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Research Output 1997 2019

2019

Anaerobic Threshold and Respiratory Compensation Point Identification During Cardiopulmonary Exercise Tests in Chronic Heart Failure

Carriere, C., Corrà, U., Piepoli, M., Bonomi, A., Merlo, M., Barbieri, S., Salvioni, E., Binno, S., Mapelli, M., Righini, F., Sciomer, S., Vignati, C., Moscucci, F., Veglia, F., Sinagra, G. & Agostoni, P., 2019, In : Chest. 156, 2, p. 338-347 10 p.

Research output: Contribution to journalArticle

Heart failure prognosis over time: how the prognostic role of oxygen consumption and ventilatory efficiency during exercise has changed in the last 20 years

Paolillo, S., Veglia, F., Salvioni, E., Corrà, U., Piepoli, M., Lagioia, R., Limongelli, G., Sinagra, G., Cattadori, G., Scardovi, A. B., Metra, M., Senni, M., Bonomi, A., Scrutinio, D., Raimondo, R., Emdin, M., Magrì, D., Parati, G., Re, F., Cicoira, M. & 59 others, Minà, C., Correale, M., Frigerio, M., Bussotti, M., Battaia, E., Guazzi, M., Badagliacca, R., Di Lenarda, A., Maggioni, A., Passino, C., Sciomer, S., Pacileo, G., Mapelli, M., Vignati, C., Clemenza, F., Binno, S., Lombardi, C., Filardi, P. P., Agostoni, P., Apostolo, A., Palermo, P., Contini, M., Farina, S., Mantegazza, V., Spadafora, E., Lattarulo, M. S., Giordano, A., Mezzani, A., Ricci, R., Ferraironi, A., Carubelli, V., Pietrucci, F., Malfatto, G., Caravita, S., Viganò, E., Valente, F., Vastarella, R., Gravino, R., Roselli, T., Buono, A., De Maria, R., Passantino, A., Santoro, D., Campanale, S., Caputo, D., Bertipaglia, D., Confalonieri, M., Gentile, P., Zambon, E., Morosin, M., Carriere, C., Ferraretti, A., Marchese, G., Iorio, A., Pastormerlo, L., Gargiulo, P., Villani, G. Q., Oliva, F. & Perna, E., 2019, In : European Journal of Heart Failure. 21, 2, p. 208-217 10 p.

Research output: Contribution to journalArticle

2018

A Numb-Mdm2 fuzzy complex reveals an isoformspecific involvement of Numb in breast cancer

Colaluca, I. N., Basile, A., Freiburger, L., D'Uva, V., Disalvatore, D., Vecchi, M., Confalonieri, S., Tosoni, D., Cecatiello, V., Malabarba, M. G., Yang, C. J., Kainosho, M., Sattler, M., Mapelli, M., Pece, S. & di Fiore, P. P., Feb 1 2018, In : Journal of Cell Biology. 217, 2, p. 745-762 18 p.

Research output: Contribution to journalArticle

Exons
Breast Neoplasms
Protein Isoforms
Ubiquitin-Protein Ligases
Homeostasis

Insc:LGN tetramers promote asymmetric divisions of mammary stem cells

Culurgioni, S., Mari, S., Bonetti, P., Gallini, S., Bonetto, G., Brennich, M., Round, A., Nicassio, F. & Mapelli, M., Dec 1 2018, In : Nature Communications. 9, 1, 1025.

