Maria Luisa Malosio

2015

Epigenomics of Neural Cells: REST-Induced Down- and Upregulation of Gene Expression in a Two-Clone PC12 Cell Model

Garcia-Manteiga, J. M., Bonfiglio, S., Malosio, M. L., Lazarevic, D., Stupka, E., Cittaro, D. & Meldolesi, J., 2015, In : BioMed Research International. 2015, 202914.

Research output: Contribution to journal › Article

Clone cells

PC12 Cells

Epigenomics

Gene expression

Up-Regulation

18 Citations (Scopus)

MR imaging monitoring of iron-labeled pancreatic islets in a small series of patients: Islet fate in successful, unsuccessful, and autotransplantation

Malosio, M. L., Esposito, A., Brigatti, C., Palmisano, A., Piemonti, L., Nano, R., Maffi, P., Cobelli, F. D., Maschio, A. D. & Secchi, A., 2015, In : Cell Transplantation. 24, 11, p. 2285-2296 12 p.

Research output: Contribution to journal › Article

Autologous Transplantation

Islets of Langerhans

Iron

Magnetic resonance

Grafts

4 Citations (Scopus)

REST-governed gene expression profiling in a neuronal cell model reveals novel direct and indirect processes of repression and up-regulation

Garcia-Manteiga, J. M., Bonfiglio, S., Folladori, L., Malosio, M. L., Lazarevic, D., Stupka, E., Cittaro, D. & Meldolesi, J., Nov 10 2015, In : Frontiers in Cellular Neuroscience. 9, NOVEMBER, 438.

Research output: Contribution to journal › Article

Gene Expression Profiling

Up-Regulation

Genes

Clone Cells

Neurons

2014

7 Citations (Scopus)

Liver perfusion changes occurring during pancreatic islet engraftment: A dynamic contrast-enhanced magnetic resonance study

Esposito, A., Palmisano, A., Maffi, P., Malosio, M. L., Nano, R., Canu, T., De Cobelli, F., Piemonti, L., Ironi, G., Secchi, A. & Del Maschio, A., Jan 2014, In : American Journal of Transplantation. 14, 1, p. 202-209 8 p.

Research output: Contribution to journal › Article

Islets of Langerhans

Magnetic Resonance Spectroscopy

Perfusion

Liver

Magnetic Resonance Imaging

2013

49 Citations (Scopus)

Tyrosine Kinase signal modulation: A matter of H2O2 membrane permeability?

Bertolotti, M., Bestetti, S., García-Manteiga, J. M., Medraño-Fernandez, I., Dal Mas, A., Malosio, M. L. & Sitia, R., Nov 1 2013, In : Antioxidants and Redox Signaling. 19, 13, p. 1447-1451 5 p.

Research output: Contribution to journal › Article

Protein-Tyrosine Kinases

Permeability

Modulation

Membranes

Phosphorylation

2010

29 Citations (Scopus)

On/off TLR signaling decides proinflammatory or tolerogenic dendritic cell maturation upon CD1D-mediated interaction with invariant NKT cells

Caielli, S., Conforti-Andreoni, C., Di Pietro, C., Usuelli, V., Badami, E., Malosio, M. L. & Falcone, M., Dec 15 2010, In : Journal of Immunology. 185, 12, p. 7317-7329 13 p.

Research output: Contribution to journal › Article

Natural Killer T-Cells

Dendritic Cells

Immune Tolerance

CD40 Ligand

MAP Kinase Signaling System

2009

66 Citations (Scopus)

Antiacquaporin 4 antibodies detection by different techniques in neuromyelitis optica patients

Fazio, R., Malosio, M. L., Lampasona, V., De Feo, D., Privitera, D., Marnetto, F., Centonze, D., Ghezzi, A., Comi, G., Furlan, R. & Martino, G., 2009, In : Multiple Sclerosis Journal. 15, 10, p. 1153-1163 11 p.

