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Research Output 1998 2019

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1998

Poly(ADP-ribose) synthesis in cells undergoing apoptosis: An attempt to face death before PARP degradation

Scovassi, A. I., Denegri, M., Donzelli, M., Rossi, L., Bernardi, R., Mandarino, A., Frouin, I. & Negri, C., 1998, In : European journal of histochemistry : EJH. 42, 4, p. 251-258 8 p.

Research output: Contribution to journalArticle

1999

Transcriptional down-regulation of poly(ADP-ribose) polymerase gene expression by E1A binding to pRb proteins protects murine keratinocytes from radiation-induced apoptosis

Pacini, A., Quattrone, A., Denegri, M., Fiorillo, C., Nediani, C., Ramon Y Cajal, S. & Nassi, P., Dec 3 1999, In : Journal of Biological Chemistry. 274, 49, p. 35107-35112 6 p.

Research output: Contribution to journalArticle

Poly(ADP-ribose) Polymerases
Keratinocytes
Gene expression
Down-Regulation
Radiation
2000

Evidence of poly(ADP-ribosylation) in the cockroach Periplaneta americana

Denegri, M., Lambiase, S., Donadoni, C., Rossi, L. & Ivana Scovassi, A., 2000, In : Insect Biochemistry and Molecular Biology. 30, 11, p. 1045-1050 6 p.

Research output: Contribution to journalArticle

Periplaneta
Cockroaches
Periplaneta americana
ribose
Blattodea

Structure and dynamics of hnRNP-labelled nuclear bodies induced by stress treatments

Chiodi, I., Biggiogera, M., Denegri, M., Corioni, M., Weighardt, F., Cobianchi, F., Riva, S. & Biamonti, G., 2000, In : Journal of Cell Science. 113, 22, p. 4043-4053 11 p.

Research output: Contribution to journalArticle

Heterogeneous-Nuclear Ribonucleoprotein Group M
Heterogeneous-Nuclear Ribonucleoproteins
Hot Temperature
Shock
Coiled Bodies
2001

Incidence and prevalence of all cancerous diseases in Italy: Trends and implications

Frouin, I., Prosperi, E., Denegri, M., Negri, C., Donzelli, M., Rossi, L., Riva, F., Stefanini, M. & Scovassi, A. I., 2001, In : European Journal of Cancer. 37, 9, p. 1149-1157 9 p.

Research output: Contribution to journalArticle

Italy
Incidence
Neoplasms
Mortality
Population

Stress-induced nuclear bodies are sites of accumulation of pre-mRNA processing factors

Denegri, M., Chiodi, I., Corioni, M., Cobianchi, F., Riva, S. & Biamonti, G., 2001, In : Molecular Biology of the Cell. 12, 11, p. 3502-3514 13 p.

Research output: Contribution to journalArticle

RNA Precursors
Heterogeneous-Nuclear Ribonucleoproteins
RNA
Green Fluorescent Proteins
Adenoviridae
2002

DNA ligase I is dephosphorylated during the execution step of etoposide-induced apoptosis

Rossi, R., Montecucco, A., Donzelli, M., Denegri, M., Biamonti, G. & Scovassi, A., 2002, In : Cell Death and Differentiation. 9, 1, p. 89-90 2 p.

Research output: Contribution to journalArticle

Human chromosomes 9, 12, and 15 contain the nucleation sites of stress-induced nuclear bodies

Denegri, M., Moralli, D., Rocchi, M., Biggiogera, M., Raimondi, E., Cobianchi, F., De Carli, L., Riva, S. & Biamonti, G., 2002, In : Molecular Biology of the Cell. 13, 6, p. 2069-2079 11 p.

Research output: Contribution to journalArticle

Chromosomes, Human, Pair 15
Chromosomes, Human, Pair 12
Chromosomes, Human, Pair 9
Human Chromosomes
Cricetinae

Poly(ADP-ribose) degradation by post-nuclear extracts from human cells

Rossi, L., Denegri, M., Torti, M., Poirier, G. G. & Scovassi, A. I., Dec 1 2002, In : Biochimie. 84, 12, p. 1229-1235 7 p.

