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1988 …2018
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Research Output 1988 2018

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Article
2018
5 Citations (Scopus)

Defective functional connectivity between posterior hypothalamus and regions of the diencephalic-mesencephalic junction in chronic cluster headache

Ferraro, S., Nigri, A., Bruzzone, M. G., Brivio, L., Proietti Cecchini, A., Verri, M., Chiapparini, L. & Leone, M., Nov 1 2018, In : Cephalalgia. 38, 13, p. 1910-1918 9 p.

Research output: Contribution to journalArticle

Posterior Hypothalamus
Cluster Headache
Thalamic Nuclei
Ventral Tegmental Area
Substantia Nigra
1 Citation (Scopus)

Evidence mounts for anti-CGRP treatment in cluster headache

Leone, M., Jan 1 2018, (Accepted/In press) In : Nature Reviews Neurology.

Research output: Contribution to journalArticle

Cluster Headache
Calcitonin Gene-Related Peptide
Trigeminal Nerve
Therapeutics
Pain

Migraine with aura and white matter lesions: new evidences

Galli, A., Di Fiore, P., D’Arrigo, G., Uggetti, C., Squarza, S., Leone, M., D’Amico, D. & Frediani, F., Jun 1 2018, In : Neurological Sciences. 39, p. 91-92 2 p.

Research output: Contribution to journalArticle

2017
12 Citations (Scopus)

Abnormal tyrosine metabolism in chronic cluster headache

D'Andrea, G., Leone, M., Bussone, G., Fiore, P. D., Bolner, A., Aguggia, M., Saracco, M. G., Perini, F., Giordano, G., Giordano, G., Gucciardi, A. & Leon, A., Feb 1 2017, In : Cephalalgia. 37, 2, p. 148-153 6 p.

Research output: Contribution to journalArticle

Cluster Headache
Synephrine
Octopamine
Tyramine
Tyrosine
3 Citations (Scopus)

Cluster headache: present and future therapy

Leone, M., Giustiniani, A. & Cecchini, A. P., May 1 2017, In : Neurological Sciences. 38, p. 45-50 6 p.

Research output: Contribution to journalArticle

Cluster Headache
Vagus Nerve Stimulation
Sumatriptan
Therapeutics
Pain
23 Citations (Scopus)

Long-term occipital nerve stimulation for drug-resistant chronic cluster headache

Leone, M., Proietti Cecchini, A., Messina, G. & Franzini, A., Jul 1 2017, In : Cephalalgia. 37, 8, p. 756-763 8 p.

Research output: Contribution to journalArticle

Cluster Headache
Pharmaceutical Preparations
Headache
Electrodes
4 Citations (Scopus)

Migraine with aura white matter lesions: preliminary data on clinical aspects

Galli, A., Di Fiore, P., D’Arrigo, G., Uggetti, C., Squarza, S., Leone, M., D’Amico, D. & Frediani, F., May 1 2017, In : Neurological Sciences. 38, p. 7-10 4 p.

Research output: Contribution to journalArticle

Migraine with Aura
Magnetic Resonance Imaging
Brain
Blood Vessels
Stroke
104 Citations (Scopus)

Overexpression of the cytokine BAFF and autoimmunity risk

Steri, M., Orru, V., Idda, M. L., Pitzalis, M., Pala, M., Zara, I., Sidore, C., Faa, V., Floris, M., Deiana, M., Asunis, I., Porcu, E., Mulas, A., Piras, M. G., Lobina, M., Lai, S., Marongiu, M., Serra, V., Marongiu, M., Sole, G. & 61 others, Busonero, F., Maschio, A., Cusano, R., Cuccuru, G., Deidda, F., Poddie, F., Farina, G., Dei, M., Virdis, F., Olla, S., Satta, M. A., Pani, M., Delitala, A., Cocco, E., Frau, J., Coghe, G., Lorefice, L., Fenu, G., Ferrigno, P., Ban, M., Barizzone, N., Leone, M., Guerini, F. R., Piga, M., Firinu, D., Kockum, I., Bomfim, I. L., Olsson, T., Alfredsson, L., Suarez, A., Carreira, P. E., Castillo-Palma, M. J., Marcus, J. H., Congia, M., Angius, A., Melis, M., Gonzalez, A., Riquelme, M. E. A., Da Silva, B. M., Marchini, M., Danieli, M. G., Del Giacco, S. R., Mathieu, A., Pani, A., Montgomery, S. B., Rosati, G., Hillert, J., Sawcer, S., D'FAlfonso, S., Todd, J. A., Novembre, J., Abecasis, G. R., Whalen, M. B., Marrosu, M. G., Meloni, A., Sanna, S., Gorospe, M., Schlessinger, D., Fiorillo, E., Zoledziewska, M. & Cucca, F., 2017, In : New England Journal of Medicine. 376, 17, p. 1615-1626 12 p.

