1986 …2019

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Article
2019

High-throughput Screening of Human Tumor Antigen–specific CD4 T Cells, including Neoantigen-reactive T Cells

Costa-Nunes, C., Cachot, A., Bobisse, S., Arnaud, M., Genolet, R., Baumgaertner, P., Speiser, D. E., Sousa Alves, P. M., Sandoval, F., Adotevi, O., Reith, W., Protti, M. P., Coukos, G., Harari, A., Romero, P. & Jandus, C., Jan 1 2019, In : Clinical Cancer Research. 25, 14, p. 4320-4331 12 p.

Research output: Contribution to journalArticle

Open Access
2018

Immunomodulatory drugs in the context of autologous hematopoietic stem cell transplantation associate with reduced pro-tumor t cell subsets in multiple myeloma

Lullo, G. D., Marcatti, M., Heltai, S., Tresoldi, C., Paganoni, A. M., Bordignon, C., Ciceri, F. & Protti, M. P., Jan 1 2018, In : Frontiers in Immunology. 9, 3171.

Research output: Contribution to journalArticle

Open Access
2017

T cells redirected to a minor histocompatibility antigen instruct intratumoral TNFα expression and empower adoptive cell therapy for solid tumors

Manzo, T., Sturmheit, T., Basso, V., Petrozziello, E., Hess-Michelini, R., Riba, M., Freschi, M., Elia, AR., Grioni, M., Curnis, F., Protti, MP., Schumacher, TN., Debets, R., Swartz, MA., Corti, A., Bellone, M. & Mondino, A., 2017, In : Cancer Research. 77, 3, p. 658-671 14 p.

Research output: Contribution to journalArticle

Tumor-derived factors affecting immune cells

Russo, V. & Protti, MP., 2017, In : Cytokine and Growth Factor Reviews. 36, 2, p. 79-87 9 p.

Research output: Contribution to journalArticle

2016

Basophil recruitment into tumor-draining lymph nodes correlates with Th2 inflammation and reduced survival in pancreatic cancer patients

De Monte, L., Wörmann, S., Brunetto, E., Heltai, S., Magliacane, G., Reni, M., Paganoni, A. M., Recalde, H., Mondino, A., Falconi, M., Aleotti, F., Balzano, G., Algül, H., Doglioni, C. & Protti, M. P., Apr 1 2016, In : Cancer Research. 76, 7, p. 1792-1803 12 p.

Research output: Contribution to journalArticle

Loss of P53 Function Activates JAK2–STAT3 Signaling to Promote Pancreatic Tumor Growth, Stroma Modification, and Gemcitabine Resistance in Mice and Is Associated With Patient Survival

Wörmann, S. M., Song, L., Ai, J., Diakopoulos, K. N., Kurkowski, M. U., Görgülü, K., Ruess, D., Campbell, A., Doglioni, C., Jodrell, D., Neesse, A., Demir, I. E., Karpathaki, A. P., Barenboim, M., Hagemann, T., Rose-John, S., Sansom, O., Schmid, R. M., Protti, M. P., Lesina, M. & 1 others, Algül, H., Jul 1 2016, In : Gastroenterology. 151, 1, p. 180-193.e12

Research output: Contribution to journalArticle

Non-redundant roles for Th17 and Th22 cells in multiple myeloma clinical correlates

Di Lullo, G., Marcatti, M. & Protti, M. P., Apr 2 2016, In : OncoImmunology. 5, 4

Research output: Contribution to journalArticle

Vaccination of stage III/IV melanoma patients with long NY-ESO-1 peptide and CpG-B elicits robust CD8+ and CD4+ T-cell responses with multiple specificities including a novel DR7-restricted epitope

Baumgaertner, P., Costa Nunes, C., Cachot, A., Maby-El Hajjami, H., Cagnon, L., Braun, M., Derré, L., Rivals, J. P., Rimoldi, D., Gnjatic, S., Abed Maillard, S., Marcos Mondéjar, P., Protti, M. P., Romano, E., Michielin, O., Romero, P., Speiser, D. E. & Jandus, C., Oct 2 2016, In : OncoImmunology. 5, 10

Research output: Contribution to journalArticle

2015

Th22 cells increase in poor prognosis multiple myeloma and promote tumor cell growth and survival

Lullo, G. D., Marcatti, M., Heltai, S., Brunetto, E., Tresoldi, C., Bondanza, A., Bonini, C., Ponzoni, M., Tonon, G., Ciceri, F., Bordignon, C. & Protti, M. P., Jan 1 2015, In : OncoImmunology. 4, 5

Research output: Contribution to journalArticle

2014
2013

Immune infiltrates as predictive markers of survival in pancreatic cancer patients

Protti, M. P. & De Monte, L., 2013, In : Frontiers in Physiology. 4 AUG, Article 210.

