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2020

Prognostic relevance of a blastic plasmacytoid dendritic cell neoplasm-like immunophenotype in cytogenetically normal acute myeloid leukemia patients

Guolo, F., Minetto, P., Clavio, M., Marcolin, R., Miglino, M., Passannante, M., Caviglia, F., Ballerini, F., Tedone, E., Kunkl, A., Mangerini, R., Contini, P., Colombo, N., Cagnetta, A., Cea, M., Carminati, E., Pugliese, G., Gobbi, M. & Lemoli, R. M., Jan 1 2020, (Accepted/In press) In : Leukemia and Lymphoma.

Research output: Contribution to journalArticle

2019

Plasma and Brain Concentrations of Doxycycline after Single and Repeated Doses in Wild-Type and APP23 Mice

Lucchetti, J., Fracasso, C., Balducci, C., Passoni, A., Forloni, G., Salmona, M. & Gobbi, M., Jan 2019, In : Journal of Pharmacology and Experimental Therapeutics. 368, 1, p. 32-40 9 p.

Research output: Contribution to journalArticle

Response of high-risk MDS to azacitidine and lenalidomide is impacted by baseline and acquired mutations in a cluster of three inositide-specific genes

Follo, M. Y., Pellagatti, A., Armstrong, R. N., Ratti, S., Mongiorgi, S., De Fanti, S., Bochicchio, M. T., Russo, D., Gobbi, M., Miglino, M., Parisi, S., Martinelli, G., Cavo, M., Luiselli, D., McCubrey, J. A., Suh, P. G., Manzoli, L., Boultwood, J., Finelli, C. & Cocco, L., Sep 1 2019, In : Leukemia. 33, 9, p. 2276-2290 15 p.

Research output: Contribution to journalArticle

Open Access
2018

Brain disposition, metabolism and behavioral effects of the synthetic opioid AH-7921 in rats

Lucchetti, J., Marzo, C. M., Passoni, A., Moro, F., di Clemente, A., Bagnati, R., Cervo, L. & Gobbi, M., May 1 2018, In : Neuropharmacology. 133, p. 51-62 12 p.

Research output: Contribution to journalArticle

Doxycycline counteracts neuroinflammation restoring memory in Alzheimer's disease mouse models

Balducci, C., Santamaria, G., La Vitola, P., Brandi, E., Grandi, F., Viscomi, A. R., Beeg, M., Gobbi, M., Salmona, M., Ottonello, S. & Forloni, G., Oct 2018, In : Neurobiology of Aging. 70, p. 128-139 12 p.

Research output: Contribution to journalArticle

Prompt detection of L-asparaginase inactivation is crucial to optimize treatment efficacy also in aggressive lymphomas

Guolo, F., Ferrari, M., Minetto, P., Matteo, C., Clavio, M., Coviello, E., Ballerini, F., Miglino, M., Gobbi, M., D'Incalci, M., Lemoli, R. M. & Zucchetti, M., Apr 2018, In : Hematological Oncology. 36, 2, p. 498-499 2 p.

Research output: Contribution to journalArticle

2017

An antipsychotic drug exerts anti-prion effects by altering the localization of the cellular prion protein

Stincardini, C., Massignan, T., Biggi, S., Elezgarai, S. R., Sangiovanni, V., Vanni, I., Pancher, M., Adami, V., Moreno, J., Stravalaci, M., Maietta, G., Gobbi, M., Negro, A., Requena, J. R., Castilla, J., Nonno, R. & Biasini, E., Aug 1 2017, In : PLoS One. 12, 8, p. e0182589

Research output: Contribution to journalArticle

Ascites interferes with the activity of lurbinectedin and trabectedin: Potential role of their binding to alpha 1-acid glycoprotein

Erba, E., Romano, M., Gobbi, M., Zucchetti, M., Ferrari, M., Matteo, C., Panini, N., Colmegna, B., Caratti, G., Porcu, L., Fruscio, R., Perlangeli, M. V., Mezzanzanica, D., Lorusso, D., Raspagliesi, F. & D'Incalci, M., Nov 15 2017, In : Biochemical Pharmacology. 144, p. 52-62 11 p.

