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Research Output 2004 2020

  • 76 Article
  • 8 Review article
  • 2 Conference contribution
  • 1 Chapter
2020

Organs-on-a-chip as model systems for multifactorial musculoskeletal diseases

Arrigoni, C., Lopa, S., Candrian, C. & Moretti, M., Jan 2020, In : Current Opinion in Biotechnology. 63, p. 79-88 10 p.

Research output: Contribution to journalReview article

Musculoskeletal Diseases
Tissue
Bone and Bones
Neuromuscular Diseases
Bone
2019

Achilles tendon repair by decellularized and engineered xenografts in a rabbit model

Bottagisio, M., D'Arrigo, D., Talò, G., Bongio, M., Ferroni, M., Boschetti, F., Moretti, M. & Lovati, A. B., 2019, In : Stem Cells International. 2019, 5267479.

Research output: Contribution to journalArticle

Open Access
Achilles Tendon
Heterografts
Rabbits
Tendons
Transplants

Bone Marrow-Derived Cell Therapies to Heal Long-Bone Nonunions: A Systematic Review and Meta-Analysis-Which Is the Best Available Treatment?

Palombella, S., Lopa, S., Gianola, S., Zagra, L., Moretti, M. & Lovati, A. B., 2019, In : Stem Cells International. 2019, 3715964.

Research output: Contribution to journalReview article

Cell- and Tissue-Based Therapy
Bone Marrow Cells
Meta-Analysis
Bone Marrow
Bone and Bones
Knee Osteoarthritis
Mesenchymal Stromal Cells
Osteoarthritis
Therapeutic Uses
Therapeutics

Secretome and Extracellular Vesicles as New Biological Therapies for Knee Osteoarthritis: A Systematic Review

D'Arrigo, D., Roffi, A., Cucchiarini, M., Moretti, M., Candrian, C. & Filardo, G., Nov 4 2019, In : Journal of Clinical Medicine. 8, 11, p. 1-16 16 p.

Research output: Contribution to journalReview article

Biological Therapy
Knee Osteoarthritis
Mesenchymal Stromal Cells
PubMed
Osteoarthritis

Secretome and Extracellular Vesicles as New Biological Therapies for Knee Osteoarthritis: A Systematic Review

D'Arrigo, D., Roffi, A., Cucchiarini, M., Moretti, M., Candrian, C. & Filardo, G., Nov 1 2019, In : Journal of Clinical Medicine. 8, 11

Research output: Contribution to journalArticle

Biological Therapy
Knee Osteoarthritis
Mesenchymal Stromal Cells
PubMed
Osteoarthritis
2018

A combined microfluidic-transcriptomic approach to characterize the extravasation potential of cancer cells

Bersini, S., Miermont, A., Pavesi, A., Kamm, R. D., Thiery, J. P., Moretti, M. & Adriani, G., Nov 1 2018, In : Oncotarget. 9, 90, p. 36110-36125 16 p.

Research output: Contribution to journalArticle

Microfluidics
Neoplasms
Circulating Neoplastic Cells
Endothelium
Metalloproteases

Evaluation of benzodiazepines and zolpidem in nails and their stability after prolonged exposure to chlorinated water

Moretti, M., Andrello, L., Visonà, S., Vignali, C., Groppi, A., Freni, F., Osculati, A., Tajana, L. & Morini, L., Apr 15 2018, In : Journal of Pharmaceutical and Biomedical Analysis. 152, p. 137-142 6 p.

Research output: Contribution to journalArticle

Nails
Benzodiazepines
Diazepam
Bromazepam
Water

Industrialization of a perfusion bioreactor: Prime example of a non-straightforward process

Talò, G., Turrisi, C., Arrigoni, C., Recordati, C., Gerges, I., Tamplenizza, M., Cappelluti, A., Riboldi, S. A. & Moretti, M., Feb 2018, In : Journal of Tissue Engineering and Regenerative Medicine. 12, 2, p. 405-415

Research output: Contribution to journalArticle

Bioreactors
Perfusion
Tissue Engineering
Tissue engineering
Intellectual Property

Silk/fibroin microcarriers for mesenchymal stem cell delivery: Optimization of cell seeding by the design of experiment

Orfei, C. P., Talò, G., Viganò, M., Perteghella, S., Lugano, G., Fontana, F. F., Ragni, E., Colombini, A., De Luca, P., Moretti, M., Torre, M. L. & de Girolamo, L., Dec 1 2018, In : Pharmaceutics. 10, 4, 200.

