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Research Output 1989 2019

2019

An update on emerging drugs in osteosarcoma: towards tailored therapies?

Hattinger, C. M., Patrizio, M. P., Magagnoli, F., Luppi, S. & Serra, M., Sep 2019, In : Expert Opinion on Emerging Drugs. 24, 3, p. 153-171 19 p.

Research output: Contribution to journalArticle

Osteosarcoma
Pharmaceutical Preparations
Clinical Trials
Therapeutics
Neoplasms

Current understanding of pharmacogenetic implications of DNA damaging drugs used in osteosarcoma treatment

Hattinger, C. M., Patrizio, M. P., Luppi, S., Magagnoli, F., Picci, P. & Serra, M., Apr 1 2019, In : Expert opinion on drug metabolism & toxicology. 15, 4, p. 299-311 13 p.

Research output: Contribution to journalArticle

Pharmacogenetics
Osteosarcoma
DNA
Polymorphism
Pharmaceutical Preparations

Hyaluronated liposomes containing H2S-releasing doxorubicin are effective against P-glycoprotein-positive/doxorubicin-resistant osteosarcoma cells and xenografts

Gazzano, E., Buondonno, I., Marengo, A., Rolando, B., Chegaev, K., Kopecka, J., Saponara, S., Sorge, M., Hattinger, C. M., Gasco, A., Fruttero, R., Brancaccio, M., Serra, M., Stella, B., Fattal, E., Arpicco, S. & Riganti, C., Aug 2019, In : Cancer Letters. 456, p. 29-39 11 p.

Research output: Contribution to journalArticle

P-Glycoprotein
Osteosarcoma
Hyaluronic Acid
Heterografts
Liposomes

Prenylated Curcumin Analogues as Multipotent Tools to Tackle Alzheimer's Disease

Bisceglia, F., Seghetti, F., Serra, M., Zusso, M., Gervasoni, S., Verga, L., Vistoli, G., Lanni, C., Catanzaro, M., De Lorenzi, E. & Belluti, F., Jan 1 2019, (Accepted/In press) In : ACS Chemical Neuroscience.

Research output: Contribution to journalArticle

Curcumin
Alzheimer Disease
Poisons
Oligomers
Capillary electrophoresis
2018

Agave negatively regulates YAP and TAZ transcriptionally and post-translationally in osteosarcoma cell lines

Ferraiuolo, M., Pulito, C., Finch-Edmondson, M., Korita, E., Maidecchi, A., Donzelli, S., Muti, P., Serra, M., Sudol, M., Strano, S. & Blandino, G., Oct 1 2018, In : Cancer Letters. 433, p. 18-32 15 p.

Research output: Contribution to journalArticle

Agave
Osteosarcoma
Cell Line
Proteins
NF-kappa B

An RGD small-molecule integrin antagonist induces detachment-mediated anoikis in glioma cancer stem cells

Paolillo, M., Galiazzo, M. C., Daga, A., Ciusani, E., Serra, M., Colombo, L. & Schinelli, S., Dec 1 2018, In : International Journal of Oncology. 53, 6, p. 2683-2694 12 p.

Research output: Contribution to journalArticle

Anoikis
Neoplastic Stem Cells
Integrins
Glioma
Glioblastoma

Endoplasmic reticulum-targeting doxorubicin: a new tool effective against doxorubicin-resistant osteosarcoma

Buondonno, I., Gazzano, E., Tavanti, E., Chegaev, K., Kopecka, J., Fanelli, M., Rolando, B., Fruttero, R., Gasco, A., Hattinger, C., Serra, M. & Riganti, C., Nov 14 2018, In : Cellular and Molecular Life Sciences. 76, 3, p. 609-625 17 p.

Research output: Contribution to journalArticle

Osteosarcoma
Endoplasmic Reticulum
Doxorubicin
P-Glycoprotein
Endoplasmic Reticulum Stress

Establishment and characterization of in vivo orthotopic bioluminescent xenograft models from human osteosarcoma cell lines in Swiss nude and NSG mice

Marques da Costa, M. E., Daudigeos-Dubus, E., Gomez-Brouchet, A., Bawa, O., Rouffiac, V., Serra, M., Scotlandi, K., Santos, C., Geoerger, B. & Gaspar, N., Mar 1 2018, In : Cancer Medicine. 7, 3, p. 665-676 12 p.

Research output: Contribution to journalArticle

Osteosarcoma
Heterografts
Nude Mice
Cell Line
Neoplasms

Functionalized Keratin as Nanotechnology-Based Drug Delivery System for the Pharmacological Treatment of Osteosarcoma

Martella, E., Ferroni, C., Guerrini, A., Ballestri, M., Columbaro, M., Santi, S., Sotgiu, G., Serra, M., Donati, D. M., Lucarelli, E., Varchi, G. & Duchi, S., Nov 20 2018, In : International Journal of Molecular Sciences. 19, 11, p. 1-16 16 p.

Research output: Contribution to journalArticle

keratins
Keratin
Nanotechnology
Osteosarcoma
Drug Delivery Systems

Genetic testing for high-grade osteosarcoma: a guide for future tailored treatments?

Hattinger, C. M., Patrizio, M. P., Tavanti, E., Luppi, S., Magagnoli, F., Picci, P. & Serra, M., Nov 2018, In : Expert Review of Molecular Diagnostics. 18, 11, p. 947-961 15 p.

Research output: Contribution to journalReview article

Genetic Testing
Osteosarcoma
Patient Selection
Biomarkers
Technology
2017

Doxorubicin-resistant osteosarcoma: Novel therapeutic approaches in sight?

