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Research Output

2019

Antibody-Fc/FcR interaction on macrophages as a mechanism for hyperprogressive disease in non-small cell lung cancer subsequent to PD-1/PD-L1 blockade

Russo, G. L., Moro, M., Sommariva, M., Cancila, V., Boeri, M., Centonze, G., Ferro, S., Ganzinelli, M., Gasparini, P., Huber, V., Milione, M., Porcu, L., Proto, C., Pruneri, G., Signorelli, D., Sangaletti, S., Sfondrini, L., Storti, C., Tassi, E., Bardelli, A. & 9 others, Marsoni, S., Torri, V., Tripodo, C., Colombo, M. P., Anichini, A., Rivoltini, L., Balsari, A., Sozzi, G. & Garassino, M. C., 2019, In : Clinical Cancer Research. 25, 3, p. 989-999 11 p.

Research output: Contribution to journalArticle

Association between antibiotic-immunotherapy exposure ratio and outcome in metastatic non small cell lung cancer

Galli, G., Triulzi, T., Proto, C., Signorelli, D., Imbimbo, M., Poggi, M., Fucà, G., Ganzinelli, M., Vitali, M., Palmieri, D., Tessari, A., de Braud, F., Garassino, M. C., Colombo, M. P. & Lo Russo, G., Jun 2019, In : Lung Cancer. 132, p. 72-78 7 p.

Research output: Contribution to journalArticle

Choosing wisely first line immunotherapy in non-small cell lung cancer (NSCLC): what to add and what to leave out

Proto, C., Ferrara, R., Signorelli, D., Lo Russo, G., Galli, G., Imbimbo, M., Prelaj, A., Zilembo, N., Ganzinelli, M., Pallavicini, L. M., De Simone, I., Colombo, M. P., Sica, A., Torri, V. & Garassino, M. C., May 2019, In : Cancer Treatment Reviews. 75, p. 39-51 13 p.

Research output: Contribution to journalReview article

Choosing wisely first line immunotherapy in non-small cell lung cancer (NSCLC): what to add and what to leave out

Proto, C., Ferrara, R., Signorelli, D., Lo Russo, G., Galli, G., Imbimbo, M., Prelaj, A., Zilembo, N., Ganzinelli, M., Pallavicini, L. M., De Simone, I., Colombo, M. P., Sica, A., Torri, V. & Garassino, M. C., May 2019, In : Cancer Treatment Reviews. 75, p. 39-51 13 p.

Research output: Contribution to journalArticle

DNA threads released by activated CD4+ T lymphocytes provide autocrine costimulation

Costanza, M., Poliani, P. L., Portararo, P., Cappetti, B., Musio, S., Pagani, F., Steinman, L., Colombo, M. P., Pedotti, R. & Sangaletti, S., Apr 30 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 18, p. 8985-8994 10 p.

Research output: Contribution to journalArticle

Open Access

Exploiting FAsting-mimicking Diet and MEtformin to Improve the Efficacy of Platinum-pemetrexed Chemotherapy in Advanced LKB1-inactivated Lung Adenocarcinoma: The FAME Trial

Vernieri, C., Signorelli, D., Galli, G., Ganzinelli, M., Moro, M., Fabbri, A., Tamborini, E., Marabese, M., Caiola, E., Broggini, M., Hollander, L., Gallucci, R., Vandoni, G., Gavazzi, C., Triulzi, T., Colombo, M. P., Rizzo, A. M., Corsetto, P. A., Pruneri, G., de Braud, F. & 3 others, Sozzi, G., Torri, V. & Garassino, M. C., May 2019, In : Clinical Lung Cancer. 20, 3, p. e413-e417

Research output: Contribution to journalArticle

Frontline Science: Mast cells regulate neutrophil homeostasis by influencing macrophage clearance activity

Jachetti, E., D'Incà, F., Danelli, L., Magris, R., Dal Secco, C., Vit, F., Cancila, V., Tripodo, C., Scapini, P., Colombo, M. P., Pucillo, C. & Frossi, B., Apr 2019, In : Journal of Leukocyte Biology. 105, 4, p. 633-644 12 p.

