• 162 Citations
  • 7 h-Index
20162019
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Research Output 2016 2019

  • 162 Citations
  • 7 h-Index
  • 21 Article
  • 1 Letter
  • 1 Review article
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Article
2019

Olaptesed pegol (NOX-A12) with bendamustine and rituximab: a phase IIa study in patients with relapsed/refractory chronic lymphocytic leukemia

Steurer, M., Montillo, M., Scarfò, L., Mauro, F. R., Andel, J., Wildner, S., Trentin, L., Janssens, A., Burgstaller, S., Frömming, A., Dümmler, T., Riecke, K., Baumann, M., Beyer, D., Vauléon, S., Ghia, P., Foà, R., Caligaris-Cappio, F. & Gobbi, M., Oct 1 2019, In : Haematologica. 104, 10, p. 2053-2060 8 p.

Research output: Contribution to journalArticle

Open Access
B-Cell Chronic Lymphocytic Leukemia
Oligoribonucleotides
Chemokine CXCL12
Patient Safety
Life Cycle Stages
2018

A retinoic acid-dependent stroma-leukemia crosstalk promotes chronic lymphocytic leukemia progression

Farinello, D., Wozińska, M., Lenti, E., Genovese, L., Bianchessi, S., Migliori, E., Sacchetti, N., Di Lillo, A., Bertilaccio, MTS., De Lalla, C., Valsecchi, R., Gleave, SB., Lligé, D., Scielzo, C., Mauri, L., Ciampa, MG., Scarfò, L., Bernardi, R., Lazarevic, D., Gonzalez-Farre, B. & 8 others, Bongiovanni, L., Campo, E., Cerutti, A., Ponzoni, M., Pattini, L., Caligaris-Cappio, F., Ghia, P. & Brendolan, A., 2018, In : Nature Communications. 9, 4, 1787.

Research output: Contribution to journalArticle

leukemias
Retinoids
B-Cell Chronic Lymphocytic Leukemia
Crosstalk
Tretinoin

Highly similar genomic landscapes in monoclonal b-cell lymphocytosis and ultra-stable chronic lymphocytic leukemia with low frequency of driver mutations

Agathangelidis, A., Ljungström, V., Scarfò, L., Fazi, C., Gounari, M., Pandzic, T., Sutton, LA., Stamatopoulos, K., Tonon, G., Rosenquist, R. & Ghia, P., 2018, In : Haematologica. 103, 5, p. 865-873 9 p.

Research output: Contribution to journalArticle

Lymphocytosis
Mutation Rate
B-Cell Chronic Lymphocytic Leukemia
Mutation
B-Lymphocytes
Lymphocytosis
B-Lymphocytes
Population

No improvement in long-term survival over time for chronic lymphocytic leukemia patients in stereotyped subsets #1 and #2 treated with chemo(immuno)therapy

Baliakas, P., Mattsson, M., Hadzidimitriou, A., Minga, E., Agathangelidis, A., Sutton, LA., Scarfò, L., Davis, Z., Yan, XJ., Plevova, K., Sandberg, Y., Vojdeman, FJ., Tzenou, T., Chu, CC., Veronese, S., Mansouri, L., Smedby, KE., Giudicelli, V., Nguyen-Khac, F., Panagiotidis, P. & 20 others, Juliusson, G., Anagnostopoulos, A., Lefranc, MP., Trentin, L., Catherwood, M., Montillo, M., Niemann, CU., Langerak, AW., Pospisilova, S., Stavroyianni, N., Chiorazzi, N., Oscier, D., Jelinek, DF., Shanafelt, T., Darzentas, N., Belessi, C., Davi, F., Ghia, P., Rosenquist, R. & Stamatopoulos, K., 2018, In : Haematologica. 103, 4, p. e158-e161

Research output: Contribution to journalArticle

B-Cell Chronic Lymphocytic Leukemia
Survival
Therapeutics
2017
3 Citations (Scopus)

