19972019

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Anaerobic Threshold and Respiratory Compensation Point Identification During Cardiopulmonary Exercise Tests in Chronic Heart Failure

Carriere, C., Corrà, U., Piepoli, M., Bonomi, A., Merlo, M., Barbieri, S., Salvioni, E., Binno, S., Mapelli, M., Righini, F., Sciomer, S., Vignati, C., Moscucci, F., Veglia, F., Sinagra, G. & Agostoni, P., 2019, In : Chest. 156, 2, p. 338-347 10 p.

Research output: Contribution to journalArticle

A Numb-Mdm2 fuzzy complex reveals an isoformspecific involvement of Numb in breast cancer

Colaluca, I. N., Basile, A., Freiburger, L., D'Uva, V., Disalvatore, D., Vecchi, M., Confalonieri, S., Tosoni, D., Cecatiello, V., Malabarba, M. G., Yang, C. J., Kainosho, M., Sattler, M., Mapelli, M., Pece, S. & di Fiore, P. P., Feb 1 2018, In : Journal of Cell Biology. 217, 2, p. 745-762 18 p.

Research output: Contribution to journalArticle

Application of NMR microscopy to the morphological study of the silkworm, Bombyx mori, during its metamorphosis

Mapelli, M., Greco, F., Gussoni, M., Consonni, R. & Zetta, L., 1997, In : Magnetic Resonance Imaging. 15, 6, p. 693-700 8 p.

Research output: Contribution to journalArticle

Cdk5 is essential for adult hippocampal neurogenesis

Lagace, D. C., Benavides, D. R., Kansy, J. W., Mapelli, M., Greengard, P., Bibb, J. A. & Eisch, A. J., Nov 25 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 47, p. 18567-18571 5 p.

Research output: Contribution to journalArticle

Concomitant binding of Afadin to LGN and F-actin directs planar spindle orientation

Carminati, M., Gallini, S., Pirovano, L., Alfieri, A., Bisi, S. & Mapelli, M., Feb 3 2016, In : Nature Structural and Molecular Biology. 23, 2, p. 155-163 9 p.

Research output: Contribution to journalArticle

Crystal structure of the tetrameric Mad1-Mad2 core complex: Implications of a 'safety belt' binding mechanism for the spindle checkpoint

Sironi, L., Mapelli, M., Knapp, S., De Antoni, A., Jeang, K. T. & Musacchio, A., May 15 2002, In : EMBO Journal. 21, 10, p. 2496-2506 11 p.

Research output: Contribution to journalArticle

Crystal Structure of the Ubiquitin Binding Domains of Rabex-5 Reveals Two Modes of Interaction with Ubiquitin

Penengo, L., Mapelli, M., Murachelli, A. G., Confalonieri, S., Magri, L., Musacchio, A., Di Fiore, P. P., Polo, S. & Schneider, T. R., Mar 24 2006, In : Cell. 124, 6, p. 1183-1195 13 p.

Research output: Contribution to journalArticle

Defining Cdk5 ligand chemical space with small molecule inhibitors of tau phosphorylation

Ahn, J. S., Radhakrishnan, M. L., Mapelli, M., Choi, S., Tidor, B., Cuny, G. D., Musacchio, A., Yeh, L. A. & Kosik, K. S., Jul 2005, In : Chemistry and Biology. 12, 7, p. 811-823 13 p.

Research output: Contribution to journalArticle

Determinants of conformational dimerization of Mad2 and its inhibition by p31comet

Mapelli, M., Filipp, F. V., Rancati, G., Massimiliano, L., Nezi, L., Stier, G., Hagan, R. S., Confalonieri, S., Piatti, S., Sattler, M. & Musacchio, A., Mar 22 2006, In : EMBO Journal. 25, 6, p. 1273-1284 12 p.