Research output: Contribution to journalArticle

IL-10-producing B cells are characterized by a specific methylation signature

Tonon, S., Mion, F., Dong, J., Chang, H. D., Dalla, E., Scapini, P., Perruolo, G., Zanello, A., Dugo, M., Cassatella, M. A., Colombo, M. P., Radbruch, A., Tripodo, C. & Pucillo, C. E., Jan 1 2019, In : European Journal of Immunology. 49, 8, p. 1213-1225 13 p.

Research output: Contribution to journalArticle

Immune checkpoint ligand reverse signaling: Looking back to go forward in cancer therapy

Lecis, D., Sangaletti, S., Colombo, M. P. & Chiodoni, C., May 2019, In : Cancers. 11, 5, 624.

Research output: Contribution to journalArticle

Open Access

Is GPnMB the Achilles' heel of Mo-MDSC while marking their suppressive activity?

Colombo, M. P., Jan 15 2019, In : Clinical Cancer Research. 25, 2, p. 453-454 2 p.

Research output: Contribution to journalArticle

Neoadjuvant eribulin mesylate following anthracycline and taxane in triple negative breast cancer: Results from the HOPE study

Cosimo, S. D., Verde, N. L., Moretti, A., Cazzaniga, M. E., Generali, D., Bianchi, G. V., Mariani, L., Torri, V., Crippa, F., Paolini, B., Scaperrotta, G., De Santis, M. C., Nicola, M. D., Apolone, G., Gulino, A., Tripodo, C., Colombo, M. P., Folli, S. & de Braud, F., Jan 1 2019, In : PLoS One. 14, 8, e0220644.

Research output: Contribution to journalArticle

Open Access

Nicotinamide phosphoribosyltransferase acts as a metabolic gate for mobilization of myeloid-derived suppressor cells

Travelli, C., Consonni, F. M., Sangaletti, S., Storto, M., Morlacchi, S., Grolla, A. A., Galli, U., Tron, G. C., Portararo, P., Rimassa, L., Pressiani, T., Mazzone, M., Trovato, R., Ugel, S., Bronte, V., Tripodo, C., Colombo, M. P., Genazzani, A. A. & Sica, A., Apr 15 2019, In : Cancer Research. 79, 8, p. 1938-1951 14 p.

Research output: Contribution to journalArticle

Nicotinamide phosphoribosyltransferase acts as a metabolic gate for mobilization of myeloid-derived suppressor cells

Travelli, C., Consonni, F. M., Sangaletti, S., Storto, M., Morlacchi, S., Grolla, A. A., Galli, U., Tron, G. C., Portararo, P., Rimassa, L., Pressiani, T., Mazzone, M., Trovato, R., Ugel, S., Bronte, V., Tripodo, C., Colombo, M. P., Genazzani, A. A. & Sica, A., Apr 15 2019, In : Cancer Research. 79, 8, p. 1938-1951 14 p.

Research output: Contribution to journalArticle

Phenethyl isothiocyanate hampers growth and progression of HER2-positive breast and ovarian carcinoma by targeting their stem cell compartment

Koschorke, A., Faraci, S., Giani, D., Chiodoni, C., Iorio, E., Canese, R., Colombo, M. P., Lamolinara, A., Iezzi, M., Ladomery, M., Vernieri, C., de Braud, F., Di Nicola, M., Tagliabue, E., Castagnoli, L. & Pupa, S. M., Dec 1 2019, In : Cellular Oncology. 42, 6, p. 815-828 14 p.

Research output: Contribution to journalArticle

Phenethyl isothiocyanate hampers growth and progression of HER2-positive breast and ovarian carcinoma by targeting their stem cell compartment

Koschorke, A., Faraci, S., Giani, D., Chiodoni, C., Iorio, E., Canese, R., Colombo, M. P., Lamolinara, A., Iezzi, M., Ladomery, M., Vernieri, C., de Braud, F., Di Nicola, M., Tagliabue, E., Castagnoli, L. & Pupa, S. M., 2019, In : Cellular Oncology. 42, 6, p. 815-828 14 p.

