1993 …2019

Research output per year

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Research Output

2019

L-carnitine reduces oxidative stress and promotes cells differentiation and bone matrix proteins expression in human osteoblast-like cells: BioMed Research International

Terruzzi, I., Montesano, A., Senesi, P., Villa, I., Ferraretto, A., Bottani, M., Vacante, F., Spinello, A., Bolamperti, S., Luzi, L. & Rubinacci, A., 2019, In : BioMed Research International. 2019

Research output: Contribution to journalArticle

p53 Loss in Breast Cancer Leads to Myc Activation, Increased Cell Plasticity, and Expression of a Mitotic Signature with Prognostic Value

Santoro, A., Vlachou, T., Luzi, L., Melloni, G., Mazzarella, L., D'Elia, E., Aobuli, X., Pasi, C. E., Reavie, L., Bonetti, P., Punzi, S., Casoli, L., Sabò, A., Moroni, M. C., Dellino, G. I., Amati, B., Nicassio, F., Lanfrancone, L. & Pelicci, P. G., Jan 15 2019, In : Cell Reports. 26, 3, p. 624-638.e8

Research output: Contribution to journalArticle

Open Access

Release of paused RNA polymerase II at specific loci favors DNA double-strand-break formation and promotes cancer translocations

Dellino, G. I., Palluzzi, F., Chiariello, A. M., Piccioni, R., Bianco, S., Furia, L., De Conti, G., Bouwman, B. A. M., Melloni, G., Guido, D., Giacò, L., Luzi, L., Cittaro, D., Faretta, M., Nicodemi, M., Crosetto, N. & Pelicci, P. G., Jun 1 2019, In : Nature Genetics. 51, 6, p. 1011-1023 13 p.

Research output: Contribution to journalArticle

2018

PREP1 tumor suppressor protects the late-replicating DNA by controlling its replication timing and symmetry

Palmigiano, A., Santaniello, F., Cerutti, A., Penkov, D., Purushothaman, D., Makhija, E., Luzi, L., Di Fagagna, F. D. A., Pelicci, P. G., Shivashankar, V., Dellino, G. I. & Blasi, F., Dec 1 2018, In : Scientific Reports. 8, 1, 3198.

Research output: Contribution to journalArticle

2017

A knowledge-based framework for the discovery of cancer-predisposing variants using large-scale sequencing breast cancer data

Melloni, G. E. M., Mazzarella, L., Bernard, L., Bodini, M., Russo, A., Luzi, L., Pelicci, P. G. & Riva, L., May 31 2017, In : Breast Cancer Research. 19, 1, 63.

Research output: Contribution to journalArticle

Effect of Sugar versus Mixed Breakfast on Metabolic and Neurofunctional Responses in Healthy Individuals

Codella, R., Benedini, S., Paini, S., Caumo, A., Adamo, M., Terruzzi, I., Ferrulli, A., MacRì, C., Andreoni, L., Sterlicchio, M. & Luzi, L., 2017, In : Journal of Diabetes Research. 2017

Research output: Contribution to journalArticle

PML-RARA-Associated cooperating mutations belong to a transcriptional network that is deregulated in myeloid leukemias

Ronchini, C., Brozzi, A., Riva, L., Luzi, L., Gruszka, A. M., Melloni, G. E. M., Scanziani, E., Dharmalingam, G., Mutarelli, M., Belcastro, V., Lavorgna, S., Rossi, V., Spinelli, O., Biondi, A., Rambaldi, A., Lo-Coco, F., Di Bernardo, D. & Pelicci, P. G., 2017, In : Leukemia. 31, 9, p. 1975-1986 12 p.

Research output: Contribution to journalArticle

Why should people with type 1 diabetes exercise regularly?

Codella, R., Terruzzi, I. & Luzi, L., 2017, In : Acta Diabetologica. 54, 7, p. 615-630 16 p.

Research output: Contribution to journalArticle

2016

In Vivo Genetic Screens of Patient-Derived Tumors Revealed Unexpected Frailty of the Transformed Phenotype

Bossi, D., Cicalese, A., Dellino, G. I., Luzi, L., Riva, L., D'Alesio, C., Diaferia, G. R., Carugo, A., Cavallaro, E., Piccioni, R., Barberis, M., Mazzarol, G., Testori, A., Punzi, S., Pallavicini, I., Tosti, G., Giacó, L., Melloni, G. E. M., Heffernan, T. P., Natoli, G. & 4 others, Draetta, G. F., Minucci, S., Pelicci, P. G. & Lanfrancone, L., Jun 2016, In : Cancer Discovery. 6, 6, p. 650-63 14 p.

