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2018

pH regulators to target the tumor immune microenvironment in human hepatocellular carcinoma

Kuchuk, O., Tuccitto, A., Citterio, D., Huber, V., Camisaschi, C., Milione, M., Vergani, B., Villa, A., Alison, M. R., Carradori, S., Supuran, C. T., Rivoltini, L., Castelli, C. & Mazzaferro, V., 2018, In : OncoImmunology. 7, 7

Research output: Contribution to journalArticle

RET fusions in a small subset of advanced colorectal cancers at risk of being neglected

Pietrantonio, F., Di Nicolantonio, F., Schrock, A. B., Lee, J., Morano, F., Fuca, G., Nikolinakos, P., Drilon, A., Hechtman, J. F., Christiansen, J., Gowen, K., Frampton, G. M., Gasparini, P., Rossini, D., Gigliotti, C., Kim, S. T., Prisciandaro, M., Hodgson, J., Zaniboni, A., Chiu, V. K. & 16 others, Milione, M., Patel, R., Miller, V., Bardelli, A., Novara, L., Wang, L., Pupa, S. M., Sozzi, G., Ross, J., Di Bartolomeo, M., Bertotti, A., Ali, S., Trusolino, L., Falcone, A., de Braud, F. & Cremolini, C., Jun 1 2018, In : Annals of oncology : official journal of the European Society for Medical Oncology. 29, 6, p. 1394-1401 8 p.

Research output: Contribution to journalArticle

Treatment of Advanced Merkel Cell Carcinoma: Current Therapeutic Options and Novel Immunotherapy Approaches

Femia, D., Prinzi, N., Anichini, A., Mortarini, R., Nichetti, F., Corti, F., Torchio, M., Peverelli, G., Pagani, F., Maurichi, A., Mattavelli, I., Milione, M., Bedini, N., Corti, A., Di Bartolomeo, M., de Braud, F. & Pusceddu, S., Oct 2018, In : Targeted Oncology. 13, 5, p. 567-582 16 p.

Research output: Contribution to journalArticle

2017

Digital PCR assessment of MGMT promoter methylation coupled with reduced protein expression optimises prediction of response to alkylating agents in metastatic colorectal cancer patients

Sartore-Bianchi, A., Pietrantonio, F., Amatu, A., Milione, M., Cassingena, A., Ghezzi, S., Caporale, M., Berenato, R., Falcomatà, C., Pellegrinelli, A., Bardelli, A., Nichelatti, M., Tosi, F., De Braud, F., Di Nicolantonio, F., Barault, L. & Siena, S., Jan 1 2017, In : European Journal of Cancer. 71, p. 43-50 8 p.

Research output: Contribution to journalArticle

Digital PCR assessment of MGMT promoter methylation coupled with reduced protein expression optimises prediction of response to alkylating agents in metastatic colorectal cancer patients.

Sartore-Bianchi, A., Pietrantonio, F., Amatu, A., Milione, M., Cassingena, A., Ghezzi, S., Caporale, M., Berenato, R., Falcomata, C., Pellegrinelli, A., Bardelli, A., Nichelatti, M., Tosi, F., De Braud, F., Di Nicolantonio, F., Barault, L. & Siena, S., Jan 1 2017, In : European Journal of Cancer. 71, p. 43-50 8 p.

Research output: Contribution to journalArticle

Efficacy of FOLFOXIRI plus bevacizumab in liver-limited metastatic colorectal cancer: A pooled analysis of clinical studies by Gruppo Oncologico del Nord Ovest

Cremolini, C., Casagrande, M., Loupakis, F., Aprile, G., Bergamo, F., Masi, G., Moretto R, R., Pietrantonio, F., Marmorino, F., Zucchelli, G., Tomasello, G., Tonini, G., Allegrini, G., Granetto, C., Ferrari, L., Urbani, L., Cillo, U., Pilati, P., Sensi, E., Pellegrinelli, A. & 3 others, Milione, M., Fontanini, G. & Falcone, A., Mar 2017, In : European Journal of Cancer. 73, p. 74-84 11 p.

Research output: Contribution to journalArticle

Efficacy of FOLFOXIRI plus bevacizumab in liver-limited metastatic colorectal cancer: A pooled analysis of clinical studies by Gruppo Oncologico del Nord Ovest.

