1993 …2019

Research output per year

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Research Output

2019

Dichotomous Toll-like receptor responses in chronic lymphocytic leukemia patients under ibrutinib treatment

Gounari, M., Ntoufa, S., Gerousi, M., Vilia, M. G., Moysiadis, T., Kotta, K., Papakonstantinou, N., Scarfò, L., Agathangelidis, A., Fonte, E., Ranghetti, P., Nenou, A., Xochelli, A., Coscia, M., Tedeschi, A., Stavroyianni, N., Muzio, M., Stamatopoulos, K. & Ghia, P., Apr 1 2019, In : Leukemia. 33, 4, p. 1030-1051 22 p.

Research output: Contribution to journalLetter

IL1R8 deficiency drives autoimmunity-associated lymphoma development: Cancer Immunology Research

Riva, F., Ponzoni, M., Supino, D., Bertilaccio, MTS., Polentarutti, N., Massara, M., Pasqualini, F., Carriero, R., Innocenzi, A., Anselmo, A., Veliz-Rodriguez, T., Simonetti, G., Anders, HJ., Caligaris-Cappio, F., Mantovani, A., Muzio, M. & Garlanda, C., 2019, In : Cancer immunology research. 7, 6, p. 874-885 12 p.

Research output: Contribution to journalArticle

IL1R8 Deficiency Drives Autoimmunity-Associated Lymphoma Development

Riva, F., Ponzoni, M., Supino, D., Bertilaccio, M. T. S., Polentarutti, N., Massara, M., Pasqualini, F., Carriero, R., Innocenzi, A., Anselmo, A., Veliz-Rodriguez, T., Simonetti, G., Anders, H-J., Caligaris-Cappio, F., Mantovani, A., Muzio, M. & Garlanda, C., Jun 2019, In : Cancer immunology research. 7, 6, p. 874-885 12 p.

Research output: Contribution to journalArticle

2017

Characterization of a long isoform of IL-1R8 (TIR8/SIGIRR)

Vilia, MG., Tocchetti, M., Fonte, E., Sana, I. & Muzio, M., 2017, In : European Cytokine Network. 28, 2, p. 63-69 7 p.

Research output: Contribution to journalArticle

The inhibitory receptor toll interleukin-1R 8 (TIR8/IL-1R8/SIGIRR) is downregulated in chronic lymphocytic leukemia

Vilia, MG., Fonte, E., Veliz Rodriguez, T., Tocchetti, M., Ranghetti, P., Scarfò, L., Papakonstantinou, N., Ntoufa, S., Stamatopoulos, K., Ghia, P. & Muzio, M., 2017, In : Leukemia and Lymphoma. 58, 10, p. 2419-2425 7 p.

Research output: Contribution to journalArticle

Toll-like receptor 9 stimulation can induce IκBζ expression and IgM secretion in chronic lymphocytic leukemia cells

Fonte, E., Vilia, M. G., Reverberi, D., Sana, I., Scarfò, L., Ranghetti, P., Orfanelli, U., Cenci, S., Cutrona, G., Ghia, P., Ghia, P. & Muzio, M., Oct 27 2017, In : Haematologica. 102, 11, p. 1901-1912 12 p.

Research output: Contribution to journalArticle

Toll-like receptor 9 stimulation can induce IκBζ expression and IgM secretion in chronic lymphocytic leukemia cells

Fonte, E., Vilia, MG., Reverberi, D., Sana, I., Scarfò, L., Ranghetti, P., Orfanelli, U., Cenci, S., Cutrona, G., Ghia, P. & Muzio, M., 2017, In : Haematologica. 102, 11, p. 1901-1912 12 p.

Research output: Contribution to journalArticle

2016

B cell anergy modulated by TLR1/2 and the MIR-17∼92 cluster underlies the indolent clinical course of chronic lymphocytic leukemia stereotyped subset #4

Ntoufa, S., Papakonstantinou, N., Apollonio, B., Gounari, M., Galigalidou, C., Fonte, E., Anagnostopoulos, A., Belessi, C., Muzio, M., Ghia, P. & Stamatopoulos, K., May 15 2016, In : Journal of Immunology. 196, 10, p. 4410-4417 8 p.