Research output: Contribution to journalArticle

Fibroins
Silk
Mesenchymal Stromal Cells
Bioreactors
Cell Size

Silk/Fibroin Microcarriers for Mesenchymal Stem Cell Delivery: Optimization of Cell Seeding by the Design of Experiment

Perucca Orfei, C., Talò, G., Viganò, M., Perteghella, S., Lugano, G., Fabro Fontana, F., Ragni, E., Colombini, A., De Luca, P., Moretti, M., Torre, M. L. & de Girolamo, L., Oct 24 2018, In : Pharmaceutics. 10, 4

Research output: Contribution to journalArticle

Fibroins
Silk
Mesenchymal Stromal Cells
Bioreactors
Cell Size

Subcapsular renal hematoma after retrograde ureterorenoscopic lithotripsy: Our experience

Campobasso, D., Grande, M., Ferretti, S., Moretti, M., Hini, F. F., Larosa, M., Salsi, P., Granelli, P., Pozzoli, G. L. & Frattini, A., Dec 1 2018, In : Minerva Urologica e Nefrologica. 70, 6, p. 617-623 7 p.

Research output: Contribution to journalArticle

Lithotripsy
Hematoma
Kidney
Ureteroscopy
Flank Pain

Tackling muscle fibrosis: From molecular mechanisms to next generation engineered models to predict drug delivery

Bersini, S., Gilardi, M., Mora, M., Krol, S., Arrigoni, C., Candrian, C., Zanotti, S. & Moretti, M., Apr 1 2018, In : Advanced Drug Delivery Reviews. 129, p. 64-77 14 p.

Research output: Contribution to journalReview article

Fibrosis
Muscles
Pharmaceutical Preparations
Muscular Dystrophies
Intercellular Signaling Peptides and Proteins

The role of MSCs for nonsurgical treatment of OA

Lopa, S., Moretti, M. & de Girolamo, L., Jun 12 2018, Cartilage Restoration: Practical Clinical Applications: Second Edition. p. 165-175 11 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Translational application of microfluidics and bioprinting for stem cell-based cartilage repair

Lopa, S., Mondadori, C., Mainardi, V. L., Talò, G., Costantini, M., Candrian, C., Swieszkowski, W. & Moretti, M., Jan 1 2018, In : Stem Cells International. 2018, 6594841.

Research output: Contribution to journalReview article

Bioprinting
Microfluidics
Cartilage
Stem Cells
Cell- and Tissue-Based Therapy
2017

Advanced glycation end-products: Mechanics of aged collagen from molecule to tissue

Gautieri, A., Passini, F. S., Silván, U., Guizar-Sicairos, M., Carimati, G., Volpi, P., Moretti, M., Schoenhuber, H., Redaelli, A., Berli, M. & Snedeker, J. G., May 2017, In : Matrix Biology. p. 95-108 14 p.

Research output: Contribution to journalArticle

Advanced Glycosylation End Products
Mechanics
Collagen
Benchmarking
Ribose

Bioprinting and Organ-on-Chip Applications Towards Personalized Medicine for Bone Diseases

Arrigoni, C., Gilardi, M., Bersini, S., Candrian, C. & Moretti, M., Jun 1 2017, In : Stem Cell Reviews and Reports. 13, 3, p. 407-417 11 p.

Research output: Contribution to journalArticle

Bioprinting
Precision Medicine
Bone Diseases
Bone and Bones
Transplants

Catch-and-Release of Target Cells Using Aptamer-Conjugated Electroactive Zwitterionic Oligopeptide SAM

Enomoto, J., Kageyama, T., Osaki, T., Bonalumi, F., Marchese, F., Gautieri, A., Bianchi, E., Dubini, G., Arrigoni, C., Moretti, M. & Fukuda, J., Mar 7 2017, In : Scientific Reports. 7, 43375.

Research output: Contribution to journalArticle

Oligopeptides
Self assembled monolayers
Cells
Molecular recognition
Fibroblasts

Death after 25C-NBOMe and 25H-NBOMe consumption

Morini, L., Bernini, M., Vezzoli, S., Restori, M., Moretti, M., Crenna, S., Papa, P., Locatelli, C., Osculati, A. M. M., Vignali, C. & Groppi, A., Oct 1 2017, In : Forensic Science International. 279, p. e1-e6

Research output: Contribution to journalArticle

Urine
2-(4-chloro-2,5-dimethoxyphenyl)-N-((2-methoxyphenyl)methyl)ethanamine
Dronabinol
Poisons
Hallucinations

Death after 25C-NBOMe and 25H-NBOMe consumption

Morini, L., Bernini, M., Vezzoli, S., Restori, M., Moretti, M., Crenna, S., Papa, P., Locatelli, C., Osculati, A. M. M., Vignali, C. & Groppi, A., Oct 2017, In : Forensic Science International. 279, p. e1-e6 6 p.