Research output: Contribution to journalArticle

Open Access

Single-Cell Sequencing of Mouse Heart Immune Infiltrate in Pressure Overload-Driven Heart Failure Reveals Extent of Immune Activation

Martini, E., Kunderfranco, P., Peano, C., Carullo, P., Cremonesi, M., Schorn, T., Carriero, R., Termanini, A., Colombo, F. S., Jachetti, E., Panico, C., Faggian, G., Fumero, A., Torracca, L., Molgora, M., Cibella, J., Pagiatakis, C., Brummelman, J., Alvisi, G., Mazza, E. M. C. & 4 others, Colombo, M. P., Lugli, E., Condorelli, G. & Kallikourdis, M., Dec 17 2019, In : Circulation. 140, 25, p. 2089-2107 19 p.

Research output: Contribution to journalArticle

SPARC is a new myeloid-derived suppressor cell marker licensing suppressive activities

Sangaletti, S., Talarico, G., Chiodoni, C., Cappetti, B., Botti, L., Portararo, P., Gulino, A., Consonni, F. M., Sica, A., Randon, G., Nicola, M. D., Tripodo, C. & Colombo, M. P., Jan 1 2019, In : Frontiers in Immunology. 10, JUN, 1369.

Research output: Contribution to journalArticle

Open Access

SPARC is a new myeloid-derived suppressor cell marker licensing suppressive activities

Sangaletti, S., Talarico, G., Chiodoni, C., Cappetti, B., Botti, L., Portararo, P., Gulino, A., Consonni, F. M., Sica, A., Randon, G., Nicola, M. D., Tripodo, C. & Colombo, M. P., Jan 1 2019, In : Frontiers in Immunology. 10, JUN

Research output: Contribution to journalArticle

The P2X7 receptor modulates immune cells infiltration, ectonucleotidases expression and extracellular ATP levels in the tumor microenvironment

De Marchi, E., Orioli, E., Pegoraro, A., Sangaletti, S., Portararo, P., Curti, A., Colombo, M. P., Di Virgilio, F. & Adinolfi, E., May 9 2019, In : Oncogene. 38, 19, p. 3636-3650 15 p.

Research output: Contribution to journalArticle

Open Access
2018

Choosing the best chemotherapy agent to boost immune checkpoint inhibition activity

Garassino, M. C., Torri, V., Colombo, M. P. & Sica, A., Oct 15 2018, In : Cancer Research. 78, 20, p. 5729-5730 2 p.

Research output: Contribution to journalArticle

CIAP1 regulates the EGFR/Snai2 axis in triple-negative breast cancer cells

Majorini, M. T., Manenti, G., Mano, M., De Cecco, L., Conti, A., Pinciroli, P., Fontanella, E., Tagliabue, E., Chiodoni, C., Colombo, M. P., Delia, D. & Lecis, D., 2018, In : Cell Death and Differentiation. 25, 12, p. 2147-2164 18 p.

Research output: Contribution to journalArticle

Cross-Talk between Myeloid-Derived Suppressor Cells and Mast Cells Mediates Tumor-Specific Immunosuppression in Prostate Cancer

Jachetti, E., Cancila, V., Rigoni, A., Bongiovanni, L., Cappetti, B., Belmonte, B., Enriquez, C., Casalini, P., Ostano, P., Frossi, B., Sangaletti, S., Chiodoni, C., Chiorino, G., Pucillo, C. E., Tripodo, C. & Colombo, M. P., May 2018, In : Cancer immunology research. 6, 5, p. 552-565 14 p.

Research output: Contribution to journalArticle

Mast cells, basophils and eosinophils: From allergy to cancer

Rigoni, A., Colombo, M. P. & Pucillo, C., Feb 2018, In : Seminars in Immunology. 35, p. 29-34 6 p.