Hattinger, C. M., Fanelli, M., Tavanti, E., Vella, S., Riganti, C., Picci, P. & Serra, M., Apr 1 2017, In : Future Oncology. 13, 8, p. 673-677 5 p.

Research output: Contribution to journalComment/debate

Osteosarcoma
Doxorubicin
Therapeutics
Ifosfamide
Methotrexate

Genome-wide association study identifies the GLDC/IL33 locus associated with survival of osteosarcoma patients

Koster, R., Panagiotou, O. A., Wheeler, W. A., Karlins, E., Gastier-Foster, J. M., de Toledo, S. R. C., Petrilli, A. S., Flanagan, A. M., Tirabosco, R., Andrulis, I. L., Wunder, J. S., Gokgoz, N., Patino-Garcia, A., Lecanda, F., Serra, M., Hattinger, C., Picci, P., Scotlandi, K., Thomas, D. M., Ballinger, M. L. & 11 others, Gorlick, R., Barkauskas, D. A., Spector, L. G., Tucker, M., Belynda, DH., Yeager, D. H., Hoover, R. N., Wacholder, S., Chanock, S. J., Savage, S. A. & Mirabello, L., 2017, In : International Journal of Cancer. p. 1-9 9 p.

Research output: Contribution to journalArticle

Genome-Wide Association Study
Osteosarcoma
Survival
Confidence Intervals
Meta-Analysis

Pharmacogenomics of genes involved in antifolate drug response and toxicity in osteosarcoma

Hattinger, C. M., Tavanti, E., Fanelli, M., Vella, S., Picci, P. & Serra, M., Mar 4 2017, In : Expert Opinion on Drug Metabolism and Toxicology. 13, 3, p. 245-257 13 p.

Research output: Contribution to journalReview article

Folic Acid Antagonists
Pharmacogenetics
Osteosarcoma
Drug-Related Side Effects and Adverse Reactions
Toxicity

The pharmacogenomics of osteosarcoma

Serra, M. & Hattinger, C. M., Jan 2017, In : Pharmacogenomics Journal. 17, 1, p. 11-20 10 p.

Research output: Contribution to journalArticle

Pharmacogenetics
Osteosarcoma
Biomarkers
Molecular Targeted Therapy
Therapeutics
2016

Analysis of heritability and shared heritability based on genome-wide association studies for thirteen cancer types