Research output: Contribution to journalArticle

Evaluation of the efficacy of a new oral gel containing carvacrol and thymol for home oral care in the management of chronic periodontitis using PCR analysis: A microbiological pilot study

Lauritano, D., Pazzi, D., Iapichino, A., Gaudio, R. M., Muzio, M. D. I., Russo, L. L. O. & Pezzetti, F., 2016, In : Journal of Biological Regulators and Homeostatic Agents. 30, 2, p. 129-134 6 p.

Research output: Contribution to journalArticle

Toll-like receptors signaling: A complex network for NF-κB activation in B-cell lymphoid malignancies

Ntoufa, S., Vilia, M. G., Stamatopoulos, K., Ghia, P. & Muzio, M., May 6 2016, (Accepted/In press) In : Seminars in Cancer Biology.

Research output: Contribution to journalArticle

Toll-like receptors signaling: A complex network for NF-κB activation in B-cell lymphoid malignancies

Ntoufa, S., Vilia, M. G., Stamatopoulos, K., Ghia, P. & Muzio, M. F., Aug 1 2016, In : Seminars in Cancer Biology. 39, p. 15 - 25 11 p.

Research output: Contribution to journalReview article

2015

Toll-like receptor stimulation in splenic marginal zone lymphoma can modulate cell signaling, activation and proliferation

Fonte, E., Agathangelidis, A., Reverberi, D., Ntoufa, S., Scarfò, L., Ranghetti, P., Cutrona, G., Tedeschi, A., Xochelli, A., Caligaris-Cappio, F., Ponzoni, M., Belessi, C., Davis, Z., Piris, M. A., Oscier, D., Ghia, P., Stamatopoulos, K. & Muzio, M., Oct 31 2015, In : Haematologica. 100, 11, p. 1460-1468 9 p.

Research output: Contribution to journalArticle

2014

Heterogeneous functional effects of concomitant B cell receptor and TLR stimulation in chronic lymphocytic leukemia with mutated versus unmutated Ig genes

Chatzouli, M., Ntoufa, S., Papakonstantinou, N., Chartomatsidou, E., Anagnostopoulos, A., Kollia, P., Ghia, P., Muzio, M., Stamatopoulos, K. & Belessi, C., May 15 2014, In : Journal of Immunology. 192, 10, p. 4518-4524 7 p.

Research output: Contribution to journalArticle

2013

Differential microRNA profiles and their functional implications in different immunogenetic subsets of chronic lymphocytic leukemia

Papakonstantinou, N., Ntoufa, S., Chartomatsidou, E., Papadopoulos, G., Hatzigeorgiou, A., Anagnostopoulos, A., Chlichlia, K., Ghia, P., Muzio, M., Belessi, C. & Stamatopoulos, K., 2013, In : Molecular medicine (Cambridge, Mass.). 19, 1, p. 115-123 9 p.

Research output: Contribution to journalArticle

In vitro sensitivity of CLL cells to fludarabine may be modulated by the stimulation of toll-like receptors

Fonte, E., Apollonio, B., Scarfò, L., Ranghetti, P., Fazi, C., Ghia, P., Caligaris-Cappio, F. & Muzio, M., Jan 15 2013, In : Clinical Cancer Research. 19, 2, p. 367-379 13 p.

Research output: Contribution to journalArticle

Targeting B-cell anergy in chronic lymphocytic leukemia.

Apollonio, B., Scielzo, C., Bertilaccio, M. T. S., Ten Hacken, E., Scarfò, L., Ranghetti, P., Stevenson, F., Packham, G., Ghia, P., Muzio, M. & Caligaris-Cappio, F., May 9 2013, In : Blood. 121, 19

Research output: Contribution to journalArticle

2012

Distinct innate immunity pathways to activation and tolerance in subgroups of chronic lymphocytic leukemia with distinct immunoglobulin receptors

Ntoufa, S., Vardi, A., Papakonstantinou, N., Anagnostopoulos, A., Aleporou-Marinou, V., Belessi, C., Ghia, P., Caligaris-Cappio, F., Muzio, M. & Stamatopoulos, K., 2012, In : Molecular medicine (Cambridge, Mass.). 18, 9, p. 1281-1291 11 p.