Cremolini, C., Casagrande, M., Loupakis, F., Aprile, G., Bergamo, F., Masi, G., Moretto R, R., Pietrantonio, F., Marmorino, F., Zucchelli, G., Tomasello, G., Tonini, G., Allegrini, G., Granetto, C., Ferrari, L., Urbani, L., Cillo, U., Pilati, P., Sensi, E., Pellegrinelli, A. & 3 others, Milione, M., Fontanini, G. & Falcone, A., Mar 1 2017, In : European Journal of Cancer. 73, p. 74-84 11 p.

Research output: Contribution to journalArticle

Four Neuroendocrine Tumor Types and Neuroendocrine Carcinoma of the Duodenum: Analysis of 203 Cases

Vanoli, A., Rosa, S. L., Klersy, C., Grillo, F., Albarello, L., Inzani, F., Maragliano, R., Manca, R., Luinetti, O., Milione, M., Doglioni, C., Rindi, G., Capella, C. & Solcia, E., 2017, In : Neuroendocrinology. 104, 2, p. 112-125 14 p.

Research output: Contribution to journalArticle

Four Neuroendocrine Tumor Types and the Neuroendocrine Carcinoma of the Duodenum. Analysis of 203 Cases

Vanoli, A., La Rosa, S., Klersy, C., Grillo, F., Albarello, L., Inzani, F., Maragliano, R., Manca, R., Luinetti, O., Milione, M., Doglioni, C., Rindi, G., Capella, C. & Solcia, E., 2017, In : Neuroendocrinology.

Research output: Contribution to journalArticle

Gastroenteropancreatic neuroendocrine carcinomas: The NET G3 subcategory is a reality

Fazio, N. & Milione, M., 2017, In : Oncologist. 22, 3, p. 359-360 2 p.

Research output: Contribution to journalArticle

Heterogeneity of acquired resistance to anti-EGFR monoclonal antibodies in patients with metastatic colorectal cancer

Pietrantonio, F., Vernieri, C., Siravegna, G., Mennitto, A., Berenato, R., Perrone, F., Gloghini, A., Tamborini, E., Lonardi, S., Morano, F., Picciani, B., Busico, A., Volpi, C. C., Martinetti, A., Battaglin, F., Bossi, I., Pellegrinelli, A., Milione, M., Cremolini, C., Di Bartolomeo, M. & 2 others, Bardelli, A. & De Braud, F., May 15 2017, In : Clinical Cancer Research. 23, 10, p. 2414-2422 9 p.

Research output: Contribution to journalArticle

Heterogeneity of acquired resistance to anti-EGFR monoclonal antibodies in patients with metastatic colorectal cancer

Pietrantonio, F., Vernieri, C., Siravegna, G., Mennitto, A., Berenato, R., Perrone, F., Gloghini, A., Tamborini, E., Lonardi, S., Morano, F., Picciani, B., Busico, A., Volpi, C. C., Martinetti, A., Battaglin, F., Bossi, I., Pellegrinelli, A., Milione, M., Cremolini, C., Di Bartolomeo, M. & 2 others, Bardelli, A. & De Braud, F., May 15 2017, In : Clinical Cancer Research. 23, 10, p. 2414-2422 9 p.

Research output: Contribution to journalArticle

Hyperthermic Intraperitoneal Chemotherapy (HIPEC) at the Time of Primary Curative Surgery in Patients with Colorectal Cancer at High Risk for Metachronous Peritoneal Metastases.

Baratti, D., Kusamura, S., Iusco, D., Gimondi, S., Pietrantonio, F., Milione, M., Guaglio, M., Bonomi, S., Grassi, A., Virzi, S., Leo, E. & Deraco, M., Jan 1 2017, In : Annals of Surgical Oncology. 24, 1, p. 167-175 9 p.

Research output: Contribution to journalArticle

Identification and characterization of a novel SCYL3-NTRK1 rearrangement in a colorectal cancer patient

Milione, M., Ardini, E., Christiansen, J., Valtorta, E., Veronese, S., Bosotti, R., Pellegrinelli, A., Testi, A., Pietrantonio, F., Fucà, G., Wei, G., Murphy, D., Siena, S., Isacchi, A. & De Braud, F., Jan 1 2017, In : Oncotarget. 8, 33, p. 55353-55360 8 p.

Research output: Contribution to journalArticle

IMP3 expression in small-intestine neuroendocrine neoplasms: a new predictor of recurrence

Massironi, S., Del Gobbo, A., Cavalcoli, F., Fiori, S., Conte, D., Pellegrinelli, A., Milione, M. & Ferrero, S., 2017, In : Endocrine. 58, 2, p. 360-367 8 p.