Sampson, J. N., Wheeler, W. A., Yeager, M., Panagiotou, O., Wang, Z., Berndt, S. I., Lan, Q., Abnet, C. C., Amundadottir, L. T., Figueroa, J. D., Landi, M. T., Mirabello, L., Savage, S. A., Taylor, P. R., De Vivo, I., McGlynn, K. A., Purdue, M. P., Rajaraman, P., Adami, H. O., Ahlbom, A. & 388 others, Albanes, D., Amary, M. F., An, S. J., Andersson, U., Andriole, G., Andrulis, I. L., Angelucci, E., Ansell, S. M., Arici, C., Armstrong, B. K., Arslan, A. A., Austin, M. A., Baris, D., Barkauskas, D. A., Bassig, B. A., Becker, N., Benavente, Y., Benhamou, S., Berg, C., Van Den Berg, D., Bernstein, L., Bertrand, K. A., Birmann, B. M., Black, A., Boeing, H., Boffetta, P., Boutron-Ruault, M. C., Bracci, P. M., Brinton, L., Brooks-Wilson, A. R., Bueno-De-Mesquita, H. B., Burdett, L., Buring, J., Butler, M. A., Cai, Q., Cancel-Tassin, G., Canzian, F., Carrato, A., Carreon, T., Carta, A., Chan, J. K. C., Chang, E. T., Chang, G. C., Chang, I. S., Chang, J., Chang-Claude, J., Chen, C. J., Chen, C. Y., Chen, C., Chen, C. H., Chen, C., Chen, H., Chen, K., Chen, K. Y., Chen, K. C., Chen, Y., Chen, Y. H., Chen, Y. S., Chen, Y. M., Chien, L. H., Chirlaque, M. D., Choi, J. E., Choi, Y. Y., Chow, W. H., Chung, C. C., Clavel, J., Clavel-Chapelon, F., Cocco, P., Colt, J. S., Comperat, E., Conde, L., Connors, J. M., Conti, D., Cortessis, V. K., Cotterchio, M., Cozen, W., Crouch, S., Crous-Bou, M., Cussenot, O., Davis, F. G., Ding, T., Diver, W. R., Dorronsoro, M., Dossus, L., Duell, E. J., Ennas, M. G., Erickson, R. L., Feychting, M., Flanagan, A. M., Foretova, L., Fraumeni, J. F., Freedman, N. D., Freeman, L. E. B., Fuchs, C., Gago-Dominguez, M., Gallinger, S., Gao, Y. T., Gapstur, S. M., Garcia-Closas, M., García-Closas, R., Gascoyne, R. D., Gastier-Foster, J., Gaudet, M. M., Gaziano, J. M., Giffen, C., Giles, G. G., Giovannucci, E., Glimelius, B., Goggins, M., Gokgoz, N., Goldstein, A. M., Gorlick, R., Gross, M., Grubb, R., Gu, J., Guan, P., Gunter, M., Guo, H., Habermann, T. M., Haiman, C. A., Halai, D., Hallmans, G., Hassan, M., Hattinger, C., He, Q., He, X., Helzlsouer, K., Henderson, B., Henriksson, R., Hjalgrim, H., Hoffman-Bolton, J., Hohensee, C., Holford, T. R., Holly, E. A., Hong, Y. C., Hoover, R. N., Horn-Ross, P. L., Hosain, G. M. M., Hosgood, H. D., Hsiao, C. F., Hu, N., Hu, W., Hu, Z., Huang, M. S., Huerta, J. M., Hung, J. Y., Hutchinson, A., Inskip, P. D., Jackson, R. D., Jacobs, E. J., Jenab, M., Jeon, H. S., Ji, B. T., Jin, G., Jin, L., Johansen, C., Johnson, A., Jung, Y. J., Kaaks, R., Kamineni, A., Kane, E., Kang, C. H., Karagas, M. R., Kelly, R. S., Khaw, K. T., Kim, C., Kim, H. N., Kim, J. H., Kim, J. S., Kim, Y. H., Kim, Y. T., Kim, Y. C., Kitahara, C. M., Klein, A. P., Klein, R. J., Kogevinas, M., Kohno, T., Kolonel, L. N., Kooperberg, C., Kricker, A., Krogh, V., Kunitoh, H., Kurtz, R. C., Kweon, S. S., La Croix, A., Lawrence, C., Lecanda, F., Lee, V. H. F., Li, D., Li, H., Li, J., Li, Y. J., Li, Y., Liao, L. M., Liebow, M., Lightfoot, T., Lim, W. Y., Lin, C. C., Lin, D., Lindstrom, S., Linet, M. S., Link, B. K., Liu, C., Liu, J., Liu, L., Ljungberg, B., Lloreta, J., Di Lollo, S., Lu, D., Lund, E., Malats, N., Mannisto, S., Marchand, L. L., Marina, N., Masala, G., Mastrangelo, G., Matsuo, K., Maynadie, M., McKay, J., McKean-Cowdin, R., Melbye, M., Melin, B. S., Michaud, D. S., Mitsudomi, T., Monnereau, A., Montalvan, R., Moore, L. E., Mortensen, L. M., Nieters, A., North, K. E., Novak, A. J., Oberg, A. L., Offit, K., Oh, I. J., Olson, S. H., Palli, D., Pao, W., Park, I. K., Park, J. Y., Park, K. H., Patiño-Garcia, A., Pavanello, S., Peeters, P. H. M., Perng, R. P., Peters, U., Petersen, G. M., Picci, P., Pike, M. C., Porru, S., Prescott, J., Prokunina-Olsson, L., Qian, B., Qiao, Y. L., Rais, M., Riboli, E., Riby, J., Risch, H. A., Rizzato, C., Rodabough, R., Roman, E., Roupret, M., Ruder, A. M., De Sanjose, S., Scelo, G., Schned, A., Schumacher, F., Schwartz, K., Schwenn, M., Scotlandi, K., Seow, A., Serra, C., Serra, M., Sesso, H. D., Setiawan, V. W., Severi, G., Severson, R. K., Shanafelt, T. D., Shen, H., Shen, W., Shin, M. H., Shiraishi, K., Shu, X. O., Siddiq, A., Sierrasesúmaga, L., Sihoe, A. D. L., Skibola, C. F., Smith, A., Smith, M. T., Southey, M. C., Spinelli, J. J., Staines, A., Stampfer, M., Stern, M. C., Stevens, V. L., Stolzenberg-Solomon, R. S., Su, J., Su, W. C., Sund, M., Sung, J. S., Sung, S. W., Tan, W., Tang, W., Tardón, A., Thomas, D., Thompson, C. A., Tinker, L. F., Tirabosco, R., Tjønneland, A., Travis, R. C., Trichopoulos, D., Tsai, F. Y., Tsai, Y. H., Tucker, M., Turner, J., Vajdic, C. M., Vermeulen, R. C. H., Villano, D. J., Vineis, P., Virtamo, J., Visvanathan, K., Wactawski-Wende, J., Wang, C., Wang, C. L., Wang, J. C., Wang, J., Wei, F., Weiderpass, E., Weiner, G. J., Weinstein, S., Wentzensen, N., White, E., Witzig, T. E., Wolpin, B. M., Wong, M. P., Wu, C., Wu, G., Wu, J., Wu, T., Wu, W., Wu, X., Wu, Y. L., Wunder, J. S., Xiang, Y. B., Xu, J., Xu, P., Yang, P. C., Yang, T. Y., Ye, Y., Yin, Z., Yokota, J., Yoon, H. I., Yu, C. J., Yu, H., Yu, K., Yuan, J. M., Zelenetz, A., Zeleniuch-Jacquotte, A., Zhang, X. C., Zhang, Y., Zhao, X., Zhao, Z., Zheng, H., Zheng, T., Zheng, W., Zhou, B., Zhu, M., Zucca, M., Boca, S. M., Cerhan, J. R., Ferri, G. M., Hartge, P., Hsiung, C. A., Magnani, C., Miligi, L., Morton, L. M., Smedby, K. E., Teras, L. R., Vijai, J., Wang, S. S., Brennan, P., Caporaso, N. E., Hunter, D. J., Kraft, P., Rothman, N., Silverman, D. T., Slager, S. L., Chanock, S. J. & Chatterjee, N., 2016, In : Journal of the National Cancer Institute. 107, 12, djv279.