Research output: Contribution to journalArticle

PML-RARA-associated cooperating mutations belong to a transcriptional network that is deregulated in myeloid leukemias

Ronchini, C., Brozzi, A., Riva, L., Luzi, L., Gruszka, A. M., Melloni, G. E. M., Scanziani, E., Dharmalingam, G., Mutarelli, M., Belcastro, V., Lavorgna, S., Rossi, V., Spinelli, O., Biondi, A., Rambaldi, A., Lo-Coco, F., Di Bernardo, D. & Pelicci, P. G., Dec 27 2016, In : Leukemia.

Research output: Contribution to journalArticle

2015

The hidden genomic landscape of acute myeloid leukemia: Subclonal structure revealed by undetected mutations

Bodini, M., Ronchini, C., Giacò, L., Russo, A., Melloni, G. E. M., Luzi, L., Sardella, D., Volorio, S., Hasan, S. K., Ottone, T., Lavorgna, S., Lo-Coco, F., Candoni, A., Fanin, R., Toffoletti, E., Iacobucci, I., Martinelli, G., Cignetti, A., Tarella, C., Bernard, L. & 2 others, Pelicci, P. G. & Riva, L., Jan 22 2015, In : Blood. 125, 4, p. 600-605 6 p.

Research output: Contribution to journalArticle

2014

Erratum: Acute promyelocytic leukemias share cooperative mutations with other myeloid-leukemia subgroups (Blood Cancer Journal (2013) 3 (e147) DOI:10.1038/bcj.2013.46)

Riva, L., Ronchini, C., Bodini, M., Lo-Coco, F., Lavorgna, S., Ottone, T., Martinelli, G., Iacobucci, I., Tarella, C., Cignetti, A., Volorio, S., Bernard, L., Russo, A., Melloni, G. E. M., Luzi, L., Alcalay, M., Dellino, G. I. & Pelicci, P. G., 2014, In : Blood Cancer Journal. 4, 3, e195.

Research output: Contribution to journalArticle

The Genomic and Epigenomic Landscapes of AML

Mazzarella, L., Riva, L., Luzi, L., Ronchini, C. & Pelicci, P. G., Oct 1 2014, In : Seminars in Hematology. 51, 4, p. 259-272 14 p.

Research output: Contribution to journalArticle

2013

Acute promyelocytic leukemias share cooperative mutations with other myeloid-leukemia subgroups

Riva, L., Ronchini, C., Bodini, M., Lo-Coco, F., Lavorgna, S., Ottone, T., Martinelli, G., Iacobucci, I., Tarella, C., Cignetti, A., Volorio, S., Bernard, L., Russo, A., Melloni, G. E. M., Luzi, L., Alcalay, M., Dellino, G. I. & Pelicci, P. G., Sep 2013, In : Blood Cancer Journal. 3, 9, e147.

Research output: Contribution to journalArticle

Genome-wide mapping of human DNA-replication origins: Levels of transcription at ORC1 sites regulate origin selection and replication timing

Dellino, G. I., Cittaro, D., Piccioni, R., Luzi, L., Banfi, S., Segalla, S., Cesaroni, M., Mendoza-Maldonado, R., Giacca, M. & Pelicci, P. G., Jan 2013, In : Genome Research. 23, 1, p. 1-11 11 p.

Research output: Contribution to journalArticle

Insulin receptor substrate-2 is expressed in kidney epithelium and up-regulated in diabetic nephropathy

Hookham, M. B., O'Donovan, H. C., Church, R. H., Mercier-Zuber, A., Luzi, L., Curran, S. P., Carew, R. M., Droguett, A., Mezzano, S., Schubert, M., White, M. F., Crean, J. K. & Brazil, D. P., Jul 2013, In : FEBS Journal. 280, 14, p. 3232-3243 12 p.

Research output: Contribution to journalArticle

Oxidative stress activates a specific p53 transcriptional response that regulates cellular senescence and aging

Gambino, V., De Michele, G., Venezia, O., Migliaccio, P., Dall'Olio, V., Bernard, L., Minardi, S. P., Fazia, M. A. D., Bartoli, D., Servillo, G., Alcalay, M., Luzi, L., Giorgio, M., Scrable, H., Pelicci, P. G. & Migliaccio, E., Jun 2013, In : Aging Cell. 12, 3, p. 435-445 11 p.

Research output: Contribution to journalArticle

2012

Genomics of acute myeloid leukemia: The next generation

Riva, L., Luzi, L. & Pelicci, P. G., 2012, In : Frontiers in Oncology. 2 MAY, Article 40.