Research output: Contribution to journalArticle

Asymmetric Cell Division
stem cells
Stem cells
division
Breast
2017

Heart failure and anemia: Effects on prognostic variables

Cattadori, G., Agostoni, P., Corrà, U., Sinagra, G., Veglia, F., Salvioni, E., Bonomi, A., La Gioia, R., Scardovi, A. B., Ferraironi, A., Emdin, M., Metra, M., Di Lenarda, A., Limongelli, G., Raimondo, R., Re, F., Guazzi, M., Belardinelli, R., Parati, G., Caravita, S. & 30 others, Magrì, D., Lombardi, C., Frigerio, M., Oliva, F., Girola, D., Mezzani, A., Farina, S., Mapelli, M., Scrutinio, D., Pacileo, G., Apostolo, A., Iorio, A., Paolillo, S., Filardi, P. P., Gargiulo, P., Bussotti, M., Marchese, G., Correale, M., Badagliacca, R., Sciomer, S., Palermo, P., Contini, M., Giannuzzi, P., Battaia, E., Cicoira, M., Clemenza, F., Minà, C., Binno, S., Passino, C. & Piepoli, M. F., Jan 2017, In : European Journal of Internal Medicine. 37, p. 56-63 8 p.

Research output: Contribution to journalArticle

Heart failure and anemia: Effects on prognostic variables

Cattadori, G., Agostoni, P., Corrà, U., Sinagra, G., Veglia, F., Salvioni, E., Bonomi, A., La Gioia, R., Scardovi, A. B., Ferraironi, A., Emdin, M., Metra, M., Di Lenarda, A., Limongelli, G., Raimondo, R., Re, F., Guazzi, M., Belardinelli, R., Parati, G., Caravita, S. & 30 others, Magrì, D., Lombardi, C., Frigerio, M., Oliva, F., Girola, D., Mezzani, A., Farina, S., Mapelli, M., Scrutinio, D., Pacileo, G., Apostolo, A., Iorio, A., Paolillo, S., Filardi, P. P., Gargiulo, P., Bussotti, M., Marchese, G., Correale, M., Badagliacca, R., Sciomer, S., Palermo, P., Contini, M., Giannuzzi, P., Battaia, E., Cicoira, M., Clemenza, F., Minà, C., Binno, S., Passino, C. & Piepoli, M. F., 2017, In : European Journal of Internal Medicine. 37, p. 56-63 8 p.

Research output: Contribution to journalArticle

Loss of the canonical spindle orientation function in the Pins/LGN homolog AGS3

Saadaoui, M., Konno, D., Loulier, K., Goiame, R., Jadhav, V., Mapelli, M., Matsuzaki, F. & Morin, X., Sep 1 2017, In : EMBO Reports. 18, 9, p. 1509-1520 12 p.

Research output: Contribution to journalArticle

Drosophila
Vertebrates
Spindle Apparatus
Neocortex
Microtubules

Prognostic role of β-blocker selectivity and dosage regimens in heart failure patients. Insights from the MECKI score database

Paolillo, S., Mapelli, M., Bonomi, A., Corrà, U., Piepoli, M., Veglia, F., Salvioni, E., Gentile, P., Lagioia, R., Metra, M., Limongelli, G., Sinagra, G., Cattadori, G., Scardovi, A. B., Carubelli, V., Scrutino, D., Badagliacca, R., Raimondo, R., Emdin, M., Magrì, D. & 30 others, Correale, M., Parati, G., Caravita, S., Spadafora, E., Re, F., Cicoira, M., Frigerio, M., Bussotti, M., Minà, C., Oliva, F., Battaia, E., Belardinelli, R., Mezzani, A., Pastormerlo, L., Di Lenarda, A., Passino, C., Sciomer, S., Iorio, A., Zambon, E., Guazzi, M., Pacileo, G., Ricci, R., Contini, M., Apostolo, A., Palermo, P., Clemenza, F., Marchese, G., Lombardi, C., Passantino, A. & Agostoni, P., 2017, In : European Journal of Heart Failure. 19, 7, p. 904-914 11 p.

Research output: Contribution to journalArticle

Heart Failure
Databases
Heart-Assist Devices
Heart Transplantation
Treatment Failure

Reference Values for Peak Exercise Cardiac Output in Healthy Individuals

Agostoni, P., Vignati, C., Gentile, P., Boiti, C., Farina, S., Salvioni, E., Mapelli, M., Magrì, D., Paolillo, S., Corrieri, N., Sinagra, G. & Cattadori, G., 2017, In : Chest. 151, 6, p. 1329-1337 9 p.