Research output: Contribution to journalArticle

Genome-Wide Association Study
Smoking
Neoplasms
Lung Neoplasms
Confidence Intervals

Candidate germline polymorphisms of genes belonging to the pathways of four drugs used in osteosarcoma standard chemotherapy associated with risk, survival and toxicity in non-metastatic high-grade osteosarcoma

Hattinger, C., Biason, P., Iacoboni, E., Gagno, S., Fanelli, M., Tavanti, E., Vella, S., Ferrari, S., Roli, A., Roncato, R., Giodini, L., Scotlandi, K., Picci, P., Toffoli, G. & Serra, M., 2016, In : Oncotarget. 7, 38, p. 61970-61987 18 p.

Research output: Contribution to journalArticle

Osteosarcoma
Drug Therapy
Survival
Pharmaceutical Preparations
Genes

Candidate germline polymorphisms of genes belonging to the pathways of four drugs used in osteosarcoma standard chemotherapy associated with risk, survival and toxicity in non-metastatic high-grade osteosarcoma

Hattinger, C., Biason, P., Iacoboni, E., Gagno, S., Fanelli, M., Tavanti, E., Vella, S., Ferrari, S., Roli, A., Roncato, R., Giodini, L., Scotlandi, K., Picci, P., Toffoli, G. & Serra, M., 2016, In : Oncotarget. 7, 38, p. 61970-61987 18 p.

Research output: Contribution to journalArticle

Osteosarcoma
Drug Therapy
Survival
Pharmaceutical Preparations
Genes

Candidate germline polymorphisms of genes belonging to the pathways of four drugs used in osteosarcoma standard chemotherapy associated with risk, survival and toxicity in non-metastatic high-grade osteosarcoma

Hattinger, C. M., Biason, P., Iacoboni, E., Gagno, S., Fanelli, M., Tavanti, E., Vella, S., Ferrari, S., Roli, A., Roncato, R., Giodini, L., Scotlandi, K., Picci, P., Toffoli, G. & Serra, M., 2016, In : Oncotarget. 7, 38, p. 61970-61987 18 p.

Research output: Contribution to journalArticle

Osteosarcoma
Drug Therapy
Survival
Pharmaceutical Preparations
Genes

H2S-Donating Doxorubicins May Overcome Cardiotoxicity and Multidrug Resistance

Chegaev, K., Rolando, B., Cortese, D., Gazzano, E., Buondonno, I., Lazzarato, L., Fanelli, M., Hattinger, C. M., Serra, M., Riganti, C., Fruttero, R., Ghigo, D. & Gasco, A., May 26 2016, In : Journal of Medicinal Chemistry. 59, 10, p. 4881-4889 9 p.

Research output: Contribution to journalArticle

Multiple Drug Resistance
Doxorubicin
Poisons
Osteosarcoma
Cardiotoxicity

Identification of genetic variants in pharmacokinetic genes associated with Ewing Sarcoma treatment outcome

Ruiz-Pinto, S., Pita, G., Patiño-García, A., García-Miguel, P., Alonso, J., Pérez-Martínez, A., Sastre, A., Gómez-Mariano, G., Lissat, A., Scotlandi, K., Serra, M., Ladenstein, R., Lapouble, E., Pierron, G., Kontny, U., Picci, P., Kovar, H., Delattre, O. & González-Neira, A., Sep 1 2016, In : Annals of Oncology. 27, 9, p. 1788-1793 6 p., mdw234.

Research output: Contribution to journalArticle

Ewing's Sarcoma
Confidence Intervals
Genetic Association Studies
Adenosine Triphosphate
Survival

Mitochondria-targeted doxorubicin: A new therapeutic strategy against doxorubicin-resistant osteosarcoma

Buondonno, I., Gazzano, E., Jean, S. R., Audrito, V., Kopecka, J., Fanelli, M., Salaroglio, I. C., Costamagna, C., Roato, I., Mungo, E., Hattinger, C. M., Deaglio, S., Kelley, S. O., Serra, M. & Riganti, C., Nov 1 2016, In : Molecular Cancer Therapeutics. 15, 11, p. 2640-2652 13 p.

Research output: Contribution to journalArticle

Osteosarcoma
Doxorubicin
Mitochondria
P-Glycoprotein
Therapeutics

Pharmacogenomics of second-line drugs used for treatment of unresponsive or relapsed osteosarcoma patients

Hattinger, C., Vella, S., Fanelli, M., Tavanti, E., Picci, P. & Serra, M., Dec 1 2016, In : Pharmacogenomics. 17, 18, p. 2097-2114 18 p.

Research output: Contribution to journalReview article

Pharmacogenetics
Osteosarcoma
Pharmaceutical Preparations
Drug Therapy
Therapeutics

Targeting ABCB1 and ABCC1 with their specific inhibitor CBT-1® can overcome drug resistance in osteosarcoma

Fanelli, M., Hattinger, C. M., Vella, S., Tavanti, E., Michelacci, F., Gudeman, B., Barnett, D., Picci, P. & Serra, M., Mar 1 2016, In : Current Cancer Drug Targets. 16, 3, p. 261-274 14 p.

Research output: Contribution to journalArticle

Osteosarcoma
Drug Resistance
tetrandrine
Pharmaceutical Preparations
docetaxel

Targeting CDKs with roscovitine increases sensitivity to DNA damaging drugs of human osteosarcoma cells

Vella, S., Tavanti, E., Hattinger, C., Fanelli, M., Versteeg, R., Koster, J., Picci, P. & Serra, M., Nov 1 2016, In : PLoS One. 11, 11, 20 p., e0166233.