Research output: Contribution to journal › Article

Neuromyelitis Optica

Aquaporin 4

Antibodies

Transverse Myelitis

Seroepidemiologic Studies

21 Citations (Scopus)

Improving the procedure for detection of intrahepatic transplanted islets by magnetic resonance imaging

Malosio, M. L., Esposito, A., Poletti, A., Chiaretti, S., Piemonti, L., Melzi, R., Nano, R., Tedoldi, F., Canu, T., Santambrogio, P., Brigatti, C., De Cobelli, F., Maffi, P., Secchi, A. & Del Maschio, A., Oct 2009, In : American Journal of Transplantation. 9, 10, p. 2372-2382 11 p.

Research output: Contribution to journal › Article

Magnets

Magnetic Resonance Imaging

Transplants

Islets of Langerhans Transplantation

Feasibility Studies

2008

9 Citations (Scopus)

Beta cell chromogranin B is partially segregated in distinct granules and can be released separately from insulin in response to stimulation

Giordano, T., Brigatti, C., Podini, P., Bonifacio, E., Meldolesi, J. & Malosio, M. L., Jun 2008, In : Diabetologia. 51, 6, p. 997-1007 11 p.

Research output: Contribution to journal › Article

Chromogranin B

Insulin

trans-Golgi Network

Ionomycin

Computer-Assisted Image Processing

32 Citations (Scopus)

Expression of the neurosecretory process in pc12 cells is governed by rest

D'Alessandro, R., Klajn, A., Stucchi, L., Podini, P., Malosio, M. L. & Meldolesi, J., May 2008, In : Journal of Neurochemistry. 105, 4, p. 1369-1383 15 p.

Research output: Contribution to journal › Article

PC12 Cells

Chromogranins

Exocytosis

Secretory Vesicles

Genes

107 Citations (Scopus)

The chemokine receptor CX3CR1 is involved in the neural tropism and malignant behavior of pancreatic ductal adenocarcinoma

Marchesi, F., Piemonti, L., Fedele, G., Destro, A., Roncalli, M., Albarello, L., Doglioni, C., Anselmo, A., Doni, A., Bianchi, P., Laghi, L., Malesci, A., Cervo, L., Malosio, M., Reni, M., Zerbi, A., Di Carlo, V., Mantovani, A. & Allavena, P., Nov 1 2008, In : Cancer Research. 68, 21, p. 9060-9069 10 p.

Research output: Contribution to journal › Article

Tropism

Chemokine Receptors

Adenocarcinoma

Neoplasms

Peripheral Nerves

2006

20 Citations (Scopus)

Monoclonal antibody 76F distinguishes IA-2 from IA-2β and overlaps an autoantibody epitope

Piquer, S., Valera, L., Lampasona, V., Jardin-Watelet, B., Roche, S., Granier, C., Roquet, F., Christie, M. R., Giordano, T., Malosio, M. L., Bonifacio, E. & Laune, D., May 2006, In : Journal of Autoimmunity. 26, 3, p. 215-222 8 p.

Research output: Contribution to journal › Article

Epitopes

Monoclonal Antibodies

Autoantibodies

Autoantigens

Type 1 Diabetes Mellitus

2005

453 Citations (Scopus)

Bone marrow mesenchymal stem cells express a restricted set of functionally active chemokine receptors capable of promoting migration to pancreatic islets

Sordi, V., Malosio, M. L., Marchesi, F., Mercalli, A., Melzi, R., Giordano, T., Belmonte, N., Ferrari, G., Leone, B. E., Bertuzzi, F., Zerbini, G., Allavena, P., Bonifacio, E. & Piemonti, L., Jul 15 2005, In : Blood. 106, 2, p. 419-427 9 p.

Research output: Contribution to journal › Article

Chemokine Receptors

Stem cells

Mesenchymal Stromal Cells

Islets of Langerhans

Bone

2004

55 Citations (Scopus)

Dense-core granules: A specific hallmark of the neuronal/neurosecretory cell phenotype

Malosio, M. L., Giordano, T., Laslop, A. & Meldolesi, J., Feb 15 2004, In : Journal of Cell Science. 117, 5, p. 743-749 7 p.