Research output: Contribution to journalArticle

Cardiac Output
Reference Values
Exercise
Noble Gases
Exercise Test
2016

Concomitant binding of Afadin to LGN and F-actin directs planar spindle orientation

Carminati, M., Gallini, S., Pirovano, L., Alfieri, A., Bisi, S. & Mapelli, M., Feb 3 2016, In : Nature Structural and Molecular Biology. 23, 2, p. 155-163 9 p.

Research output: Contribution to journalArticle

Actins
Dyneins
Spindle Apparatus
Spindle Poles
Microtubule Proteins
Microfilament Proteins
Crystallization
X-Ray Diffraction
crystallization
proteins

Diverse functions of myosin VI elucidated by an isoform-specific α-helix domain

Wollscheid, H. P., Biancospino, M., He, F., Magistrati, E., Molteni, E., Lupia, M., Soffientini, P., Rottner, K., Cavallaro, U., Pozzoli, U., Mapelli, M., Walters, K. J. & Polo, S., Apr 5 2016, In : Nature Structural and Molecular Biology. 23, 4, p. 300-308 9 p.

Research output: Contribution to journalArticle

Protein Isoforms
Cell Movement
myosin VI
Clathrin
Alternative Splicing

Diverse functions of myosin VI elucidated by an isoform-specific α-helix domain

Wollscheid, H. P., Biancospino, M., He, F., Magistrati, E., Molteni, E., Lupia, M., Soffientini, P., Rottner, K., Cavallaro, U., Pozzoli, U., Mapelli, M., Walters, K. J. & Polo, S., Apr 5 2016, In : Nature Structural and Molecular Biology. 23, 4, p. 300-308 9 p.

Research output: Contribution to journalArticle

Protein Isoforms
Cell Movement
myosin VI
Clathrin
Alternative Splicing

NuMA phosphorylation by aurora-a orchestrates spindle orientation

Gallini, S., Carminati, M., De Mattia, F., Pirovano, L., Martini, E., Oldani, A., Asteriti, I. A., Guarguaglini, G. & Mapelli, M., Feb 22 2016, In : Current Biology. 26, 4, p. 458-469 12 p.

Research output: Contribution to journalArticle

Dyneins
Phosphorylation
Microtubules
microtubules
Poles
2015

Dichotomy of short and long thymic stromal lymphopoietin isoforms in inflammatory disorders of the bowel and skin

Fornasa, G., Tsilingiri, K., Caprioli, F., Botti, F., Mapelli, M., Meller, S., Kislat, A., Homey, B., Di Sabatino, A., Sonzogni, A., Viale, G., Diaferia, G., Gori, A., Longhi, R., Penna, G. & Rescigno, M., Aug 1 2015, In : Journal of Allergy and Clinical Immunology. 136, 2, p. 413-422 10 p.

Research output: Contribution to journalArticle

Protein Isoforms
Skin
thymic stromal lymphopoietin
Cytokines
Introduced Species

The Drosophila TNF receptor Grindelwald couples loss of cell polarity and neoplastic growth

Andersen, D. S., Colombani, J., Palmerini, V., Chakrabandhu, K., Boone, E., Röthlisberger, M., Toggweiler, J., Basler, K., Mapelli, M., Hueber, A. O. & Léopold, P., Jun 25 2015, In : Nature. 522, 7557, p. 482-486 5 p.

Research output: Contribution to journalArticle

Cell Polarity
Tumor Necrosis Factor Receptors
Drosophila
Growth
Neoplasms
2014

p600 regulates spindle orientation in apical neural progenitors and contributes to neurogenesis in the developing neocortex

Belzil, C., Asada, N., Ishiguro, K. I., Nakaya, T., Parsons, K., Pendolino, V., Neumayer, G., Mapelli, M., Nakatani, Y., Sanada, K. & Nguyen, M. D., Jun 15 2014, In : Biology Open. 3, 6, p. 475-485 11 p.