Research output: Contribution to journalReview article

OX40 triggering concomitant to IL12-engineered cell vaccine hampers the immunoprevention of HER2/neu-driven mammary carcinogenesis

Nanni, P., De Giovanni, C., Burocchi, A., Nicoletti, G., Landuzzi, L., Palladini, A., Ianzano, M. L., Arioli, I., Colombo, M. P. & Lollini, P-L., 2018, In : OncoImmunology. 7, 8, p. e1465164

Research output: Contribution to journalArticle

OX40 triggering concomitant to IL12-engineered cell vaccine hampers the immunoprevention of HER2/neu-driven mammary carcinogenesis

Nanni, P., De Giovanni, C., Burocchi, A., Nicoletti, G., Landuzzi, L., Palladini, A., Ianzano, M. L., Arioli, I., Colombo, M. P. & Lollini, P. L., Jun 11 2018, In : OncoImmunology. 7, 8, p. 1-7 7 p.

Research output: Contribution to journalArticle

Separation of Dual Oxidase 2 and Lactoperoxidase Expression in Intestinal Crypts and Species Differences May Limit Hydrogen Peroxide Scavenging during Mucosal Healing in Mice and Humans

Rigoni, A., Poulsom, R., Jeffery, R., Mehta, S., Lewis, A., Yau, C., Giannoulatou, E., Feakins, R., Lindsay, J. O., Colombo, M. P. & Silver, A., 2018, In : Inflammatory Bowel Diseases. 24, 1, p. 136-148 13 p.

Research output: Contribution to journalArticle

2017

Antibody-mediated blockade of JMJD6 interaction with collagen I exerts antifibrotic and antimetastatic activities

Miotti, S., Gulino, A., Ferri, R., Parenza, M., Chronowska, A., Lecis, D., Sangaletti, S., Tagliabue, E., Tripodo, C. & Colombo, M. P., Jan 1 2017, In : FASEB Journal. 31, 12, p. 5356-5370 15 p.

Research output: Contribution to journalArticle

ATP release from chemotherapy-treated dying leukemia cells Elicits an immune suppressive effect by increasing regulatory T cells and Tolerogenic dendritic cells

Lecciso, M., Ocadlikova, D., Sangaletti, S., Trabanelli, S., De Marchi, E., Orioli, E., Pegoraro, A., Portararo, P., Jandus, C., Bontadini, A., Redavid, A., Salvestrini, V., Romero, P., Colombo, M. P., Di Virgilio, F., Cavo, M., Adinolfi, E. & Curti, A., Dec 22 2017, In : Frontiers in Immunology. 8, DEC, 1918.

Research output: Contribution to journalArticle

Common extracellular matrix regulation of myeloid cell activity in the bone marrow and tumor microenvironments

Sangaletti, S., Chiodoni, C., Tripodo, C. & Colombo, M. P., Aug 1 2017, In : Cancer Immunology, Immunotherapy. 66, 8, p. 1059-1067 9 p.

Research output: Contribution to journalReview article

Goals and objectives of the Italian Network for Tumor Biotherapy (NIBIT)

Russo, V., Amadori, A., Bregni, M., Calabrò, L., Colombo, M. P., Di Nicola, M., Ferrucci, P. F., Proietti, E., Maio, M. & Bellone, M., 2017, In : Cytokine and Growth Factor Reviews. 36, p. 1-3 3 p.

Research output: Contribution to journalArticle

Goals and objectives of the Italian Network for Tumor Biotherapy (NIBIT)

Russo, V., Amadori, A., Bregni, M., Calabrò, L., Colombo, M. P., Di Nicola, M., Ferrucci, P. F., Proietti, E., Maio, M. & Bellone, M., Aug 1 2017, In : Cytokine and Growth Factor Reviews. 36, p. 1-3 3 p.