Research output: Contribution to journal › Article

Chromogranin A

Phenotype

Chromogranin B

Clone Cells

Organelles

38 Citations (Scopus)

Requirements for the identification of dense-core granules

Meldolesi, J., Chieregatti, E. & Malosio, M. L., Jan 2004, In : Trends in Cell Biology. 14, 1, p. 13-19 7 p.

Research output: Contribution to journal › Article

Organelles

Chromogranins

Cytoplasmic Granules

Exocytosis

Electron Microscopy

2002

Erratum: Neurosecretion competence. A comprehensive gene expression program identified in PC12 cells. (Journal of Biological Chemistry (2002) 277 (36715-36724))

Grundschober, C., Malosio, M. L., Astolfi, L., Giordano, T., Nef, P. & Meldolesi, J., Nov 29 2002, In : Journal of Biological Chemistry. 277, 48, p. 46840 1 p.

Research output: Contribution to journal › Article

36 Citations (Scopus)

Neurosecretion competence. A comprehensive gene expression program identified in PC12 cells

Grundschober, C., Malosio, M. L., Astolfi, L., Giordano, T., Nef, P. & Meldolesi, J., Sep 27 2002, In : Journal of Biological Chemistry. 277, 39, p. 36715-36724 10 p.

Research output: Contribution to journal › Article

Neurosecretion

PC12 Cells

Gene expression

Mental Competency

Clone Cells

1999

78 Citations (Scopus)

Blockade of membrane transport and disassembly of the Golgi complex by expression of syntaxin 1A in neurosecretion-incompetent cells: Prevention by rbSEC1

Rowe, J., Corradi, N., Malosio, M. L., Taverna, E., Halban, P., Meldolesi, J. & Rosa, P., 1999, In : Journal of Cell Science. 112, 12, p. 1865-1877 13 p.

Research output: Contribution to journal › Article

Syntaxin 1

Neurosecretion

Golgi Apparatus

Membranes

SNARE Proteins

18 Citations (Scopus)

Neurosecretory cells without neurosecretion: Evidence of an independently regulated trait of the cell phenotype

Malosio, M. L., Benfante, R., Racchetti, G., Borgonovo, B., Rosa, P. & Meldolesi, J., Oct 1 1999, In : Journal of Physiology. 520, 1, p. 43-52 10 p.

Research output: Contribution to journal › Article

Neurosecretion

Phenotype

Exocytosis

Organelles

Mental Competency

1998

13 Citations (Scopus)

Neurosecretion competence, an independently regulated trait of the neurosecretory cell phenotype

Borgonovo, B., Racchetti, G., Malosio, M., Benfante, R., Podini, P., Rosa, P. & Meldolesi, J., Dec 25 1998, In : Journal of Biological Chemistry. 273, 52, p. 34683-34686 4 p.

Research output: Contribution to journal › Article

Neurosecretion

Mental Competency

Rats

Phenotype

Transcription

1997

60 Citations (Scopus)

Differential expression of distinct members of rho family GTP-binding proteins during neuronal development: Identification of RAC1B, a new neural- specific member of the family

Malosio, M. L., Gilardelli, D., Paris, S., Albertinazzi, C. & De Curtis, I., 1997, In : Journal of Neuroscience. 17, 17, p. 6717-6728 12 p.

Research output: Contribution to journal › Article

rho GTP-Binding Proteins

Genes

Neurites

Nervous System

Vertebrates

1996

3 Citations (Scopus)

Exposure to perinatal morphine promotes developmental changes in rat striatum

Gorio, A., Malosio, M. L., Vergani, L. & Giulio, A. M. D., Jul 1996, In : International Journal of Developmental Neuroscience. 14, 4, p. 471-479 9 p.

Research output: Contribution to journal › Article

Morphine

Dopamine

Methionine Enkephalin

Messenger RNA

Tyrosine 3-Monooxygenase

8 Citations (Scopus)

In situ hybridization study of myelin protein mRNA in rats with an experimental diabetic neuropathy

Conti, A. M., Scarpini, E., Malosio, M. L., Di Giulio, A. M., Baron, P., Scarlato, G., Mantegazza, P. & Gorio, A., Mar 22 1996, In : Neuroscience Letters. 207, 1, p. 65-69 5 p.