Research output: Contribution to journalArticle

2012

Estimating point and interval frequency of antigen-specific CD4+ T cells based on short in vitro expansion and improved poisson distribution analysis

Di Lullo, G., Ieva, F., Longhi, R., Paganoni, A. M. & Protti, M. P., Aug 7 2012, In : PLoS One. 7, 8, e42340.

Research output: Contribution to journalArticle

2011
2010

CD4+ T cells against human papillomavirus-18 E7 in patients with high-grade cervical lesions associate with the absence of the virus in the cervix

Seresini, S., Origoni, M., Caputo, L., Lillo, F., Longhi, R., Vantini, S., Paganoni, A. M. & Protti, M. P., Sep 2010, In : Immunology. 131, 1, p. 89-98 10 p.

Research output: Contribution to journalArticle

Seventh annual meeting of the Italian Network for Tumor Biotherapy (NIBIT), Siena, 1-3 October 2009

Maio, M., Nicolay, H. J. M., Ascierto, P. A., Belardelli, F., Camerini, R., Colombo, M. P., Queirolo, P., Ridolfi, R., Russo, V., Fonsatti, E., Parmiani, G., Allavena, P., Anichini, A., Bellone, M., Bronte, V., Calabrò, L., Camisaschi, C., Castelli, C., Corti, A., Danova, M. & 18 others, Dellabona, P., Di Giacomo, A. M., Di Nicola, M., Ferlazzo, G., Gentilcore, G., Giovannoni, L., Hwu, P., Lehmann, F., Maccalli, C., Melero, I., Monsurrò, V., Montagna, D., Moschella, F., Ponzoni, M., Protti, M. P., Puccetti, P., Sangiolo, D. & Schuler, G., Dec 2010, In : Cancer Immunology, Immunotherapy. 59, 12, p. 1895-1901 7 p.

Research output: Contribution to journalArticle

The CD4+ T-cell epitope-binding register is a critical parameter when generating functional HLA-DR tetramers with promiscuous peptides

Cecconi, V., Moro, M., Del Mare, S., Sidney, J., Bachi, A., Longhi, R., Sette, A., Protti, M. P., Dellabona, P. & Casorati, G., Jun 2010, In : European Journal of Immunology. 40, 6, p. 1603-1616 14 p.

Research output: Contribution to journalArticle

2009

Non-redundant role for IL-12 and IL-27 in modulating Th2 polarization of carcinoembryonic antigen specific CD4 T cells from pancreatic cancer patients

Tassi, E., Braga, M., Longhi, R., Gavazzi, F., Parmiani, G., Di Carlo, V. & Protti, M. P., Oct 2 2009, In : PLoS One. 4, 10, e7234.

Research output: Contribution to journalArticle

2008

Carcinoembryonic antigen-specific but not antiviral CD4+ T cell immunity is impaired in pancreatic carcinoma patients

Tassi, E., Gavazzi, F., Albarello, L., Senyukov, V., Longhi, R., Dellabona, P., Doglioni, C., Braga, M., Di Carlo, V. & Protti, M. P., Nov 1 2008, In : Journal of Immunology. 181, 9, p. 6595-6603 9 p.

Research output: Contribution to journalArticle

Endosomal proteases influence the repertoire of MAGE-A3 epitopes recognized in vivo by CD4+ T cells

Marturano, J., Longhi, R., Russo, V. & Protti, M. P., Mar 1 2008, In : Cancer Research. 68, 5, p. 1555-1562 8 p.

Research output: Contribution to journalArticle

Serological immunoreactivity against colon cancer proteome varies upon disease progression

De Monte, L., Sanvito, F., Olivieri, S., Viganò, F., Doglioni, C., Frasson, M., Braga, M., Bachi, A., Dellabona, P., Protti, M. P. & Alessio, M., Feb 2008, In : Journal of Proteome Research. 7, 2, p. 504-514 11 p.

Research output: Contribution to journalArticle

2007

IFN-γ produced by human papilloma virus-18 E6-specific CD4 + T cells predicts the clinical outcome after surgery in patients with high-grade cervical lesions

Seresini, S., Origoni, M., Lillo, F., Caputo, L., Paganoni, A. M., Vantini, S., Longhi, R., Taccagni, G., Ferrari, A., Doglioni, C., Secchi, P. & Protti, M. P., Nov 15 2007, In : Journal of Immunology. 179, 10, p. 7176-7183 8 p.

Research output: Contribution to journalArticle

2006

Identification of novel subdominant epitopes on the carcinoembryonic antigen recognized by CD4+ T cells of lung cancer patients

Crosti, M., Longhi, R., Consogno, G., Melloni, G., Zannini, P. & Protti, M. P., Apr 15 2006, In : Journal of Immunology. 176, 8, p. 5093-5099 7 p.