Research output: Contribution to journalArticle

Autoimmunity
Multiple Sclerosis
Systemic Lupus Erythematosus
Cytokines
Humoral Immunity
4 Citations (Scopus)

Personality disorders in cluster headache: a study using the Millon Clinical Multiaxial Inventory-III

Piacentini, S. H. M. J., Draghi, L., Cecchini, A. P. & Leone, M., May 1 2017, In : Neurological Sciences. 38, p. 181-184 4 p.

Research output: Contribution to journalArticle

Millon Clinical Multiaxial Inventory
Cluster Headache
Personality Disorders
Diagnostic and Statistical Manual of Mental Disorders
Psychology
2016
7 Citations (Scopus)

Long-term use of daily sumatriptan injections in severe drug-resistant chronic cluster headache

Leone, M. & Proietti Cecchini, A., Jan 12 2016, In : Neurology. 86, 2, p. 194-195 2 p.

Research output: Contribution to journalArticle

2015

Analysis of genes, pathways and networks involved in disease severity and age at onset in primary-progressive multiple sclerosis

Giacalone, G., Clarelli, F., Osiceanu, A. M., Guaschino, C., Brambilla, P., Sorosina, M., Liberatore, G., Zauli, A., Esposito, F., Rodegher, M., Ghezzi, A., Galimberti, D., Patti, F., Barizzone, N., Guerini, F., Martinelli, V., Leone, M., Comi, G., Dalfonso, S. & Martinelli Boneschi, F., Oct 2015, In : Multiple Sclerosis. 21, 11, p. 1431-1442 12 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Resting state fMRI in cluster headache: which role?

Chiapparini, L., Ferraro, S., Nigri, A., Proietti, A., Bruzzone, M. G. & Leone, M., May 30 2015, In : Neurological Sciences. 36, p. 47-50 4 p.

Research output: Contribution to journalArticle

Cluster Headache
Magnetic Resonance Imaging
Hypothalamus
Brain Stem
Posterior Hypothalamus

The burden of multiple sclerosis variants in continental Italians and Sardinians

Barizzone, N., Zara, I., Sorosina, M., Lupoli, S., Porcu, E., Pitzalis, M., Zoledziewska, M., Esposito, F., Leone, M., Mulas, A., Cocco, E., Ferrigno, P., Guerini, F. R., Brambilla, P., Farina, G., Murru, R., Deidda, F., Sanna, S., Loi, A. M., Barlassina, C. & 18 others, Vecchio, D., Zauli, A., Clarelli, F., Braga, D., Poddie, F., Cantello, R., Martinelli, V., Comi, G., Frau, J., Lorefice, L., Pugliatti, M., Rosati, G., Melis, M., Marrosu, M. G., Cusi, D., Cucca, F., Martinelli-Boneschi, F. & D'Alfonso, S., Oct 2015, In : Multiple Sclerosis Journal. 21, 11, p. 1385-1395 11 p.

Research output: Contribution to journalArticle

Multiple Sclerosis
Population
Italy
HLA Antigens
ROC Curve
2014

Exploring cerebral networks in cluster headache: Insights and perspectives

Leone, M., Nigri, A., Chiapparini, L. & Ferraro, S., 2014, In : Cephalalgia. 34, 5, p. 323-324 2 p.

Research output: Contribution to journalArticle

2013
2 Citations (Scopus)

Cluster headache: What has changed since 1999?

Leone, M., Cecchini, A. P., Tullo, V., Curone, M., Di Fiore, P. & Bussone, G., 2013, In : Neurological Sciences. 34, SUPPL. 1

Research output: Contribution to journalArticle

Cluster Headache
Headache Disorders
Pain
Brain
100 Citations (Scopus)

Neuromodulation of chronic headaches: position statement from the European Headache Federation

Martelletti, P., Jensen, R. H., Antal, A., Arcioni, R., Brighina, F., de Tommaso, M., Franzini, A., Fontaine, D., Heiland, M., Jürgens, T. P., Leone, M., Magis, D., Paemeleire, K., Palmisani, S., Paulus, W. & May, A., 2013, In : Journal of Headache and Pain. 14, p. 86 1 p.