Calreticulin as a novel B-cell receptor antigen in chronic lymphocytic leukemia

Ten Hacken, E., Gounari, M., Back, JW., Shimanovskaya, E., Scarfò, L., Kim, E., Burks, J., Ponzoni, M., Ramirez, GA., Wierda, WG., Estrov, Z., Keating, MJ., Ferrajoli, A., Stamatopoulos, K., Ghia, P. & Burger, JA., 2017, In : Haematologica. 102, 10, p. e394-e396

Research output: Contribution to journalArticle

Calreticulin
B-Cell Antigen Receptors
B-Cell Chronic Lymphocytic Leukemia
5 Citations (Scopus)

Chronic lymphocytic leukemia with mutated IGHV4-34 receptors: Shared and distinct immunogenetic features and clinical outcomes

Xochelli, A., Baliakas, P., Kavakiotis, I., Agathangelidis, A., Sutton, LA., Minga, E., Ntoufa, S., Tausch, E., Yan, XJ., Shanafelt, T., Plevova, K., Boudjogra, M., Rossi, D., Davis, Z., Navarro, A., Sandberg, Y., Vojdeman, FJ., Scarfò, L., Stavroyianni, N., Sudarikov, A. & 42 others, Veronese, S., Tzenou, T., Karan-Djurasevic, T., Catherwood, M., Kienle, D., Chatzouli, M., Facco, M., Bahlo, J., Pott, C., Pedersen, LB., Mansouri, L., Smedby, KE., Chu, CC., Giudicelli, V., Lefranc, MP., Panagiotidis, P., Juliusson, G., Anagnostopoulos, A., Vlahavas, I., Antic, D., Trentin, L., Montillo, M., Niemann, C., Dohner, H., Langerak, AW., Pospisilova, S., Hallek, M., Campo, E., Chiorazzi, N., Maglaveras, N., Oscier, D., Gaidano, G., Jelinek, DF., Stilgenbauer, S., Chouvarda, I., Darzentas, N., Belessi, C., Davi, F., Hadzidimitriou, A., Rosenquist, R., Ghia, P. & Stamatopoulos, K., 2017, In : Clinical Cancer Research. 23, 17, p. 5292-5301 10 p.

Research output: Contribution to journalArticle

Immunogenetics
B-Cell Chronic Lymphocytic Leukemia
B-Lymphocytes
Immunoglobulin G
Immunoglobulin M

Distinct homotypic B-cell receptor interactions shape the outcome of chronic lymphocytic leukaemia

Minici, C., Gounari, M., Übelhart, R., Scarfò, L., Dühren-von Minden, M., Schneider, D., Tasdogan, A., Alkhatib, A., Agathangelidis, A., Ntoufa, S., Chiorazzi, N., Jumaa, H., Stamatopoulos, K., Ghia, P. & Degano, M., 2017, In : Nature Communications. 8, 11, 15746.

Research output: Contribution to journalArticle

leukemias
B-Cell Chronic Lymphocytic Leukemia
Cell Communication
B-Lymphocytes
Cells
15 Citations (Scopus)

Efficacy and safety of dinaciclib vs ofatumumab in patients with relapsed/refractory chronic lymphocytic leukemia

Ghia, P., Scarfò, L., Perez, S., Pathiraja, K., Derosier, M., Small, K., Sisk, CMC. & Patton, N., 2017, In : Blood. 129, 13, p. 1876-1878 3 p.

Research output: Contribution to journalArticle

B-Cell Chronic Lymphocytic Leukemia
Refractory materials
Safety
dinaciclib
ofatumumab
23 Citations (Scopus)

Invariant NKT cells contribute to chronic lymphocytic leukemia surveillance and prognosis

Gorini, F., Azzimonti, L., Delfanti, G., Scarfò, L., Scielzo, C., Bertilaccio, MT., Ranghetti, P., Gulino, A., Doglioni, C., Di Napoli, A., Capri, M., Franceschi, C., Caligaris-Cappio, F., Ghia, P., Bellone, M., Dellabona, P., Casorati, G. & De Lalla, C., 2017, In : Blood. 129, 26, p. 3440-3451 12 p.

