effects on human cone-driven retinal function

Esposito Veneruso, P., Ziccardi, L., Magli, G., Parisi, V., Falsini, B. & Magli, A., 2016, (Accepted/In press) In : Acta Ophthalmologica.

Research output: Contribution to journalArticle

Retinal Cone Photoreceptor Cells
Cataract
Light
Visual Acuity
Healthy Volunteers

Investigation of adaptive optics imaging biomarkers for detecting pathological changes of the cone mosaic in patients with type 1 diabetes mellitus

Lombardo, M., Parravano, M., Serrao, S., Ziccardi, L., Giannini, D. & Lombardo, G., Mar 10 2016, In : PLoS One. 11, 3, e0151380.

Research output: Contribution to journalArticle

Adaptive optics
insulin-dependent diabetes mellitus
cones (retina)
Biomarkers
Medical problems

Ocular and systemic safety of a recombinant AAV8 vector for X-linked retinoschisis gene therapy: GLP studies in rabbits and Rs1-KO mice

Marangoni, D., Bush, R. A., Zeng, Y., Wei, L. L., Ziccardi, L., Vijayasarathy, C., Bartoe, J. T., Palyada, K., Santos, M., Hiriyanna, S., Wu, Z., Colosi, P. & Sieving, P. A., Mar 16 2016, In : Molecular Therapy - Methods and Clinical Development. 5, 16011.

Research output: Contribution to journalArticle

Retinoschisis
X-Linked Genes
Genetic Therapy
Rabbits
Safety

Pigmentary degenerative maculopathy as prominent phenotype in an Italian SPG56/CYP2U1 family

Leonardi, L., Ziccardi, L., Marcotulli, C., Rubegni, A., Longobardi, A., Serrao, M., Storti, E., Pierelli, F., Tessa, A., Parisi, V., Santorelli, F. M. & Carlo, C., Apr 1 2016, In : Journal of Neurology. 263, 4, p. 781-783 3 p.

Research output: Contribution to journalArticle

Hereditary Spastic Paraplegia
Phenotype
Ophthalmoscopy
Mutation
Visual Evoked Potentials

Pigmentary degenerative maculopathy as prominent phenotype in an Italian SPG56/CYP2U1 family

Leonardi, L., Ziccardi, L., Marcotulli, C., Rubegni, A., Longobardi, A., Serrao, M., Storti, E., Pierelli, F., Tessa, A., Parisi, V., Santorelli, F. M. & Carlo, C., Apr 1 2016, In : Journal of Neurology. 263, 4, p. 781-783 3 p.

Research output: Contribution to journalArticle

Hereditary Spastic Paraplegia
Phenotype
Ophthalmoscopy
Mutation
Visual Evoked Potentials
2015
Leber's Hereditary Optic Atrophy
Optic Nerve
Nerve Fibers
Visual Evoked Potentials
Retina

Multimodal Approach to Monitoring and Investigating Cone Structure and Function in an Inherited Macular Dystrophy

Ziccardi, L., Giannini, D., Lombardo, G., Serrao, S., Dell'Omo, R., Nicoletti, A., Bertelli, M. & Lombardo, M., Aug 1 2015, In : American Journal of Ophthalmology. 160, 2, p. 301-312.e6

Research output: Contribution to journalArticle

Macular Degeneration
Electroretinography
Optical Coherence Tomography
Missense Mutation
Fathers

Optical coherence tomography in Alzheimer's disease: A meta-analysis

Coppola, G., Di Renzo, A., Ziccardi, L., Martelli, F., Fadda, A., Manni, G., Barboni, P., Pierelli, F., Sadun, A. A. & Parisi, V., Aug 7 2015, In : PLoS One. 10, 8, e0134750.

Research output: Contribution to journalArticle

Optical tomography
tomography
Optical Coherence Tomography
Alzheimer disease
meta-analysis

Synaptic pathology and therapeutic repair in adult retinoschisis mouse by AAV-RS1 transfer

Ou, J., Vijayasarathy, C., Ziccardi, L., Chen, S., Zeng, Y., Marangoni, D., Pope, J. G., Bush, R. A., Wu, Z., Li, W. & Sieving, P. A., Jul 1 2015, In : Journal of Clinical Investigation. 125, 7, p. 2891-2903 13 p.

Research output: Contribution to journalArticle

Retinoschisis
Retina
Synapses
Pathology
Dependovirus

Treatment with citicoline eye drops enhances retinal function and neural conduction along the visual pathways in open angle glaucoma

Parisi, V., Centofanti, M., Ziccardi, L., Tanga, L., Michelessi, M., Roberti, G. & Manni, G., Aug 1 2015, In : Graefe's Archive for Clinical and Experimental Ophthalmology. 253, 8, p. 1327-1340 14 p.

Research output: Contribution to journalArticle

Cytidine Diphosphate Choline
Visual Pathways
Ophthalmic Solutions
Open Angle Glaucoma
Neural Conduction
2014
Retinoschisis
Transducin
Pathology
Rod Cell Outer Segment
Retinal Rod Photoreceptor Cells

Sequential spectral domain optical coherence tomography imaging of an eye after successful removal of subfoveal perfluorcarbon liquid collection

Savastano, M. C., Ziccardi, L., Zinzanella, G., Falsini, B. & Minnella, A. M., 2014, In : Retinal Cases and Brief Reports. 8, 3, p. 215-218 4 p.