Research output: Contribution to journalArticle

Fingolimod Limits Acute Aβ Neurotoxicity and Promotes Synaptic Versus Extrasynaptic NMDA Receptor Functionality in Hippocampal Neurons

Joshi, P., Gabrielli, M., Ponzoni, L., Pelucchi, S., Stravalaci, M., Beeg, M., Mazzitelli, S., Braida, D., Sala, M., Boda, E., Buffo, A., Gobbi, M., Gardoni, F., Matteoli, M., Marcello, E. & Verderio, C., Jan 30 2017, In : Scientific Reports. 7, 41734.

Research output: Contribution to journalArticle

Fingolimod Limits Acute Aβ Neurotoxicity and Promotes Synaptic Versus Extrasynaptic NMDA Receptor Functionality in Hippocampal Neurons

Joshi, P., Gabrielli, M., Ponzoni, L., Pelucchi, S., Stravalaci, M., Beeg, M., Mazzitelli, S., Braida, D., Sala, M., Boda, E., Buffo, A., Gobbi, M., Gardoni, F., Matteoli, M., Marcello, E. & Verderio, C., Jan 30 2017, In : Scientific Reports. 7, p. 41734

Research output: Contribution to journalArticle

Humanin Specifically Interacts with Amyloid-β Oligomers and Counteracts Their in vivo Toxicity

Romeo, M., Stravalaci, M., Beeg, M., Rossi, A., Fiordaliso, F., Corbelli, A., Salmona, M., Gobbi, M., Cagnotto, A. & Diomede, L., 2017, In : Journal of Alzheimer's Disease. 57, 3, p. 857-871 15 p.

Research output: Contribution to journalArticle

Pharmacological inhibition of mannose-binding lectin ameliorates neurobehavioral dysfunction following experimental traumatic brain injury

De Blasio, D., Fumagalli, S., Longhi, L., Orsini, F., Palmioli, A., Stravalaci, M., Vegliante, G., Zanier, E. R., Bernardi, A., Gobbi, M. & De Simoni, M. G., Mar 1 2017, In : Journal of Cerebral Blood Flow and Metabolism. 37, 3, p. 938-950 13 p.

Research output: Contribution to journalArticle

QSAR model for blood-brain barrier permeation

Toropov, A. A., Toropova, A. P., Beeg, M., Gobbi, M. & Salmona, M., Nov 1 2017, In : Journal of Pharmacological and Toxicological Methods. 88, p. 7-18 12 p.

Research output: Contribution to journalArticle

2016

A cationic tetrapyrrole inhibits toxic activities of the cellular prion protein

Massignan, T., Cimini, S., Stincardini, C., Cerovic, M., Vanni, I., Elezgarai, S. R., Moreno, J., Stravalaci, M., Negro, A., Sangiovanni, V., Restelli, E., Riccardi, G., Gobbi, M., Castilla, J., Borsello, T., Nonno, R. & Biasini, E., Mar 15 2016, In : Scientific Reports. 6, 23180.

Research output: Contribution to journalArticle

A New Surface Plasmon Resonance Assay for in Vitro Screening of Mannose-Binding Lectin Inhibitors

Stravalaci, M., De Blasio, D., Orsini, F., Perego, C., Palmioli, A., Goti, G., Bernardi, A., De Simoni, M. G. & Gobbi, M., Aug 1 2016, In : Journal of Biomolecular Screening. 21, 7, p. 749-757 9 p.

Research output: Contribution to journalArticle

Clusterin binds to Aβ1-42 Oligomers with high affinity and interferes with peptide aggregation by inhibiting primary and secondary nucleation

Beeg, M., Stravalaci, M., Romeo, M., Carrá, A. D., Cagnotto, A., Rossi, A., Diomede, L., Salmona, M. & Gobbi, M., Mar 25 2016, In : Journal of Biological Chemistry. 291, 13, p. 6958-6966 9 p.