Research output: Contribution to journalArticle

Adenosine Diphosphate Ribose
Poly Adenosine Diphosphate Ribose
Cell Extracts
Cells
Degradation
2003

Effect of apoptogenic stimuli on colon carcinoma cell lines with a different c-myc expression level.

Gorrini, C., Donzelli, M., Torriglia, A., Supino, R., Brison, O., Bernardi, R., Negri, C., Denegri, M., Counis, M. F., Ranzani, G. N. & Scovassi, A. I., Jun 2003, In : International Journal of Molecular Medicine. 11, 6, p. 737-742 6 p.

Research output: Contribution to journalArticle

Colon
Apoptosis
Carcinoma
Cell Line
CD95 Antigens

Human proliferating cell nuclear antigen, poly(ADP-ribose) polymerase-1, and p21waf1/cip1. A dynamic exchange of partners

Frouin, I., Maga, G., Denegri, M., Riva, F., Savio, M., Spadari, S., Prosperi, E. & Scovassi, A. I., Oct 10 2003, In : Journal of Biological Chemistry. 278, 41, p. 39265-39268 4 p.

Research output: Contribution to journalArticle

Poly(ADP-ribose) Polymerases
Proliferating Cell Nuclear Antigen
Association reactions
DNA Repair
DNA

Poly(ADPR) polymerase-1 and poly(ADPR) glycohydrolase level and distribution in differentiating rat germinal cells

Di Meglio, S., Denegri, M., Vallefuoco, S., Tramontano, F., Scovassi, A. I. & Quesada, P., Jun 2003, In : Molecular and Cellular Biochemistry. 248, 1-2, p. 85-91 7 p.

Research output: Contribution to journalArticle

Poly Adenosine Diphosphate Ribose
Poly(ADP-ribose) Polymerases
Glycoside Hydrolases
Rats
Spermatocytes
2004

Transcriptional Activation of a Constitutive Heterochromatic Domain of the Human Genome in Response to Heat Shock

Rizzi, N., Denegri, M., Chiodi, I., Corioni, M., Valgardsdottir, R., Cobianchi, F., Riva, S. & Biamonti, G., Feb 2004, In : Molecular Biology of the Cell. 15, 2, p. 543-551 9 p.

Research output: Contribution to journalArticle

Heat-Shock Response
Human Genome
Transcriptional Activation
Shock
Hot Temperature
2005

Changes in extranucleolar transcription during actinomycin D-induced apoptosis

Fraschini, A., Bottone, M. G., Scovassi, A. I., Denegri, M., Risueño, M. C., Testillano, P. S., Martin, T. E., Biggiogera, M. & Pellicciari, C., Jan 2005, In : Histology and Histopathology. 20, 1, p. 107-117 11 p.

Research output: Contribution to journalArticle

Dactinomycin
Apoptosis
Chromatin
RNA Precursors
RNA
2007

Isolation and characterization of mesenchymal cells from human fetal membranes

Soncini, M., Vertua, E., Gibelli, L., Zorzi, F., Denegri, M., Albertini, A., Wengler, G. S. & Parolini, O., Jul 2007, In : Journal of Tissue Engineering and Regenerative Medicine. 1, 4, p. 296-305 10 p.

Research output: Contribution to journalArticle

Extraembryonic Membranes
Chorion
Amnion
Mesenchymal Stromal Cells
Bone
2008

Spatial mapping of splicing factor complexes involved in exon and intron definition

Ellis, J. D., Llères, D., Denegri, M., Lamond, A. & Cáceres, J., Jun 2008, In : Chemtracts. 21, 6, p. 243-244 2 p.