Research output: Contribution to journalArticle

Development of an assay to screen for inhibitors of tau phosphorylation by Cdk5

Ahn, J. S., Musacchio, A., Mapelli, M., Ni, J., Scinto, L., Stein, R., Kosik, K. S. & Yeh, L. A., Mar 2004, In : Journal of Biomolecular Screening. 9, 2, p. 122-131 10 p.

Research output: Contribution to journalArticle

Dichotomy of short and long thymic stromal lymphopoietin isoforms in inflammatory disorders of the bowel and skin

Fornasa, G., Tsilingiri, K., Caprioli, F., Botti, F., Mapelli, M., Meller, S., Kislat, A., Homey, B., Di Sabatino, A., Sonzogni, A., Viale, G., Diaferia, G., Gori, A., Longhi, R., Penna, G. & Rescigno, M., Aug 1 2015, In : Journal of Allergy and Clinical Immunology. 136, 2, p. 413-422 10 p.

Research output: Contribution to journalArticle

Diverse functions of myosin VI elucidated by an isoform-specific α-helix domain

Wollscheid, H. P., Biancospino, M., He, F., Magistrati, E., Molteni, E., Lupia, M., Soffientini, P., Rottner, K., Cavallaro, U., Pozzoli, U., Mapelli, M., Walters, K. J. & Polo, S., Apr 5 2016, In : Nature Structural and Molecular Biology. 23, 4, p. 300-308 9 p.

Research output: Contribution to journalArticle

Diverse functions of myosin VI elucidated by an isoform-specific α-helix domain

Wollscheid, H. P., Biancospino, M., He, F., Magistrati, E., Molteni, E., Lupia, M., Soffientini, P., Rottner, K., Cavallaro, U., Pozzoli, U., Mapelli, M., Walters, K. J. & Polo, S., Apr 5 2016, In : Nature Structural and Molecular Biology. 23, 4, p. 300-308 9 p.

Research output: Contribution to journalArticle

Elastomeric polymers. 1. Application of proton NMR imaging to the morphological study of a silicone rubber

Gussoni, M., Greco, F., Mapelli, M., Vezzoli, A., Ranucci, E., Ferruti, P. & Zetta, L., Feb 26 2002, In : Macromolecules. 35, 5, p. 1714-1721 8 p.

Research output: Contribution to journalArticle

Elastomeric polymers. 2. NMR and NMR imaging characterization of cross-linked PDMS

Gussoni, M., Greco, F., Mapelli, M., Vezzoli, A., Ranucci, E., Ferruti, P. & Zetta, L., Feb 26 2002, In : Macromolecules. 35, 5, p. 1722-1729 8 p.

Research output: Contribution to journalArticle

Going vertical: Functional role and working principles of the protein Inscuteable in asymmetric cell divisions

Culurgioni, S. & Mapelli, M., Nov 2013, In : Cellular and Molecular Life Sciences. 70, 21, p. 4039-4046 8 p.

Research output: Contribution to journalArticle

Heart failure and anemia: Effects on prognostic variables

Cattadori, G., Agostoni, P., Corrà, U., Sinagra, G., Veglia, F., Salvioni, E., Bonomi, A., La Gioia, R., Scardovi, A. B., Ferraironi, A., Emdin, M., Metra, M., Di Lenarda, A., Limongelli, G., Raimondo, R., Re, F., Guazzi, M., Belardinelli, R., Parati, G., Caravita, S. & 30 others, Magrì, D., Lombardi, C., Frigerio, M., Oliva, F., Girola, D., Mezzani, A., Farina, S., Mapelli, M., Scrutinio, D., Pacileo, G., Apostolo, A., Iorio, A., Paolillo, S., Filardi, P. P., Gargiulo, P., Bussotti, M., Marchese, G., Correale, M., Badagliacca, R., Sciomer, S., Palermo, P., Contini, M., Giannuzzi, P., Battaia, E., Cicoira, M., Clemenza, F., Minà, C., Binno, S., Passino, C. & Piepoli, M. F., 2017, In : European Journal of Internal Medicine. 37, p. 56-63 8 p.