Research output: Contribution to journalArticle

neocortex
neurogenesis
Neocortex
Neurogenesis
Proteins
2013

Going vertical: Functional role and working principles of the protein Inscuteable in asymmetric cell divisions

Culurgioni, S. & Mapelli, M., Nov 2013, In : Cellular and Molecular Life Sciences. 70, 21, p. 4039-4046 8 p.

Research output: Contribution to journalArticle

Asymmetric Cell Division
Ependymoglial Cells
Macromolecular Substances
Spindle Apparatus
Keratinocytes
2012
Competitive Binding
Asymmetric Cell Division
Macromolecular Substances
Spindle Apparatus
Mitosis

On WD40 proteins propelling our knowledge of transcriptional control?

Migliori, V., Mapelli, M. & Guccione, E., Aug 2012, In : Epigenetics. 7, 8, p. 815-822 8 p.

Research output: Contribution to journalArticle

Histones
Lysine
Arginine
Post Translational Protein Processing
Chromatin

Symmetric dimethylation of H3R2 is a newly identified histone mark that supports euchromatin maintenance

Migliori, V., Müller, J., Phalke, S., Low, D., Bezzi, M., Mok, W. C., Sahu, S. K., Gunaratne, J., Capasso, P., Bassi, C., Cecatiello, V., De Marco, A., Blackstock, W., Kuznetsov, V., Amati, B., Mapelli, M. & Guccione, E., Feb 2012, In : Nature Structural and Molecular Biology. 19, 2, p. 136-145 10 p.

Research output: Contribution to journalArticle

Histone Code
Euchromatin
Histones
Maintenance
Co-Repressor Proteins
2011

Inscuteable and NuMA proteins bind competitively to Leu-Gly-Asn repeat-enriched protein (LGN) during asymmetric cell divisions

Culurgioni, S., Alfieri, A., Pendolino, V., Laddomada, F. & Mapelli, M., Dec 27 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 52, p. 20998-21003 6 p.

Research output: Contribution to journalArticle

Asymmetric Cell Division
Drosophila
Epithelial Cells
Proteins
In Vitro Techniques
2009

The influence of catalysis on Mad2 activation dynamics

Simonetta, M., Manzoni, R., Mosca, R., Mapelli, M., Massimiliano, L., Vink, M., Novak, B., Musacchio, A. & Ciliberto, A., Jan 2009, In : PLoS Biology. 7, 1, e1000010.

Research output: Contribution to journalArticle

dimerization
Dimerization
Catalysis
catalytic activity
Chemical activation
2008

Cdk5 is essential for adult hippocampal neurogenesis

Lagace, D. C., Benavides, D. R., Kansy, J. W., Mapelli, M., Greengard, P., Bibb, J. A. & Eisch, A. J., Nov 25 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 47, p. 18567-18571 5 p.

Research output: Contribution to journalArticle

Cyclin-Dependent Kinase 5
Neurogenesis
Neurons
Dentate Gyrus
Stem Cells
2007

MAD contortions: conformational dimerization boosts spindle checkpoint signaling

Mapelli, M. & Musacchio, A., Dec 2007, In : Current Opinion in Structural Biology. 17, 6, p. 716-725 10 p.

Research output: Contribution to journalArticle

M Phase Cell Cycle Checkpoints
Dimerization
Kinetochores
Proteins
mycophenolic adenine dinucleotide

The Mad2 Conformational Dimer: Structure and Implications for the Spindle Assembly Checkpoint

Mapelli, M., Massimiliano, L., Santaguida, S. & Musacchio, A., Nov 16 2007, In : Cell. 131, 4, p. 730-743 14 p.

