• 216 Citations
  • 9 h-Index
20162018
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Research Output 2016 2018

  • 216 Citations
  • 9 h-Index
  • 11 Article
  • 2 Review article
  • 1 Chapter
2018
8 Citations (Scopus)

Adipose-derived stem cell-mediated paclitaxel delivery inhibits breast cancer growth

Scioli, M. G., Artuso, S., D’Angelo, C., Porru, M., D’Amico, F., Bielli, A., Gentile, P., Cervelli, V., Leonetti, C. & Orlandi, A., Sep 1 2018, In : PLoS One. 13, 9, p. e0203426

Research output: Contribution to journalArticle

paclitaxel
Paclitaxel
Stem cells
breast neoplasms
stem cells
1 Citation (Scopus)

Chitosan-based polyelectrolyte complexes for doxorubicin and zoledronic acid combined therapy to overcome multidrug resistance

Giarra, S., Zappavigna, S., Campani, V., Abate, M., Cossu, A. M., Leonetti, C., Porru, M., Mayol, L., Caraglia, M. & De Rosa, G., Dec 1 2018, In : Pharmaceutics. 10, 4, p. 180

Research output: Contribution to journalArticle

zoledronic acid
Chitosan
Multiple Drug Resistance
Doxorubicin
Therapeutics
15 Citations (Scopus)
Oncogenes
Colorectal Neoplasms
Research
Neoplasms
Pharmacology
1 Citation (Scopus)

Xenograft as in vivo experimental model

Porru, M., Pompili, L., Caruso, C. & Leonetti, C., Jan 1 2018, Methods in Molecular Biology. Humana Press Inc., p. 97-105 9 p. (Methods in Molecular Biology; vol. 1692).

Research output: Chapter in Book/Report/Conference proceedingChapter

Heterografts
Theoretical Models
Neoplastic Stem Cells
Neoplasms
Drug Resistance
2017
17 Citations (Scopus)

BRCA1 and BRCA2 tumor suppressors protect against endogenous acetaldehyde toxicity

Tacconi, E. M., Lai, X., Folio, C., Porru, M., Zonderland, G., Badie, S., Michl, J., Sechi, I., Rogier, M., Garcia, V. M., Batra, A. S., Rueda, O. M., Bouwman, P., Jonkers, J., Ryan, A., Reina-San-Martin, B., Hui, J., Tang, N., Bruna, A., Biroccio, A. & 1 others, Tarsounas, M., Oct 1 2017, In : EMBO Molecular Medicine. 9, 10, p. 1398-1414 17 p.

Research output: Contribution to journalArticle

Acetaldehyde
Neoplasms
Homologous Recombination
Fanconi Anemia
Disulfiram
4 Citations (Scopus)

EMICORON: A multi-targeting G4 ligand with a promising preclinical profile

Porru, M., Zizza, P., Franceschin, M., Leonetti, C. & Biroccio, A., May 2017, In : Biochimica et Biophysica Acta - General Subjects. 1861, 5 Pt B, p. 1362-1370 9 p.

Research output: Contribution to journalReview article

G-Quadruplexes
Ligands
Molecules
Perylene
Pharmaceutical Preparations
16 Citations (Scopus)

Focal adhesion kinase depletion reduces human hepatocellular carcinoma growth by repressing enhancer of zeste homolog 2

Gnani, D., Romito, I., Artuso, S., Chierici, M., Stefanis, C. D., Panera, N., Crudele, A., Ceccarelli, S., Carcarino, E., D'Oria, V., Porru, M., Giorda, E., Ferrari, K., Miele, L., Villa, E., Balsano, C., Pasini, D., Furlanello, C., Locatelli, F., Nobili, V. & 3 others, Rota, R., Leonetti, C. & Alisi, A., May 1 2017, In : Cell Death and Differentiation. 24, 5, p. 889-902 14 p.

Research output: Contribution to journalArticle

Focal Adhesion Protein-Tyrosine Kinases
Protein-Tyrosine Kinases
Hepatocellular Carcinoma
Growth
Neoplasm Genes
16 Citations (Scopus)

Focal adhesion kinase depletion reduces human hepatocellular carcinoma growth by repressing enhancer of zeste homolog 2

Gnani, D., Romito, I., Artuso, S., Chierici, M., De Stefanis, C., Panera, N., Crudele, A., Ceccarelli, S., Carcarino, E., D'Oria, V., Porru, M., Giorda, E., Ferrari, K., Miele, L., Villa, E., Balsano, C., Pasini, D., Furlanello, C., Locatelli, F., Nobili, V. & 3 others, Rota, R., Leonetti, C. & Alisi, A., May 1 2017, In : Cell Death and Differentiation. 24, 5, p. 889-902 14 p.