Research output: Contribution to journalArticle

Urine
2-(4-chloro-2,5-dimethoxyphenyl)-N-((2-methoxyphenyl)methyl)ethanamine
Dronabinol
Poisons
Hallucinations

Different combinations of growth factors for the tenogenic differentiation of bone marrow mesenchymal stem cells in monolayer culture and in fibrin-based three-dimensional constructs

Bottagisio, M., Lopa, S., Granata, V., Talò, G., Bazzocchi, C., Moretti, M. & Barbara Lovati, A., May 1 2017, In : Differentiation. 95, p. 44-53 10 p.

Research output: Contribution to journalArticle

Growth Differentiation Factors
Fibrin
Mesenchymal Stromal Cells
Bone Marrow
Tendons

Generating Multicompartmental 3D Biological Constructs Interfaced through Sequential Injections in Microfluidic Devices

Ugolini, G. S., Visone, R., Redaelli, A., Moretti, M. & Rasponi, M., May 24 2017, In : Advanced healthcare materials. 6, 10, 1601170.

Research output: Contribution to journalArticle

Lab-On-A-Chip Devices
Hydrogels
Microfluidics
Molding
Biological Models

Herringbone-like hydrodynamic structures in microchannels: A CFD model to evaluate the enhancement of surface binding

Bianchi, E., Piergiovanni, M., Arrigoni, C., Fukuda, J., Gautieri, A., Moretti, M. & Dubini, G., Oct 1 2017, In : Medical Engineering and Physics. 48, p. 62-67 6 p.

Research output: Contribution to journalArticle

Hydrodynamics
Microchannels
Adsorption
Dynamic models
Computational fluid dynamics

Multicenter evaluation of an enzymatic method for glycated albumin

Paleari, R., Bonetti, G., Callà, C., Carta, M., Ceriotti, F., Di Gaetano, N., Ferri, M., Guerra, E., Lavalle, G., Cascio, C. L., Martino, F. G., Montagnana, M., Moretti, M., Santini, G., Scribano, D., Testa, R., Vero, A. & Mosca, A., 2017, In : Clinica Chimica Acta. 469, p. 81-86 6 p.

Research output: Contribution to journalArticle

Tissue engineering approaches to develop decellularized tendon matrices functionalized with progenitor cells cultured under undifferentiated and tenogenic conditions

D'Arrigo, D., Bottagisio, M., Lopa, S., Moretti, M. & Lovati, A. B., 2017, In : AIMS BIOENGINEERING. 4, 4, p. 431-445 15 p.

Research output: Contribution to journalArticle

Tissue Engineering
Tendons
Stem Cells
Mesenchymal Stromal Cells
Transplants
2016

A 3D vascularized bone remodeling model combining osteoblasts and osteoclasts in a CaP nanoparticle-enriched matrix

Bongio, M., Lopa, S., Gilardi, M., Bersini, S. & Moretti, M., May 1 2016, In : Nanomedicine. 11, 9, p. 1073-1091 19 p.

Research output: Contribution to journalArticle

Bone Remodeling
Osteoblasts
Osteoclasts
Mesenchymal Stromal Cells
Nanoparticles

Advanced glycation end-products: Mechanics of aged collagen from molecule to tissue

Gautieri, A., Passini, F. S., Silván, U., Guizar-Sicairos, M., Carimati, G., Volpi, P., Moretti, M., Schoenhuber, H., Redaelli, A., Berli, M. & Snedeker, J. G., 2016, In : Matrix Biology.

Research output: Contribution to journalArticle

A new strategy for the decellularisation of large equine tendons as biocompatible tendon substitutes

Bottagisio, M., Pellegata, A. F., Boschetti, F., Ferroni, M., Moretti, M. & Lovati, A. B., Jul 1 2016, In : European Cells and Materials. 32, p. 58-73 16 p.

Research output: Contribution to journalArticle

Tendons
Horses
Peracetic Acid
Scaffolds
Fibroblasts

Bioprinting 3D microfibrous scaffolds for engineering endothelialized myocardium and heart-on-a-chip

Zhang, Y. S., Arneri, A., Bersini, S., Shin, S. R., Zhu, K., Goli-Malekabadi, Z., Aleman, J., Colosi, C., Busignani, F., Dell'Erba, V., Bishop, C., Shupe, T., Demarchi, D., Moretti, M., Rasponi, M., Dokmeci, M. R., Atala, A. & Khademhosseini, A., Dec 1 2016, In : Biomaterials. 110, p. 45-59 15 p.