Research output: Contribution to journal › Article

Myelin Proteins

Diabetic Neuropathies

Myelin Basic Protein

In Situ Hybridization

Messenger RNA

4 Citations (Scopus)

Perinatal exposure to morphine: Reactive changes in the brain after 6-hydroxydopamine

Gorio, A., Vergani, L., Malosio, M. L., Lesma, E. & Di Giulio, A. M., May 6 1996, In : European Journal of Pharmacology. 303, 1-2, p. 21-26 6 p.

Research output: Contribution to journal › Article

Oxidopamine

Morphine

Synapsins

Brain

Messenger RNA

8 Citations (Scopus)

Tyrosine phosphorylation induced by integrin-mediated adhesion of retinal neurons to laminin

Malosio, M. L. & Curtis, I. D., 1996, In : International Journal of Developmental Neuroscience. 14, 3, p. 269-281 13 p.

Research output: Contribution to journal › Article

Retinal Neurons

Laminin

Integrins

Tyrosine

Phosphorylation

1995

10 Citations (Scopus)

Perinatal morphine I: Effects on synapsin and neurotransmitter systems in the brain

Di Giulio, A. M., Tenconi, B., Malosio, M. L., Vergani, L., Bertelli, A. & Gorio, A., 1995, In : Journal of Neuroscience Research. 42, 4, p. 479-485 7 p.

Research output: Contribution to journal › Article

Synapsins

Morphine

Neurotransmitter Agents

Methionine Enkephalin

Substance P

1993

79 Citations (Scopus)

Distribution of gephyrin transcripts in the adult and developing rat brain

Kirsch, J., Malosio, M. L., Wolters, I. & Betz, H., 1993, In : European Journal of Neuroscience. 5, 9, p. 1109-1117 9 p.

Research output: Contribution to journal › Article

Glycine Receptors

Brain

Messenger RNA

Spinal Cord

Oligonucleotide Probes

8 Citations (Scopus)

Myelin protein transcripts increase in experimental diabetic neuropathy

Conti, A. M., Malosio, M. L., Scarpini, E., Di Giulio, A. M., Scarlato, G., Mantegazza, P. & Gorio, A., Oct 29 1993, In : Neuroscience Letters. 161, 2, p. 203-206 4 p.

Research output: Contribution to journal › Article

Myelin Proteins

Diabetic Neuropathies

Messenger RNA

Myelin P0 Protein

Insulin

1992

Cellular and molecular mechanisms underlying the effects on neuronal plasticity by substances of abuse such as alcoholand opiates

Gorio, A., Di Giulio, A. M., Tenconi, B., Finco, C., Germani, E., Malosio, M. L., Bertelli, A. & Mantegazza, P., Sep 1992, In : Pharmacological Research. 26, SUPPL. 1, p. 41 1 p.

Research output: Contribution to journal › Article

11 Citations (Scopus)

Diabetes-induced alterations of central nervous system G proteins - ADP-ribosylation, immunoreactivity, and gene-expression studies in rat striatum

Finco, C., Abbracchio, M. P., Malosio, M. L., Cattabeni, F., Di Giulio, A. M., Paternieri, B., Mantegazza, P. & Gorio, A., Dec 1992, In : Molecular and Chemical Neuropathology. 17, 3, p. 259-272 14 p.

Research output: Contribution to journal › Article

GTP-Binding Proteins

Adenosine Diphosphate

Central Nervous System

Pertussis Toxin

Gene Expression

G-proteins and diabetic encephalopathy: molecular mechanisms underlying the functional alterations

Finco, C., Abbracchio, M. P., Paternieri, B., Cattabeni, F., Di Giulio, A. M., Malosio, M. L., Mantegazza, P. & Gorio, A., 1992, In : Pharmacological Research. 25, SUPPL. 1, p. 109-110 2 p.