Research output: Contribution to journalArticle

Monte Carlo method for predicting of cardiac toxicity: hERG blocker compounds

Gobbi, M., Beeg, M., Toropova, M. A., Toropov, A. A. & Salmona, M., May 27 2016, In : Toxicology Letters. 250-251, p. 42-46 5 p.

Research output: Contribution to journalArticle

Pulmonary administration of functionalized nanoparticles significantly reduces beta-amyloid in the brain of an Alzheimer’s disease murine model

Sancini, G., Dal Magro, R., Ornaghi, F., Balducci, C., Forloni, G., Gobbi, M., Salmona, M. & Re, F., 2016, In : Nano Research. 9, p. 2190-2201

Research output: Contribution to journalArticle

Scaffold Optimisation of Tetravalent Antagonists of the Mannose Binding Lectin

Goti, G., Palmioli, A., Stravalaci, M., Sattin, S., De Simoni, M. G., Gobbi, M. & Bernardi, A., Mar 7 2016, In : Chemistry - A European Journal. 22, 11, p. 3686-3691 6 p.

Research output: Contribution to journalArticle

The Anti-Prion Antibody 15B3 Detects Toxic Amyloid-β Oligomers

Stravalaci, M., Tapella, L., Beeg, M., Rossi, A., Joshi, P., Pizzi, E., Mazzanti, M., Balducci, C., Forloni, G., Biasini, E., Salmona, M., DIomede, L., Chiesa, R. & Gobbi, M., 2016, In : Journal of Alzheimer's Disease. 53, 4, p. 1485-1497 13 p.

Research output: Contribution to journalArticle

2015

Brain Uptake of Tetrahydrohyperforin and Potential Metabolites after Repeated Dosing in Mice

Fracasso, C., Bagnati, R., Passoni, A., Guiso, G., Cantoni, L., Riva, A., Morazzoni, P. & Gobbi, M., Aug 28 2015, In : Journal of Natural Products. 78, 8, p. 2029-2035 7 p.

Research output: Contribution to journalArticle

Exposing native cyprinid (Barbus plebejus) juveniles to river sediments leads to gonadal alterations, genotoxic effects and thyroid disruption

Viganò, L., De Flora, S., Gobbi, M., Guiso, G., Izzotti, A., Mandich, A., Mascolo, G. & Roscioli, C., Dec 1 2015, In : Aquatic Toxicology. 169, p. 223-239 17 p.

Research output: Contribution to journalArticle

2014

A new surface plasmon resonance-based immunoassay for rapid, reproducible and sensitive quantification of pentraxin-3 in human plasma

Canovi, M., Lucchetti, J., Stravalaci, M., Valentino, S., Bottazzi, B., Salmona, M., Bastone, A. & Gobbi, M., 2014, In : Sensors (Switzerland). 14, 6, p. 10864-10875 12 p.

Research output: Contribution to journalArticle

Doxycycline in Creutzfeldt-Jakob disease: A phase 2, randomised, double-blind, placebo-controlled trial

Haïk, S., Marcon, G., Mallet, A., Tettamanti, M., Welaratne, A., Giaccone, G., Azimi, S., Pietrini, V., Fabreguettes, J. R., Imperiale, D., Cesaro, P., Buffa, C., Aucan, C., Lucca, U., Peckeu, L., Suardi, S., Tranchant, C., Zerr, I., Houillier, C., Redaelli, V. & 16 others, Vespignani, H., Campanella, A., Sellal, F., Krasnianski, A., Seilhean, D., Heinemann, U., Sedel, F., Canovi, M., Gobbi, M., Di Fede, G., Laplanche, J. L., Pocchiari, M., Salmona, M., Forloni, G., Brandel, J. P. & Tagliavini, F., Feb 2014, In : The Lancet Neurology. 13, 2, p. 150-158 9 p.