Research output: Contribution to journalArticle

osteosarcoma
Osteosarcoma
Cyclin-Dependent Kinase 2
cyclin-dependent kinase
drugs
2015

Advances in emerging drugs for osteosarcoma

Hattinger, C. M., Fanelli, M., Tavanti, E., Vella, S., Ferrari, S., Picci, P. & Serra, M., Jul 3 2015, In : Expert Opinion on Emerging Drugs. 20, 3, p. 495-514 20 p.

Research output: Contribution to journalArticle

Osteosarcoma
Pharmaceutical Preparations
Therapeutics
Neoplasms
Expert Testimony

A genome-wide scan identifies variants in NFIB associated with metastasis in patients with osteosarcoma

Mirabello, L., Koster, R., Moriarity, B. S., Spector, L. G., Meltzer, P. S., Gary, J., Machiela, M. J., Pankratz, N., Panagiotou, O. A., Largaespada, D., Wang, Z., Gastier-Foster, J. M., Gorlick, R., Khanna, C., de Toledo, S. R. C., Petrilli, A. S., Patiño-Garcia, A., Sierrasesúmaga, L., Lecanda, F., Andrulis, I. L. & 32 others, Wunder, J. S., Gokgoz, N., Serra, M., Hattinger, C., Picci, P., Scotlandi, K., Flanagan, A. M., Tirabosco, R., Amary, M. F., Halai, D., Ballinger, M. L., Thomas, D. M., Davis, S., Barkauskas, D. A., Marina, N., Helman, L., Otto, G. M., Becklin, K. L., Wolf, N. K., Weg, M. T., Tucker, M., Wacholder, S., Fraumeni, J. F., Caporaso, N. E., Boland, J. F., Hicks, B. D., Vogt, A., Burdett, L., Yeager, M., Hoover, R. N., Chanock, S. J. & Savage, S. A., Sep 1 2015, In : Cancer Discovery. 5, 9, p. 920-931 12 p.

Research output: Contribution to journalArticle

Osteosarcoma
Genome
Neoplasm Metastasis
Cause of Death
Genome-Wide Association Study

An update on chemotherapy for osteosarcoma

Ferrari, S. & Serra, M., Dec 12 2015, In : Expert Opinion on Pharmacotherapy. 16, 18, p. 2727-2736 10 p.

Research output: Contribution to journalArticle

Osteosarcoma
Drug Therapy
Pharmacogenetics
Expert Testimony
Therapeutics
Osteosarcoma
DNA Repair
Drug Therapy
Survival
Proteins

Human Osteoclast-Like Cells from Giant Cell Tumors of Bone: A New Tool for Investigating Bone Resorption and Osteoclast Biology

Zallone, A. Z., Grano, M., Colucci, S., Zigrino, P., De Bellis, M., Zambonin, G. & Serra, M., Mar 14 2015, In : Calcified Tissue International. 56, 1, p. S24

Research output: Contribution to journalArticle

Pharmacogenetics
Osteosarcoma
Tumors
Enzymes
Chemotherapy
2014

An aza-macrocycle containing maltolic side-arms (maltonis) as potential drug against human pediatric sarcomas

Guerzoni, C., Amatori, S., Giorgi, L., Manara, M. C., Landuzzi, L., Lollini, P. L., Tassoni, A., Balducci, M., Manfrini, M., Pratelli, L., Serra, M., Picci, P., Magnani, M., Fusi, V., Fanelli, M. & Scotlandi, K., Feb 27 2014, In : BMC Cancer. 14, 1, 137.

Research output: Contribution to journalArticle

Sarcoma
Pediatrics
Pharmaceutical Preparations
Ewing's Sarcoma
Aptitude

Copy number alterations and neoplasia-specific mutations in MELK, PDCD1LG2, TLN1, and PAX5 at 9p in different neoplasias

Sarhadi, V. K., Lahti, L., Scheinin, I., Ellonen, P., Kettunen, E., Serra, M., Scotlandi, K., Picci, P. & Knuutila, S., 2014, In : Genes Chromosomes and Cancer. 53, 7, p. 579-588 10 p.

Research output: Contribution to journalArticle

Mutation
Sarcoma
Neoplasms
Genes
Malignant Fibrous Histiocytoma

Imputation and subset-based association analysis across different cancer types identifies multiple independent risk loci in the TERT-CLPTM1L region on chromosome 5p15.33