Research output: Contribution to journal › Article

9 Citations (Scopus)

Perinatal morphine exposure alters peptidergic development in the striatum

Tenconi, B., Donadoni, M. L., Finco, C., Germani, E., Malosio, M. L., Di Giulio, A. M., Mantegazza, P. & Gorio, A., 1992, In : International Journal of Developmental Neuroscience. 10, 6, p. 517-526 10 p.

Research output: Contribution to journal › Article

Substance P

Morphine

Opiate Alkaloids

Methionine Enkephalin

Messenger RNA

1991

104 Citations (Scopus)

Alternative splicing generates two isoforms of the α2 subunit of the inhibitory glycine receptor

Kuhse, J., Kuryatov, A., Maulet, Y., Malosio, M. L., Schmieden, V. & Betz, H., May 20 1991, In : FEBS Letters. 283, 1, p. 73-77 5 p.

Research output: Contribution to journal › Article

Glycine Receptors

Alternative Splicing

Protein Isoforms

Rats

Ligand-Gated Ion Channels

101 Citations (Scopus)

Alternative splicing generates two variants of the α1 subunit of the inhibitory glycine receptor

Malosio, M. L., Grenningloh, G., Kuhse, J., Schmieden, V., Schmitt, B., Prior, P. & Betz, H., Feb 5 1991, In : Journal of Biological Chemistry. 266, 4, p. 2048-2053 6 p.

Research output: Contribution to journal › Article

Glycine Receptors

Alternative Splicing

Strychnine

RNA Splice Sites

Spinal Cord

90 Citations (Scopus)

Differential expression of synaptophysin and synaptoporin mRNAs in the postnatal rat central nervous system

Marqueze-Pouey, B., Wisden, W., Malosio, M. L. & Betz, H., 1991, In : Journal of Neuroscience. 11, 11, p. 3388-3397 10 p.

Research output: Contribution to journal › Article

Synaptophysin

Central Nervous System

Messenger RNA

Telencephalon

Oligonucleotide Probes

11 Citations (Scopus)

Heterogeneity of the inhibitory glycine receptor

Kuhse, J., Becker, C. M., Schmieden, V., Hoch, W., Pribilla, I., Langosch, D., Malosio, M. L., Muntz, M. & Betz, H., 1991, In : Annals of the New York Academy of Sciences. 625, p. 129-135 7 p.

Research output: Contribution to journal › Article

17 Citations (Scopus)

How to build a glycinergic postsynaptic membrane

Betz, H., Kuhse, J., Schmieden, V., Malosio, M. L., Langosch, D., Prior, P., Schmitt, B. & Kirsch, J., 1991, In : Journal of Cell Science. 100, SUPPL. 15, p. 23-25 3 p.

Research output: Contribution to journal › Article

Glycine Receptors

Protein Isoforms

Chloride Channels

Microtubule-Associated Proteins

Membranes

22 Citations (Scopus)

Structure and expression of inhibitory glycine receptors

Betz, H., Langosch, D., Hoch, W., Prior, P., Pribilla, I., Kuhse, J., Schmieden, V., Malosio, M. L., Matzenbach, B., Holzinger, F., Kuryatov, A., Schmitt, B., Maulet, Y. & Becker, C. M., 1991, In : Advances in Experimental Medicine and Biology. 287, p. 421-430 10 p.

Research output: Contribution to journal › Article

420 Citations (Scopus)

Widespread expression of glycine receptor subunit mRNAs in the adult and developing rat brain

Malosio, M. L., Marquèze-Pouey, B., Kuhse, J. & Betz, H., 1991, In : EMBO Journal. 10, 9, p. 2401-2409 9 p.

Research output: Contribution to journal › Article

Glycine Receptors

Rats

Brain

Messenger RNA

Spinal Cord

1989

1 Citation (Scopus)

Homology and analogy in transmembrane channel design: Lessons from synaptic membrane proteins

Betz, H., Becker, C. M., Grenningloh, G., Hoch, W., Knaus, P., Langosch, D., Malosio, M. L., Schmitt, B. & Thomas, L., Jun 1989, In : Journal of Protein Chemistry. 8, 3, p. 325 1 p.

Research output: Contribution to journal › Article