Research output: Contribution to journalArticle

Headache Disorders
Headache
Secondary Headache Disorders
Consensus
Vagus Nerve Stimulation

Neurostimulators for the treatment of primary headaches

Leone, M., Cecchini, A. P., Franzini, A. & Bussone, G., Jul 2013, In : Future Neurology. 8, 4, p. 457-467 11 p.

Research output: Contribution to journalArticle

Headache
Cluster Headache
Pharmaceutical Preparations
Vagus Nerve Stimulation
Transcutaneous Electric Nerve Stimulation

Occipital neurostimulation in primary headaches: Update

Proietti Cecchini, A., Leone, M., Tullo, V., Curone, M., Di Fiore, P. & Bussone, G., 2013, In : Neurological Sciences. 34, SUPPL. 1

Research output: Contribution to journalArticle

Headache
Migraine Disorders
Headache Disorders
Cluster Headache
Therapeutics
32 Citations (Scopus)

Pearls and pitfalls: Neurostimulation in headache

Jürgens, T. P. & Leone, M., Jun 2013, In : Cephalalgia. 33, 8, p. 512-525 14 p.

Research output: Contribution to journalArticle

Cluster Headache
Headache
Transcutaneous Electric Nerve Stimulation
Migraine Disorders
Vagus Nerve Stimulation
12 Citations (Scopus)

Secondary chronic cluster headache treated by posterior hypothalamic deep brain stimulation: First reported case

Messina, G., Rizzi, M., Cordella, R., Caraceni, A., Zecca, E., Bussone, G., Franzini, A. & Leone, M., Jan 2013, In : Cephalalgia. 33, 2, p. 136-138 3 p.

Research output: Contribution to journalArticle

Cluster Headache
Deep Brain Stimulation
Posterior Hypothalamus
Soft Tissue Neoplasms
Pharmaceutical Preparations
49 Citations (Scopus)

Success, failure, and putative mechanisms in hypothalamic stimulation for drug-resistant chronic cluster headache

Leone, M., Franzini, A., Proietti Cecchini, A. & Bussone, G., Jan 2013, In : Pain. 154, 1, p. 89-94 6 p.

Research output: Contribution to journalArticle

Cluster Headache
Pharmaceutical Preparations
Electrodes
Headache
Third Ventricle
2012
9 Citations (Scopus)

Drug-resistant chronic migraine: The Italian GON project

Proietti Cecchini, A., Leone, M., Manzoni, G. C., Torelli, P. & Bussone, G., May 2012, In : Neurological Sciences. 33, SUPPL. 1

Research output: Contribution to journalArticle

Migraine Disorders
Headache Disorders
Pharmaceutical Preparations
Secondary Headache Disorders
Headache
4 Citations (Scopus)

Efficacy of hypothalamic stimulation for chronic drug-resistant cluster headache

Leone, M., Franzini, A., Cecchini, A. P. & Bussone, G., Mar 2012, In : Cephalalgia. 32, 4, p. 267-268 2 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

From neuroimaging to patients' bench: What we have learnt from trigemino-autonomic pain syndromes

Leone, M., Proietti Cecchini, A., Franzini, A., Messina, G. & Bussone, G., May 2012, In : Neurological Sciences. 33, SUPPL. 1

Research output: Contribution to journalArticle

Trigeminal Autonomic Cephalalgias
Neuroimaging
Pain
Posterior Hypothalamus
Headache

Surgical treatment of primary headaches

Franzini, A., Messina, G., Cordella, R., Proietti Cecchini, A., Leone, M. & Bussone, G., May 2012, In : Neurological Sciences. 33, SUPPL. 1

Research output: Contribution to journalArticle

Headache
Physicians
Research
Pharmaceutical Preparations
Therapeutics
14 Citations (Scopus)

Targeting the brain: Considerations in 332 consecutive patients treated by deep brain stimulation (DBS) for severe neurological diseases

Franzini, A., Cordella, R., Messina, G., Marras, C. E., Romito, L. M., Albanese, A., Rizzi, M., Nardocci, N., Zorzi, G., Zekaj, E., Villani, F., Leone, M., Gambini, O. & Broggi, G., Mar 23 2012, In : Neurological Sciences. 33, 6, p. 1285-1303 19 p.

Research output: Contribution to journalArticle

Deep Brain Stimulation
Brain
Cluster Headache
Implanted Electrodes
Dystonia
2011
9 Citations (Scopus)
Intracranial Hypotension
Headache Disorders
Headache
Differential Diagnosis
Magnetic Resonance Imaging
8 Citations (Scopus)

Management of chronic cluster headache

Leone, M., Franzini, A., Proietti Cecchini, A., Mea, E., Broggi, G. & Bussone, G., Feb 2011, In : Current Treatment Options in Neurology. 13, 1, p. 56-70 15 p.