Research output: Contribution to journalArticle

Mad2 Proteins
M Phase Cell Cycle Checkpoints
Chromosome Segregation
Dimerization
Mitosis
2006

Crystal Structure of the Ubiquitin Binding Domains of Rabex-5 Reveals Two Modes of Interaction with Ubiquitin

Penengo, L., Mapelli, M., Murachelli, A. G., Confalonieri, S., Magri, L., Musacchio, A., Di Fiore, P. P., Polo, S. & Schneider, T. R., Mar 24 2006, In : Cell. 124, 6, p. 1183-1195 13 p.

Research output: Contribution to journalArticle

Ubiquitin
Crystal structure
Ubiquitinated Proteins
Guanine Nucleotide Exchange Factors
Zinc Fingers

Determinants of conformational dimerization of Mad2 and its inhibition by p31comet

Mapelli, M., Filipp, F. V., Rancati, G., Massimiliano, L., Nezi, L., Stier, G., Hagan, R. S., Confalonieri, S., Piatti, S., Sattler, M. & Musacchio, A., Mar 22 2006, In : EMBO Journal. 25, 6, p. 1273-1284 12 p.

Research output: Contribution to journalArticle

M Phase Cell Cycle Checkpoints
Dimerization
Kinetochores
Chromosomes
Microtubules

In Vitro FRAP Identifies the Minimal Requirements for Mad2 Kinetochore Dynamics

Vink, M., Simonetta, M., Transidico, P., Ferrari, K., Mapelli, M., De Antoni, A., Massimiliano, L., Ciliberto, A., Faretta, M., Salmon, E. D. & Musacchio, A., Apr 18 2006, In : Current Biology. 16, 8, p. 755-766 12 p.

Research output: Contribution to journalArticle

Fluorescence Recovery After Photobleaching
Kinetochores
Photobleaching
kinetochores
Fluorescence
2005

Defining Cdk5 ligand chemical space with small molecule inhibitors of tau phosphorylation

Ahn, J. S., Radhakrishnan, M. L., Mapelli, M., Choi, S., Tidor, B., Cuny, G. D., Musacchio, A., Yeh, L. A. & Kosik, K. S., Jul 2005, In : Chemistry and Biology. 12, 7, p. 811-823 13 p.

Research output: Contribution to journalArticle

Cyclin-Dependent Kinase 5
Phosphorylation
Adenosine Triphosphate
Ligands
Molecules

Mechanism of Aurora B activation by INCENP and inhibition by hesperadin

Sessa, F., Mapelli, M., Ciferri, C., Tarricone, C., Areces, L. B., Schneider, T. R., Stukenberg, P. T. & Musacchio, A., Apr 29 2005, In : Molecular Cell. 18, 3, p. 379-391 13 p.

Research output: Contribution to journalArticle

Centromere
Centromere Protein B
Phosphotransferases
Aurora Kinases
Proteins

Mechanism of CDK5/p25 binding by CDK inhibitors

Mapelli, M., Massimiliano, L., Crovace, C., Seeliger, M. A., Tsai, L. H., Meijer, L. & Musacchio, A., Feb 10 2005, In : Journal of Medicinal Chemistry. 48, 3, p. 671-679 9 p.

Research output: Contribution to journalArticle

Cyclin-Dependent Kinases
Glycine
Crystals
Type C Niemann-Pick Disease
Neurodegenerative diseases

Molecular basis for the specificity of p27 toward cyclin-dependent kinases that regulate cell division

Lacy, E. R., Wang, Y., Post, J., Nourse, A., Webb, W., Mapelli, M., Musacchio, A., Siuzdak, G. & Kriwacki, R. W., Jun 17 2005, In : Journal of Molecular Biology. 349, 4, p. 764-773 10 p.