Wang, Z., Zhu, B., Zhang, M., Parikh, H., Jia, J., Chung, C. C., Sampson, J. N., Hoskins, J. W., Hutchinson, A., Burdette, L., Ibrahim, A., Hautman, C., Raj, P. S., Abnet, C. C., Adjei, A. A., Ahlbom, A., Albanes, D., Allen, N. E., Ambrosone, C. B., Aldrich, M. & 331 others, Amiano, P., Amos, C., Andersson, U., Gerald Andriole, G. A., Andrulis, I. L., Arici, C., Arslan, A. A., Austin, M. A., Baris, D., Barkauskas, D. A., Bassig, B. A., Freeman, L. E. B., Berg, C. D., Berndt, S. I., Bertazzi, P. A., Biritwum, R. B., Black, A., Blot, W., Boeing, H., Boffetta, P., Bolton, K., Boutron-Ruault, M. C., Bracci, P. M., Brennan, P., Brinton, L. A., Brotzman, M., Bueno-de-Mesquita, H. B., Buring, J. E., Butler, M. A., Cai, Q., Cancel-Tassin, G., Canzian, F., Cao, G., Caporaso, N. E., Carrato, A., Carreon, T., Carta, A., Chang, G. C., Chang, I. S., Chang-Claude, J., Che, X., Chen, C. J., Chen, C. Y., Chen, C. H., Chen, C., Chen, K. Y., Chen, Y. M., Chokkalingam, A. P., Chu, L. W., Clavel-Chapelon, F., Colditz, G. A., Colt, J. S., Conti, D., Cook, M. B., Cortessis, V. K., Crawford, E. D., Cussenot, O., Davis, F. G., De Vivo, I., Deng, X., Ding, T., Dinney, C. P., Di Stefano, A. L., Diver, W. R., Duell, E. J., Elena, J. W., Fan, J. H., Feigelson, H. S., Feychting, M., Figueroa, J. D., Flanagan, A. M., Fraumeni, J. F., Freedman, N. D., Fridley, B. L., Fuchs, C. S., Gago-Dominguez, M., Gallinger, S., Gao, Y. T., Gapstur, S. M., Garcia-Closas, M., Garcia-Closas, R., Gastier-Foster, J. M., Gaziano, J. M., Gerhard, D. S., Giffen, C. A., Giles, G. G., Gillanders, E. M., Giovannucci, E. L., Goggins, M., Gokgoz, N., Goldstein, A. M., Gonzalez, C., Gorlick, R., Greene, M. H., Gross, M., Grossman, H. B., Grubb, R., Gu, J., Guan, P., Haiman, C. A., Hallmans, G., Hankinson, S. E., Harris, C. C., Hartge, P., Hattinger, C., Hayes, R. B., He, Q., Helman, L., Henderson, B. E., Henriksson, R., Hoffman-Bolton, J., Hohensee, C., Holly, E. A., Hong, Y. C., Hoover, R. N., Dean Hosgood, H., Hsiao, C. F., Hsing, A. W., Hsiung, C. A., Hu, N., Hu, W., Hu, Z., Huang, M. S., Hunter, D. J., Inskip, P. D., Ito, H., Jacobs, E. J., Jacobs, K. B., Jenab, M., Ji, B. T., Johansen, C., Johansson, M., Johnson, A., Kaaks, R., Kamat, A. M., Kamineni, A., Karagas, M., Khanna, C., Khaw, K. T., Kim, C., Kim, I. S., Kim, J. H., Kim, Y. H., Kim, Y. C., Kim, Y. T., Kang, C. H., Jung, Y. J., Kitahara, C. M., Klein, A. P., Klein, R., Kogevinas, M., Koh, W. P., Kohno, T., Kolonel, L. N., Kooperberg, C., Kratz, C. P., Krogh, V., Kunitoh, H., Kurtz, R. C., Kurucu, N., Lan, Q., Lathrop, M., Lau, C. C., Lecanda, F., Lee, K. M., Lee, M. P., Marchand, L. L., Lerner, S. P., Li, D., Liao, L. M., Lim, W. Y., Lin, D., Lin, J., Lindstrom, S., Linet, M. S., Lissowska, J., Liu, J., Ljungberg, B., Lloreta, J., Lu, D., Ma, J., Malats, N., Mannisto, S., Marina, N., Mastrangelo, G., Matsuo, K., McGlynn, K. A., McKean-Cowdin, R., McNeil, L. H., McWilliams, R. R., Melin, B. S., Meltzer, P. S., Mensah, J. E., Miao, X., Michaud, D. S., Mondul, A. M., Moore, L. E., Muir, K., Niwa, S., Olson, S. H., Orr, N., Panico, S., Park, J. Y., Patel, A. V., Patino-Garcia, A., Pavanello, S., Peeters, P. H. M., Peplonska, B., Peters, U., Petersen, G. M., Picci, P., Pike, M. C., Porru, S., Prescott, J., Pu, X., Purdue, M. P., Qiao, Y. L., Rajaraman, P., Riboli, E., Risch, H. A., Rodabough, R. J., Rothman, N., Ruder, A. M., Ryu, J. S., Sanson, M., Schned, A., Schumacher, F. R., Schwartz, A. G., Schwartz, K. L., Schwenn, M., Scotlandi, K., Seow, A., Serra, C., Serra, M., Sesso, H. D., Severi, G., Shen, H., Shen, M., Shete, S., Shiraishi, K., Shu, X. O., Siddiq, A., Sierrasesumaga, L., Sierri, S., Sihoe, A. D. L., Silverman, D. T., Simon, M., Southey, M. C., Spector, L., Spitz, M., Stampfer, M., Stattin, P., Stern, M. C., Stevens, V. L., Stolzenberg-Solomon, R. Z., Stram, D. O., Strom, S. S., Su, W. C., Sund, M., Sung, S. W., Swerdlow, A., Tan, W., Tanaka, H., Tang, W., Tang, Z. Z., Tardon, A., Tay, E., Taylor, P. R., Tettey, Y., Thomas, D. M., Tirabosco, R., Tjonneland, A., Tobias, G. S., Toro, J. R., Travis, R. C., Trichopoulos, D., Troisi, R., Truelove, A., Tsai, Y. H., Tucker, M. A., Tumino, R., Van Den Berg, D., Van Den Eeden, S. K., Vermeulen, R., Vineis, P., Visvanathan, K., Vogel, U., Wang, C., Wang, C., Wang, J., Wang, S. S., Weiderpass, E., Weinstein, S. J., Wentzensen, N., Wheeler, W., White, E., Wiencke, J. K., Wolk, A., Wolpin, B. M., Wong, M. P., Wrensch, M., Wu, C., Wu, T., Wu, X., Wu, Y. L., Wunder, J. S., Xiang, Y. B., Xu, J., Yang, H. P., Yang, P. C., Yatabe, Y., Ye, Y., Yeboah, E. D., Yin, Z., Ying, C., Yu, C. J., Yu, K., Yuan, J. M., Zanetti, K. A., Zeleniuch-Jacquotte, A., Zheng, W., Zhou, B., Mirabello, L., Savage, S. A., Kraft, P., Chanock, S. J., Yeager, M., Landi, M. T., Shi, J., Chatterjee, N. & Amundadottir, L. T., Nov 15 2014, In : Human Molecular Genetics. 23, 24, p. 6616-6633 18 p.