Research output: Contribution to journalShort survey

Goals and objectives of the Italian Network for Tumor Biotherapy (NIBIT)

Russo, V., Amadori, A., Bregni, M., Calabrò, L., Colombo, M. P., Di Nicola, M., Ferrucci, P. F., Proietti, E., Maio, M. & Bellone, M., Aug 2017, In : Cytokine and Growth Factor Reviews. 36, p. 1-3 3 p.

Research output: Contribution to journalArticle

Imatinib Spares cKit-Expressing Prostate Neuroendocrine Tumors, whereas Kills Seminal Vesicle Epithelial-Stromal Tumors by Targeting PDGFR-beta.

Jachetti, E., Rigoni, A., Bongiovanni, L., Arioli, I., Botti, L., Parenza, M., Cancila, V., Chiodoni, C., Festinese, F., Bellone, M., Tardanico, R., Tripodo, C. & Colombo, M. P., Feb 1 2017, In : Molecular Cancer Therapeutics. 16, 2, p. 365-375 11 p.

Research output: Contribution to journalArticle

Innovative Therapy, Monoclonal Antibodies and Beyond

Di Nicola, M., Apetoh, L., Bellone, M., Colombo, M. P., Dotti, G., Ferrone, S., Muscolini, M., Hiscott, J., Anichini, A., Pupa, S. M., Braud, F. D. & Del Vecchio, M., Dec 1 2017, In : Cytokine and Growth Factor Reviews. 38, p. 1-9 9 p.

Research output: Contribution to journalShort survey

Matricellular proteins tune myeloid-derived suppressor cell recruitment and function in breast cancer

Chiodoni, C., Sangaletti, S. & Colombo, M. P., Aug 1 2017, In : Journal of Leukocyte Biology. 102, 2, p. 287-292 6 p.

Research output: Contribution to journalReview article

On OX40 and PD-1 combination: Why should OX40 be first in sequence?

Colombo, M. P., Oct 15 2017, In : Clinical Cancer Research. 23, 20, p. 5999-6001 3 p.

Research output: Contribution to journalReview article

Persistent immune stimulation exacerbates genetically driven myeloproliferative disorders via stromal remodeling

Tripodo, C., Burocchi, A., Piccaluga, P. P., Chiodoni, C., Portararo, P., Cappetti, B., Botti, L., Gulino, A., Isidori, A., Liso, A., Visani, G., Martelli, M. P., Falini, B., Pandolfi, P. P., Colombo, M. P. & Sangaletti, S., Jul 1 2017, In : Cancer Research. 77, 13, p. 3685-3699 15 p.

Research output: Contribution to journalArticle

Reciprocal influence of B cells and tumor macro and microenvironments in the ApcMin/+ model of colorectal cancer

Mion, F., Vetrano, S., Tonon, S., Valeri, V., Piontini, A., Burocchi, A., Petti, L., Frossi, B., Gulino, A., Tripodo, C., Colombo, M. P. & Pucillo, C. E., Aug 3 2017, In : OncoImmunology. 6, 8, e1336593.

Research output: Contribution to journalArticle

Reciprocal influence of B cells and tumor macro and microenvironments in the ApcMin/+ model of colorectal cancer

Mion, F., Vetrano, S., Tonon, S., Valeri, V., Piontini, A., Burocchi, A., Petti, L., Frossi, B., Gulino, A., Tripodo, C., Colombo, M. P. & Pucillo, C. E., 2017, In : OncoImmunology. 6, 8, e1336593.

Research output: Contribution to journalArticle

Rheostatic Functions of Mast Cells in the Control of Innate and Adaptive Immune Responses

Frossi, B., Mion, F., Tripodo, C., Colombo, M. P. & Pucillo, C. E., Sep 1 2017, In : Trends in Immunology. 38, 9, p. 648-656 9 p.

Research output: Contribution to journalReview article

Sarcoma eradication by doxorubicin and targeted TNF relies upon CD8+ T-cell recognition of a retroviral antigen

Probst, P., Kopp, J., Oxenius, A., Colombo, M. P., Ritz, D., Fugmann, T. & Neri, D., Jul 1 2017, In : Cancer Research. 77, 13, p. 3644-3654 11 p.