Research output: Contribution to journalArticle

Early activation of the kynurenine pathway predicts early death and long-term outcome in patients resuscitated from out-of-hospital cardiac arrest

Ristagno, G., Latini, R., Vaahersalo, J., Masson, S., Kurola, J., Varpula, T., Lucchetti, J., Fracasso, C., Guiso, G., Montanelli, A., Barlera, S., Gobbi, M., Tiainen, M., Pettilä, V., Skrifvars, M. B., Lund, V., Tuominen, P., Johansson, S., Perkola, P., Kumpulainen, E. & 52 others, Suvela, M., Hirvonen, S., Kauppinen, S., Laru-Sompa, R., Reilama, M., Laine, H., Kettunen, P., Smolander, I., Reinikainen, M., Surakka, T., Saarinen, K., Lähdeaho, P., Soini, J., Hovilehto, S., Koivisto, S. P., Hautamäki, R., Alaspää, A., Heikkilä, T., Kiviniemi, O., Lintula, E., Kaminski, T., Roiko, J., Alila, S., Pentti, J., Koskinen, R., Heikkinen, J., Oksanen, T., Eronen, A., Hult, T., Nieminen, T., Bäcklund, T., Kauhanen, L., Kaukonen, K. M., Pettilä, V., Pettilä, L., Sutinen, S., Hoppu, S., Tenhunen, J., Karlsson, S., Kukkurainen, A., Varila, S., Kortelainen, S., Peltola, M. L., Hiltunen, P., Kurola, J., Ruokonen, E., Halonen, E., Rissanen, S., Rahikainen, S., Ahola, R., Ala-Kokko, T. & Sälkiö, S., 2014, In : Journal of the American Heart Association. 3, 4, e001094.

Research output: Contribution to journalArticle

Expression of A2V-mutated Aβ in Caenorhabditis elegans results in oligomer formation and toxicity

Diomede, L., Di Fede, G., Romeo, M., Bagnati, R., Ghidoni, R., Fiordaliso, F., Salio, M., Rossi, A., Catania, M., Paterlini, A., Benussi, L., Bastone, A., Stravalaci, M., Gobbi, M., Tagliavini, F. & Salmona, M., 2014, In : Neurobiology of Disease. 62, p. 521-532 12 p.

Research output: Contribution to journalArticle

Memantine prevents reference and working memory impairment caused by sleep deprivation in both young and aged Octodon degus

Tarragon, E., Lopez, D., Estrada, C., Gonzalez-Cuello, A., Ros, C. M., Lamberty, Y., Pifferi, F., Cella, M., Canovi, M., Guiso, G., Gobbi, M., Fernández-Villalba, E., Blin, O., Bordet, R., Richardson, J. C. & Herrero, M. T., 2014, In : Neuropharmacology. 85, p. 206-214 9 p.

Research output: Contribution to journalArticle

Ranolazine ameliorates postresuscitation electrical instability and myocardial dysfunction and improves survival with good neurologic recovery in a rat model of cardiac arrest

Fumagalli, F., Russo, I., Staszewsky, L., Li, Y., Letizia, T., Masson, S., Novelli, D., Rocchetti, M., Canovi, M., Veglianese, P., Gobbi, M., Latini, R., Zaza, A. & Ristagno, G., 2014, In : Heart Rhythm. 11, 9, p. 1641-1647 7 p.

Research output: Contribution to journalArticle

Ranolazine prevents INaL enhancement and blunts myocardial remodelling in a model of pulmonary hypertension

Rocchetti, M., Sala, L., Rizzetto, R., Irene Staszewsky, L., Alemanni, M., Zambelli, V., Russo, I., Barile, L., Cornaghi, L., Altomare, C., Ronchi, C., Mostacciuolo, G., Lucchetti, J., Gobbi, M., Latini, R. & Zaza, A., Oct 1 2014, In : Cardiovascular Research. 104, 1, p. 37-48 12 p.