Research output: Contribution to journalArticle

Immunogenic and structural properties of the Asn-Gly-Arg (NGR) tumor neovasculature-homing motif

Di Matteo, P., Curnis, F., Longhi, R., Colombo, G., Sacchi, A., Crippa, L., Protti, M. P., Ponzoni, M., Toma, S. & Corti, A., Apr 2006, In : Molecular Immunology. 43, 10, p. 1509-1518 10 p.

Research output: Contribution to journalArticle

Peptidome from renal cell carcinoma contains antigens recognized by CD4+ T cells and shared among tumors of different histology

Tassi, E., Facchinetti, V., Seresini, S., Borri, A., Dell'Antonio, G., Garavaglia, C., Casorati, G. & Protti, M. P., Aug 15 2006, In : Clinical Cancer Research. 12, 16, p. 4949-4957 9 p.

Research output: Contribution to journalArticle

2005

CD4+ T cell immunity against the human papillomavirus-18 E6 transforming protein in healthy donors: Identification of promiscuous naturally processed epitopes

Facchinetti, V., Seresini, S., Longhi, R., Garavaglia, C., Casorati, G. & Protti, M. P., Mar 2005, In : European Journal of Immunology. 35, 3, p. 806-815 10 p.

Research output: Contribution to journalArticle

Dendritic cell-derived IL-2 production is regulated by IL-15 in humans and in mice

Feau, S., Facchinetti, V., Granucci, F., Citterio, S., Jarrossay, D., Seresini, S., Protti, M. P., Lanzavecchia, A. & Ricciardi-Castagnoli, P., Jan 15 2005, In : Blood. 105, 2, p. 697-702 6 p.

Research output: Contribution to journalArticle

Generation of functional HLA-DR*1101 tetramers receptive for loading with pathogen or tumour derived synthetic peptides

Moro, M., Cecconi, V., Martinoli, C., Dallegno, E., Giabbai, B., Degano, M., Glaichenhaus, N., Protti, M. P., Dellabona, P. & Casorati, G., Dec 5 2005, In : BMC Immunology. 6, 24.

Research output: Contribution to journalArticle

2004

T-cell receptor-mediated cross-allergenicity

Burastero, S. E., Paolucci, C., Breda, D., Longhi, R., Silvestri, M., Hammer, J., Protti, M. P. & Rossi, G. A., 2004, In : International Archives of Allergy and Immunology. 135, 4, p. 296-305 10 p.

Research output: Contribution to journalArticle

2003

CD4+ T Cells from Healthy Subjects and Colon Cancer Patients Recognize a Carcinoembryonic Antigen-specific Immunodominant Epitope

Campi, G., Crosti, M., Consogno, G., Facchinetti, V., Conti-Fine, B. M., Longhi, R., Casorati, G., Dellabona, P. & Protti, M. P., Dec 1 2003, In : Cancer Research. 63, 23, p. 8481-8486 6 p.

Research output: Contribution to journalArticle

Identification of immunodominant regions among promiscuous HLA-DR-restricted CD4+ T-cell epitopes on the tumor antigen MAGE-3

Consogno, G., Manici, S., Facchinetti, V., Bachi, A., Hammer, J., Conti-Fine, B. M., Rugarli, C., Traversari, C. & Protti, M. P., Feb 1 2003, In : Blood. 101, 3, p. 1038-1044 7 p.

Research output: Contribution to journalArticle

1999

Blockade of the Fas-triggered intracellular signaling pathway in human melanomas is circumvented by cytotoxic lymphocytes

Ferrarini, M., Imro, M. A., Sciorati, C., Heltai, S., Protti, M. P., Pellicciari, C., Rovere, P., Manfredi, A. A. & Rugarli, C., 1999, In : International Journal of Cancer. 81, 4, p. 573-579 7 p.

Research output: Contribution to journalArticle

Cancer immunotherapy: Synthetic and natural peptides in the balance

Bellone, M., Iezzi, G., Imro, M. A. & Protti, M. P., Oct 1 1999, In : Immunology Today. 20, 10, p. 457-462 6 p.

Research output: Contribution to journalArticle

Generation of tissue-specific and promiscuous HLA ligand databases using DNA microarrays and virtual HLA class II matrices

Sturniolo, T., Bono, E., Ding, J., Raddrizzani, L., Tuereci, O., Sahin, U., Braxenthaler, M., Gallazzi, F., Protti, M. P., Sinigaglia, F. & Hammer, J., Jun 1999, In : Nature Biotechnology. 17, 6, p. 555-561 7 p.