Research output: Contribution to journalArticle

Cyclin A
Cyclins
Cyclin-Dependent Kinases
Cell Division
Cyclin-Dependent Kinase Inhibitor p27
Single-Stranded DNA
Human Herpesvirus 1
Viruses
Carrier Proteins
Crystal structure

The Mad1/Mad2 complex as a template for Mad2 activation in the spindle assembly checkpoint

De Antoni, A., Pearson, C. G., Cimini, D., Canman, J. C., Sala, V., Nezi, L., Mapelli, M., Sironi, L., Faretta, M., Salmon, E. D. & Musacchio, A., Feb 8 2005, In : Current Biology. 15, 3, p. 214-225 12 p.

Research output: Contribution to journalArticle

M Phase Cell Cycle Checkpoints
Kinetochores
kinetochores
Chemical activation
Anaphase
2004

Development of an assay to screen for inhibitors of tau phosphorylation by Cdk5

Ahn, J. S., Musacchio, A., Mapelli, M., Ni, J., Scinto, L., Stein, R., Kosik, K. S. & Yeh, L. A., Mar 2004, In : Journal of Biomolecular Screening. 9, 2, p. 122-131 10 p.

Research output: Contribution to journalArticle

Phosphorylation
Assays
Epitopes
Serine
Throughput
2003

The structural perspective on CDK5

Mapelli, M. & Musacchio, A., 2003, In : NeuroSignals. 12, 4-5, p. 164-172 9 p.

Research output: Contribution to journalArticle

Cyclin-Dependent Kinase 5
Amyotrophic Lateral Sclerosis
Neurodegenerative Diseases
Embryonic Development
Alzheimer Disease
2002

Crystal structure of the tetrameric Mad1-Mad2 core complex: Implications of a 'safety belt' binding mechanism for the spindle checkpoint

Sironi, L., Mapelli, M., Knapp, S., De Antoni, A., Jeang, K. T. & Musacchio, A., May 15 2002, In : EMBO Journal. 21, 10, p. 2496-2506 11 p.

Research output: Contribution to journalArticle

Crystal structure
Ligands
Safety
Kinetochores
Binding energy

Elastomeric polymers. 1. Application of proton NMR imaging to the morphological study of a silicone rubber

Gussoni, M., Greco, F., Mapelli, M., Vezzoli, A., Ranucci, E., Ferruti, P. & Zetta, L., Feb 26 2002, In : Macromolecules. 35, 5, p. 1714-1721 8 p.

Research output: Contribution to journalArticle

Silicone Elastomers
Silicones
Protons
Rubber
Polymers

Elastomeric polymers. 2. NMR and NMR imaging characterization of cross-linked PDMS

Gussoni, M., Greco, F., Mapelli, M., Vezzoli, A., Ranucci, E., Ferruti, P. & Zetta, L., Feb 26 2002, In : Macromolecules. 35, 5, p. 1722-1729 8 p.

Research output: Contribution to journalArticle

Polymers
Nuclear magnetic resonance
Imaging techniques
Silicon Dioxide
Silicones
2000

The 60-residue C-terminal region of the single-stranded DNA binding protein of herpes simplex virus type 1 is required for cooperative DNA binding

Mapelli, M., Muhleisen, M., Persico, G., Van Der Zandt, H. & Tucker, P. A., 2000, In : Journal of Virology. 74, 19, p. 8812-8822 11 p.

Research output: Contribution to journalArticle

Human herpesvirus 1
single-stranded DNA
DNA-binding proteins
Single-Stranded DNA
DNA-Binding Proteins
1999
DNA-Binding Proteins
Human Herpesvirus 1
Crystallization
X-Rays
Amino Acids
1997

Application of NMR microscopy to the morphological study of the silkworm, Bombyx mori, during its metamorphosis

Mapelli, M., Greco, F., Gussoni, M., Consonni, R. & Zetta, L., 1997, In : Magnetic Resonance Imaging. 15, 6, p. 693-700 8 p.

Research output: Contribution to journalArticle

silkworms
silk
glands
Bombyx
Silk