Research output: Contribution to journalArticle

Introns
Exons
Fluorescence Resonance Energy Transfer
HeLa Cells
RNA Precursors

Spatial mapping of splicing factor complexes involved in exon and intron definition

Ellis, J. D., Llères, D., Denegri, M., Lamond, A. I. & Cáceres, J. F., Jun 16 2008, In : Journal of Cell Biology. 181, 6, p. 921-934 14 p.

Research output: Contribution to journalArticle

Introns
Fluorescence Resonance Energy Transfer
Microscopy
Exons
Optical Imaging
2009

Blom7α is a novel heterogeneous nuclear ribonucleoprotein K homology domain protein involved in pre-mRNA splicing that interacts with SNEVPrp19-Pso4

Grillari, J., Löscher, M., Denegri, M., Lee, K., Fortschegger, K., Eisenhaber, F., Ajuh, P., Lamond, A. I., Katinger, H. & Grillari-Voglauer, R., Oct 16 2009, In : Journal of Biological Chemistry. 284, 42, p. 29193-29204 12 p.

Research output: Contribution to journalArticle

Heterogeneous-Nuclear Ribonucleoprotein K
RNA Precursors
Spliceosomes
Site selection
Proteins
2010

Ability of polyurethane foams to support placenta-derived cell adhesion and osteogenic differentiation: Preliminary results

Bertoldi, S., Farè, S., Denegri, M., Rossi, D., Haugen, H. J., Parolini, O. & Tanzi, M. C., Mar 2010, In : Journal of Materials Science: Materials in Medicine. 21, 3, p. 1005-1011 7 p.

Research output: Contribution to journalArticle

Chorion
Cell adhesion
Cell Adhesion
Placenta
Polyurethanes

Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice

Llères, D., Denegri, M., Biggiogera, M., Ajuh, P. & Lamond, A. I., Jun 2010, In : EMBO Reports. 11, 6, p. 445-451 7 p.

Research output: Contribution to journalArticle

Heterogeneous-Nuclear Ribonucleoprotein Group M
RNA Splice Sites
Cell Cycle
Spliceosomes
Heat-Shock Response

Trafficking defects and gating abnormalities of a novel SCN5A mutation question gene-specific therapy in long QT syndrome type 3

Ruan, Y., Denegri, M., Liu, N., Bachetti, T., Seregni, M., Morotti, S., Severi, S., Napolitano, C. & Priori, S. G., Apr 30 2010, In : Circulation Research. 106, 8, p. 1374-1383 10 p.

Research output: Contribution to journalArticle

Mexiletine
Genetic Therapy
Mutation
Sodium Channel Blockers
Action Potentials
2011
Calcium-Calmodulin-Dependent Protein Kinase Type 2
Calcium-Calmodulin-Dependent Protein Kinases
Cardiac Arrhythmias
Ryanodine Receptor Calcium Release Channel
Adrenergic Agents

Short communication: Flecainide exerts an antiarrhythmic effect in a mouse model of catecholaminergic polymorphic ventricular tachycardia by increasing the threshold for triggered activity

Liu, N., Denegri, M., Ruan, Y., Avelino-Cruz, J. E., Perissi, A., Negri, S., Napolitano, C., Coetzee, W. A., Boyden, P. A. & Priori, S. G., Jul 22 2011, In : Circulation Research. 109, 3, p. 291-295 5 p.

Research output: Contribution to journalArticle

Flecainide
Communication
Ryanodine Receptor Calcium Release Channel
Isoproterenol
Muscle Cells
2012

Inherited calcium channelopathies in the pathophysiology of arrhythmias

Venetucci, L., Denegri, M., Napolitano, C. & Priori, S. G., Oct 2012, In : Nature Reviews Cardiology. 9, 10, p. 561-575 15 p.

Research output: Contribution to journalArticle

Channelopathies
Cardiac Arrhythmias
Calcium
Mutation
Calsequestrin

Viral gene transfer rescues arrhythmogenic phenotype and ultrastructural abnormalities in adult calsequestrin-null mice with inherited arrhythmias

Denegri, M., Avelino-Cruz, J. E., Boncompagni, S., De Simone, S. A., Auricchio, A., Villani, L., Volpe, P., Protasi, F., Napolitano, C. & Priori, S. G., Mar 2 2012, In : Circulation Research. 110, 5, p. 663-668 6 p.