Research output: Contribution to journalArticle

2009

Melanoma: Targeting signaling pathways and RaLP

Pasini, L., Turco, M. Y., Luzi, L., Aladowicz, E., Fagiani, E. & Lanfrancone, L., Jan 2009, In : Expert Opinion on Therapeutic Targets. 13, 1, p. 93-104 12 p.

Research output: Contribution to journalArticle

Transcription factor binding sites are genetic determinants of retroviral integration in the human genome

Felice, B., Cattoglio, C., Cittaro, D., Testa, A., Miccios, A., Ferrari, G., Luzi, L., Recchia, A. & Mavilio, F., Feb 24 2009, In : PLoS One. 4, 2, e4571.

Research output: Contribution to journalArticle

2008

AML1/ETO oncoprotein is directed to AML1 binding regions and co-localizes with AML1 and HEB on its targets

Gardini, A., Cesaroni, M., Luzi, L., Okumura, A. J., Biggs, J. R., Minardi, S. P., Venturini, E., Zhang, D. E., Pelicci, P. G. & Alcalay, M., Nov 2008, In : PLoS Genetics. 4, 11, e1000275.

Research output: Contribution to journalArticle

CARPET: A web-based package for the analysis of ChIP-chip and expression tiling data

Cesaroni, M., Cittaro, D., Brozzi, A., Pelicci, P. G. & Luzi, L., Dec 2008, In : Bioinformatics. 24, 24, p. 2918-2920 3 p.

Research output: Contribution to journalArticle

2007

RaLP, a new member of the Src homology and collagen family, regulates cell migration and tumor growth of metastatic melanomas

Fagiani, E., Giardina, G., Luzi, L., Cesaroni, M., Quarto, M., Capra, M., Germano, G., Bono, M., Capillo, M., Pelicci, P. & Lanfrancone, L., Apr 1 2007, In : Cancer Research. 67, 7, p. 3064-3073 10 p.

Research output: Contribution to journalArticle

2006

Complex Loci in human and mouse genomes.

Engström, P. G., Suzuki, H., Ninomiya, N., Akalin, A., Sessa, L., Lavorgna, G., Brozzi, A., Luzi, L., Tan, S. L., Yang, L., Kunarso, G., Ng, E. L. C., Batalov, S., Wahlestedt, C., Kai, C., Kawai, J., Carninci, P., Hayashizaki, Y., Wells, C., Bajic, V. B. & 4 others, Orlando, V., Reid, J. F., Lenhard, B. & Lipovich, L., Apr 2006, In : PLoS Genetics. 2, 4

Research output: Contribution to journalArticle

Cytoplasmic localization of NPM in myeloid leukemias is dictated by gain-of-function mutations that create a functional nuclear export signal

Mariano, A. R., Colombo, E., Luzi, L., Martinelli, P., Volorio, S., Bernard, L., Meani, N., Bergomas, R., Alcalay, M. & Pelicci, P. G., Jul 20 2006, In : Oncogene. 25, 31, p. 4376-4380 5 p.

Research output: Contribution to journalArticle

Delocalization and destabilization of the Arf tumor suppressor by the leukemia-associated NPM mutant

Colombo, E., Martinelli, P., Zamponi, R., Shing, D. C., Bonetti, P., Luzi, L., Volorio, S., Bernard, L., Pruneri, G., Alcalay, M. & Pelicci, P. G., Mar 15 2006, In : Cancer Research. 66, 6, p. 3044-3050 7 p.

Research output: Contribution to journalArticle

Immunohistochemistry predicts nucleophosmin (NPM) mutations in acute myeloid leukemia

Falini, B., Martelli, M. P., Bolli, N., Bonasso, R., Ghia, E., Pallotta, M. T., Diverio, D., Nicoletti, I., Pacini, R., Tabarrini, A., Galletti, B. V., Mannucci, R., Roti, G., Rosati, R., Specchia, G., Liso, A., Tiacci, E., Alcalay, M., Luzi, L., Volorio, S. & 10 others, Bernard, L., Guarini, A., Amadori, S., Mandelli, F., Pane, F., Lo-Coco, F., Saglio, G., Pelicci, P. G., Martelli, M. F. & Mecucci, C., Sep 15 2006, In : Blood. 108, 6, p. 1999-2005 7 p.

Research output: Contribution to journalArticle

Myc-binding-site recognition in the human genome is determined by chromatin context

Guccione, E., Martinato, F., Finocchiaro, G., Luzi, L., Tizzoni, L., Dall' Olio, V., Zardo, G., Nervi, C., Bernard, L. & Amati, B., Jul 2006, In : Nature Cell Biology. 8, 7, p. 764-770 7 p.