Research output: Contribution to journalArticle

Chromosomes
Alleles
Neoplasms
Genome-Wide Association Study
Telomerase

Kinome and mRNA expression profiling of high-grade osteosarcoma cell lines implies Akt signaling as possible target for therapy

Kuijjer, M. L., Van Den Akker, B. E. W. M., Hilhorst, R., Mommersteeg, M., Buddingh, E. P., Serra, M., Bürger, H., Hogendoorn, P. C. W. & Cleton-Jansen, A. M., Jan 21 2014, In : BMC Medical Genomics. 7, 1, 4.

Research output: Contribution to journalArticle

Osteosarcoma
Cell Line
Messenger RNA
Genomic Instability
Neoplasms

Molecular profiling of chordoma

Scheil-Bertram, S., Kappler, R., Von Baer, A., Hartwig, E., Sarkar, M., Serra, M., Brüderlein, S., Westhoff, B., Melzner, I., Bassaly, B., Herms, J., Hugo, H. H., Schulte, M. & Möller, P., Apr 2014, In : International Journal of Oncology. 44, 4, p. 1041-1055 15 p.

Research output: Contribution to journalArticle

Chordoma
Cell Line
Chondrosarcoma
Oligonucleotide Array Sequence Analysis
Gene Expression

Targeting polo-like kinase 1 by NMS-P937 in osteosarcoma cell lines inhibits tumor cell growth and partially overcomes drug resistance

Sero, V., Tavanti, E., Vella, S., Hattinger, C. M., Fanelli, M., Michelacci, F., Versteeg, R., Valsasina, B., Gudeman, B., Picci, P. & Serra, M., Dec 1 2014, In : Investigational New Drugs. 32, 6, p. 1167-1180 14 p.

Research output: Contribution to journalArticle

Osteosarcoma
Tumor Cell Line
Drug Resistance
Growth
Cell Line

The fine-tuning of TRAF2-GSTP1-1 interaction: effect of ligand binding and in situ detection of the complex.

De Luca, A., Mei, G., Rosato, N., Nicolai, E., Federici, L., Palumbo, C., Pastore, A., Serra, M. & Caccuri, A. M., 2014, In : Cell Death and Disease. 5

Research output: Contribution to journalArticle

TNF Receptor-Associated Factor 2
Ligands
G2 Phase
Cell Division
Catalytic Domain
2013

Genome-wide association study identifies two susceptibility loci for osteosarcoma

Savage, S. A., Mirabello, L., Wang, Z., Gastier-Foster, J. M., Gorlick, R., Khanna, C., Flanagan, A. M., Tirabosco, R., Andrulis, I. L., Wunder, J. S., Gokgoz, N., Patiño-Garcia, A., Sierrasesúmaga, L., Lecanda, F., Kurucu, N., Ilhan, I. E., Sari, N., Serra, M., Hattinger, C., Picci, P. & 30 others, Spector, L. G., Barkauskas, D. A., Marina, N., De Toledo, S. R. C., Petrilli, A. S., Amary, M. F., Halai, D., Thomas, D. M., Douglass, C., Meltzer, P. S., Jacobs, K., Chung, C. C., Berndt, S. I., Purdue, M. P., Caporaso, N. E., Tucker, M., Rothman, N., Landi, M. T., Silverman, D. T., Kraft, P., Hunter, D. J., Malats, N., Kogevinas, M., Wacholder, S., Troisi, R., Helman, L., Fraumeni, J. F., Yeager, M., Hoover, R. N. & Chanock, S. J., Jul 2013, In : Nature Genetics. 45, 7, p. 799-803 5 p.

Research output: Contribution to journalArticle

Genome-Wide Association Study
Osteosarcoma
Genes
Young Adult
Neoplasms

IR/IGF1R signaling as potential target for treatment of high-grade osteosarcoma

Kuijjer, M. L., Peterse, E. F. P., van den Akker, B. E. W. M., Briaire-de Bruijn, I. H., Serra, M., Meza-Zepeda, L. A., Myklebost, O., Hassan, A. B., Hogendoorn, P. C. W. & Cleton-Jansen, A. M., May 20 2013, In : BMC Cancer. 13, 245.

Research output: Contribution to journalArticle

Osteosarcoma
Cell Line
Therapeutics
Somatomedin Receptors
Bone and Bones

Preclinical validation of Aurora kinases-targeting drugs in osteosarcoma

Tavanti, E., Sero, V., Vella, S., Fanelli, M., Michelacci, F., Landuzzi, L., Magagnoli, G., Versteeg, R., Picci, P., Hattinger, C. M. & Serra, M., Nov 12 2013, In : British Journal of Cancer. 109, 10, p. 2607-2618 12 p.