Research output: Contribution to journalArticle

Lack of TIR8/SIGIRR triggers progression of chronic lymphocytic leukemia in mouse models (Blood (2011) 1183, 3 (660-669))

Bertilaccio, M. T. S., Simonetti, G., Dagklis, A., Rocchi, M., Rodriguez, T. V., Apollonio, B., Mantovani, A., Ponzoni, M., Ghia, P., Garlanda, C., Caligaris-Cappio, F. & Muzio, M., Sep 27 2012, In : Blood. 120, 13, p. 2773 1 p.

Research output: Contribution to journalArticle

Toll-like receptors in chronic lymphocytic leukemia

Muzio, M., Fonte, E. & Caligaris-Cappio, F., 2012, In : Mediterranean Journal of Hematology and Infectious Diseases. 4, 1, e2012055.

Research output: Contribution to journalArticle

2011

Erratum: The functional in vitro response to CD40 ligation reflects a different clinical outcome in patients with chronic lymphocytic leukemia (Leukemia (2011) 25 (1760-1767) doi: 10.1038/leu.2011.149)

Scielzo, C., Apollonio, B., Scarfò, L., Janus, A., Muzio, M., Ten Hacken, E., Ghia, P. & Caligaris-Cappio, F., Nov 2011, In : Leukemia. 25, 11, p. 1794 1 p.

Research output: Contribution to journalArticle

Lack of TIR8/SIGIRR triggers progression of chronic lymphocytic leukemia in mouse models

Bertilaccio, M. T. S., Simonetti, G., Dagklis, A., Rocchi, M., Rodriguez, T. V., Apollonio, B., Mantovani, A., Ponzoni, M., Ghia, P., Garlanda, C., Caligaris-Cappio, F. & Muzio, M., Jul 21 2011, In : Blood. 118, 3, p. 660-669 10 p.

Research output: Contribution to journalArticle

The functional in vitro response to CD40 ligation reflects a different clinical outcome in patients with chronic lymphocytic leukemia

Scielzo, C., Apollonio, B., Scarfò, L., Janus, A., Muzio, M., Ten Hacken, E., Ghia, P. & Caligaris-Cappio, F., Nov 2011, In : Leukemia. 25, 11, p. 1760-1767 8 p.

Research output: Contribution to journalArticle

Toll-like receptor signaling pathway in chronic lymphocytic leukemia: Distinct gene expression profiles of potential pathogenic significance in specific subsets of patients

Arvaniti, E., Ntoufa, S., Papakonstantinou, N., Touloumenidou, T., Laoutaris, N., Anagnostopoulos, A., Lamnissou, K., Caligaris-Cappio, F., Stamatopoulos, K., Ghia, P., Muzio, M. & Belessi, C., Nov 1 2011, In : Haematologica. 96, 11, p. 1644-1652 9 p.

Research output: Contribution to journalArticle

2010

A novel Rag2-/-γc -/--xenograft model of human CLL

Bertilaccio, M. T. S., Scielzo, C., Simonetti, G., Ponzoni, M., Apollonio, B., Fazi, C., Scarfò, L., Rocchi, M., Muzio, M., Caligaris-Cappio, F. & Ghia, P., Feb 25 2010, In : Blood. 115, 8, p. 1605-1609 5 p.

Research output: Contribution to journalArticle

An overview of chronic lymphocytic leukaemia biology

Bertilaccio, M. T. S., Scielzo, C., Muzio, M. & Caligaris-Cappio, F., Mar 2010, In : Best Practice and Research: Clinical Haematology. 23, 1, p. 21-32 12 p.