Research output: Contribution to journalArticle

2005

Acute myeloid leukemia bearing cytoplasmic nucleophosmin (NPMc+ AML) shows a distinct gene expression profile characterized by up-regulation of genes involved in stem-cell maintenance

Alcalay, M., Tiacci, E., Bergomas, R., Bigerna, B., Venturini, E., Minardi, S. P., Meani, N., Diverio, D., Bernard, L., Tizzoni, L., Volorio, S., Luzi, L., Colombo, E., Lo Coco, F., Mecucci, C., Falini, B. & Pelicci, P. G., Aug 1 2005, In : Blood. 106, 3, p. 899-902 4 p.

Research output: Contribution to journalArticle

DG-CST (Disease Gene Conserved Sequence Tags), a database of human-mouse conserved elements associated to disease genes

Boccia, A., Petrillo, M., di Bernardo, D., Guffanti, A., Mignone, F., Confalonieri, S., Luzi, L., Pesole, G., Paolella, G., Ballabio, A. & Banfi, S., Jan 1 2005, In : Nucleic Acids Research. 33, DATABASE ISS.

Research output: Contribution to journalArticle

Electron transfer between cytochrome c and p66Shc generates reactive oxygen species that trigger mitochondrial apoptosis

Giorgio, M., Migliaccio, E., Orsini, F., Paolucci, D., Moroni, M., Contursi, C., Pelliccia, G., Luzi, L., Minucci, S., Marcaccio, M., Pinton, P., Rizzuto, R., Bernardi, P., Paolucci, F. & Pelicci, P. G., Jul 29 2005, In : Cell. 122, 2, p. 221-233 13 p.

Research output: Contribution to journalArticle

2003

Acute myeloid leukemia fusion proteins deregulate genes involved in stem cell maintenance and DNA repair

Alcalay, M., Meani, N., Gelmetti, V., Fantozzi, A., Fagioli, M., Orleth, A., Riganelli, D., Sebastiani, C., Cappelli, E., Casciari, C., Sciurpi, M. T., Mariano, A. R., Minardi, S. P., Luzi, L., Muller, H., Di Fiore, P. P., Frosina, G. & Pelicci, P. G., Dec 2003, In : Journal of Clinical Investigation. 112, 11, p. 1751-1761 11 p.

Research output: Contribution to journalArticle

Automated DNA chip annotation tables at IFOM: the importance of synchronisation and cross-referencing of sequence databases.

Guffanti, A., Finocchiaro, G., Reid, J. F., Luzi, L., Alcalay, M., Confalonieri, S., Lassandro, L. & Muller, H., 2003, In : Applied Bioinformatics. 2, 4, p. 245-249 5 p.

Research output: Contribution to journalArticle

The PML gene is not involved in the regulation of MHC class I expression in human cell lines

Bruno, S., Ghiotto, F., Fais, F., Fagioli, M., Luzi, L., Pelicci, P. G., Grossi, C. E. & Ciccone, E., May 1 2003, In : Blood. 101, 9, p. 3514-3519 6 p.

Research output: Contribution to journalArticle

2002

The p66Shc longevity gene is silenced through epigenetic modifications of an alternative promoter

Ventura, A., Luzi, L., Pacini, S., Baldari, C. T. & Pelicci, P. G., Jun 21 2002, In : Journal of Biological Chemistry. 277, 25, p. 22370-22376 7 p.

Research output: Contribution to journalArticle

2001

The tripartite motif family identifies cell compartments

Reymond, A., Meroni, G., Fantozzi, A., Merla, G., Cairo, S., Luzi, L., Riganelli, D., Zanaria, E., Messali, S., Cainarca, S., Guffanti, A., Minucci, S., Pelicci, P. G. & Ballabio, A., May 1 2001, In : EMBO Journal. 20, 9, p. 2140-2151 12 p.

Research output: Contribution to journalArticle

2000
1995

Adenosine triphosphate catabolism in bovine spermatozoa

Minelli, A., Miscetti, P., Proietti, A., Luzi, L. & Mezzasoma, I., 1995, In : Comparative Biochemistry and Physiology - B Biochemistry and Molecular Biology. 110, 3, p. 605-611 7 p.

Research output: Contribution to journalArticle

1993

Effects of adenine nucleotides on low Km 5′ nucleotidase from human seminal plasma

Minelli, A., Moroni, M., Luzi, L. & Mezzasoma, I., 1993, In : International Journal of Biochemistry. 25, 8, p. 1203-1207 5 p.

Research output: Contribution to journalArticle