Research output: Contribution to journalArticle

Heart failure and anemia: Effects on prognostic variables

Cattadori, G., Agostoni, P., Corrà, U., Sinagra, G., Veglia, F., Salvioni, E., Bonomi, A., La Gioia, R., Scardovi, A. B., Ferraironi, A., Emdin, M., Metra, M., Di Lenarda, A., Limongelli, G., Raimondo, R., Re, F., Guazzi, M., Belardinelli, R., Parati, G., Caravita, S. & 30 others, Magrì, D., Lombardi, C., Frigerio, M., Oliva, F., Girola, D., Mezzani, A., Farina, S., Mapelli, M., Scrutinio, D., Pacileo, G., Apostolo, A., Iorio, A., Paolillo, S., Filardi, P. P., Gargiulo, P., Bussotti, M., Marchese, G., Correale, M., Badagliacca, R., Sciomer, S., Palermo, P., Contini, M., Giannuzzi, P., Battaia, E., Cicoira, M., Clemenza, F., Minà, C., Binno, S., Passino, C. & Piepoli, M. F., Jan 2017, In : European Journal of Internal Medicine. 37, p. 56-63 8 p.

Research output: Contribution to journalArticle

Heart failure prognosis over time: how the prognostic role of oxygen consumption and ventilatory efficiency during exercise has changed in the last 20 years

Paolillo, S., Veglia, F., Salvioni, E., Corrà, U., Piepoli, M., Lagioia, R., Limongelli, G., Sinagra, G., Cattadori, G., Scardovi, A. B., Metra, M., Senni, M., Bonomi, A., Scrutinio, D., Raimondo, R., Emdin, M., Magrì, D., Parati, G., Re, F., Cicoira, M. & 59 others, Minà, C., Correale, M., Frigerio, M., Bussotti, M., Battaia, E., Guazzi, M., Badagliacca, R., Di Lenarda, A., Maggioni, A., Passino, C., Sciomer, S., Pacileo, G., Mapelli, M., Vignati, C., Clemenza, F., Binno, S., Lombardi, C., Filardi, P. P., Agostoni, P., Apostolo, A., Palermo, P., Contini, M., Farina, S., Mantegazza, V., Spadafora, E., Lattarulo, M. S., Giordano, A., Mezzani, A., Ricci, R., Ferraironi, A., Carubelli, V., Pietrucci, F., Malfatto, G., Caravita, S., Viganò, E., Valente, F., Vastarella, R., Gravino, R., Roselli, T., Buono, A., De Maria, R., Passantino, A., Santoro, D., Campanale, S., Caputo, D., Bertipaglia, D., Confalonieri, M., Gentile, P., Zambon, E., Morosin, M., Carriere, C., Ferraretti, A., Marchese, G., Iorio, A., Pastormerlo, L., Gargiulo, P., Villani, G. Q., Oliva, F. & Perna, E., 2019, In : European Journal of Heart Failure. 21, 2, p. 208-217 10 p.

Research output: Contribution to journalArticle

Hexameric NuMA:LGN structures promote multivalent interactions required for planar epithelial divisions

Pirovano, L., Culurgioni, S., Carminati, M., Alfieri, A., Monzani, S., Cecatiello, V., Gaddoni, C., Rizzelli, F., Foadi, J., Pasqualato, S. & Mapelli, M., Dec 1 2019, In : Nature Communications. 10, 1, 2208.

Research output: Contribution to journalArticle

Open Access

Insc:LGN tetramers promote asymmetric divisions of mammary stem cells

Culurgioni, S., Mari, S., Bonetti, P., Gallini, S., Bonetto, G., Brennich, M., Round, A., Nicassio, F. & Mapelli, M., Dec 1 2018, In : Nature Communications. 9, 1, 1025.