Research output: Contribution to journalArticle

Immunogenicity of apoptotic cells in vivo: Role of antigen load, antigen-presenting cells, and cytokines

Ronchetti, A., Rovere, P., Iezzi, G., Galati, G., Heltai, S., Protti, M. P., Garancini, M. P., Manfredi, A. A., Rugarli, C. & Bellone, M., Jul 1 1999, In : Journal of Immunology. 163, 1, p. 130-136 7 p.

Research output: Contribution to journalArticle

Major histocompatibility complex class I restricted cytotoxic T cells specific for natural melanoma peptides recognize unidentified shared melanoma antigen(s)

Imro, M. A., Manici, S., Russo, V., Consogno, G., Bellone, M., Rugarli, C., Traversari, C. & Protti, M. P., May 15 1999, In : Cancer Research. 59, 10, p. 2287-2291 5 p.

Research output: Contribution to journalArticle

Melanoma cells present a MAGE-3 epitope to CD4+ cytotoxic T cells in association with histocompatibility leukocyte antigen DR11

Manici, S., Sturniolo, T., Imro, M. A., Hammer, J., Sinigaglia, F., Noppen, C., Spagnoli, G., Mazzi, B., Bellone, M., Dellabona, P. & Protti, M. P., Mar 1 1999, In : Journal of Experimental Medicine. 189, 5, p. 871-876 6 p.

Research output: Contribution to journalArticle

Role of antigen-presenting cells in cross-priming of cytotoxic T lymphocytes by apoptotic cells

Ronchetti, A., Iezzi, G., Crosti, M. C., Garancini, M. P., Protti, M. P. & Bellone, M., 1999, In : Journal of Leukocyte Biology. 66, 2, p. 247-251 5 p.

Research output: Contribution to journalArticle

1998

Acetylcholine receptor-specific CD4+ T cell in myasthenia gravis patients have individual, but restricted TCR Vβ usage

Raju, R., Navaneetham, D., Protti, M. P., Horton, R. M., Hoppe, B. L., Howard J., J. & Conti-Fine, B. M., 1998, In : Annals of the New York Academy of Sciences. 841, p. 324-328 5 p.

Research output: Contribution to journalArticle

Human melanoma cells transfected with the B7-2 co-stimulatory molecule induce tumor-specific CD8+ cytotoxic T lymphocytes in vitro

Imro, M. A., Dellabona, P., Manici, S., Heltai, S., Consogno, G., Bellone, M., Rugarli, C. & Protti, M. P., Jun 10 1998, In : Human Gene Therapy. 9, 9, p. 1335-1344 10 p.

Research output: Contribution to journalArticle

Immunotherapy: natural versus synthetic peptides.

Protti, M. P. & Bellone, M., Feb 1998, In : Immunology Today. 19, 2, p. 98 1 p.

Research output: Contribution to journalArticle

1997

Processing of Engulfed Apoptotic Bodies Yields T Cell Epitopes

Bellone, M., Iezzi, G., Rovere, P., Galati, G., Ronchetti, A., Protti, M. P., Davoust, J., Rugarli, C. & Manfredi, A. A., Dec 1 1997, In : Journal of Immunology. 159, 11, p. 5391-5399 9 p.

Research output: Contribution to journalArticle

Rejection of a Nonimmunogenic Melanoma by Vaccination with Natural Melanoma Peptides on Engineered Antigen-Presenting Cells

Bellone, M., Iezzi, G., Martin-Fontecha, A., Rivolta, L., Manfredi, A. A., Protti, M. P., Freschi, M., Dellabona, P., Casorati, G. & Rugarli, C., Jan 15 1997, In : Journal of Immunology. 158, 2, p. 783-789 7 p.

Research output: Contribution to journalArticle

TCR Vβ usage by acetylcholine receptor-specific CD4+ T cells in myasthenia gravis

Raju, R., Navaneetham, D., Protti, M. P., Norton, R. M., Hoppe, B. L., Howard, J. & Conti-Fine, B. M., Apr 1997, In : Journal of Autoimmunity. 10, 2, p. 203-217 15 p.

Research output: Contribution to journalArticle

The immunogenicity of experimental tumors is strongly biased by the expression of dominant viral cytotoxic T-lymphocyte epitopes

Iezzi, G., Rivolta, L., Ronchetti, A., Martin-Fontecha, A., Rosato, A., Protti, M. P., Sabbadini, M. G. & Bellone, M., Jul 1 1997, In : Cancer Research. 57, 13, p. 2564-2568 5 p.

Research output: Contribution to journalArticle

1996

Particulate naturally processed peptides prime a cytotoxic response against human melanoma in vitro

Protti, M. P., Imro, M. A., Manfredi, A. A., Consogno, G., Heltai, S., Arcelloni, C., Bellone, M., Dellabona, P., Casorati, G. & Rugarli, C., Mar 15 1996, In : Cancer Research. 56, 6, p. 1210-1213 4 p.

Research output: Contribution to journalArticle