Research output: Contribution to journalArticle

Bioprinting
Hydrogel
Endothelial cells
Blood vessels
Bioreactors

Cardiac meets skeletal: What's new in microfluidic models for muscle tissue engineering

Visone, R., Gilardi, M., Marsano, A., Rasponi, M., Bersini, S. & Moretti, M., Sep 1 2016, In : Molecules. 21, 9, 1128.

Research output: Contribution to journalReview article

Tissue engineering
Microfluidics
Muscle
Tissue
Microfabrication

Cell-microenvironment interactions and architectures in microvascular systems

Bersini, S., Yazdi, I. K., Talo', G., Shin, S. R., Moretti, M. & Khademhosseini, A., Nov 1 2016, In : Biotechnology Advances. 34, 6, p. 1113-1130 18 p.

Research output: Contribution to journalReview article

Cellular Microenvironment
Cell Communication
Microtechnology
Tissue
Microvessels

Chondrogenic capability of osteoarthritic chondrocytes from the trapeziometacarpal and hip joints

Lovati, A. B., Colombini, A., Recordati, C., Ceriani, C., Zagra, L., Berzero, G. & Moretti, M., Mar 1 2016, In : Cell and Tissue Banking. 17, 1, p. 171-177 7 p.

Research output: Contribution to journalArticle

Hip Joint
Cartilage
Chondrocytes
Thigh
Glycosaminoglycans

Creep-resistant dextran-based polyurethane foam as a candidate scaffold for bone tissue engineering: Synthesis, chemico-physical characterization, and in vitro and in vivo biocompatibility

Gerges, I., Tamplenizza, M., Lopa, S., Recordati, C., Martello, F., Tocchio, A., Ricotti, L., Arrigoni, C., Milani, P., Moretti, M. & Lenardi, C., Sep 21 2016, In : International Journal of Polymeric Materials. 65, 14, p. 729-740 12 p.

Research output: Contribution to journalArticle

Dextran
Scaffolds (biology)
Dextrans
Biocompatibility
Tissue engineering

Decellularized and Engineered Tendons as Biological Substitutes: A Critical Review

Lovati, A. B., Bottagisio, M. & Moretti, M., 2016, In : Stem Cells International. 2016, 7276150.

Research output: Contribution to journalArticle

Tendons
Rupture
Animal Models
Achilles Tendon
Mesenchymal Stromal Cells

Engineered miniaturized models of musculoskeletal diseases

Bersini, S., Arrigoni, C., Lopa, S., Bongio, M., Martin, I. & Moretti, M., 2016, (Accepted/In press) In : Drug Discovery Today.

Research output: Contribution to journalArticle

Musculoskeletal Diseases
Musculoskeletal System
Human Body
Skeletal Muscle
Animal Models

Gelatin hydrogels via thiol-ene chemistry

Russo, L., Sgambato, A., Visone, R., Occhetta, P., Moretti, M., Rasponi, M., Nicotra, F. & Cipolla, L., Mar 1 2016, In : Monatshefte fur Chemie. 147, 3, p. 587-592 6 p.

Research output: Contribution to journalArticle

Hydrogels
Gelatin
Sulfhydryl Compounds
Hydrogel
Assays

Human in vitro 3D co-culture model to engineer vascularized bone-mimicking tissues combining computational tools and statistical experimental approach

Bersini, S., Gilardi, M., Arrigoni, C., Talò, G., Zamai, M., Zagra, L., Caiolfa, V. & Moretti, M. G., 2016, In : Biomaterials. 76, p. 157-172 16 p.

Research output: Contribution to journalArticle

Coculture Techniques
Bone
Tissue
Engineers
Bone and Bones

Human in vitro 3D co-culture model to engineer vascularized bone-mimicking tissues combining computational tools and statistical experimental approach

Bersini, S., Gilardi, M., Arrigoni, C., Talò, G., Zamai, M., Zagra, L., Caiolfa, V. & Moretti, M., 2016, In : Biomaterials. 76, p. 157-172 16 p.

Research output: Contribution to journalArticle

Coculture Techniques
Bone
Tissue
Engineers
Bone and Bones

Interstitial perfusion culture with specific soluble factors inhibits type i collagen production from human osteoarthritic chondrocytes in clinical-grade collagen sponges

Mayer, N., Lopa, S., Talo', G., Lovati, A. B., Pasdeloup, M., Riboldi, S. A., Moretti, M. & Mallein-Gerin, F., Sep 1 2016, In : PLoS One. 11, 9, e0161479.