Research output: Contribution to journalArticle

Aurora Kinases
Osteosarcoma
Drug Delivery Systems
Pharmaceutical Preparations
Cell Line
2012

Anti-EGFR antibody cetuximab enhances the cytolytic activity of natural killer cells toward osteosarcoma

Pahl, J. H. W., Ruslan, S. E. N., Buddingh, E. P., Santos, S. J., Szuhai, K., Serra, M., Gelderblom, H., Hogendoorn, P. C. W., Egeler, R. M., Schilham, M. W. & Lankester, A. C., Jan 15 2012, In : Clinical Cancer Research. 18, 2, p. 432-441 10 p.

Research output: Contribution to journalArticle

Osteosarcoma
Epidermal Growth Factor Receptor
Natural Killer Cells
Antibodies
Ewing's Sarcoma

Integrative Analysis Reveals Relationships of Genetic and Epigenetic Alterations in Osteosarcoma

Kresse, S. H., Rydbeck, H., Skårn, M., Namløs, H. M., Barragan-Polania, A. H., Cleton-Jansen, A. M., Serra, M., Liestøl, K., Hogendoorn, P. C. W., Hovig, E., Myklebost, O. & Meza-Zepeda, L. A., Nov 7 2012, In : PLoS One. 7, 11, e48262.

Research output: Contribution to journalArticle

osteosarcoma
Osteosarcoma
Epigenomics
epigenetics
genetic relationships

miR-34a predicts survival of Ewing's sarcoma patients and directly influences cell chemo-sensitivity and malignancy

Nakatani, F., Ferracin, M., Manara, M. C., Ventura, S., Del Monaco, V., Ferrari, S., Alberghini, M., Grilli, A., Knuutila, S., Schaefer, K. L., Mattia, G., Negrini, M., Picci, P., Serra, M. & Scotlandi, K., Apr 2012, In : Journal of Pathology. 226, 5, p. 796-805 10 p.

Research output: Contribution to journalArticle

Ewing's Sarcoma
MicroRNAs
Survival
Neoplasms
Doxorubicin

Modulation of the Osteosarcoma Expression Phenotype by MicroRNAs

Namløs, H. M., Meza-Zepeda, L. A., Barøy, T., Østensen, I. H. G., Kresse, S. H., Kuijjer, M. L., Serra, M., Bürger, H., Cleton-Jansen, A. M. & Myklebost, O., Oct 25 2012, In : PLoS One. 7, 10, e48086.

Research output: Contribution to journalArticle

osteosarcoma
Osteosarcoma
MicroRNAs
microRNA
Modulation

Nucleotide excision repair gene variants and association with survival in osteosarcoma patients treated with neoadjuvant chemotherapy

Biason, P., Hattinger, C. M., Innocenti, F., Talamini, R., Alberghini, M., Scotlandi, K., Zanusso, C., Serra, M. & Toffoli, G., Dec 2012, In : Pharmacogenomics Journal. 12, 6, p. 476-483 8 p.

Research output: Contribution to journalArticle

Osteosarcoma
DNA Repair
Drug Therapy
Survival
Genes

Targeting GSTP1-1 induces JNK activation and leads to apoptosis in cisplatin-sensitive and -resistant human osteosarcoma cell lines

Sau, A., Filomeni, G., Pezzola, S., D'Aguanno, S., Tregno, F. P., Urbani, A., Serra, M., Pasello, M., Picci, P., Federici, G. & Caccuri, A. M., Mar 2012, In : Molecular BioSystems. 8, 4, p. 994-1006 13 p.

Research output: Contribution to journalArticle

TNF Receptor-Associated Factor 2
Hexanols
Osteosarcoma
Tumor Necrosis Factor Receptor-Associated Peptides and Proteins
Cisplatin
2011

Array comparative genomic hybridization reveals frequent alterations of G1/S checkpoint genes in undifferentiated pleomorphic sarcoma of bone

Niini, T., Lahti, L., Michelacci, F., Ninomiya, S., Hattinger, C. M., Guled, M., Böhling, T., Picci, P., Serra, M. & Knuutila, S., May 2011, In : Genes Chromosomes and Cancer. 50, 5, p. 291-306 16 p.

Research output: Contribution to journalArticle

Comparative Genomic Hybridization
Sarcoma
Fibrosarcoma
Bone and Bones
Genes

Chemotherapy-resistant osteosarcoma is highly susceptible to IL-15-activated allogeneic and autologous NK cells

Buddingh, E. P., Schilham, M. W., Ruslan, S. E. N., Berghuis, D., Szuhai, K., Suurmond, J., Taminiau, A. H. M., Gelderblom, H., Egeler, R. M., Serra, M., Hogendoorn, P. C. W. & Lankester, A. C., Apr 2011, In : Cancer Immunology, Immunotherapy. 60, 4, p. 575-586 12 p.

Research output: Contribution to journalArticle

Interleukin-15
Osteosarcoma
Natural Killer Cells
Drug Therapy
Natural Killer Cell Receptors

Clinicopathological significance of cell cycle regulation markers in a large series of genetically confirmed Ewing's Sarcoma Family of Tumors

Lõpez-Guerrero, J. A., MacHado, I., Scotlandi, K., Noguera, R., Pellín, A., Navarro, S., Serra, M., Calabuig-Fariñas, S., Picci, P. & Llombart-Bosch, A., Mar 1 2011, In : International Journal of Cancer. 128, 5, p. 1139-1150 12 p.

Research output: Contribution to journalArticle

Ewing's Sarcoma
Cell Cycle
Disease-Free Survival
Survival
Neoplasms