Research output: Contribution to journalArticle

Inscuteable and NuMA proteins bind competitively to Leu-Gly-Asn repeat-enriched protein (LGN) during asymmetric cell divisions

Culurgioni, S., Alfieri, A., Pendolino, V., Laddomada, F. & Mapelli, M., Dec 27 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 52, p. 20998-21003 6 p.

Research output: Contribution to journalArticle

In Vitro FRAP Identifies the Minimal Requirements for Mad2 Kinetochore Dynamics

Vink, M., Simonetta, M., Transidico, P., Ferrari, K., Mapelli, M., De Antoni, A., Massimiliano, L., Ciliberto, A., Faretta, M., Salmon, E. D. & Musacchio, A., Apr 18 2006, In : Current Biology. 16, 8, p. 755-766 12 p.

Research output: Contribution to journalArticle

Loss of the canonical spindle orientation function in the Pins/LGN homolog AGS3

Saadaoui, M., Konno, D., Loulier, K., Goiame, R., Jadhav, V., Mapelli, M., Matsuzaki, F. & Morin, X., Sep 1 2017, In : EMBO Reports. 18, 9, p. 1509-1520 12 p.

Research output: Contribution to journalArticle

MAD contortions: conformational dimerization boosts spindle checkpoint signaling

Mapelli, M. & Musacchio, A., Dec 2007, In : Current Opinion in Structural Biology. 17, 6, p. 716-725 10 p.

Research output: Contribution to journalArticle

Mechanism of Aurora B activation by INCENP and inhibition by hesperadin

Sessa, F., Mapelli, M., Ciferri, C., Tarricone, C., Areces, L. B., Schneider, T. R., Stukenberg, P. T. & Musacchio, A., Apr 29 2005, In : Molecular Cell. 18, 3, p. 379-391 13 p.

Research output: Contribution to journalArticle

Mechanism of CDK5/p25 binding by CDK inhibitors

Mapelli, M., Massimiliano, L., Crovace, C., Seeliger, M. A., Tsai, L. H., Meijer, L. & Musacchio, A., Feb 10 2005, In : Journal of Medicinal Chemistry. 48, 3, p. 671-679 9 p.

Research output: Contribution to journalArticle

Molecular basis for the specificity of p27 toward cyclin-dependent kinases that regulate cell division

Lacy, E. R., Wang, Y., Post, J., Nourse, A., Webb, W., Mapelli, M., Musacchio, A., Siuzdak, G. & Kriwacki, R. W., Jun 17 2005, In : Journal of Molecular Biology. 349, 4, p. 764-773 10 p.

Research output: Contribution to journalArticle

NuMA phosphorylation by aurora-a orchestrates spindle orientation

Gallini, S., Carminati, M., De Mattia, F., Pirovano, L., Martini, E., Oldani, A., Asteriti, I. A., Guarguaglini, G. & Mapelli, M., Feb 22 2016, In : Current Biology. 26, 4, p. 458-469 12 p.

Research output: Contribution to journalArticle

On WD40 proteins propelling our knowledge of transcriptional control?

Migliori, V., Mapelli, M. & Guccione, E., Aug 2012, In : Epigenetics. 7, 8, p. 815-822 8 p.

Research output: Contribution to journalArticle

p600 regulates spindle orientation in apical neural progenitors and contributes to neurogenesis in the developing neocortex

Belzil, C., Asada, N., Ishiguro, K. I., Nakaya, T., Parsons, K., Pendolino, V., Neumayer, G., Mapelli, M., Nakatani, Y., Sanada, K. & Nguyen, M. D., Jun 15 2014, In : Biology Open. 3, 6, p. 475-485 11 p.