Research output: Contribution to journalArticle

Natural Killer T-Cells
T-cells
B-Cell Chronic Lymphocytic Leukemia
Disease Progression
Lymphocytes
17 Citations (Scopus)

Lenalidomide maintenance in patients with relapsed diffuse large B-cell lymphoma who are not eligible for autologous stem cell transplantation: an open label, single-arm, multicentre phase 2 trial

Ferreri, A. J. M., Sassone, M., Zaja, F., Re, A., Spina, M., Rocco, A. D., Fabbri, A., Stelitano, C., Frezzato, M., Rusconi, C., Zambello, R., Couto, S., Ren, Y., Arcari, A., Bertoldero, G., Nonis, A., Scarfò, L., Calimeri, T., Cecchetti, C., Chiozzotto, M. & 2 others, Govi, S. & Ponzoni, M., Mar 1 2017, In : The Lancet Haematology. 4, 3, p. e137-e146 9 p.

Research output: Contribution to journalArticle

Lymphoma, Large B-Cell, Diffuse
Stem Cell Transplantation
Maintenance
Recurrence
lenalidomide
17 Citations (Scopus)

Lenalidomide maintenance in patients with relapsed diffuse large B-cell lymphoma who are not eligible for autologous stem cell transplantation: an open label, single-arm, multicentre phase 2 trial

Ferreri, A. J. M., Sassone, M., Zaja, F., Re, A., Spina, M., Rocco, A. D., Fabbri, A., Stelitano, C., Frezzato, M., Rusconi, C., Zambello, R., Couto, S., Ren, Y., Arcari, A., Bertoldero, G., Nonis, A., Scarfò, L., Calimeri, T., Cecchetti, C., Chiozzotto, M. & 2 others, Govi, S. & Ponzoni, M., Mar 1 2017, In : The Lancet Haematology. 4, 3, p. e137-e146

Research output: Contribution to journalArticle

Lymphoma, Large B-Cell, Diffuse
Stem Cell Transplantation
Maintenance
Recurrence
lenalidomide
17 Citations (Scopus)

Lenalidomide maintenance in patients with relapsed diffuse large B-cell lymphoma who are not eligible for autologous stem cell transplantation: an open label, single-arm, multicentre phase 2 trial

Ferreri, AJM., Sassone, M., Zaja, F., Re, A., Spina, M., Rocco, AD., Fabbri, A., Stelitano, C., Frezzato, M., Rusconi, C., Zambello, R., Couto, S., Ren, Y., Arcari, A., Bertoldero, G., Nonis, A., Scarfò, L., Calimeri, T., Cecchetti, C., Chiozzotto, M. & 2 others, Govi, S. & Ponzoni, M., 2017, In : The Lancet Haematology. 4, 3, p. e137-e146

Research output: Contribution to journalArticle

Lymphoma, Large B-Cell, Diffuse
Stem Cell Transplantation
Maintenance
Recurrence
lenalidomide

Synthetic high-density lipoproteins as targeted monotherapy for chronic lymphocytic leukemia

McMahon, KM., Scielzo, C., Angeloni, NL., Deiss-Yehiely, E., Scarfò, L., Ranghetti, P., Ma, S., Kaplan, J., Barbaglio, F., Gordon, LI., Giles, FJ., Thaxton, CS. & Ghia, P., 2017, In : Oncotarget. 8, 7, p. 11219-11227 9 p.

Research output: Contribution to journalArticle

B-Cell Chronic Lymphocytic Leukemia
HDL Lipoproteins
Scavenger Receptors
B-Lymphocytes
Cholesterol
5 Citations (Scopus)

The inhibitory receptor toll interleukin-1R 8 (TIR8/IL-1R8/SIGIRR) is downregulated in chronic lymphocytic leukemia

Vilia, MG., Fonte, E., Veliz Rodriguez, T., Tocchetti, M., Ranghetti, P., Scarfò, L., Papakonstantinou, N., Ntoufa, S., Stamatopoulos, K., Ghia, P. & Muzio, M., 2017, In : Leukemia and Lymphoma. 58, 10, p. 2419-2425 7 p.