Research output: Contribution to journalArticle

2013

6-Methoxy-7-benzofuranoxy and 6-methoxy-7-indolyloxy analogues of 2-[2-(2,6-Dimethoxyphenoxy)ethyl]aminomethyl-1,4-benzodioxane (WB4101): 1 Discovery of a potent and selective α1D-adrenoceptor antagonist

Fumagalli, L., Pallavicini, M., Budriesi, R., Bolchi, C., Canovi, M., Chiarini, A., Chiodini, G., Gobbi, M., Laurino, P., Micucci, M., Straniero, V. & Valoti, E., Aug 22 2013, In : Journal of Medicinal Chemistry. 56, 16, p. 6402-6412 11 p.

Research output: Contribution to journalArticle

A Mouse Model of Familial ALS Has Increased CNS Levels of Endogenous Ubiquinol9/10 and Does Not Benefit from Exogenous Administration of Ubiquinol10

Lucchetti, J., Marino, M., Papa, S., Tortarolo, M., Guiso, G., Pozzi, S., Bonetto, V., Caccia, S., Beghi, E., Bendotti, C. & Gobbi, M., Jul 23 2013, In : PLoS One. 8, 7, e69540.

Research output: Contribution to journalArticle

An N-terminal fragment of the prion protein binds to amyloid-β oligomers and inhibits their neurotoxicity in vivo

Fluharty, B. R., Biasini, E., Stravalaci, M., Sclip, A., Diomede, L., Balducci, C., La Vitola, P., Messa, M., Colombo, L., Forloni, G., Borsello, T., Gobbi, M. & Harris, D. A., Mar 15 2013, In : Journal of Biological Chemistry. 288, 11, p. 7857-7866 10 p.

Research output: Contribution to journalArticle

Benefit of doxycycline treatment on articular disability caused by dialysis related amyloidosis

Montagna, G., Cazzulani, B., Obici, L., Uggetti, C., Giorgetti, S., Porcari, R., Ruggiero, R., Patrizia Mangione, P., Brambilla, M., Lucchetti, J., Guiso, G., Gobbi, M., Merlini, G., Salmona, M., Stoppini, M., Villa, G. & Bellotti, V., Sep 2013, In : Amyloid. 20, 3, p. 173-178 6 p.

Research output: Contribution to journalArticle

Epitope scanning indicates structural differences in brain-derived monomeric and aggregated mutant prion proteins related to genetic prion diseases

Tapella, L., Stravalaci, M., Bastone, A., Biasini, E., Gobbi, M. & Chiesa, R., Sep 15 2013, In : Biochemical Journal. 454, 3, p. 417-425 9 p.

Research output: Contribution to journalArticle

Functionalization with TAT-peptide enhances blood-brain barrier crossing in vitro of nanoliposomes carrying a curcumin-derivative to bind amyloid-β peptide

Sancini, G., Gregori, M., Salvati, E., Cambianica, I., Re, F., Ornaghi, F., Canovi, M., Fracasso, C., Cagnotto, A., Colombo, M., Zona, C., Gobbi, M., Salmona, M., La Ferla, B., Nicotra, F. & Masserini, M., 2013, In : Journal of Nanomedicine and Nanotechnology. 4, 3

Research output: Contribution to journalArticle

New insights into the molecular mechanisms underlying sensitivity/ resistance to the atypical retinoid ST1926 in acute myeloid leukaemia cells: The role of histone H2A.Z, cAMP-dependent protein kinase A and the proteasome

Fratelli, M., Fisher, J. N., Paroni, G., Di Francesco, A. M., Pierri, F., Pisano, C., Godl, K., Marx, S., Tebbe, A., Valli, C., Gianni, M., Stravalaci, M., Gobbi, M., Terao, M. & Garattini, E., Apr 2013, In : European Journal of Cancer. 49, 6, p. 1491-1500 10 p.