Research output: Contribution to journalArticle

Focal Adhesion Protein-Tyrosine Kinases
Protein-Tyrosine Kinases
Hepatocellular Carcinoma
Growth
Neoplasm Genes
16 Citations (Scopus)

Focal adhesion kinase depletion reduces human hepatocellular carcinoma growth by repressing enhancer of zeste homolog 2

Gnani, D., Romito, I., Artuso, S., Chierici, M., De Stefanis, C., Panera, N., Crudele, A., Ceccarelli, S., Carcarino, E., D'Oria, V., Porru, M., Giorda, E., Ferrari, K., Miele, L., Villa, E., Balsano, C., Pasini, D., Furlanello, C., Locatelli, F., Nobili, V. & 3 others, Rota, R., Leonetti, C. & Alisi, A., May 1 2017, In : Cell Death and Differentiation. 24, 5, p. 889-902 14 p.

Research output: Contribution to journalArticle

Focal Adhesion Protein-Tyrosine Kinases
Protein-Tyrosine Kinases
Hepatocellular Carcinoma
Growth
Neoplasm Genes
2016
4 Citations (Scopus)

EMICORON: A multi-targeting G4 ligand with a promising preclinical profile

Porru, M., Zizza, P., Franceschin, M., Leonetti, C. & Biroccio, A., Sep 30 2016, (Accepted/In press) In : Biochimica et Biophysica Acta - General Subjects.

Research output: Contribution to journalArticle

G-Quadruplexes
Ligands
Molecules
Perylene
Pharmaceutical Preparations
16 Citations (Scopus)

Intragenic G-quadruplex structure formed in the human CD133 and its biological and translational relevance

Zizza, P., Cingolani, C., Artuso, S., Salvati, E., Rizzo, A., D'Angelo, C., Porru, M., Pagano, B., Amato, J., Randazzo, A., Novellino, E., Stoppacciaro, A., Gilson, E., Stassi, G., Leonetti, C. & Biroccio, A., Feb 29 2016, In : Nucleic Acids Research. 44, 4, p. 1579-1590 12 p.

Research output: Contribution to journalArticle

G-Quadruplexes
Neoplastic Stem Cells
Alternative Splicing
Drug Discovery
Colonic Neoplasms
29 Citations (Scopus)

Patient-derived xenografts: A relevant preclinical model for drug development

Pompili, L., Porru, M., Caruso, C., Biroccio, A. & Leonetti, C., Dec 5 2016, In : Journal of Experimental and Clinical Cancer Research. 35, 1, 189.

Research output: Contribution to journalReview article

Heterografts
Pharmaceutical Preparations
Neoplasms
Therapeutics
56 Citations (Scopus)

Targeting BRCA1 and BRCA2 Deficiencies with G-Quadruplex-Interacting Compounds

Zimmer, J., Tacconi, E. M. C., Folio, C., Badie, S., Porru, M., Klare, K., Tumiati, M., Markkanen, E., Halder, S., Ryan, A., Jackson, S. P., Ramadan, K., Kuznetsov, S. G., Biroccio, A., Sale, J. E. & Tarsounas, M., Feb 4 2016, In : Molecular Cell. 61, 3, p. 449-460 12 p.

Research output: Contribution to journalArticle

G-Quadruplexes
Homologous Recombination
Telomere
Double-Stranded DNA Breaks
Guanine
17 Citations (Scopus)

Transferrin-targeted nanoparticles containing zoledronic acid as a potential tool to inhibit glioblastoma growth

Salzano, G., Zappavigna, S., Luce, A., D'Onofrio, N., Balestrieri, M. L., Grimaldi, A., Lusa, S., Ingrosso, D., Artuso, S., Porru, M., Leonetti, C., Caraglia, M. & De Rosa, G., Apr 1 2016, In : Journal of Biomedical Nanotechnology. 12, 4, p. 811-830 20 p.

Research output: Contribution to journalArticle

zoledronic acid
Glioblastoma
Transferrin
Nanoparticles
Acids