Research output: Contribution to journalArticle

Cluster Headache
Steroids
Verapamil
Lithium
Ergotamine
3 Citations (Scopus)

Neuromodulation in drug-resistant primary headaches: What have we learned?

Leone, M., Cecchini, A. P., Franzini, A. & Bussone, G., May 2011, In : Neurological Sciences. 32, SUPPL. 1

Research output: Contribution to journalArticle

Headache
Cluster Headache
Pharmaceutical Preparations
Migraine Disorders
Therapeutics
7 Citations (Scopus)

Treatment of alterations in CSF dynamics

Mea, E., Franzini, A., D'Amico, D., Leone, M., Cecchini, A. P., Tullo, V., Chiapparini, L. & Bussone, G., May 2011, In : Neurological Sciences. 32, SUPPL. 1

Research output: Contribution to journalArticle

Intracranial Hypotension
Pseudotumor Cerebri
Intracranial Pressure
Hydrodynamics
Headache
2010
24 Citations (Scopus)

Deep Brain Stimulation in Trigeminal Autonomic Cephalalgias

Leone, M., Franzini, A., Proietti Cecchini, A., Mea, E., Broggi, G. & Bussone, G., Apr 2010, In : Neurotherapeutics. 7, 2, p. 220-228 9 p.

Research output: Contribution to journalArticle

Trigeminal Autonomic Cephalalgias
Cluster Headache
Deep Brain Stimulation
Pain Threshold
Paroxysmal Hemicrania
4 Citations (Scopus)

Drug-resistant primary headache patients undergoing surgical therapies: How should we assess outcomes?

Leone, M., Franzini, A., Cecchini, A. P., Mea, E., Peccarisi, C., Tullo, V., Broggi, G. & Bussone, G., Jun 2010, In : Neurological Sciences. 31, SUPPL.1

Research output: Contribution to journalArticle

Headache
Pharmaceutical Preparations
Patient Satisfaction
Hope
Therapeutics
10 Citations (Scopus)

Efficacy of almotriptan in early intervention for treatment of acute migraine in a primary care setting: The START*study

Lanteri-Minet, M., Díaz-Insa, S., Leone, M., Vila, C. & Clissold, S. P., Jun 2010, In : International Journal of Clinical Practice. 64, 7, p. 936-943 8 p.

Research output: Contribution to journalArticle

Migraine Disorders
Primary Health Care
Pain
Therapeutics
Intention to Treat Analysis
31 Citations (Scopus)

Hypothalamic deep brain stimulation in the treatment of chronic cluster headache

Leone, M., Franzini, A., Proietti Cecchini, A., Broggi, G. & Bussone, G., May 2010, In : Therapeutic Advances in Neurological Disorders. 3, 3, p. 187-195 9 p.

Research output: Contribution to journalArticle

Cluster Headache
Deep Brain Stimulation
Posterior Hypothalamus
Hypothalamus
Pain Threshold
16 Citations (Scopus)
Migraine Disorders
Primary Health Care
Pain
Sleep
Fatigue
34 Citations (Scopus)

Sphenopalatine endoscopic ganglion block in cluster headache: A reevaluation of the procedure after 5 years

Pipolo, C., Bussone, G., Leone, M., Lozza, P. & Felisati, G., Jun 2010, In : Neurological Sciences. 31, SUPPL.1

Research output: Contribution to journalArticle

Sphenopalatine Ganglion Block
Cluster Headache
Headache
Pain
Pharmaceutical Preparations
62 Citations (Scopus)
Intracranial Hypotension
Epidural Blood Patch
Epidural Space
Fibrin Tissue Adhesive
Palatine Tonsil
2009
30 Citations (Scopus)

Application of IHS criteria to headache attributed to spontaneous intracranial hypotension in a large population

Mea, E., Chiapparini, L., Savoiardo, M., Franzini, A., Grimaldi, D., Bussone, G. & Leone, M., Apr 2009, In : Cephalalgia. 29, 4, p. 418-422 5 p.

Research output: Contribution to journalArticle

Intracranial Hypotension
Headache
Population
Epidural Blood Patch
23 Citations (Scopus)

Clinical features and outcomes in spontaneous intracranial hypotension: A survey of 90 consecutive patients

Mea, E., Chiapparini, L., Savoiardo, M., Franzini, A., Bussone, G. & Leone, M., 2009, In : Neurological Sciences. 30, SUPPL. 1

Research output: Contribution to journalArticle

Intracranial Hypotension
Headache
Neurologic Examination
Delayed Diagnosis
Lost to Follow-Up
15 Citations (Scopus)

Cluster headache: Pharmacological treatment and neurostimulation

Leone, M., Franzini, A., Cecchini, A. P., Mea, E., Broggi, G. & Bussone, G., 2009, In : Nature clinical practice. Neurology. 5, 3, p. 153-162 10 p.