Research output: Contribution to journalArticle

How the microenvironment shapes chronic lymphocytic leukemia: The cytoskeleton connection

Scielzo, C., Ten Hacken, E., Bertilaccio, M. T. S., Muzio, M., Calissano, C., Ghia, P. & Caligaris-Cappio, F., Aug 2010, In : Leukemia and Lymphoma. 51, 8, p. 1371-1374 4 p.

Research output: Contribution to journalArticle

HS1 has a central role in the trafficking and homing of leukemic B cells

Scielzo, C., Bertilaccio, M. T. S., Simonetti, G., Dagklis, A., Ten Hacken, E., Fazi, C., Muzio, M., Caiolfa, V., Kitamura, D., Restuccia, U., Bachi, A., Rocchi, M., Ponzoni, M., Ghia, P. & Caligaris-Cappio, F., Nov 4 2010, In : Blood. 116, 18, p. 3537-3546 10 p.

Research output: Contribution to journalArticle

MicroRNA and proliferation control in chronic lymphocytic leukemia: Functional relationship between miR-221/222 cluster and p27

Frenquelli, M., Muzio, M., Scielzo, C., Fazi, C., Scarfò, L., Rossi, C., Ferrari, G., Ghia, P. & Caligaris-Cappio, F., May 13 2010, In : Blood. 115, 19, p. 3949-3959 11 p.

Research output: Contribution to journalArticle

2009

Are we getting closer to understanding the pathogenesis of chronic lymphocytic leukemia?

Caligaris-Cappio, F., Scielzo, C., Bertilaccio, S., Muzio, M. & Ghia, P., 2009, In : Haematologica Meeting Reports. 3, 3, p. 78-80 3 p.

Research output: Contribution to journalArticle

Expression and function of toll like receptors in chronic lymphocytic leukaemia cells

Muzio, M., Scielzo, C., Bertilaccio, M. T. S., Frenquelli, M., Ghia, P. & Caligaris-Cappio, F., Feb 2009, In : British Journal of Haematology. 144, 4, p. 507-516 10 p.

Research output: Contribution to journalArticle

The role of Toll-like receptors in chronic B cell malignancies

Muzio, M., Bertilaccio, M. T. S., Simonetti, G., Frenquelli, M. & Caligaris-Cappio, F., 2009, In : Leukemia and Lymphoma. 50, 10, p. 1573-1580 8 p.

Research output: Contribution to journalArticle

2008

Constitutive activation of distinct BCR-signaling pathways in a subset of CLL patients: a molecular signature of anergy

Muzio, M., Apollonio, B., Scielzo, C., Frenquelli, M., Vandoni, I., Boussiotis, V., Caligaris-Cappio, F. & Ghia, P., Jul 1 2008, In : Blood. 112, 1, p. 188-195 8 p.

Research output: Contribution to journalArticle

2007

Chronic lymphocytic leukemia: An enigma for both the clinician and the immunologist

Scielzo, C., Frenquelli, M., Muzio, M., Bertilaccio, M. T. S., Dagklis, A., Caligaris-Cappio, F. & Ghia, P., 2007, In : Haematologica Meeting Reports. 1, 7, p. 1-7 7 p.

Research output: Contribution to journalArticle

From normal to clonal B cells: Chronic lymphocytic leukemia (CLL) at the crossroad between neoplasia and autoimmunity

Ghia, P., Scielzo, C., Frenquelli, M., Muzio, M. & Caligaris-Cappio, F., Dec 2007, In : Autoimmunity Reviews. 7, 2, p. 127-131 5 p.

Research output: Contribution to journalArticle

HS1 complexes with cytoskeleton adapters in normal and malignant chronic lymphocytic leukemia B cells [14]

Muzio, M., Scielzo, C., Frenquelli, M., Bachi, A., De Palma, M., Alessio, M., Ghia, P. & Caligaris-Cappio, F., Sep 2007, In : Leukemia. 21, 9, p. 2067-2070 4 p.