Research output: Contribution to journalArticle

Prognostic role of β-blocker selectivity and dosage regimens in heart failure patients. Insights from the MECKI score database

Paolillo, S., Mapelli, M., Bonomi, A., Corrà, U., Piepoli, M., Veglia, F., Salvioni, E., Gentile, P., Lagioia, R., Metra, M., Limongelli, G., Sinagra, G., Cattadori, G., Scardovi, A. B., Carubelli, V., Scrutino, D., Badagliacca, R., Raimondo, R., Emdin, M., Magrì, D. & 30 others, Correale, M., Parati, G., Caravita, S., Spadafora, E., Re, F., Cicoira, M., Frigerio, M., Bussotti, M., Minà, C., Oliva, F., Battaia, E., Belardinelli, R., Mezzani, A., Pastormerlo, L., Di Lenarda, A., Passino, C., Sciomer, S., Iorio, A., Zambon, E., Guazzi, M., Pacileo, G., Ricci, R., Contini, M., Apostolo, A., Palermo, P., Clemenza, F., Marchese, G., Lombardi, C., Passantino, A. & Agostoni, P., 2017, In : European Journal of Heart Failure. 19, 7, p. 904-914 11 p.

Research output: Contribution to journalArticle

Reference Values for Peak Exercise Cardiac Output in Healthy Individuals

Agostoni, P., Vignati, C., Gentile, P., Boiti, C., Farina, S., Salvioni, E., Mapelli, M., Magrì, D., Paolillo, S., Corrieri, N., Sinagra, G. & Cattadori, G., 2017, In : Chest. 151, 6, p. 1329-1337 9 p.

Research output: Contribution to journalArticle

Symmetric dimethylation of H3R2 is a newly identified histone mark that supports euchromatin maintenance

Migliori, V., Müller, J., Phalke, S., Low, D., Bezzi, M., Mok, W. C., Sahu, S. K., Gunaratne, J., Capasso, P., Bassi, C., Cecatiello, V., De Marco, A., Blackstock, W., Kuznetsov, V., Amati, B., Mapelli, M. & Guccione, E., Feb 2012, In : Nature Structural and Molecular Biology. 19, 2, p. 136-145 10 p.

Research output: Contribution to journalArticle

The 60-residue C-terminal region of the single-stranded DNA binding protein of herpes simplex virus type 1 is required for cooperative DNA binding

Mapelli, M., Muhleisen, M., Persico, G., Van Der Zandt, H. & Tucker, P. A., 2000, In : Journal of Virology. 74, 19, p. 8812-8822 11 p.

Research output: Contribution to journalArticle

The Drosophila TNF receptor Grindelwald couples loss of cell polarity and neoplastic growth

Andersen, D. S., Colombani, J., Palmerini, V., Chakrabandhu, K., Boone, E., Röthlisberger, M., Toggweiler, J., Basler, K., Mapelli, M., Hueber, A. O. & Léopold, P., Jun 25 2015, In : Nature. 522, 7557, p. 482-486 5 p.

Research output: Contribution to journalArticle

The influence of catalysis on Mad2 activation dynamics

Simonetta, M., Manzoni, R., Mosca, R., Mapelli, M., Massimiliano, L., Vink, M., Novak, B., Musacchio, A. & Ciliberto, A., Jan 2009, In : PLoS Biology. 7, 1, e1000010.

Research output: Contribution to journalArticle

The Mad1/Mad2 complex as a template for Mad2 activation in the spindle assembly checkpoint

De Antoni, A., Pearson, C. G., Cimini, D., Canman, J. C., Sala, V., Nezi, L., Mapelli, M., Sironi, L., Faretta, M., Salmon, E. D. & Musacchio, A., Feb 8 2005, In : Current Biology. 15, 3, p. 214-225 12 p.

Research output: Contribution to journalArticle

The Mad2 Conformational Dimer: Structure and Implications for the Spindle Assembly Checkpoint

Mapelli, M., Massimiliano, L., Santaguida, S. & Musacchio, A., Nov 16 2007, In : Cell. 131, 4, p. 730-743 14 p.

Research output: Contribution to journalArticle

The structural perspective on CDK5

Mapelli, M. & Musacchio, A., 2003, In : NeuroSignals. 12, 4-5, p. 164-172 9 p.

Research output: Contribution to journalArticle