Research output: Contribution to journalArticle

Separation of Dual Oxidase 2 and Lactoperoxidase Expression in Intestinal Crypts and Species Differences May Limit Hydrogen Peroxide Scavenging During Mucosal Healing in Mice and Humans

Rigoni, A., Poulsom, R., Jeffery, R., Mehta, S., Lewis, A., Yau, C., Giannoulatou, E., Feakins, R., Lindsay, J. O., Colombo, M. P. & Silver, A., Dec 19 2017, In : Inflammatory Bowel Diseases. 24, 1, p. 136-148 13 p.

Research output: Contribution to journalArticle

The good and bad of targeting cancer-associated extracellular matrix

Sangaletti, S., Chiodoni, C., Tripodo, C. & Colombo, M. P., Aug 1 2017, In : Current Opinion in Pharmacology. 35, p. 75-82 8 p.

Research output: Contribution to journalReview article

Trabectedin overrides osteosarcoma differentiative block and reprograms the tumor immune environment enabling effective combination with immune checkpoint inhibitors

Ratti, C., Botti, L., Cancila, V., Galvan, S., Torselli, I., Garofalo, C., Manara, M. C., Bongiovanni, L., Valenti, C. F., Burocchi, A., Parenza, M., Cappetti, B., Sangaletti, S., Tripodo, C., Scotlandi, K., Colombo, M. P. & Chiodoni, C., Sep 1 2017, In : Clinical Cancer Research. 23, 17, p. 5149-5161 13 p.

Research output: Contribution to journalArticle

Trabectedin Overrides Osteosarcoma Differentiative Block and Reprograms the Tumor Immune Environment Enabling Effective Combination with Immune Checkpoint Inhibitors

Ratti, C., Botti, L., Cancila, V., Galvan, S., Torselli, I., Garofalo, C., Manara, M. C., Bongiovanni, L., Valenti, C. F., Burocchi, A., Parenza, M., Cappetti, B., Sangaletti, S., Tripodo, C., Scotlandi, K., Colombo, M. P. & Chiodoni, C., Sep 1 2017, In : Clinical Cancer Research. 23, 17, p. 5149-5161 13 p.

Research output: Contribution to journalArticle

Trabectedin Overrides Osteosarcoma Differentiative Block and Reprograms the Tumor Immune Environment Enabling Effective Combination with Immune Checkpoint Inhibitors.

Ratti, C., Botti, L., Cancila, V., Galvan, S., Torselli, I., Garofalo, C., Manara, M. C., Bongiovanni, L., Valenti, C. F., Burocchi, A., Parenza, M., Cappetti, B., Sangaletti, S., Tripodo, C., Scotlandi, K., Colombo, M. P. & Chiodoni, C., Jun 9 2017, In : Clinical Cancer Research. 23, 17, p. 5149-5161 13 p.

Research output: Contribution to journalArticle

2016

CD99 regulates neural differentiation of Ewing sarcoma cells through MIR-34a-Notch-mediated control of NF-κB signaling

Ventura, S., Aryee, D. N. T., Felicetti, F., de Feo, A., Mancarella, C., Manara, M. C., Picci, P., Colombo, M. P., Kovar, H., Care, A. & Scotlandi, K., 2016, In : Oncogene. 35, 30, p. 3944-3954 11 p.

Research output: Contribution to journalArticle

CD99 triggering induces methuosis of Ewing sarcoma cells through IGF-1R/RAS/Rac1 signaling

Manara, M. C., Terracciano, M., Mancarella, C., Sciandra, M., Guerzoni, C., Pasello, M., Grilli, A., Zini, N., Picci, P., Colombo, M. P., Morrione, A. & Scotlandi, K., 2016, In : Oncotarget. 7, 48, p. 79925-79942 18 p.

Research output: Contribution to journalArticle