Research output: Contribution to journalArticle

2006

Dissecting the natural history of chronic lymphocytic leukemia to discover new therapeutic targets

Caligaris-Cappio, F., Scielzo, C., Muzio, M., Carletti, R. M., Camporeale, A., Frenquelli, M., Fazi, C., Alessio, M., Bachi, A. & Ghia, P., 2006, In : Haematologica Reports. 2, 7, p. 27-29 3 p.

Research output: Contribution to journalArticle

Intestinal inflammation in mice deficient in Tir8, an inhibitory member of the IL-1 receptor family

Garlanda, C., Riva, F., Polentarutti, N., Buracchi, C., Sironi, M., De Bortoli, M., Muzio, M., Bergottini, R., Scanziani, E., Vecchi, A., Hirsch, E. & Mantovani, A., Mar 9 2004, In : Proceedings of the National Academy of Sciences of the United States of America. 101, 10, p. 3522-3526 5 p.

Research output: Contribution to journalArticle

The death domain protein p84N5, but not the short isoform p84N5s, is cell cycle-regulated and shuttles between the nucleus and the cytoplasm

Gasparri, F., Sola, F., Locatelli, G. & Muzio, M., Sep 10 2004, In : FEBS Letters. 574, 1-3, p. 13-19 7 p.

Research output: Contribution to journalArticle

TNF signaling: key protocols.

Muzio, M. & Saccani, S., 2004, In : Methods in molecular medicine. 98, p. 81-100 20 p.

Research output: Contribution to journalArticle

2003

Acetaminophen down-regulates interleukin-1β-induced nuclear factor-κB nuclear translocation in a human astrocytic cell line

Mancini, F., Landolfi, C., Muzio, M., Aquilini, L., Soldo, L., Coletta, I., Guglielmotti, A., Mantovani, A., Pinza, M. & Milanese, C., Dec 19 2003, In : Neuroscience Letters. 353, 2, p. 79-82 4 p.

Research output: Contribution to journalArticle

Monitoring of apoptosis of HL60 cells by fourier-transform infrared spectroscopy

Gasparri, F. & Muzio, M., Jan 15 2003, In : Biochemical Journal. 369, 2, p. 239-248 10 p.

Research output: Contribution to journalArticle

Unique pattern of expression and inhibition of IL-1 signaling by the IL-1 receptor family member TIR8/SIGIRR

Polentarutti, N., Rol, G. P., Muzio, M., Bosisio, D., Camnasio, M., Riva, F., Zoja, C., Benigni, A., Tomasoni, S., Vecchi, A., Garlanda, C. & Mantovani, A., Oct 2003, In : European Cytokine Network. 14, 4, p. 211-218 8 p.

Research output: Contribution to journalArticle

2002

Stimulation of toll-like receptor 4 expression in human mononuclear phagocytes by interferon-γ: A molecular basis for priming and synergism with bacterial lipopolysaccharide

Bosisio, D., Polentarutti, N., Sironi, M., Bernasconi, S., Miyake, K., Webb, G. R., Martin, M. U., Mantovani, A. & Muzio, M., May 1 2002, In : Blood. 99, 9, p. 3427-3431 5 p.

Research output: Contribution to journalArticle

Macrophage control of inflammation: Negative pathways of regulation of inflammatory cytokines

Mantovani, A., Muzio, M., Garlanda, C., Sozzani, S. & Allavena, P., 2001, Novartis Foundation Symposium. Vol. 234. p. 120-135 16 p. (Novartis Foundation Symposium; vol. 234).

Research output: Chapter in Book/Report/Conference proceedingChapter

Micrococci and peptidoglycan activate TLR2 →Myd88 →IRAK→TRAF→NIK→IKK→NF-κB signal transduction pathway that induces transcription of interleukin-8

Wang, Q., Dziarski, R., Kirschning, C. J., Muzio, M. & Gupta, D., 2001, In : Infection and Immunity. 69, 4, p. 2270-2276 7 p.

Research output: Contribution to journalArticle

The Toll receptor family

Muzio, M. & Mantovani, A., 2001, In : Allergy: European Journal of Allergy and Clinical Immunology. 56, 2, p. 103-108 6 p.

Research output: Contribution to journalArticle