Research output: Contribution to journalArticle

Novel approaches for studying amyloidogenic peptides/proteins

Beeg, M., Diomede, L., Stravalaci, M., Salmona, M. & Gobbi, M., Oct 2013, In : Current Opinion in Pharmacology. 13, 5, p. 797-801 5 p.

Research output: Contribution to journalArticle

Pharmacology in the high tech age - New developments, opportunities and limitations

Gescher, A. & Gobbi, M., Oct 2013, In : Current Opinion in Pharmacology. 13, 5, p. 775-777 3 p.

Research output: Contribution to journalArticle

Selective nanovector mediated treatment of activated proinflammatory microglia/macrophages in spinal cord injury

Papa, S., Rossi, F., Ferrari, R., Mariani, A., De Paola, M., Caron, I., Fiordaliso, F., Bisighini, C., Sammali, E., Colombo, C., Gobbi, M., Canovi, M., Lucchetti, J., Peviani, M., Morbidelli, M., Forloni, G., Perale, G., Moscatelli, D. & Veglianese, P., Nov 26 2013, In : ACS Nano. 7, 11, p. 9881-9895 15 p.

Research output: Contribution to journalArticle

Tetrahydro-β-carboline-based spirocyclic lactam as type II′ β-turn: Application to the synthesis and biological evaluation of somatostatine mimetics

Lesma, G., Cecchi, R., Cagnotto, A., Gobbi, M., Meneghetti, F., Musolino, M., Sacchetti, A. & Silvani, A., Mar 15 2013, In : Journal of Organic Chemistry. 78, 6, p. 2600-2610 11 p.

Research output: Contribution to journalArticle

The GTPase-activating protein RN-tre controls focal adhesion turnover and cell migration

Palamidessi, A., Frittoli, E., Ducano, N., Offenhauser, N., Sigismund, S., Kajiho, H., Parazzoli, D., Oldani, A., Gobbi, M., Serini, G., Di Fiore, P. P., Scita, G. & Lanzetti, L., Dec 2 2013, In : Current Biology. 23, 23, p. 2355-2364 10 p.

Research output: Contribution to journalArticle

2012

Affinity and activity profiling of unichiral 8-substituted 1,4-benzodioxane analogues of WB4101 reveals a potent and selective α1B- adrenoceptor antagonist

Fumagalli, L., Pallavicini, M., Budriesi, R., Gobbi, M., Straniero, V., Zagami, M., Chiodini, G., Bolchi, C., Chiarini, A., Micucci, M. & Valoti, E., Dec 2012, In : European Journal of Medicinal Chemistry. 58, p. 184-191 8 p.

Research output: Contribution to journalArticle

A novel spirocyclic tropanyl-Δ2-isoxazoline derivative enhances citalopram and paroxetine binding to serotonin transporters as well as serotonin uptake

Dallanoce, C., Canovi, M., Matera, C., Mennini, T., De Amici, M., Gobbi, M. & De Micheli, C., Nov 1 2012, In : Bioorganic and Medicinal Chemistry. 20, 21, p. 6344-6355 12 p.

Research output: Contribution to journalArticle

Applications of Surface Plasmon Resonance (SPR) for the characterization of nanoparticles developed for biomedical purposes

Canovi, M., Lucchetti, J., Stravalaci, M., Re, F., Moscatelli, D., Bigini, P., Salmona, M. & Gobbi, M., Dec 2012, In : Sensors (Switzerland). 12, 12, p. 16420-16432 13 p.

Research output: Contribution to journalArticle

Doxycycline plus tauroursodeoxycholic acid for transthyretin amyloidosis: A phase II study

Obici, L., Cortese, A., Lozza, A., Lucchetti, J., Gobbi, M., Palladini, G., Perlini, S., Saraiva, M. J. & Merlini, G., Jun 2012, In : Amyloid. 19, SUPPL. 1, p. 34-36 3 p.

Research output: Contribution to journalArticle