Research output: Contribution to journalArticle

Cluster Headache
Pharmacology
Therapeutics
Headache Disorders
Periodicity
19 Citations (Scopus)

Costs of hypothalamic stimulation in chronic drug-resistant cluster headache: Preliminary data

Leone, M., Franzini, A., Proietti Cecchini, A., Mea, E., Broggi, G. & Bussone, G., 2009, In : Neurological Sciences. 30, SUPPL. 1

Research output: Contribution to journalArticle

Cluster Headache
Sumatriptan
Costs and Cost Analysis
Pharmaceutical Preparations
Injections

Erratum: Application of IHS criteria to headache attributed to spontaneous intracranial hypotension in a large population (Cephalalgia (2009) 29 (418-422))

Mea, E., Chiapparini, L., Savoiardo, M., Franzini, A., Grimaldi, D., Bussone, G. & Leone, M., Jul 2009, In : Cephalalgia. 29, 7, p. 805 1 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Feasibility of simultaneous vagal nerve and deep brain stimulation in chronic cluster headache: Case report and considerations

Franzini, A., Messina, G., Leone, M., Proietti Cecchini, A., Broggi, G. & Bussone, G., 2009, In : Neurological Sciences. 30, SUPPL. 1

Research output: Contribution to journalArticle

Cluster Headache
Deep Brain Stimulation
Vagus Nerve Stimulation
Tonic-Clonic Epilepsy
Craniocerebral Trauma
38 Citations (Scopus)

Hypothalamic deep-brain stimulation modulates thermal sensitivity and pain thresholds in cluster headache

Jürgens, T. P., Leone, M., Proietti-Cecchini, A., Busch, V., Mea, E., Bussone, G. & May, A., Nov 2009, In : Pain. 146, 1-2, p. 84-90 7 p.

Research output: Contribution to journalArticle

Cluster Headache
Pain Threshold
Deep Brain Stimulation
Hot Temperature
Posterior Hypothalamus
27 Citations (Scopus)

Occipital nerve stimulation (ONS). Surgical technique and prevention of late electrode migration

Franzini, A., Messina, G., Leone, M. & Broggi, G., Jul 2009, In : Acta Neurochirurgica. 151, 7, p. 861-865 5 p.

Research output: Contribution to journalArticle

Electrodes
Facial Neuralgia
Headache
Therapeutics
Conservative Treatment
10 Citations (Scopus)

Painful ophthalmoplegia: A retrospective study of 23 cases

Curone, M., Tullo, V., Proietti-Cecchini, A., Peccarisi, C., Leone, M. & Bussone, G., 2009, In : Neurological Sciences. 30, SUPPL. 1

Research output: Contribution to journalArticle

Retrospective Studies
Cavernous Sinus
Incidence
Vasculitis
Meningitis
122 Citations (Scopus)

Pathophysiology of trigeminal autonomic cephalalgias

Leone, M. & Bussone, G., Aug 2009, In : The Lancet Neurology. 8, 8, p. 755-764 10 p.

Research output: Contribution to journalArticle

Trigeminal Autonomic Cephalalgias
Headache
Posterior Hypothalamus
Cluster Headache
Paroxysmal Hemicrania
75 Citations (Scopus)

Vagus nerve stimulation in drug-resistant daily chronic migraine with depression: Preliminary data

Proietti Cecchini, A., Mea, E., Tullo, V., Curone, M., Franzini, A., Broggi, G., Savino, M., Bussone, G. & Leone, M., 2009, In : Neurological Sciences. 30, SUPPL. 1

Research output: Contribution to journalArticle

Vagus Nerve Stimulation
Migraine Disorders
Depression
Headache Disorders
Pharmaceutical Preparations
2008
32 Citations (Scopus)
Myoclonus
Brain Stem
Sarcoglycans
Somatosensory Evoked Potentials
Transcranial Magnetic Stimulation
13 Citations (Scopus)

Epidemiology of fixed unilateral headaches

Leone, M., Cecchini, A. P., Mea, E., Tullo, V. & Bussone, G., Jul 2008, In : Cephalalgia. 28, SUPPL. 1, p. 8-11 4 p.

Research output: Contribution to journalArticle

Headache
Epidemiology
Cluster Headache
Post-Traumatic Headache
Tension-Type Headache