Research output: Contribution to journalArticle

Calsequestrin
Ryanodine Receptor Calcium Release Channel
Viral Genes
Cardiac Arrhythmias
Phenotype
2013

Abnormal propagation of calcium waves and ultrastructural remodeling in recessive catecholaminergic polymorphic ventricular tachycardia

Liu, N., Denegri, M., Dun, W., Boncompagni, S., Lodola, F., Protasi, F., Napolitano, C., Boyden, P. A. & Priori, S. G., Jul 5 2013, In : Circulation Research. 113, 2, p. 142-152 11 p.

Research output: Contribution to journalArticle

Calsequestrin
Calcium Signaling
Muscle Cells
Sarcoplasmic Reticulum
Ryanodine Receptor Calcium Release Channel
Calcium-Calmodulin-Dependent Protein Kinase Type 2
Phenotype
Induced Pluripotent Stem Cells
Ryanodine Receptor Calcium Release Channel
Cardiac Myocytes

KCNJ2 mutation in short QT syndrome 3 results in atrial fibrillation and ventricular proarrhythmia

Deo, M., Ruan, Y., Pandit, S. V., Shah, K., Berenfeld, O., Blaufox, A., Cerrone, M., Noujaim, S. F., Denegri, M., Jalife, J. & Priori, S. G., Mar 12 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 11, p. 4291-4296 6 p.

Research output: Contribution to journalArticle

Atrial Fibrillation
Mutation
Inwardly Rectifying Potassium Channel
Phenotype
Genetic Testing
2014

Single delivery of an adeno-associated viral construct to transfer the CASQ2 gene to knock-in mice affected by catecholaminergic polymorphic ventricular tachycardia is able to cure the disease from birth to advanced age

Denegri, M., Bongianino, R., Lodola, F., Boncompagni, S., De Giusti, V. C., E. Avelino-Cruz, J., Liu, N., Persampieri, S., Curcio, A., Esposito, F., Pietrangelo, L., Marty, I., Villani, L., Moyaho, A., Baiardi, P., Auricchio, A., Protasi, F., Napolitano, C. & Priori, S. G., Jun 24 2014, In : Circulation. 129, 25, p. 2673-2681 9 p.

Research output: Contribution to journalArticle

Gene Knock-In Techniques
Calsequestrin
Parturition
Viral Genes
Implantable Defibrillators

Subclinical abnormalities in sarcoplasmic reticulum Ca2+ release promote eccentric myocardial remodeling and pump failure death in response to pressure overload

Sedej, S., Schmidt, A., Denegri, M., Walther, S., Matovina, M., Arnstein, G., Gutschi, E. M., Windhager, I., Ljubojević, S., Negri, S., Heinzel, F. R., Bisping, E., Vos, M. A., Napolitano, C., Priori, S. G., Kockskämper, J. & Pieske, B., Apr 22 2014, In : Journal of the American College of Cardiology. 63, 15, p. 1569-1579 11 p.

Research output: Contribution to journalArticle

Ryanodine Receptor Calcium Release Channel
Sarcoplasmic Reticulum
Pressure
Constriction
Heart Failure
2016

Adeno-associated virus-mediated CASQ2 delivery rescues phenotypic alterations in a patient-specific model of recessive catecholaminergic polymorphic ventricular tachycardia

Lodola, F., Morone, D., Denegri, M., Bongianino, R., Nakahama, H., Rutigliano, L., Gosetti, R., Rizzo, G., Vollero, A., Buonocore, M., Napolitano, C., Condorelli, G., Priori, S. G. & Di Pasquale, E., Oct 6 2016, In : Cell Death and Disease. 7, 10, e2393.