Research output: Contribution to journalArticle

IMP3 expression in small-intestine neuroendocrine neoplasms: a new predictor of recurrence

Massironi, S., Del Gobbo, A., Cavalcoli, F., Fiori, S., Conte, D., Pellegrinelli, A., Milione, M. & Ferrero, S., Nov 2017, In : Endocrine. 58, 2, p. 360-367 8 p.

Research output: Contribution to journalArticle

Loss of succinate dehydrogenase subunit B (SDHB) as a prognostic factor in advanced ileal well-differentiated neuroendocrine tumors

Milione, M., Maisonneuve, P., Pellegrinelli, A., Pusceddu, S., Centonze, G., Dominoni, F., Brambilla, C., Rubino, M., Faggiano, A., Buzzoni, R., Concas, L., Giacomelli, L., Coppa, J., Mazzaferro, V. & de Braud, F., 2017, In : Endocrine. 57, 3, p. 512-517 6 p.

Research output: Contribution to journalArticle

MIF/CD74 axis is a target for novel therapies in colon carcinomatosis

Bozzi, F., Mogavero, A., Varinelli, L., Belfiore, A., Manenti, G., Caccia, C., Volpi, C. C., Beznoussenko, G. V., Milione, M., Leoni, V., Gloghini, A., Mironov, A. A., Leo, E., Pilotti, S., Pierotti, M. A., Bongarzone, I. & Gariboldi, M., Jan 23 2017, In : Journal of Experimental and Clinical Cancer Research. 36, 1, p. 1-15 15 p.

Research output: Contribution to journalArticle

MIF/CD74 axis is a target for novel therapies in colon carcinomatosis.

Bozzi, F., Mogavero, A., Varinelli, L., Belfiore, A., Manenti, G., Caccia, C., Volpi, C. C., Beznoussenko, G. V., Milione, M., Leoni, V., Gloghini, A., Mironov, A. A., Leo, E., Pilotti, S., Alessandro Pierotti, M., Bongarzone, I. & Gariboldi, M., Jan 1 2017, In : Journal of Experimental and Clinical Cancer Research. 36, 1, p. 16 1 p.

Research output: Contribution to journalArticle

mir-660-p53-mir-486 Network: A New Key Regulatory Pathway in Lung Tumorigenesis.

Borzi, C., Calzolari, L., Centonze, G., Milione, M., Sozzi, G. & Fortunato, O., Jan 1 2017, In : International Journal of Molecular Sciences. 18, 1

Research output: Contribution to journalArticle

Negative hyper-selection of metastatic colorectal cancer patients for anti-EGFR monoclonal antibodies: the PRESSING case-control study

Cremolini, C., Morano, F., Moretto, R., Berenato, R., Tamborini, E., Perrone, F., Rossini, D., Gloghini, A., Busico, A., Zucchelli, G., Baratelli, C., Tamburini, E., Tampellini, M., Sensi, E., Fucà, G., Volpi, C., Milione, M., Di Maio, M., Fontanini, G., De Braud, F. & 2 others, Falcone, A. & Pietrantonio, F., Dec 1 2017, In : Annals of oncology : official journal of the European Society for Medical Oncology. 28, 12, p. 3009-3014 6 p.

Research output: Contribution to journalArticle

Protein drug target activation homogeneity in the face of intratumor heterogeneity: Implications for precision medicine

Parasido, E. M., Silvestri, A., Canzonieri, V., Belluco, C., Diodoro, M. G., Milione, M., Melotti, F., De Maria, R., Liotta, L., Petricoin, E. F. & Pierobon, M., Jan 1 2017, In : Oncotarget. 8, 30, p. 48534-48544 11 p.

Research output: Contribution to journalArticle

Protein drug target activation homogeneity in the face of intratumor heterogeneity: Implications for precision medicine

Parasido, E. M., Silvestri, A., Canzonieri, V., Belluco, C., Diodoro, M. G., Milione, M., Melotti, F., De Maria, R., Liotta, L., Petricoin, E. F. & Pierobon, M., Jan 1 2017, In : Oncotarget. 8, 30, p. 48534-48544 11 p.

Research output: Contribution to journalArticle

Protein drug target activation homogeneity in the face of intra-tumor heterogeneity: implications for precision medicine

Parasido, E. M., Silvestri, A., Canzonieri, V., Belluco, C., Diodoro, M. G., Milione, M., Melotti, F., De Maria, R., Liotta, L., Petricoin, E. F. & Pierobon, M., Jul 25 2017, In : Oncotarget. 8, 30, p. 48534-48544 11 p.