Research output: Contribution to journalArticle

B-Cell Chronic Lymphocytic Leukemia
Interleukin-8
Down-Regulation
Inflammation
Azacitidine

Toll-like receptor 9 stimulation can induce IκBζ expression and IgM secretion in chronic lymphocytic leukemia cells

Fonte, E., Vilia, MG., Reverberi, D., Sana, I., Scarfò, L., Ranghetti, P., Orfanelli, U., Cenci, S., Cutrona, G., Ghia, P. & Muzio, M., 2017, In : Haematologica. 102, 11, p. 1901-1912 12 p.

Research output: Contribution to journalArticle

Toll-Like Receptor 9
B-Cell Chronic Lymphocytic Leukemia
Immunoglobulin M
Toll-Like Receptors
Ligands

Toll-like receptor 9 stimulation can induce IκBζ expression and IgM secretion in chronic lymphocytic leukemia cells

Fonte, E., Vilia, M. G., Reverberi, D., Sana, I., Scarfò, L., Ranghetti, P., Orfanelli, U., Cenci, S., Cutrona, G., Ghia, P., Ghia, P. & Muzio, M., Oct 27 2017, In : Haematologica. 102, 11, p. 1901-1912 12 p.

Research output: Contribution to journalArticle

Toll-Like Receptor 9
B-Cell Chronic Lymphocytic Leukemia
Immunoglobulin M
Toll-Like Receptors
Ligands
2016
19 Citations (Scopus)

HIF-1α regulates the interaction of chronic lymphocytic leukemia cells with the tumor microenvironment

Valsecchi, R., Coltella, N., Belloni, D., Ponente, M., Ten Hacken, E., Scielzo, C., Scarfò, L., Bertilaccio, M. T. S., Brambilla, P., Lenti, E., Boneschi, F. M., Brendolan, A., Ferrero, E., Ferrarini, M., Ghia, P., Tonon, G., Ponzoni, M., Caligaris-Cappio, F. & Bernardi, R., 2016, In : Blood. 127, 16, p. 1987-1997 11 p.

Research output: Contribution to journalArticle

Hypoxia-Inducible Factor 1
Tumor Microenvironment
B-Cell Chronic Lymphocytic Leukemia
Tumors
Transcription Factors

Inhibition of chronic lymphocytic leukemia progression by full-length chromogranin A and its N-terminal fragment in mouse models

Bianco, M., Gasparri, A., Generoso, L., Assi, E., Colombo, B., Scarfo, L., Bertilaccio, M. T., Scielzo, C., Ranghetti, P., Dondossola, E., Ponzoni, M., Caligaris-Cappio, F., Ghia, P. & Corti, A., 2016, In : Oncotarget. 7, 27, p. 41725-41736 12 p.

Research output: Contribution to journalArticle

Chromogranin A
B-Cell Chronic Lymphocytic Leukemia
Bone Marrow
Heterografts
Dromaiidae
39 Citations (Scopus)

Targeting Macrophages Sensitizes Chronic Lymphocytic Leukemia to Apoptosis and Inhibits Disease Progression

Galletti, G., Scielzo, C., Barbaglio, F., Rodriguez, T. V., Riba, M., Lazarevic, D., Cittaro, D., Simonetti, G., Ranghetti, P., Scarfò, L., Ponzoni, M., Rocchi, M., Corti, A., Anselmo, A., van Rooijen, N., Klein, C., Ries, C. H., Ghia, P., De Palma, M., Caligaris-Cappio, F. & 1 others, Bertilaccio, M. T. S., Feb 23 2016, In : Cell Reports. 14, 7, p. 1748-1760 13 p.

Research output: Contribution to journalArticle

Macrophages
B-Cell Chronic Lymphocytic Leukemia
Disease Progression
Apoptosis
Monocytes

What does it mean i have a monoclonal B-cell lymphocytosis?: Recent insights and new challenges

Scarfò, L. & Ghia, P., Apr 1 2016, In : Seminars in Oncology. 43, 2, p. 201 - 208 8 p.

Research output: Contribution to journalArticle

Lymphocytosis
B-Lymphocytes