Research output: Contribution to journalArticle

Calsequestrin
Dependovirus
Cardiac Myocytes
Genetic Therapy
Induced Pluripotent Stem Cells

Adeno-associated virus-mediated CASQ2 delivery rescues phenotypic alterations in a patient-specific model of recessive catecholaminergic polymorphic ventricular tachycardia

Lodola, F., Morone, D., Denegri, M., Bongianino, R., Nakahama, H., Rutigliano, L., Gosetti, R., Rizzo, G., Vollero, A., Buonocore, M., Napolitano, C., Condorelli, G., Priori, S. G. & Di Pasquale, E., Oct 6 2016, In : Cell Death and Disease. 7, 10, e2393.

Research output: Contribution to journalArticle

Calsequestrin
Dependovirus
Cardiac Myocytes
Genetic Therapy
Induced Pluripotent Stem Cells

Role of the JP45-calsequestrin complex on calcium entry in slow twitch skeletal muscles

Mosca, B., Eckhardt, J., Bergamelli, L., Treves, S., Bongianino, R., Denegri, M., Priori, S. G., Protasi, F. & Zorzato, F., Jul 8 2016, In : Journal of Biological Chemistry. 291, 28, p. 14555-14565 11 p.

Research output: Contribution to journalArticle

Calsequestrin
Muscle
Skeletal Muscle
Calcium
Ablation
2017

Allele-Specific Silencing of Mutant mRNA Rescues Ultrastructural and Arrhythmic Phenotype in Mice Carriers of the R4496C Mutation in the Ryanodine Receptor Gene (RYR2)

Bongianino, R., Denegri, M., Mazzanti, A., Lodola, F., Vollero, A., Boncompagni, S., Fasciano, S., Rizzo, G., Mangione, D., Barbaro, S., Di Fonso, A., Napolitano, C., Auricchio, A., Protasi, F. & Priori, S. G., Aug 18 2017, In : Circulation Research. 121, 5, p. 525-536 12 p.

Research output: Contribution to journalArticle

Ryanodine Receptor Calcium Release Channel
Alleles
Phenotype
Messenger RNA
Mutation
2018

The AMPK-activator AICAR in thyroid cancer: effects on CXCL8 secretion and on CXCL8-induced neoplastic cell migration

Awwad, O., Coperchini, F., Pignatti, P., Denegri, M., Massara, S., Croce, L., Di Buduo, C. A., Abbonante, V., Balduini, A., Chiovato, L. & Rotondi, M., Mar 15 2018, (Accepted/In press) In : Journal of Endocrinological Investigation. p. 1-8 8 p.

Research output: Contribution to journalArticle

AMP-Activated Protein Kinases
Thyroid Neoplasms
Cell Movement
Thyroid Gland
AICA ribonucleotide

The AMPK-activator AICAR in thyroid cancer: effects on CXCL8 secretion and on CXCL8-induced neoplastic cell migration

Awwad, O., Coperchini, F., Pignatti, P., Denegri, M., Massara, S., Croce, L., Di Buduo, C. A., Abbonante, V., Balduini, A., Chiovato, L. & Rotondi, M., Nov 2018, In : Journal of Endocrinological Investigation. 41, 11, p. 1275-1282 8 p.

Research output: Contribution to journalArticle

AMP-Activated Protein Kinases
Thyroid Neoplasms
Cell Movement
Thyroid Gland
AICA ribonucleotide
2019

The BRAF-inhibitor PLX4720 inhibits CXCL8 secretion in BRAFV600E mutated and normal thyroid cells: a further anti-cancer effect of BRAF-inhibitors

Coperchini, F., Croce, L., Denegri, M., Awwad, O., Ngnitejeu, S. T., Muzza, M., Capelli, V., Latrofa, F., Persani, L., Chiovato, L. & Rotondi, M., Dec 1 2019, In : Scientific Reports. 9, 1, 4390.

Research output: Contribution to journalArticle

Open Access
Thyroid Gland
Thyroid Neoplasms
Neoplasms
Cell Migration Assays
Factor IX