Research output: Contribution to journalArticle

Rationale and protocol of MetNET-2 trial: Lanreotide Autogel plus metformin in advanced gastrointestinal or lung neuroendocrine tumors

Pusceddu, S., Prinzi, N., Lo Russo, G., Femia, D., Milione, M., Perrone, F., Tamborini, E., Concas, L., Pulice, I., Vernieri, C., Corti, F., Buzzoni, R. & De Braud, F., 2017, In : Future Oncology. 13, 19, p. 1677-1683 7 p.

Research output: Contribution to journalArticle

2016

Abdominosacral resection for locally recurring rectal cancer

Belli, F., Gronchi, A., Corbellini, C., Milione, M. & Leo, E., Dec 27 2016, In : World journal of gastrointestinal surgery. 8, 12, p. 770-778 9 p.

Research output: Contribution to journalArticle

Conversion to stem-cell state in response to microenvironmental cues is regulated by balance between epithelial and mesenchymal features in lung cancer cells

Andriani, F., Bertolini, G., Facchinetti, F., Baldoli, E., Moro, M., Casalini, P., Caserini, R., Milione, M., Leone, G., Pelosi, G., Pastorino, U., Sozzi, G. & Roz, L., Feb 1 2016, In : Molecular Oncology. 10, 2, p. 253-271 19 p.

Research output: Contribution to journalArticle

Dose-Dense Temozolomide in Patients with MGMT-Silenced Chemorefractory Colorectal Cancer

Pietrantonio, F., de Braud, F., Milione, M., Maggi, C. A., Iacovelli, R., Dotti, K. F., Perrone, F., Tamborini, E., Caporale, M., Berenato, R., Leone, G., Pellegrinelli, A., Bossi, I., Festinese, F., Federici, S. & Di Bartolomeo, M., 2016, In : Targeted Oncology. 11, 3, p. 337-343 7 p.

Research output: Contribution to journalArticle

Endoscopic ultrasound-guided fine needle aspiration of splenic vein thrombosis: A novel approach to the portal venous system

Delconte, G., Bhoori, S., Milione, M., Cavallaro, F., Masci, E., Siersema, P. D. & Mazzaferro, V., Feb 1 2016, In : Endoscopy. 48, p. E40-E41

Research output: Contribution to journalArticle

Four Neuroendocrine Tumor Types and the Neuroendocrine Carcinoma of the Duodenum. Analysis of 203 Cases

Vanoli, A., La Rosa, S., Klersy, C., Grillo, F., Albarello, L., Inzani, F., Maragliano, R., Manca, R., Luinetti, O., Milione, M., Doglioni, C., Rindi, G., Capella, C. & Solcia, E., Feb 25 2016, (Accepted/In press) In : Neuroendocrinology.

Research output: Contribution to journalArticle

Four Neuroendocrine Tumor Types and the Neuroendocrine Carcinoma of the Duodenum. Analysis of 203 Cases

Vanoli, A., La Rosa, S., Klersy, C., Grillo, F., Albarello, L., Inzani, F., Maragliano, R., Manca, R., Luinetti, O., Milione, M., Doglioni, C., Rindi, G., Capella, C. & Solcia, E., Feb 25 2016, (Accepted/In press) In : Neuroendocrinology.

Research output: Contribution to journalArticle

GNAS mutations as prognostic biomarker in patients with relapsed peritoneal pseudomyxoma receiving metronomic capecitabine and bevacizumab: A clinical and translational study

Pietrantonio, F., Berenato, R., Maggi, C., Caporale, M., Milione, M., Perrone, F., Tamborini, E., Baratti, D., Kusamura, S., Mariani, L., Niger, M., Mennitto, A., Gloghini, A., Bossi, I., Settanni, G., Busico, A., Bagnoli, P. F., Di Bartolomeo, M., Deraco, M. & de Braud, F., May 6 2016, In : Journal of Translational Medicine. 14, 1, 125.