Research output: Contribution to journalArticle

chondrocytes
Porifera
Chondrocytes
Bioreactors
Cartilage

In vitro co-culture models of breast cancer metastatic progression towards bone

Arrigoni, C., Bersini, S., Gilardi, M. & Moretti, M., Sep 1 2016, In : International Journal of Molecular Sciences. 17, 9, 1405.

Research output: Contribution to journalReview article

Coculture Techniques
progressions
breast
bones
Bone

In Vivo Bone Formation Within Engineered Hydroxyapatite Scaffolds in a Sheep Model

Lovati, A. B., Lopa, S., Recordati, C., Talo', G., Turrisi, C., Bottagisio, M., Losa, M., Scanziani, E. & Moretti, M., Apr 13 2016, (Accepted/In press) In : Calcified Tissue International. p. 1-15 15 p.

Research output: Contribution to journalArticle

Durapatite
Osteogenesis
Sheep
Bone and Bones
Osseointegration

PO-12 - The key role of talin-1 in cancer cell extravasation dissected through human vascularized 3D microfluidic model

Gilardi, M., Bersini, S., Calleja, A. B., Kamm, R. D., Vanoni, M. & Moretti, M., Apr 2016, In : Thrombosis Research. 140 Suppl 1, p. S180-1

Research output: Contribution to journalArticle

Talin
Microfluidics
Endothelium
Lab-On-A-Chip Devices
Neoplasms

Rational Design of Prevascularized Large 3D Tissue Constructs Using Computational Simulations and Biofabrication of Geometrically Controlled Microvessels

Arrigoni, C., Bongio, M., Talo', G., Bersini, S., Enomoto, J., Fukuda, J. & Moretti, M., Jul 6 2016, In : Advanced healthcare materials. 5, 13, p. 1617-1626 10 p.

Research output: Contribution to journalArticle

Hydrogels
Microvessels
Tissue
Cell culture
Blood Vessels

Stability of housekeeping genes in human intervertebral disc, endplate and articular cartilage cells in multiple conditions for reliable transcriptional analysis

Lopa, S., Ceriani, C., Cecchinato, R., Zagra, L., Moretti, M. & Colombini, A., Jan 1 2016, In : European Cells and Materials. 31, p. 395-406 12 p.

Research output: Contribution to journalArticle

Intervertebral Disc
Essential Genes
Cartilage
Articular Cartilage
Genes

The effect of polyurethane scaffold surface treatments on the adhesion of chondrocytes subjected to interstitial perfusion culture

Raimondi, M. T., Bertoldi, S., Caddeo, S., Farè, S., Arrigoni, C. & Moretti, M., Aug 1 2016, In : Tissue Engineering and Regenerative Medicine. 13, 4, p. 364-374 11 p.

Research output: Contribution to journalArticle

Polyurethanes
Chondrocytes
Scaffolds
Surface treatment
Adhesion
2015
Microfluidics
Microvessels
Tumors
Neoplasms
Blood

Arthritic and non-arthritic synovial fluids modulate IL10 and IL1RA gene expression in differentially activated primary human monocytes

Lopa, S., Leijs, M. J. C., Moretti, M., Lubberts, E., van Osch, G. J. V. M. & Bastiaansen-Jenniskens, Y. M., Nov 1 2015, In : Osteoarthritis and Cartilage. 23, 11, p. 1853-1857 5 p.

Research output: Contribution to journalArticle

Synovial Fluid
Gene expression
Interleukin-10
Arthritis
Monocytes

Cartilage graft engineering by co-culturing primary human articular chondrocytes with human bone marrow stromal cells

Sabatino, M. A., Santoro, R., Gueven, S., Jaquiery, C., Wendt, D. J., Martin, I., Moretti, M. & Barbero, A., Dec 1 2015, In : Journal of Tissue Engineering and Regenerative Medicine. 9, 12, p. 1394-1403 10 p.

Research output: Contribution to journalArticle

Cartilage
Chondrocytes
Mesenchymal Stromal Cells
Grafts
Scaffolds

Fabrication of multi-well chips for spheroid cultures and implantable constructs through rapid prototyping techniques

Lopa, S., Piraino, F., Kemp, R. J., Di Caro, C., Lovati, A. B., Di Giancamillo, A., Moroni, L., Peretti, G. M., Rasponi, M. & Moretti, M., Jul 1 2015, In : Biotechnology and Bioengineering. 112, 7, p. 1457-1471 15 p.

Research output: Contribution to journalArticle

Rapid prototyping
Chondrocytes
Glycosaminoglycans
Fibrin
Fabrication