Research output: Contribution to journalArticle

Optical Coherence Tomography
Visual Acuity
Ophthalmoscopes
Optical Imaging
Vitrectomy

Short-term effects of vision trainer rehabilitation in patients affected by anisometropic amblyopia: electrofunctional evaluation

Esposito Veneruso, P., Ziccardi, L., Magli, G., Falsini, B. & Magli, A., Dec 1 2014, In : Documenta Ophthalmologica. 129, 3, p. 177-189 13 p.

Research output: Contribution to journalArticle

Amblyopia
Rehabilitation
Visual Acuity
Visual Evoked Potentials
2013

Early detection of central visual function decline in cone-rod dystrophy by the use of macular focal cone electroretinogram

Galli-Resta, L., Piccardi, M., Ziccardi, L., Fadda, A., Minnella, A., Marangoni, D., Placidi, G., Resta, G. & Falsini, B., 2013, In : Investigative Ophthalmology and Visual Science. 54, 10, p. 6560-6569 10 p.

Research output: Contribution to journalArticle

Visual Acuity
Visual Fields
Disease Progression
Retrospective Studies
Cone-Rod Dystrophies
Leber's Hereditary Optic Atrophy
Visual Pathways
Visual Evoked Potentials
Neural Conduction
Retinal Ganglion Cells
Photochemotherapy
Macular Degeneration
Injections
Fluorescein Angiography
Ranibizumab
2012

Long-term decline of central cone function in retinitis pigmentosa evaluated by focal electroretinogram

Falsini, B., Galli-Resta, L., Fadda, A., Ziccardi, L., Piccardi, M., Iarossi, G. & Resta, G., Nov 2012, In : Investigative Ophthalmology and Visual Science. 53, 12, p. 7701-7709 9 p.

Research output: Contribution to journalArticle

Retinitis Pigmentosa
Visual Fields
Inheritance Patterns
Confidence Intervals

Loss of retinoschisin (RS1) cell surface protein in maturing mouse rod photoreceptors elevates the luminance threshold for light-driven translocation of transducin but not arrestin

Ziccardi, L., Vijayasarathy, C., Bush, R. A. & Sieving, P. A., Sep 19 2012, In : Journal of Neuroscience. 32, 38, p. 13010-13021 12 p.

Research output: Contribution to journalArticle

Transducin
Arrestin
Retinal Rod Photoreceptor Cells
Retina
Membrane Proteins

Macular function in eyes with open-angle glaucoma evaluated by multifocal electroretinogram

Parisi, V., Ziccardi, L., Centofanti, M., Tanga, L., Gallinaro, G., Falsini, B. & Bucci, M. G., Oct 2012, In : Investigative Ophthalmology and Visual Science. 53, 11, p. 6973-6980 8 p.

Research output: Contribution to journalArticle

Open Angle Glaucoma
Glaucoma
Visual Fields
Intraocular Pressure
Cataract
2011

Retinal functional changes measured by frequency-doubling technology in patients treated with hydroxychloroquine

Tanga, L., Centofanti, M., Oddone, F., Parravano, M., Parisi, V., Ziccardi, L., Kroegler, B., Perricone, R. & Manni, G., May 2011, In : Graefe's Archive for Clinical and Experimental Ophthalmology. 249, 5, p. 715-721 7 p.

Research output: Contribution to journalArticle

Hydroxychloroquine
Technology
Chloroquine
Visual Field Tests
Visual Fields
2010

Impact of regional retinal responses on cortical visually evoked responses: Multifocal ERGs and VEPs in the retinitis pigmentosa model

Parisi, V., Ziccardi, L., Stifano, G., Montrone, L., Gallinaro, G. & Falsini, B., Mar 2010, In : Clinical Neurophysiology. 121, 3, p. 380-385 6 p.

Research output: Contribution to journalArticle

Retinitis Pigmentosa
Photoreceptor Cells

Molecular mechanisms leading to null-protein product from retinoschisin (RS1) signal-sequence mutants in X-Linked Retinoschisis (XLRS) disease

Vijayasarathy, C., Sui, R., Zeng, Y., Yang, G., Xu, F., Caruso, R. C., Lewis, R. A., Ziccardi, L. & Sieving, P. A., Nov 2010, In : Human Mutation. 31, 11, p. 1251-1260 10 p.

Research output: Contribution to journalArticle

Retinoschisis
Protein Sorting Signals
Mutation
Proteins
Phenotype

Post-inflammatory retinal dystrophy in CINCA syndrome

Rigante, D., Stabile, A., Minnella, A., Avallone, L., Ziccardi, L., Bersani, G., Stifano, G., Compagnone, A. & Falsini, B., Jan 2010, In : Rheumatology International. 30, 3, p. 389-393 5 p.

Research output: Contribution to journalArticle

Cryopyrin-Associated Periodic Syndromes
Retinal Dystrophies
Interleukin 1 Receptor Antagonist Protein
Chorioretinitis
Aseptic Meningitis