Research output: Contribution to journalArticle

GNAS mutations as prognostic biomarker in patients with relapsed peritoneal pseudomyxoma receiving metronomic capecitabine and bevacizumab: A clinical and translational study

Pietrantonio, F., Berenato, R., Maggi, C. A., Caporale, M., Milione, M., Perrone, F., Tamborini, E., Baratti, D., Kusamura, S., Mariani, L., Niger, M., Mennitto, A., Gloghini, A., Bossi, I., Settanni, G., Busico, A., Bagnoli, P. F., Di Bartolomeo, M., Deraco, M. & de Braud, F., 2016, In : Journal of Translational Medicine. 14, 1

Research output: Contribution to journalArticle

Heterogeneity of Acquired Resistance to Anti-EGFR Monoclonal Antibodies in Patients with Metastatic Colorectal Cancer

Pietrantonio, F., Vernieri, C., Siravegna, G., Mennitto, A., Berenato, R., Perrone, F., Gloghini, A., Tamborini, E., Lonardi, S., Morano, F., Picciani, B., Busico, A., Volpi, C. C., Martinetti, A., Battaglin, F., Bossi, I., Pellegrinelli, A., Milione, M., Cremolini, C., Di Bartolomeo, M. & 2 others, Bardelli, A. & De Braud, F., 2016, In : Clinical Cancer Research.

Research output: Contribution to journalArticle

Heterogeneity of Acquired Resistance to Anti-EGFR Monoclonal Antibodies in Patients with Metastatic Colorectal Cancer

Pietrantonio, F., Vernieri, C., Siravegna, G., Mennitto, A., Berenato, R., Perrone, F., Gloghini, A., Tamborini, E., Lonardi, S., Morano, F., Picciani, B., Busico, A., Volpi, C. C., Martinetti, A., Battaglin, F., Bossi, I., Pellegrinelli, A., Milione, M., Cremolini, C., Di Bartolomeo, M. & 2 others, Bardelli, A. & de Braud, F., Oct 25 2016, In : Clinical Cancer Research.

Research output: Contribution to journalArticle

Heterogeneity of Acquired Resistance to Anti-EGFR Monoclonal Antibodies in Patients with Metastatic Colorectal Cancer.

Pietrantonio, F., Vernieri, C., Siravegna, G., Mennitto, A., Berenato, R., Perrone, F., Gloghini, A., Tamborini, E., Lonardi, S., Morano, F., Picciani, B., Busico, A., Volpi, C. C., Martinetti, A., Battaglin, F., Bossi, I., Pellegrinelli, A., Milione, M., Cremolini, C., Di Bartolomeo, M. & 2 others, Bardelli, A. & de Braud, F., Oct 1 2016, In : Clinical Cancer Research.

Research output: Contribution to journalArticle

Loss of succinate dehydrogenase subunit B (SDHB) as a prognostic factor in advanced ileal well-differentiated neuroendocrine tumors

Milione, M., Maisonneuve, P., Pellegrinelli, A., Pusceddu, S., Centonze, G., Dominoni, F., Brambilla, C., Rubino, M., Faggiano, A., Buzzoni, R., Concas, L., Giacomelli, L., Coppa, J., Mazzaferro, V. & de Braud, F., Nov 30 2016, In : Endocrine.

Research output: Contribution to journalArticle

Metformin with everolimus and octreotide in pancreatic neuroendocrine tumor patients with diabetes

Pusceddu, S., Buzzoni, R., Vernieri, C., Concas, L., Marceglia, S., Giacomelli, L., Milione, M., Leuzzi, L., Femia, D., Formisano, B., Mazzaferro, V. & De Braud, F., May 1 2016, In : Future Oncology. 12, 10, p. 1251-1260 10 p.

Research output: Contribution to journalArticle

Perioperative Triplet Chemotherapy and Cetuximab in Patients With RAS Wild Type High Recurrence Risk or Borderline Resectable Colorectal Cancer Liver Metastases

Pietrantonio, F., Di Bartolomeo, M., Cotsoglou, C., Mennitto, A., Berenato, R., Morano, F., Coppa, J., Perrone, F., Iacovelli, R., Milione, M., Alessi, A., Vaiani, M., Bossi, I., Ricchini, F., Scotti, M., Caporale, M., Bajetta, E., de Braud, F. & Mazzaferro, V., Oct 6 2016, In : Clinical Colorectal Cancer.

Research output: Contribution to journalArticle

Pseudomyxoma Peritonei of Extra-Appendiceal Origin: A Comparative Study

Baratti, D., Kusamura, S., Milione, M., Pietrantonio, F., Caporale, M., Guaglio, M. & Deraco, M., Jun 28 2016, (Accepted/In press) In : Annals of Surgical Oncology. p. 1-9 9 p.

Research output: Contribution to journalArticle